Eye drops and ointment Dexa-Gentamicin: instructions for use, price and reviews

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The drug Dex-Gentamicin contains two highly compatible active components in the optimal dosage of each of them.

Gentamicin is an antibiotic belonging to the group of aminoglycosides and is highly soluble in water. It has a pronounced bactericidal effect against a wide range of gram-positive and gram-negative microorganisms. It does not penetrate through the intact cornea. Inflammation and damage to the cornea of various origins create the possibility of penetration into the anterior chamber of the eye through the cornea 15 minutes after application of the drug.

Dexamethasone – has a strong anti-inflammatory and antiallergic effect. Penetration through the intact cornea into the anterior chamber of the eye, but when the corneal epithelium is damaged, the rate of penetration through the cornea increases.

Pharmacokinetics

Dexamethasone, when applied topically, quickly and well penetrates the tissue of the cornea and conjunctiva, reaching the required therapeutic concentration in the liquid medium of the eye.

Gentamicin sulfate , when applied topically in a therapeutic concentration in the liquid medium of the eye structures, is detected within 6 hours. The drug does not penetrate into the systemic circulation through the intact cornea.

Pharmacological properties

The composition of the Dex-Gentamicin solution includes an aminoglycoside antibiotic + glucocorticosteroid, which determines its anti-inflammatory, antiallergic and antibacterial properties.

Dexamethasone is a corticosteroid with a pronounced antiallergic and anti-inflammatory effect. Its relative anti-inflammatory activity is indicated by an index of 30.

Gentamicin is an antibacterial substance of the aminoglycoside group with a wide spectrum of action. Has activity against gram-positive and gram-negative bacterial microflora, including Pseudomonas aeruginosa, Klebsiella spp., Escherichia coli, Salmonella spp., Serratia spp., Proteus spp. Moderately active against staphylococci.

When applied topically, the components of the Dex-Gentamicin solution penetrate well through the cornea, being found in therapeutic doses in the moisture of the anterior chamber, corneal stroma, and vitreous body. They practically do not enter the systemic circulation.

Contraindications

Increased intraocular pressure ;
Mycobacterial eye infections;
Viral diseases of the conjunctiva and cornea ( dendritic keratitis , chicken pox );
Fungal infections of the eyes;
Purulent eye diseases that occur with damage to the corneal epithelium;
Corneal epitheliopathy;
High sensitivity to the drug.

When using the drug Dex-Gentamicin, it is not recommended to use contact lenses.

Dexa-Gentamicin eye drops 5ml

Instructions for use Dex-gentamicin Buy Dex-gentamicin eye drops 5ml

Dosage forms: eye drops Manufacturers Ursafarm Arzneimittel GmbH (Germany) Group Combined products containing glucocorticosteroids Composition: Gentamicin + Dexamethasone. International nonproprietary name Gentamicin + Dexamethasone Synonyms Decta-2 Pharmacological action Combined drug for topical use in ophthalmology. Gentamicin is a water-soluble antibiotic of the aminoglycoside group. It has a bactericidal effect against a wide range of gram-positive and gram-negative bacteria. Dexamethasone - has anti-inflammatory and antiallergic effects. Indications for use Infectious and inflammatory eye diseases caused by microorganisms sensitive to gentamicin: - conjunctivitis; - keratitis; - blepharitis; - barley. Allergic processes in the anterior part of the eye, complicated by bacterial infection. Prevention and treatment of inflammatory phenomena in the postoperative period (after cataract removal and anti-glaucoma operations). Contraindications Keratitis caused by Herpes simplex (tree-like keratitis); — viral diseases of the cornea and conjunctiva (including chicken pox); - mycobacterial eye infections; - fungal eye diseases; - acute purulent eye diseases with damage to the corneal epithelium; — corneal epitheliopathy; - increased intraocular pressure; - hypersensitivity to the components of the drug. It is not recommended to use contact lenses while using the drug. Side effects From the organ of vision: rarely - allergic reactions, burning sensation after using the drug; with long-term use - the development of secondary glaucoma and steroid cataracts. Interaction No data available. Method of administration and dosage Dex-Gentamicin eye drops are instilled into the conjunctival sac, 1-2 drops 4-6 times a day. The duration of treatment with Dex-Gentamicin usually does not exceed 2-3 weeks. The duration of therapy is determined by the effectiveness of the drug, the severity of symptoms and the likelihood of side effects. When using several ophthalmic drugs simultaneously, it is recommended to add Dex-Gentamicin in the form of an eye ointment no earlier than 15 minutes after using eye drops. Overdose When using the drug Dex-Gentamicin, an overdose is unlikely. Special instructions When using the drug for more than 2 weeks, as well as in patients with a history of open- and closed-angle glaucoma, it is recommended to regularly monitor intraocular pressure. If the use of contact lenses is necessary, they should be removed before using Dex-Gentamicin eye drops and reinserted no earlier than 20 minutes later. The patient should be informed that if side effects occur, treatment should be stopped immediately and contact an ophthalmologist. The use of the drug in pediatrics is possible if the expected therapeutic effect exceeds the potential risk of side effects. Immediately after using the drug Dex-Gentamicin, a short-term disturbance in visual acuity may occur, leading to a slowdown in psychomotor reactions. Therefore, it is not recommended to use the drug immediately before working with machinery or driving vehicles. Storage conditions List B. Eye drops should be stored out of the reach of children, protected from light, at a temperature not exceeding 25°C.

Instructions for use (Method and dosage)

Dex-Gentamicin ophthalmic ointment in the form of a strip about 1 cm long is placed into the conjunctival cavity 2-3 times a day. At the same time, during the procedure it is necessary to avoid contact of the tube with the surface of the conjunctiva and skin. When prescribing the simultaneous use of several ophthalmic agents, the instructions for Dex-Gentamicin ophthalmic ointment indicate the need to maintain a time interval between their use of at least 15 minutes.

Dex-Gentamicin eye drops are instilled directly into the conjunctival sac in a dosage of 1-2 drops 5-6 times a day. Dexa-Gentamicin should not be used for more than 3 weeks.

special instructions

During treatment with Dex-Gentamicin solution, it is recommended not to use contact lenses.

When using them, with the permission of the doctor, before the instillation procedure, the correction means must be removed and installed again only after 20 minutes have passed after instillation.

Patients with a history of glaucoma should regularly monitor intraocular pressure.

Immediately after instillation of the Dex-Gentamicin solution, short-term visual impairment may occur, which leads to a slowdown in psychomotor reactions. Therefore, it is not recommended to instill the drug immediately before driving a car or working with moving mechanisms.

Store Dex-Gentamicin solution in a dark place at room temperature. Keep away from children.

The shelf life of the bottle is 3 years. After opening it, the solution should be used for no more than 6 weeks.

Analogs

Level 4 ATX code matches:
Sofradex

Garazon

Maxitrol

Tobradex

Betagenot ( gentamicin + betamethasone ), Tobradex ( tobramycin + dexamethasone ), Maxitrol ( neomycin + dexamethasone + polymyxin B ), Combinil-Duo ( ciprofloxacin + dexamethasone have a similar effect .

Reviews

This complex drug in the form of drops and ointments combines antibacterial and antiallergic effects. Judging by the reviews, it was prescribed for chronic conjunctivitis , blepharitis and blepharoconjunctivitis , in cases where allergic manifestations are combined with a bacterial infection. After all, it is known that with allergic conjunctivitis, sooner or later inflammation occurs, which is chronic. The drug is also effective for episcleritis , trauma to the conjunctiva and cornea, and keratitis . All patients note the high effectiveness of ointments and drops, which have a pronounced anti-inflammatory effect.

“... The child had purulent conjunctivitis, which was treated for a month with sulfacyl and chloramphenicol drops. There was little result and the inflammation spread to the cornea. Dex-gentamicin ointment was prescribed. And we finally began to recover.”
“...Dex-Gentamicin ointment was prescribed to me for demodicosis of the eyelids, when purulent inflammation developed. I lubricated it at night for 4-5 days - the inflammation went away.”
“...Good ointment. She used it for ulcerative blepharitis: the purulent crusts disappeared after 2 days, and she treated ulcerations of the edges of the eyelids for another five days.”
“...This ointment helped my husband quickly cure stye. He is very pleased with the effectiveness of the ointment.”

Many people were prescribed drops after ophthalmological operations, and they successfully prevented postoperative complications. All patients tolerated the drug well and no adverse reactions were noted.

Price, where to buy

You can buy Dex-Gentamicin at any pharmacy. The price of Dex-Gentamicin eye ointment 2.5 g in Moscow pharmacies ranges from 107-185 rubles, and similar eye drops 5 ml can be purchased for 125-225 rubles.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

ZdravCity

Dexa-Gentamicin eye drops 5mlUrsapharm Arzneimittel GmbH
RUB 162 order
Dexa-Gentamicin eye ointment 2.5 gUrsapharm Arzneimittel GmbH
RUB 151 order

Pharmacy Dialogue

Dexa-gentamicin (ointment, 2.5 g tube) Ursapharm
RUB 154 order
Dexa-gentamicin (eye drops 5 ml)Ursapharm
166 RUR order

Pharmacy24

Dexa-Gentamicin 5 ml drops Ursafarm Arznaimittel GmbH, Nimechchina
84 UAH.order

PaniPharmacy

Dexa-gentamicin liquid Dexa-gentamicin h/c 5ml Germany, Ursapharm
99 UAH order