Directions for use and doses
Tablets: orally; adults and children over 2 years old for the treatment of herpetic diseases - 0.2 g 5 times a day for 5 days; for immunodeficiency - a single dose is increased to 0.4 g. For the prevention of herpetic infections in patients with immunodeficiency - 0.2 g 4 times a day. Infections caused by the herpes zoster virus: 0.8 g 5 times a day for 7 days. Patients with impaired renal function need to adjust the dosage regimen: if creatinine Cl is less than 10 ml/min, the daily dose is reduced to 0.4 g in 2 divided doses with an interval between doses of at least 12 hours. In the treatment of infections caused by Varicella zoster and maintenance therapy of patients with a pronounced decrease in immunity and creatinine Cl 10–25 ml/min - 2.4 g/day in 3 divided doses with an interval of 8 hours. In patients with creatinine Cl less than 10 ml/min, the daily dose is reduced to 1.6 g in 2 divided doses with at intervals of 12 hours.
Children under 2 years old - half the adult dose.
Ointment: apply a thin layer to the affected area immediately after the first signs of the disease appear 5 times a day (every 4 hours) for 5–10 days.
Acyclovir-Akrikhin ointment for external use 5% 5g
Compound
Active substance: acyclovir - 5 g; Excipients: propylene glycol, petroleum jelly, petroleum jelly, emulsion wax, macrogol (polyethylene oxide 1500), purified water.
Pharmacokinetics
When used on intact skin: absorption is minimal;
not detected in blood and urine. On affected skin: absorption is moderate; in patients with normal renal function, the concentration in the blood serum is up to 0.28 mcg/ml, in patients with chronic renal failure (CRF) - up to 0.78 mcg/ml. Excreted by the kidneys (up to 9.4% of the daily dose).
Indications for use
- skin infections caused by Herpes simplex virus types 1 and 2;
- genital herpes;
- shingles;
- chicken pox.
Contraindications
Hypersensitivity to acyclovir and other components of the drug.
With caution - pregnancy, lactation, dehydration, renal failure.
Directions for use and doses
Externally. Apply the drug with clean hands or a cotton swab 5 times a day (every 4 hours) in a thin layer to the affected and adjacent areas of the skin. Therapy should be continued until a crust forms on the blisters or until they are completely healed. The duration of therapy is on average 5 days, maximum 10 days. If there is no effect, you should consult a doctor.
Storage conditions
In a dry place, protected from light, at a temperature not exceeding 25°C. Keep out of the reach of children.
Best before date
3 years. Do not use the drug after the expiration date.
special instructions
To achieve the maximum therapeutic effect, it is necessary to use the drug as early as possible (at the first signs of the disease: burning, itching, tingling, feeling of tension and redness).
The ointment is not recommended to be applied to the mucous membranes of the mouth and eyes, as severe local inflammation may develop. When treating genital herpes, you should avoid sexual intercourse or use condoms, since the use of acyclovir does not prevent transmission of the virus to partners.
Description
Antiviral drug for external use.
Dosage form
Ointment for external use 5% white or almost white; The presence of a characteristic odor is allowed.
Action
The antiviral drug is a synthetic analogue of thymidine nucleoside. In infected cells containing viral thymidine kinase, phosphorylation occurs and is converted to acyclovir monophosphate. Under the influence of acyclovir guanylate cyclase, monophosphate is converted into diphosphate and, under the action of several cellular enzymes, into triphosphate. High selectivity of action and low toxicity to humans are due to the absence of the necessary enzyme for the formation of acyclovir triphosphate in intact cells of the macroorganism.
Acyclovir triphosphate, being integrated into the DNA synthesized by the virus, blocks the reproduction of the virus. The specificity and very high selectivity of action are also due to its predominant accumulation in cells affected by the herpes virus. Highly active against Herpes simplex virus types 1 and 2; the virus that causes chickenpox and herpes zoster (Varicella zoster); Epstein-Barr virus. Moderately active against cytomegaloviruses.
Side effects
From the skin and subcutaneous tissues: hyperemia, dryness, peeling of the skin.
Other: burning, inflammation upon contact with mucous membranes. Allergic dermatitis may develop.
Use during pregnancy and breastfeeding
The use of the drug is indicated only in cases where the expected benefit to the mother outweighs the potential risk to the fetus.
During the treatment period, it is necessary to decide whether to stop breastfeeding.
Interaction
When used externally, no interactions with other drugs were detected.
An enhanced effect is observed with the simultaneous administration of immunostimulants.
Overdose
Data on drug overdose are not provided.
Impact on the ability to drive vehicles and operate machinery
No data.
Acyclovir-acriquine 5% 5g ointment for external use
pharmachologic effect
The antiviral drug is a synthetic analogue of thymidine nucleoside.
In infected cells containing viral thymidine kinase, phosphorylation occurs and is converted to acyclovir monophosphate. Under the influence of acyclovir guanylate cyclase, monophosphate is converted into diphosphate and, under the action of several cellular enzymes, into triphosphate. High selectivity of action and low toxicity to humans are due to the absence of the necessary enzyme for the formation of acyclovir triphosphate in intact cells of the macroorganism. Acyclovir triphosphate, being integrated into the DNA synthesized by the virus, blocks the reproduction of the virus. The specificity and very high selectivity of action are also due to its predominant accumulation in cells affected by the herpes virus. Highly active against Herpes simplex virus types 1 and 2. the virus that causes chickenpox and herpes zoster (Varicella zoster). Epstein-Barr virus. Moderately active against cytomegaloviruses.
Composition and release form Acyclovir-acriquine 5% 5g ointment for external use
Ointment for external use - 100 g:
- Active ingredient: acyclovir 5 g;
- Excipients: propylene glycol - 40 g, petroleum jelly - 12.5 g, vaseline oil - 7.5 g, emulsion wax - 5 g, macrogol (polyethylene oxide 1500) - 1 g, purified water - up to 100 g.
5 g in an aluminum tube.
Description of the dosage form
Ointment for external use 5% white or almost white; The presence of a characteristic odor is allowed.
Directions for use and doses
The drug is applied 5 times a day (every 4 hours).
Therapy should be continued until a crust forms on the blisters or until they are completely healed. The duration of therapy is on average 5 days, maximum 10 days.
If there is no effect, you should consult a doctor.
Pharmacodynamics
Prevents the formation of new rash elements, reduces the likelihood of skin dissemination and visceral complications, and accelerates the formation of crusts. Relieves pain in the acute phase of herpes zoster.
Pharmacokinetics
When used on intact skin, absorption is minimal. not detected in blood and urine. On affected skin, absorption is moderate. in patients with normal renal function, the serum concentration is up to 0.28 mcg/ml, in patients with chronic renal failure (CRF) - up to 0.78 mcg/ml. Excreted by the kidneys (up to 9.4% of the daily dose).
Indications for use Acyclovir-acriquine 5% 5g ointment for external use
Skin infections caused by Herpes simplex virus types 1 and 2, genital herpes, herpes zoster, chickenpox.
Contraindications
Hypersensitivity to acyclovir and other components of the drug.
The drug should be used with caution in case of dehydration and renal failure.
Application of Acyclovir-acriquine 5% 5g ointment for external use during pregnancy and breastfeeding
The use of the drug is indicated only in cases where the expected benefit to the mother outweighs the potential risk to the fetus.
During the treatment period, it is necessary to decide whether to stop breastfeeding.
special instructions
To achieve the maximum therapeutic effect, it is necessary to use the drug as early as possible (at the first signs of the disease: burning, itching, tingling, feeling of tension and redness).
The ointment is not recommended to be applied to the mucous membranes of the mouth and eyes, because the development of severe local inflammation is possible.
When treating genital herpes, you should avoid sexual intercourse or use condoms, because the use of acyclovir does not prevent transmission of the virus to partners.
Overdose
Data on drug overdose are not provided.
Side effects Acyclovir-acriquine 5% 5g ointment for external use
From the skin and subcutaneous tissues: hyperemia, dryness, peeling of the skin.
Other: burning, inflammation upon contact with mucous membranes. Allergic dermatitis may develop.
Drug interactions
When used externally, no interactions with other drugs were detected.
An enhanced effect is observed with the simultaneous administration of immunostimulants.
Clotrimazole-Akrikhin ointment for external use 1% 20g
pharmachologic effect
Ketoconazole-Acri is an antifungal agent.
It has fungicidal and fungistatic effects. The mechanism of action is to inhibit the synthesis of ergosterol and change the lipid composition of the membrane. It is active against the causative agent of pityriasis versicolor Malassezia furfur, causative agents of some dermatomycosis (Trichophyton, Epidermophyton floccosum, Microsporum), causative agents of candidiasis (Candida), as well as causative agents of systemic mycoses (Cryptococcus). Also active against gram-positive cocci: Staphylococcus spp., Streptococcus spp.
Pharmacokinetics
Ketoconazole is a weak dibasic compound that dissolves and is absorbed in an acidic environment. The Cmax of ketoconazole in plasma is about 3.5 mcg/ml and is achieved 1-2 hours after a single oral dose of 200 mg with food. The bioavailability of ketoconazole is greatest when taken with food. Absorption of ketoconazole is reduced in patients with low gastric acidity, such as those taking antacids such as aluminum hydroxide and antisecretory drugs such as histamine H2 receptor blockers and proton pump inhibitors, as well as in patients with achlorhydria caused by disease.
Binding to plasma proteins, mainly to the albumin fraction, is 99%. Ketoconazole is widely distributed in tissues, but only a small part of the drug penetrates into the cerebrospinal fluid.
After absorption from the gastrointestinal tract, ketoconazole is metabolized in the liver to form a large number of inactive metabolites.
In vitro studies have shown that the CYP3A4 isoenzyme is involved in the metabolism of ketoconazole. The main metabolic pathways are oxidation and cleavage of the imidazole and piperazine rings, oxidative O-dealkylation and aromatic hydroxylation. Ketoconazole is not an inducer of its own metabolism. Removal from plasma is biphasic: during the first 10 hours T1/2 is 2 hours, subsequently - 8 hours.
About 13% is excreted in the urine, of which 2-4% is unchanged. It is excreted mainly with bile in the gastrointestinal tract and about 57% is excreted in feces.
Indications
- Fungal diseases of the skin, mycoses of skin folds, feet,
- pityriasis versicolor, erythrasma, superficial candidiasis caused by dermatophytes, yeast (including the genus Candida), mold and other fungi and pathogens sensitive to clotrimazole,
- mycoses complicated by secondary pyoderma.
Contraindications
Hypersensitivity to clotrimazole, first trimester of pregnancy.
special instructions
To prevent the spread of urogenital infection, simultaneous treatment of sexual partners is necessary. For trichomoniasis, for more successful treatment, other drugs with systemic effects (for example, metronidazole orally) should be prescribed together with clotrimazole. Vaginal tablets are not recommended for use during menstruation. In the case of an unintended method of using the drug (orally), the following symptoms are possible: anorexia, nausea, vomiting, gastralgia, impaired liver function, rarely drowsiness, hallucinations, pollakiuria, allergic skin reactions. In these situations, you need to take activated charcoal and consult a doctor.
If allergic reactions or irritation develop, treatment should be stopped and another therapy should be selected. For tinea pedis, it is recommended to use the solution after each foot wash. It is not recommended to apply the drug to the skin in the eye area. If after 4 weeks from the start of treatment there is no clinical improvement, it is necessary to confirm the diagnosis microbiologically and exclude another cause of the disease.
Compound
1 g ointment contains:
Active substance: clotrimazole,
Excipients: propylene glycol, nipagin, succinic acid, sodium benzoate, emulsifier No. 1 or emulsifier EM 3398, castor oil, water-soluble methylcellulose or methylcellulose SM100, distilled monoglycerides, purified water.
Directions for use and doses
For external use, apply to affected areas of the skin 2-3 times a day for 2-4 weeks.
When treating the oral cavity, use 1-2 times a day for no more than 7 days.
Intravaginally - 100-500 mg for 1-6 days.
Side effects
Local reactions: allergic contact dermatitis, redness, burning sensation.
Drug interactions
Reduces the effect of polyene antibiotics (amphotericin, nystatin, natamycin, etc.). Propyl ester of para-hydroxybenzoic acid in high concentrations enhances the antifungal effect of clotrimazole, while dexamethasone reduces it. When used simultaneously with nystatin, the activity of clotrimazole may be reduced.
Check the interaction of other drugs with Clotrimazole-Acri Add
The drugs you have chosen
Clear all Check interactions &lsaquo, Return to drug selection Do not stop taking the drug without consulting your doctor! We under no circumstances encourage you to self-medicate or diagnose yourself or your loved ones based on the data in our directory. All information is presented for informational purposes only, to make it easier for you to understand what exactly is bothering you and which specialist doctor you should contact.
Storage conditions
In a place protected from light, at a temperature below 25 C.
Best before date
3 years
