Luxfen is a medicine for glaucoma caused by increased intraocular pressure.
Within 10 days after administration, the plasma concentration of the drug is very low.
The binding rate of brimonidine is 29%. After the 2nd week of use, the concentration of the drug components in the eyes may increase 17 times.
The drug is used as an independent remedy in combination with other medications for glaucoma.
1 drop is instilled under the lower eyelid 2 times a day with an interval of 12 hours.
More information about the drug can be found here
Alphagan
The cost in Moscow pharmacies is from 733 rubles.
The medicine helps regulate fluid pressure in the eyes and removes it through microvessels. Indications: open glaucoma, ocular hypertension, increased ophthalmotonus. Directions for use: Alphagan is instilled under the lower eyelid, 1 drop 3 times a day, the interval between doses is 8 hours.
When used in combination with other drugs, a pause of 5 minutes is maintained.
Side effects:
- inflammation;
- itching;
- hyperemia;
- sinusitis;
- asthenia;
- rhinitis.
Examples of overdose have not been recorded in medical practice until now.
Luxfen eye drops 0.2% 5ml (Valeant)
The frequency of side effects is classified as follows: very often (>1/10), often (from >1/100 to 1/1000 to 1/10,000 to 1/10,000 to 1/10,000). On the part of the organs of vision: very often - allergic conjunctivitis, conjunctival hyperemia, itching of the skin of the eyelids and mucous membrane of the eyes; often - a burning sensation; folliculosis of the conjunctiva of the eyes and follicular conjunctivitis, local allergic reactions of the mucous membrane of the eyes (including keratoconjunctivitis); blepharitis, blepharoconjunctivitis, impaired clarity of visual perception, cataracts, conjunctival edema, hemorrhage in the conjunctiva, conjunctivitis, retention lacrimation, mucous discharge from the eyes, dryness and irritation of the mucous membrane of the eyes, pain, swelling of the eyelids, redness of the eyelids, sensation of a foreign body in the eyes, keratitis, damage to the eyelids, photosensitivity, superficial, macular keratopathy, lacrimation, loss of the visual field, functional damage to the vitreous body, hemorrhage into the vitreous body, floating opacities in the vitreous body and decreased visual acuity; infrequently - corneal erosion, barley. From the central nervous system: often - headache, drowsiness, insomnia, dizziness. From the cardiovascular system: often - increased blood pressure pressure; infrequently - decreased blood pressure. From the respiratory system: often - bronchitis, cough, shortness of breath; infrequently - dry nasal mucosa, apnea. From the gastrointestinal tract: often - gastrointestinal disorders - dyspepsia, dry mucous membrane of the cavity mouth Skin and subcutaneous fat: often - rashes. Infectious and parasitic diseases: often - flu-like syndrome, infectious disease (chills and respiratory infection), rhinitis, sinusitis, including infectious. Laboratory indicators: often - hypercholesterolemia. Others: often - general allergic reactions, asthenia, fatigue; infrequently - changes in taste. In children, the following were noted: apnea, bradycardia, decreased blood pressure, hypothermia, muscle hypotension. Additionally, data was obtained on the following effects: On the part of the visual organs: frequency unknown - iritis, keratoconjunctivitis, miosis. From the central nervous system: depression. From the cardiovascular system: bradycardia, tachycardia. From the gastrointestinal tract: nausea. From the skin and subcutaneous fat: local skin reactions (erythema, itching, swelling face, rash and vasodilation of eyelid skin vessels).
Xalacom
Cost in pharmacies – from 776 rubles.
It has an antiglaucoma effect and the ability to painlessly regulate intraocular pressure. Indications: open-angle glaucoma, increased ophthalmotonus. Directions for use: 1 drop is instilled under the lower eyelid once a day.
The dosage is determined by the doctor; it is not recommended to exceed it. Experts have not studied the effect of Xalacom in combination with other drugs. They do not recommend using it in combination with beta-blocker tablets. Otherwise, systemic effects increase and intraocular pressure decreases too much.
Side effects:
- the color of the iris changes;
- the quality of vision deteriorates;
- blepharitis;
- cataract.
Signs of overdose:
- conjunctivitis;
- called the eye area;
- nausea;
- bradycardia.
Contraindications:
- sinus bradycardia;
- heart failure;
- cardiogenic shock.
Pregnant women are allowed to use the medicine only after the approval of a specialist, and they are monitored regularly.
Azopt
A medicine based on brinzolamide costs from 878 rubles in pharmacies.
Indications: high intraocular pressure, glaucoma. Take one drop 2 times a day under the lower eyelid. Before use, shake the container; the tip of the pipette does not touch the eye; do not touch it with your hands. Azopt is not used in combination with systemic carbonic anhydrase inhibitors, since the body reacts sharply to the suppression of this enzyme.
Side effects:
- the mucous membrane of the eyes dries out;
- hyperemia;
- itching;
- pain;
- feeling of discomfort;
- a foreign object is felt in the eye;
- It becomes difficult to breathe through the nose.
Contraindications:
- liver problems;
- diseased kidneys;
- skin allergic reactions;
- anemia, other blood disorders.
Contact lenses are removed before use and put on after 15-20 minutes.
Luxfen 0.2% eye drops 5ml bottle
A country
Lithuania
The country of production may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.
Active substance
Brimonidine
Compound
Active ingredient: brimonidine tartrate - 2.0 mg.
pharmachologic effect
Pharmacodynamics. Brimonidine is a selective alpha2-adrenergic receptor agonist. When instilling a 0.2% brimonidine solution, the decrease in intraocular pressure is 10-12 mm. Hg Art., the maximum effect is observed after 2 hours, the duration of action is 12 hours. Brimonidine has a dual mechanism of action; it can lower intraocular pressure by reducing the synthesis of intraocular fluid and increasing uveoscleral outflow. Pharmacokinetics: After using a 0.2% solution of brimonidine eye drops twice a day for 10 days, its plasma concentration remains low (average 0 .06 ng/ml). When instilling eye drops, the maximum concentration of the drug in the blood plasma is achieved after 0.5-2.5 hours, the half-life is about 2 hours. The binding to blood proteins when applied topically is 29%. Systemic absorption of brimonidine is slow. The drug is metabolized primarily in the liver. Brimonidine and its metabolites are excreted by the kidneys.
Indications for use
Open-angle glaucoma, ocular hypertension (in monotherapy and in combination with other drugs that reduce intraocular pressure).
Mode of application
Locally. Instill 1 drop of the drug 2 times a day. The duration of treatment is determined by the doctor.
Interaction
Brimonidine at a concentration of 2 mg/ml may enhance the effects of substances that affect the central nervous system (alcohol, barbiturates, opioids, sedatives and anesthetics). Caution should be exercised when taking drugs that can affect the absorption into the blood and metabolization of adrenaline, norepinephrine and other so-called biogenic amines (chlorpromazine, methylphenidate, reserpine). In some patients, after using a solution of brimonidine at a concentration of 2 mg/ml, there is a slight decrease in blood pressure. Caution should be exercised when used concomitantly with antihypertensive drugs and/or drugs of the cardiac glycoside group (digitalis). When simultaneous systemic administration of adrenoreceptor agonists or antagonists (for example, isoprenaline or prazosin) for the first time, as well as when changing the dose of these simultaneously administered systemic drugs ( regardless of route of administration), interactions with or interference with alpha-adrenergic agonists may occur.
Side effect
From the organs of vision: very often - allergic conjunctivitis, conjunctival hyperemia, itching of the skin of the eyelids and mucous membrane of the eyes; Often - a burning sensation, follicles of the eye conjunctiva and follicular conjunctivitis, local allergic reactions of the mucous membrane of the eyes (including keratoconjunctivitis), blepharitis, blefaroconjunctivitis, disturbance of the clarity of visual perception, cataracts, edema of conjunctiva, hemorrhage in conjunctiva, conjunctivitis, and competitive tens reading, mucous discharge from the eyes, dryness and irritation of the mucous membrane of the eyes, pain, swelling of the eyelids, redness of the eyelids, foreign body sensation in the eyes, keratitis, eyelid damage, photosensitivity, superficial macular keratopathy, lacrimation, loss of visual field, functional damage to the vitreous, vitreous hemorrhage , floating opacities in the vitreous body and decreased visual acuity; infrequently - corneal erosion, barley. From the central nervous system: often - headache, drowsiness, insomnia, dizziness. From the cardiovascular system: often - increased blood pressure; infrequently - decreased blood pressure. From the respiratory system: often - bronchitis, cough, shortness of breath; infrequently - dry nasal mucosa; apnea. From the gastrointestinal tract: often - gastrointestinal disorders - dyspepsia, dryness of the oral mucosa. From the skin and subcutaneous fat: often - rashes. Infectious and parasitic diseases: often - flu-like syndrome, infectious disease (chills and respiratory infection), rhinitis, sinusitis, including infectious. Laboratory indicators: often - hypercholesterolemia. Others: often - general allergic reactions, asthenia, fatigue; infrequently - changes in taste sensations. In children, the following were noted: apnea, bradycardia, decreased blood pressure, hypothermia, muscle hypotension. Additionally, data was obtained on the following effects: From the organs of vision: frequency unknown - iritis, keratoconjunctivitis, miosis. From the central nervous system: depression. From the cardiovascular system: bradycardia, tachycardia. From the gastrointestinal tract: nausea. From the skin and subcutaneous fat: local skin reactions (erythema, itching, facial swelling, rash and vasodilation of blood vessels in the skin of the eyelids).
Contraindications
Hypersensitivity to the components of the drug. Simultaneous therapy with monoamine oxidase inhibitors (MAO) and tricyclic antidepressants. Children under 2 years of age. Breastfeeding period.
Overdose
Overdose is extremely rare. In case of accidental ingestion of the drug, the following symptoms are possible: depression of the central nervous system, drowsiness, depression and loss of consciousness, decreased blood pressure, bradycardia, decreased body temperature, cyanosis of the skin, apnea. In case of accidental ingestion of the drug: supportive symptomatic therapy , airway control.
special instructions
With caution: when using the drug in patients with severe, unstable and uncontrolled form of cardiovascular disease, with cerebral or coronary insufficiency, depression, orthostatic hypotension, Raynaud's disease, thromboangiitis obliterans; with impaired liver or kidney function; children's age from 2 to 18 years. Use during pregnancy and breastfeeding. Studies of the safety and effectiveness of brimonidine in pregnant and lactating women have not been conducted. In animal studies, topical application of brimonidine did not lead to disruption of intrauterine development. There is no precise data on the penetration of brimonidine into breast milk when applied topically. However, the risk cannot be completely eliminated. The use of brimonidine during pregnancy is allowed only in cases where the expected benefit to the mother outweighs the potential risk to the fetus or child. When prescribed during lactation, it is recommended to stop breastfeeding for the duration of treatment. Contact lenses should be removed before using the drug. The time interval between using the drug and re-inserting contact lenses should be at least 15 minutes. Impact on driving and performing potentially hazardous activities. The drug can cause fatigue or drowsiness, decreased vision clarity, so during treatment with the drug you should refrain from driving vehicles and maintenance of moving mechanisms.
Dispensing conditions in pharmacies
On prescription
Betoptik
The cost of the medicine is from 395 rubles. in Moscow pharmacies. Drops help get rid of open-angle glaucoma, hypertension, and help with therapy using laser equipment. Before use, shake the bottle and the pipette does not touch the surface of the eye. After using Betoptik, lightly squeeze the tear ducts of the inner corners with your fingers to prevent side effects.
Contraindications:
- diabetes;
- bradycardia;
- heart failure.
In case of overdose, rinse eyes with clean water. Before use, it is recommended to remove contact lenses; you can put them on after 15-20 minutes, when the medicine is absorbed.
