PANCLAV 2X
Pharmacokinetics
The main pharmacokinetic parameters of amoxicillin and clavulanic acid are similar.
Both components are well absorbed after oral administration; food intake does not affect the degree of absorption. Bioavailability is 90% for amoxicillin and 70% for clavulanic acid. Peak plasma concentrations are reached approximately 2 - 2.5 hours after administration. The maximum concentration of amoxicillin in the blood (Cmax) is about 12 μg/ml, clavulanic acid is 3.3 μg/ml. The half-life (T1/2) of amoxicillin and clavulanic acid is 1-1.5 hours. Connection with plasma proteins: amoxicillin - about 18%, clavulanic acid - 25%. The apparent volume of distribution of amoxicillin is 0.3 - 0.4 l/kg, clavulanic acid - 0.2 l/kg.
Both components are found in many organs and tissues of the body, biological fluids and pathological discharge: amoxicillin - in lung tissue, bronchial secretions and saliva; in the skin, subcutaneous, muscle and fatty tissues, in the palatine tonsils; in bone tissue and synovial fluid; intestinal mucosa, liver, gall bladder, bile, female genital organs, fetal tissues; pleural and peritoneal fluid, the contents of skin blisters, sputum, bronchial secretions (to a lesser extent in purulent discharge), in exudate from inflammation of the middle ear and paranasal sinuses; clavulanic acid - in the palatine tonsils, abdominal organs, bone, muscle and fatty tissues, synovial and peritoneal fluids, bile and purulent discharge. Neither the active components of Panclava 2X nor their metabolites accumulate in any organs or tissues.
Amoxicillin and clavulanic acid do not penetrate the intact blood-brain barrier.
Amoxicillin and clavulanic acid penetrate the placental barrier and into breast milk.
Amoxicillin is partially (10 - 25% of the absorbed dose) metabolized to inactive penicillic acid; clavulanic acid is extensively metabolized, its metabolites are excreted from the body through the kidneys, intestines and lungs.
Amoxicillin is excreted primarily by the kidneys by tubular secretion and glomerular filtration. The total clearance of the amoxicillin/clavulanic acid combination is 25 l/h. During the first 6 hours after a single dose of the drug, 60% and 40% of the administered dose of amoxicillin and clavulanic acid, respectively, are excreted from the body unchanged.
Both components are removed by hemodialysis, and to a lesser extent by peritoneal dialysis.
Elderly patients:
Due to the possible age-related decrease in renal excretory function, use with caution is recommended.
In patients with severe renal failure
The half-life increases to 7.5 hours for amoxicillin and to 4.5 hours for clavulanic acid.
Panklav 2x
Inside, with water; at the beginning of a meal (in order to reduce the risk of side effects from the gastrointestinal tract), 2 times a day, strictly observing the interval between doses of 12 hours.
Dosage with a measuring spoon, taking into account that 5 ml of the finished suspension contains amoxicillin 400 mg / clavulanic acid 57 mg. Take 0.5-1 glass of water. The dose of Panclava 2X is prescribed by a doctor, taking into account the characteristics of the pathogen, the location and severity of the infection. The dosage regimen is set individually, depending on age, body weight (for children) and kidney function. The course of treatment is 5 - 14 days; installed individually.
For infections that require a long course of therapy (for example, osteomyelitis), exceeding the maximum recommended course of therapy of 14 days is possible only after a thorough assessment by the doctor of the patient’s condition, the achieved and expected therapeutic effect and risks. The maximum daily dose of amoxicillin for adults is 6 g, for children - 45 mg/kg/day. The maximum daily dose of clavulanic acid for adults (in the form of potassium clavulaate) is 600 mg, for children - 10 mg/kg/day.
Adults and children over 12 years old (body weight > 40 kg)
Standard dosage regimen for all indications: 2 scoops (800 mg/114 mg) 2 times a day, every 12 hours.
Children from 2 to 12 years old (body weight > 40 kg)
| Daily dose (for amoxicillin) | Child's weight | Age appropriate | Amount of finished suspension, in ml |
| 25 mg/kg | 13-21 kg | 2-6 years | 2.5 ml 2 times a day |
| 22-40 kg | 7-12 years | 5 ml 2 times a day | |
| 45 mg/kg | 13-21 kg | 2-6 years | 5 ml 2 times a day |
| 22-40 kg | 7-12 years | 10 ml 2 times a day |
Children from 3 months to 3 years
| baby's weight | Daily dose 25 mg/kg (for amoxicillin) | Daily dose 45 mg/kg (for amoxicillin) |
| 5 kg | 0.8 ml 2 times a day | 1.4 ml 2 times a day |
| 6 kg | 0.9 ml 2 times a day | 1.7 ml 2 times a day |
| 7 kg | 1.1 ml 2 times a day | 2.0 ml 2 times a day |
| 8 kg | 1.3 ml 2 times a day | 2.3 ml 2 times a day |
| 9 kg | 1.4 ml 2 times a day | 2.5 ml 2 times a day |
| 10 kg | 1.6 ml 2 times a day | 2.8 ml 2 times a day |
| 11 kg | 1.7 ml 2 times a day | 3.1 ml 2 times a day |
| 12 kg | 1.9 ml 2 times a day | 3.4 ml 2 times a day |
The daily dose for children over 3 months and up to 12 years (body weight > 40 kg) is 25 - 45 mg/kg/day (based on amoxicillin), divided into two doses every 12 hours. Low doses of the drug (25 mg/kg/day) are used to treat skin and soft tissue infections, as well as recurrent tonsillitis. High doses of the drug (45 mg/kg/day) are used to treat diseases such as otitis media, sinusitis, lower respiratory tract and urinary tract infections. The duration of treatment for acute uncomplicated otitis media is 5-7 days, in children under 2 years old - 7-10 days.
Children and adults with kidney failure
If creatinine clearance is less than 30 ml/min, the drug at this dose is not recommended; when creatinine clearance is more than 30 ml/min, there is insufficient substantiated data to develop special recommendations on the dosage regimen. It is possible to reduce the dose of the drug or increase the interval between doses.
Preparation of suspension for oral administration
Water is gradually added to the bottle with the powder up to the mark (distilled water or boiled and cooled) and shaken until the powder is evenly wet (about 30 seconds). If the level of the prepared suspension is below the mark on the bottle label, add water again to the mark and shake.
The prepared suspension must be shaken before each dose.
The prepared suspension should be stored in the refrigerator (at a temperature of 2-8°C) for no more than 7 days.
Important! If a dose is missed, you should take the suspension as soon as possible without waiting for the next dose. Next, maintain equal intervals between doses - 12 hours. Never take a double dose to make up for a missed dose!
Panclave 2X tablets 875 mg + 125 mg 14 pcs. in Novosibirsk
Inside,
drinking water; at the beginning of a meal (in order to reduce the risk of side effects from the gastrointestinal tract), 2 times a day, strictly observing the interval between doses of 12 hours.
Film-coated tablets
Adults and children over 12 years of age (body weight ≥40 kg)
Take 1 tablet. 2 times a day, every 12 hours.
The maximum daily dose of amoxicillin for adults is 6 g, for children - 45 mg/kg/day.
The maximum daily dose of clavulanic acid for adults (in the form of potassium clavulanate) is 600 mg, for children - 10 mg/kg/day.
The course of treatment is 5–14 days; is established individually, taking into account the characteristics of the pathogen, localization and severity of the infection. Treatment should not continue for more than 14 days without repeated medical examination.
Dosing for renal failure
Tablets 875/125 mg should be used only in patients with Cl creatinine more than 30 ml/min, and no dose adjustment is required.
Patients on peritoneal dialysis do not require dose adjustment. Patients on hemodialysis may require dose adjustment of the drug.
Powder for suspension for oral administration
Dosage with a measuring spoon, taking into account that 5 ml of the finished suspension contains amoxicillin 400 mg/clavulanic acid 57 mg. Take with 0.5–1 glass of water.
The dose of Panclava 2X is prescribed by a doctor, taking into account the characteristics of the pathogen, the location and severity of the infection. The dosage regimen is set individually, depending on age, body weight (for children) and kidney function. The course of treatment is 5–14 days; installed individually.
For infections that require a long course of therapy (for example, osteomyelitis), exceeding the maximum recommended course of therapy of 14 days is possible only after a thorough assessment by the doctor of the patient’s condition, the achieved and expected therapeutic effects and risks.
The maximum daily dose of amoxicillin for adults is 6 g, for children - 45 mg/kg/day. The maximum daily dose of clavulanic acid for adults (in the form of potassium clavulanate) is 600 mg, for children - 10 mg/kg/day.
Adults and children over 12 years of age (body weight ≥40 kg)
Standard dosage regimen for all indications:
2 scoops (800/114 mg) 2 times a day, every 12 hours.
Children from 2 to 12 years (body weight ≥40 kg)
| Daily dose (for amoxicillin) | Child's weight | Age appropriate | Amount of finished suspension |
| 25 mg/kg | 13–21 kg | 2–6 years | 2.5 ml 2 times a day |
| 22–40 kg | 7–12 years | 5 ml 2 times a day | |
| 45 mg/kg | 13–21 kg | 2–6 years | 5 ml 2 times a day |
| 22–40 kg | 7–12 years | 10 ml 2 times a day |
Children from 3 months to 3 years
| Child's weight | Daily dose 25 mg/kg (for amoxicillin) | Daily dose 45 mg/kg (for amoxicillin) |
| 5 kg | 0.8 ml 2 times a day | 1.4 ml 2 times a day |
| 6 kg | 0.9 ml 2 times a day | 1.7 ml 2 times a day |
| 7 kg | 1.1 ml 2 times a day | 2 ml 2 times a day |
| 8 kg | 1.3 ml 2 times a day | 2.3 ml 2 times a day |
| 9 kg | 1.4 ml 2 times a day | 2.5 ml 2 times a day |
| 10 kg | 1.6 ml 2 times a day | 2.8 ml 2 times a day |
| 11 kg | 1.7 ml 2 times a day | 3.1 ml 2 times a day |
| 12 kg | 1.9 ml 2 times a day | 3.4 ml 2 times a day |
The daily dose for children over 3 months and up to 12 years (body weight ≥40 kg) is 25–45 mg/kg/day (based on amoxicillin), divided into two doses every 12 hours. Low doses of the drug (25 mg /kg/day) are used to treat skin and soft tissue infections, as well as recurrent tonsillitis. High doses of the drug (45 mg/kg/day) are used to treat diseases such as otitis media, sinusitis, lower respiratory tract and urinary tract infections. The duration of treatment for acute uncomplicated otitis media is 5–7 days, in children – 7–10 days.
Children and adults with kidney failure
When creatinine Cl is less than 30 ml/min, the drug at this dose is not recommended; if creatinine Cl is more than 30 ml/min, there is not enough substantiated data to develop special recommendations on the dosage regimen. Both a reduction in the dose of the drug and an increase in the interval between doses are allowed.
Preparation of suspension for oral administration
Water is gradually added to the bottle with the powder up to the mark (distilled water or boiled and cooled) and shaken until the powder is evenly wet (about 30 s). If the level of the prepared suspension is below the mark on the bottle label, add water again to the mark and shake.
The prepared suspension must be shaken before each dose.
Important!
If a dose is missed, you should take the tablet (or suspension) as soon as possible without waiting for the next dose.
Next, observe equal intervals of time between doses - 12 hours each. You should never take a double dose to make up for a missed dose of medication!
