Pharmacology
The medicine helps relax the smooth muscles of internal organs. After taking it, there is an improvement in the tone of the walls of blood vessels, they become less distensible, as a result of which blood stagnation disappears, the likelihood of edema decreases, and the severity of inflammatory processes decreases.
Capsules for oral administration are easily excreted from the stomach. The maximum concentration of the active element occurs 3-7 hours after administration. The second peak occurs approximately 28 hours later. The drug leaves the body completely within a day. Most of it is excreted by the liver, and a small part is excreted by the kidneys.
When the gel is applied locally, the constituent elements do not leak into the blood, but they still penetrate into the tissue adjacent to the skin.
Mechanism of action of Troskerutin gel
Troxerutin is available in the form of a gel for external application and capsules for oral administration. The combination of these two medicinal forms of the drug mutually enhances the positive therapeutic effects of each other. The active substance of the gel is troxerutin, which is a flavonoid of the plant substance rutin. 1 gram of the drug contains 20 mg of the active ingredient. The therapeutic effect of the drug is due to its active component, which contributes to the following positive therapeutic effects:
- Anti-inflammatory
- prevents and eliminates the development of inflammation in the area of veins and soft tissues. - Decongestant
- prevents tissue swelling. - Toning
- helps increase the tone of veins, increases their elasticity, normalizes permeability. As a result, blood flow to the heart area is normalized, which prevents the development of congestion in the lower extremities. - Angioprotective
- helps strengthen the vascular wall, prevents the effects of negative factors. As a result, the vessel is able to withstand even intense loads while continuing to function normally. - Antioxidant
- eliminates free radicals that can damage the walls of blood vessels, increasing their permeability.
It is necessary to know exactly what troxerutin ointment helps with before starting treatment. It is recommended to consult a doctor first. The use of the gel helps to provide a positive therapeutic effect on capillaries: it reduces their permeability and fragility, strengthens the walls, eliminates inflammatory reactions, prevents platelets from sticking to the walls, and normalizes microcirculation.
In what cases is it used
Taking the drug is advisable in the following cases:
- varicose veins (including when carrying a child);
- chronic venous insufficiency;
- haemorrhoids;
- tissue swelling;
- influenza, measles, scarlet fever;
- vascular effects resulting from radiation exposure;
- high permeability of capillary walls.
After surgery on the veins, it can be taken for preventive purposes.
The danger of varicose veins
As a rule, thrombophlebitis and other dangerous consequences of varicose veins occur at the 3rd stage of venous insufficiency. Symptoms of late stages of vascular insufficiency:
- constant heaviness in the legs;
- swelling;
- darkening of the skin in the ankle area.
Poor circulation in the extremities is caused by dermatitis, eczema, and skin inflammation. Telangiectasia is the least dangerous consequence of venous insufficiency. The condition is characterized by the appearance of vascular “networks” and “stars”, which are accompanied by swelling, fatigue of the legs, regular occurrence of a feeling of numbness and night cramps in the calves. An aesthetic defect is one of the reasons why women often turn to phlebologists in the early stages of varicose veins. In an effort to keep their legs beautiful, patients also take care of their health.
Thrombophlebitis is thrombosis due to inflammation of the venous wall and stagnation of blood in the dilated vessel. The developed disease is characterized by induration and painful palpation (palpation) of the affected vessel, as well as redness of the skin around the blood clot. Thrombophlebitis develops in approximately 25% of patients diagnosed with varicose veins. Blood clots located in superficial veins have a low risk of rupture causing harm to health, however, if the clot moves along the subcutaneous or perforated vessel, immediate hospitalization is necessary. Varicose veins of the lower extremities are among the risk factors for the development of similar pathology in other vessels of the pelvic organs of men and women.
How to take capsules correctly
The tablets must be taken with food. The capsule cannot be chewed or dissolved; it must be swallowed whole with water. The permissible dose is 1 tablet three times a day. If the drug is taken as an auxiliary medicine, then you need to take 2 tablets per day. The duration of the therapeutic course is 20-28 days. Only a doctor can extend the course of treatment.
Depending on the manufacturer of the drug, there may be minor differences in the instructions for use. Taking Troxerutin Zentiva capsules is similar to the regimen described above, while Troxerutin Vramed in the first days of therapy should be taken 1 capsule no more than 3 times a day, after which switch to maintenance therapy, taking 1 tablet per day.
Troxerutin-MIC involves administering the drug intramuscularly or intravenously. One injection will require 0.5 active substance. The procedure should be carried out every other day. The course must include at least 5 injections. After the injections, you can begin treatment with tablets.
General characteristics of the drug
Dosage forms:
- capsules: gelatin hard, size No. 0, yellow; contents of capsules - powder with granules or particles of various sizes, pressed into cylinders that disintegrate when pressed, from yellow to yellow-green, greenish-yellow or yellow-brown (10, 15, 20 pcs. in blister packs made of polyvinyl chloride film and aluminum foil or 30, 50, 60, 90, 100 pcs. in polymer cans; in a cardboard pack: 1 can; 3, 5, 6 blister packs of 10 pcs.; 2, 4, 6 blister packs of 15 pcs.; 3.5 blister packs of 20 pcs.);
- gel for external use 2%: transparent, homogeneous, yellow to yellow-green or light brown in color (20, 25, 30, 40, 50, 60, 70, 80, 90 or 100 g each in orange glass jars, in polymer cans or aluminum tubes; 1 can/tube in a cardboard pack).
Composition of 1 capsule:
- active substance: troxerutin - 300 mg;
- excipients: microcrystalline cellulose - 44.1 mg, talc - 9.25 mg, sodium carboxymethyl starch [sodium starch glycolate (type A), Primodel] - 9.25 mg, povidone (Plasdon K90, Kollidon 90F) - 3.7 mg ;
- capsule shell: iron oxide yellow dye, titanium dioxide, gelatin.
Composition of 100 mg gel:
- active substance: troxerutin - 2 mg;
- excipient: sodium hydroxide 30% - 0.7 mg; carbomer 940 - 0.6 mg; benzalkonium chloride - 0.0575 mg; edetate disodium - 0.05 mg; purified water - up to 100 mg.
How to take Troxerutin gel
The drug in the form of a gel is intended for local application. It should be applied to the problem area 2 times a day (morning and evening). The ointment should be distributed in a thin layer over the entire damaged area, without affecting healthy skin. You need to rub the product in with smooth massaging movements until the gel is completely absorbed.
The permissible dose depends on the size of the problem skin, but should not be more than 2 g. When the ointment is applied, a bandage should be applied to the surface of the skin.
The drug in the form of an ointment, regardless of the manufacturer, has a similar treatment regimen.
Contraindications
Contraindications include:
- hypersensitivity to the constituent substances of the drug;
- chronic gastritis in the acute stage;
- stomach ulcer;
- children under 15 years of age;
- lactation period;
- 1st trimester of pregnancy.
Use with caution in case of kidney problems (if long-term treatment is necessary).
special instructions
The drug in one of its forms can be used as part of a complex treatment. In case of vein thrombosis, parallel use of appropriate medications is allowed.
Shelf life: capsules – 5 years, gel – 2 years from the date of production.
Store in a dark place. Storage temperature for gel is 10-15 degrees, for capsules - 17-25 degrees.
Sold in any pharmacy without a doctor's prescription.
Manufacturers assure that the drug is absolutely harmless. It is prescribed to people who are overweight, as well as to the fair sex who wear high-heeled shoes. The medicine is recommended for people whose work requires constant standing.
To achieve maximum effect, you need to use gel and capsules from the same manufacturer. In the absence of contraindications, it is best to use Troxerutin together with ascorbic acid for a more pronounced effect.
Analogues of the drug
Cost of Troxevasin and its structural generics:
- Troxevasin: gel, capsules.
- Troxerutin: capsules, gel.
- Troxegel: gel.
- Phleboton: gel, capsules.
Troxevasin also has combined substitutes, which contain, in addition to troxerutin, other active substances. List and cost of such analogues:
- Troxevenol: gel.
- Troximethacin: gel.
- “Shark oil” with troxerutin and horse chestnut: cream.
- Natura Medica “Horse chestnut and troxerutin”: gel-balm.
Medicines can be purchased at a pharmacy or ordered online. A prescription is not required to purchase any of the above generics. There are many options for replacing Troxevasin gel, so the patient can easily make a mistake with the choice. Treatment of varicose veins and similar diseases requires an exclusively professional approach, since an incorrectly selected medicine, instead of the expected relief, can provoke a worsening of the disease. And a complicated disease will be very difficult to cure.
Troxevasin and Troxerutin, what is the difference?
Troxevasin and Troxerutin are analogue drugs that are widely used in the treatment of varicose veins, chronic venous insufficiency, phlebitis and thrombophlebitis of superficial veins. At the same time, patients are often interested in: Troxerutin or Troxevasin, which is better? Both drugs: Troxevasin Troxerutin belong to the group of angioprotectors that have a pronounced capillary stabilizing, anti-inflammatory, analgesic effect, and also eliminate swelling and congestion in the lower extremities.
According to the results of numerous studies, Troxevasin Troxerutin helps eliminate the feeling of heaviness and fatigue in the lower extremities, as well as swelling and pain.
Despite all the possible differences between Troxevasin and Troxerutin, it is known that regular use of these drugs together with elastic compression and other groups of drugs allows you to stop the progression of the disease and minimize the risk of developing serious complications.
The dosage of the active components in the drugs is identical, as well as the pharmacological effect. The list of auxiliary elements in these medicines is also the same. When considering information about other differences, one cannot help but take into account that, depending on the manufacturer, the cost of the drug is also determined. Any side effects require discontinuation of use of the drug or its analogues and consultation with your doctor.
Troxevasin or Troxerutin, which is better?
To understand which remedy fights varicose veins better, first let’s look at how Troxerutin and Troxevasin differ. Both drugs belong to the group of angioprotectors with the active component - troxerutin. Therefore, they have a similar effect:
- help stabilize small blood vessels;
- prevent the development of inflammatory processes;
- relieve pain;
- relieve swelling;
- eliminate congestion.
And yet, there are differences. What is more effective to use - Troxerutin or Troxevasin - is determined in each individual case. Since it is the nature, degree and course of the disease, as well as the individual characteristics of the body, that will indicate the possibility or impossibility of using a particular medicine.
- Price
. Troxevasin is a patented formula that was released and passed clinical trials before Troxerutin was developed. Therefore, the price per package is four times higher than the cost of the analogue. - Compound
. Medicines that are completely identical in composition, both in the content of the main substance and in the set of auxiliary substances. - Release form
. Capsules and gel for external use - no difference. - Production
. Troxevasin in capsules is produced only by Iceland, and in gel form - by Bulgaria. Troxerutin of both pharmaceutical forms is produced by pharmaceutical companies in Russia, Belarus, Bulgaria, and the Czech Republic. - Indications for use
. If you look at the instructions, you will literally see word for word a list of indications, contraindications, restrictions, side effects, dosage, and medicinal effects.
