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Aktiferrin syrup 100ml

Compound

Active ingredients: iron sulfate heptahydrate - 3.42 g, corresponding to iron (II) - 0.687 g; D,L-serine - 2.58 g. Excipients: ascorbic acid - 0.4 g, invert sugar syrup (72.7% TS) - 86.6 g, ethanol 96% - 0.3133 g, raspberry flavor - 0.1 g, cream flavor - 0.025 g, water peeled - 32.2 g.

Pharmacokinetics

After oral administration, about 10-15% of ferrous iron is absorbed in the duodenum and jejunum. Iron absorption is possible through the mechanism of passive diffusion. Iron absorption increases significantly with iron deficiency and increased erythropoiesis. In patients with low Hb values and depleted iron stores, absorption can increase up to 50-60% and decrease when these indicators normalize. Cmax of iron is achieved 2-4 hours after administration.

In the blood, iron binds to transferrin and is transported in trivalent form to the sites of hematopoiesis and to specific depots.

After iron binds to apoferritin, it is deposited in the liver, spleen and bone marrow in the form of ferritin. Iron crosses the placental barrier and minimal amounts are excreted into breast milk.

Indications for use

Treatment of iron deficiency.

Contraindications

Iron absorption disorders (sideroachrestic anemia, lead anemia, thalassemia); increased iron content in the body (hemochromatosis, hemolytic anemia); anemia not associated with iron deficiency.

Carefully

Concomitant use with dietary products and supplements containing iron salts (possible risk of overdose); patients with inflammation and ulcers of the gastrointestinal mucosa (the balance between the benefits of treatment and the risk of developing exacerbations of gastroenterological diseases during iron therapy should be assessed).

Directions for use and doses

Inside.

The daily dose for children over 2 years of age and adults is set at the rate of 5 ml per 12 kg of body weight.

Preschool children (over 2 years): average dose - 5 ml 1-2 times a day.

School-age children: average dose - 5 ml 2-3 times a day.

Storage conditions

Store out of the reach of children at a temperature not exceeding 25°C.

Best before date

2 years. Do not use after the expiration date stated on the package.

special instructions

When using the drug, persistent darkening of the teeth is possible.

Liver or kidney failure increases the risk of iron accumulation.

The use of the drug may aggravate ulcerative and inflammatory bowel diseases.

Description

Antianemic drug.

Dosage form

The syrup is transparent, from greenish to yellow-brownish in color, with a raspberry-creamy odor.

Use in children

Used in children according to indications.

Pharmacodynamics

Iron is the most important microelement in the body. As a coenzyme of cytochrome oxidase, catalase and peroxidase, as well as a component of Hb, myoglobin and cytochromes, it is involved in many metabolic processes and stimulates erythropoiesis.

The α-amino acid included in the drug, serine, promotes more efficient absorption of iron and its entry into the systemic circulation, leading to the rapid restoration of its normal content in the body. This ensures better tolerability of the drug and allows you to reduce the required dose of iron.

The daily requirement for iron in adults is 1-2 mg, in pregnant women - 2-5 mg, in children under 7 years old - 0.5-1.5 mg. On average, 10% is absorbed, so to replenish the need for iron, the dose taken orally must exceed the daily requirement by 10 times.

Side effects

From the immune system: rarely - allergic skin reactions.

From the gastrointestinal tract: very rarely - constipation, diarrhea, abdominal pain, nausea, vomiting.

When taking iron-containing drugs, stool may turn dark (black), which has no clinical significance.

Use during pregnancy and breastfeeding

Use during pregnancy and lactation is possible if the potential benefit to the mother outweighs the potential risk to the fetus and child.

Interaction

With simultaneous use of iron salts, the absorption of drugs such as tetracyclines, gyrase inhibitors (for example, ciprofloxacin, levofloxacin, levofloxacin, norfloxocin, ofloxacinofloxacin), penicillaminepenicillamine, levodopalevodopa, carbidopa and methyldopamethyldopa is reduced. In patients receiving levothyroxine sodium replacement therapy, iron salts reduce its absorption.
High doses of iron supplements reduce the renal absorption of zinc supplements (the latter are recommended to be taken 2 hours after taking iron supplements).
Iron absorption is reduced by concomitant administration of cholestyramine, antacids (containing aluminum, magnesium, calcium, bismuth) and supplements containing calcium and magnesium.
The simultaneous use of iron salts and NSAIDs can enhance the damaging effect of iron on the gastrointestinal mucosa.
In children, when used simultaneously, iron reduces the effectiveness of vitamin E. Therefore, it is recommended to take all of the above medications 3-4 hours before or after taking this medication. If it is necessary to prescribe drugs simultaneously, systematic clinical and laboratory monitoring should be carried out.
Tea, coffee, plant foods containing iron chelating agents (such as phosphates, phytates, oxalates), milk, eggs reduce iron absorption.
Ascorbic acid and citric acid increase iron absorption.
Ethanol increases iron absorption and the risk of toxic complications.

Overdose

Children have a high risk of intoxication with iron preparations; life-threatening conditions can occur when taking 1 g of iron sulfate. Therefore, iron supplements should be stored out of the reach of children.

Symptoms: with accidental ingestion of very large doses of the drug - weakness, fatigue, paresthesia, pallor of the skin, cold sticky sweat, decreased blood pressure, palpitations, acrocyanosis, abdominal pain, bloody diarrhea, cyanosis, confusion, weak pulse, hyperthermia, lethargy, seizures, symptoms of hyperventilation, coma. Signs of peripheral circular collapse appear within 30 minutes after administration; metabolic acidosis, convulsions, fever, leukocytosis, coma - within 12-24 hours; acute renal and hepatic necrosis - after 2-4 days.

Treatment: before specific therapy, measures are taken to remove the still unabsorbed drug from the stomach (gastric lavage), milk and raw eggs are given.

Specific therapy is carried out by prescribing deferoxamine (desferal) orally and parenterally. In case of acute poisoning, to bind iron that has not yet been absorbed from the gastrointestinal tract, give 5-10 g of the drug by dissolving the contents of 10-20 amps. in drinking water. When poisoning develops, deferoxamine is administered intramuscularly slowly, for children - 15 mg/hour, for adults - 5 mg/kg/hour (up to 80 mg/kg/day); for mild poisoning - children 1 g intramuscularly every 4-6 hours, adults - 50 mg/kg (up to 4 g/day).

In severe cases, accompanied by the development of shock in patients, 1 g of the drug is administered intravenously and symptomatic therapy is carried out.

Death is mainly possible due to untimely treatment of patients due to shock. Hemodialysis is ineffective for removing iron, but can be used to accelerate the removal of the iron-deferoxamine complex, and can also be prescribed for oligo- and anuria. Peritoneal dialysis is also possible. During a course of treatment with iron supplements, systematic monitoring of serum iron levels and other blood serum parameters is necessary.

Special measures: for severe intoxication - Unithiol (sodium dimercaptopropanesulfonate) parenterally.

Due to the possibility of the formation of neurotoxic complexes, Unithiol (sodium dimercaptopropanesulfonate) should be used with caution.

Impact on the ability to drive vehicles and operate machinery

Not found.

ACTIFERRIN (drops)

...in kindergarten, hemoglobin returned to normal!
Hurray!!)) Now about “Actiferrin”. My son is still breastfed. He also eats other foods, but in small portions and not varied enough (we also have allergies, so I can’t give him everything). One of the consequences is iron deficiency. There was low hemoglobin a year ago, but then it was higher, and I hoped for the best and did not treat the child with anything. That's what I've been waiting for! During the next test, the iron level dropped to 80. The doctor prescribed “Actiferrin” drops. I bought it. The bottle, 30 ml (which is very convenient - you will have time to understand whether it is effective, and you do not have to overpay for the extra volume if suddenly the drug does not suit you), is equipped with a dispenser to make it more convenient to drip. We started treatment, and then... Usually there is constipation, but my son has diarrhea! Well, I guess it's a coincidence. After the next use - the same thing, we ran to the potty several times in a row. I decided to stop using this drug. We didn’t use it for several days, and during this time the readings dropped to 76! I'm starting to panic! It's good that I thought of re-reading the instructions again. It says that it is better to start administering the medicine in small doses to avoid side effects. Considering our weight, it was necessary to give 25 drops 3 times a day. I started with 5 drops, increasing the amount by 1-2 drops every day. After just 2 weeks, hemoglobin rose to 102!! She continued to give “Actiferrin” until the bottle ran out. I hope that now all my son’s indicators will be normal.

The most important advantage is obvious - the drug works, and quickly, which is important. One caveat - do not give iron supplements at the same time as dairy products, because calcium interferes with the absorption of iron. Now about the so-called disadvantages (but personally I don’t consider these to be disadvantages, I just read other reviews - most are unhappy): - teeth darken. My opinion is that it’s better to have stained teeth than health problems. And the teeth darken in those places where the enamel is problematic, and this is certainly not Aktiferrin’s fault. Personal advice: give the drug with food, then the remaining medication will be swallowed with food and will not remain in the mouth. Here are our teeth BEFORE this is AFTER In my opinion, there is nothing wrong. - stains on clothes from spilled medicine. Also a dubious “minus”. People, are you really giving the drug to a child in formal clothes??? Well, put on a homemade T-shirt for him and always give your baby something to drink only in it, so as not to dirty anything else! And the spots can’t be called spots either. Do you see anything above the letter “a”? This is the so-called stain)) - the next point that others write about: bad taste, children categorically refuse to drink. Nothing like this. How did I do it? We take a spoon, a cup of water (so that we have it at hand), fill the spoon with water, add 5 (or as many as is convenient for you) drops of medicine, and give it to the baby. You can immediately give it a spoonful of plain water to wash it down. And so several times in a row. We needed to drink 25 drops, so we drank them with 5 tablespoons of water. Everything is simple, as you can see) Well, don’t forget to chew on food (see the previous point) - the only adequate minus is the possibility of side effects. But I have already written how to cope with such a risk.

We're done with the negatives. The advantages were higher) Draw your own conclusions, I hope my review will help you with this. All the best, don't get sick)