Indications for use
The drug for intravenous administration is prescribed for the following conditions:
- septic condition;
- inflammatory and purulent processes in the membrane of the brain.
Indications for intracavitary use:
- peritonitis;
- cystitis;
- inflammatory and purulent processes in the gallbladder.
The medicine in the form of an intracavitary solution can also be used to prevent the occurrence of various infectious diseases.
Indications for local use:
- burns, wounds;
- deep abscesses;
- infectious lesion of the skin.
Composition and dosage form of Dioxidin
Dioxidin belongs to the group of drugs with bactericidal action. The synthetic antibiotic contains a substance called hydroxymethylquinoxaline dioxide. The active component is capable of destroying the membrane cells of many bacteria. The medicine may not help in all cases; some pathogens are resistant to Dioxidin. Before prescribing the drug, the patient undergoes laboratory tests.
The antibiotic is used to treat patients with diseases caused by:
- salmonella;
- streptococcus;
- staphylococcus;
- Proteus vulgaris;
- Pseudomonas aeruginosa;
- dysentery bacillus;
- anaerobic bacteria, etc.
The antibacterial drug has several forms of release:
- In ampoules of 5 and 10 ml. A solution at a concentration of 1% is intended for local and intracavitary use. One package contains 10 ampoules. The medicine is yellowish in color, odorless, and tastes bitter.
- In ampoules of 10 and 20 ml. Solution for external and intravenous use. The concentration of the active substance is 5 mg/ml.
- Ointment 5% in tubes of 30 and 50 g. Used externally.
Contraindications and adverse reactions
You should stop taking the drug in the following cases:
- increased susceptibility to constituent components;
- period of bearing a child;
- during breastfeeding;
- childhood.
Can be used with extreme caution in chronic renal failure.
Possible side effects include:
- chills;
- headaches;
- nausea, vomiting, upset stomach;
- allergy.
Dioxidin, 1%, solution for intracavitary administration and external use, 5 ml, 10 pcs.
Ointment
Locally. Apply a thin layer to the affected area once a day. Course - up to 3 weeks.
Solution for infusion and external use, 5 mg/mg
IV,
drip. In severe septic conditions, the drug solution is administered, previously diluted in a 5% dextrose solution or in a 0.9% sodium chloride solution to a concentration of 0.1–0.2%. The highest single dose is 300 mg, the daily dose is 600 mg.
Externally
— deep wounds are packed or irrigated with a solution daily or every other day, depending on the condition of the burn wound and the course of the wound process. The maximum daily dose is 2.5 g. Duration of treatment is up to 3 weeks.
Solution for intracavitary and external use 10 mg/ml
Externally, intracavity.
Dioxidin® is prescribed in a hospital setting.
Dioxidin® 1% solution cannot be used for intravenous administration due to the instability of the solution when stored at low temperatures.
Intracavitary administration.
Depending on its size, 10 to 50 ml of a 1% Dioxidin® solution is injected into the purulent cavity per day. Dioxidin® solution is injected into the cavity through a catheter, drainage tube or syringe. The maximum daily dose for administration into cavities is 70 ml of a 1% solution. The drug is administered into the cavity usually once a day. According to indications, it is possible to administer a daily dose in two doses. If well tolerated, the drug can be administered daily for 3 weeks or more. If necessary, repeat courses are given after 1–1.5 months.
External use.
Use 0.1–1% solutions of Dioxidin®. To obtain 0.1–0.2% solutions, ampoule solutions of the drug are diluted to the desired concentration with a sterile 0.9% sodium chloride solution or water for injection.
To treat superficial infected purulent wounds, apply napkins moistened with a 0.5–1% solution of Dioxidin®. After treatment, deep wounds are loosely tamponed with napkins moistened with a 1% solution of Dioxidin®, and if there is a drainage tube, 20 to 100 ml of a 0.5% solution of the drug is injected into the cavity.
For the treatment of deep purulent wounds with osteomyelitis (wounds of the hand, foot), use 0.5–1% solutions of the drug in the form of baths or carry out a special treatment of the wound with a solution of the drug for 15–20 minutes (injection of the solution into the wound for this period) followed by application dressings with 1% Dioxidin® solution.
Dioxidin® in the form of 0.1–0.5% solutions can be used to prevent and treat infections after surgery. According to indications (patients with osteomyelitis) and if well tolerated, treatment can be carried out daily for 1.5–2 months.
How to use Dioxidin for a runny nose
The product is not sold in the form of nasal drops. Before instillation into the nose, you need to dilute the contents of the ampoule with a hypertonic solution. For a runny nose, you can use the medicine 3 times a day, 2 drops in each nostril. During instillation, the head should be tilted back so that the product passes as far as possible into the nasal passages.
From the moment of opening, the ampoule is suitable for use within 24 hours. The duration of the therapeutic course should not exceed 7 days. If drops are used by children, it is better to shorten the course to 3-4 days.
To improve the effect, it is worth additionally resorting to traditional healing methods.
How to drip?
Regarding how to drip Dioxidin into the nose of children, there are clear instructions:
- Clean the baby's nostrils from crusts and dirt with a cotton swab and boiled water.
- Open the ampoule, dilute to the desired concentration, and pipette.
- Place 1 drop of product into each nostril.
- Tilt the patient's head back for 2-3 seconds.
Dioxidin is dripped into the nose of children according to the instructions, strictly observing the dosage and course of treatment prescribed by the doctor.
You need to make sure that the baby does not swallow any drops.
Is it necessary to breed?
For external use, use 0.1%, 0.2% and 0.5% solution of the drug. Ampoules with 0.5% and 1% solution are available. Recommendations for diluting Dioxidin into the nose of children are presented in the table.
Desired concentration | Stock solution 1%, 10 ml | Stock solution 0.5%, 10 ml |
0,1% | Add 90 ml saline. solution | Add 40 ml saline. solution |
0,2% | Add 40 ml saline. solution | Add 15 ml saline. solution |
0,5% | Add 10 ml saline. solution |
Saline solution is a sterile 0.9% sodium chloride solution, sold in pharmacies. The diluted solution is stored in the cold for no more than 24 hours. Before use, warm with palms or warm water. If crystals have fallen out, they will dissolve after warming up.
Dosage
The dosage of Dioxidine for children in the nose is determined by the severity of the pathology, the course of the inflammatory process, the age and state of health of the baby. The instructions recommend treatment with an antiseptic for no more than 7-10 days, instilling 1-2 drops into each nostril three times a day. For compelling indications and with normal tolerance, treatment is extended to 6-8 weeks. Symptoms of overdose - allergies, dizziness, muscle cramps, nausea and vomiting are grounds for discontinuing the drug and seeking medical help.
With a runny nose
Dioxidin is not the drug of choice for a runny nose in children. The solution is used for a runny nose as a last resort, when other treatment regimens have not given a positive result.
Indications are long-term rhinitis with abundant purulent exudate, sinusitis. You can put 2 ml of a diluted antiseptic solution into a bottle with a spray bottle and spray it on the baby’s nasal mucosa. Uniform irrigation of the nasal mucosa with Dioxidin will increase the effectiveness of treating children with a runny nose.
For adenoids
Dioxidine for adenoids in children is an ineffective remedy. The medicine will remove bacterial contamination without affecting the size and stage of the adenoids. Adenoids are a pathological growth of the mucous membrane due to chronic inflammation. The antiseptic eliminates inflammation and prevents the appearance of adenoids in children. You can get rid of adenoids through surgery.
How to use Dioxidin for sinusitis
Medicine in the form of ampoules is often used for sinusitis in children and adults. The solution is used in the form of drops or inhalations. You need to drip 1-2 drops into each nostril twice a day.
If the condition is advanced, then you can prepare a more complex solution, which will contain dioxidine and hydrocortisone. They can be used 1 drop in each passage no more than 5 times a day. The prescription for such drops is prescribed by a specialist. You can buy it at the pharmacy or prepare it yourself.
What is the medicine in?
Pharmaceutical companies produce Dioxidin in two forms:
- In the form of a solution used for nasal instillation. It is also used externally and intravenously. It is available in two concentrations: 1% and 0.5%. If a child or adult suffers from sinusitis or sinusitis, then only 0.5% Dioxidin solution is instilled into the nose. A 1% solution is diluted with saline or used in the treatment of otitis media. When treating serious diseases caused by bacteria, 0.5% Dioxidin is injected into a vein. The liquid is available in ampoules of 5 and 10 milliliters. It is greenish-yellowish in color and odorless. One package contains from five to 10 ampoules;
- Ointment applied externally, with a 5% concentration of the active ingredient. The color of the substance is greenish-yellowish. The ointment is produced in tubes or jars of 30 or 100 grams.
How to use Dioxidin as a mouth rinse
The component of the medicine effectively copes with the infection, cleansing the affected area and accelerating the healing process of the mucous membrane.
Gargle and mouth should be used for sore throat, tonsillitis, pharyngitis, when other medications do not bring the desired result. Take a little liquid into your mouth, throw your head back and gargle for 15-20 seconds. Then spit out the contents. The procedure can be performed up to 3 times a day.
The duration of the therapeutic course is 5 days.
Precautionary measures
Dioxidin can cure all forms of bacterial rhinitis and otitis in children. In fact, this is a universal medicine that can be used only in extreme cases when other drugs are powerless.
Since a synthetic antibiotic can cause side effects, a test must be carried out before using it. The child is instilled with 1 drop of the drug into the nose or ear and his condition is monitored for 3-6 hours. If the medicine is well tolerated, treatment can be continued.
Some parents prefer not to drip children's Dioxidin onto the mucous membranes of the nose when they have a runny nose, but rather treat them with a cotton swab soaked in the medicine. However, this should never be done, since it can damage the villi and mucous membranes of the nasal cavity. Also, you should not rinse your nose with Dioxidin solution, as this can cause an overdose. The medicine can enter the Eustachian tube or gastrointestinal tract through the nasal passages.
The antibiotic is very toxic, so it is important to strictly observe its storage conditions. The medicine should be kept out of the reach of children. The opened ampoule should be stored in the dark and cold. If the expiration date has expired, the medication must be disposed of.
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Is it possible to give Dioxidin to children?
The instructions for the drug say that it should not be given to persons under 18 years of age. This is due to the fact that the active component can have a toxic effect on an incompletely formed organism.
But there are still exceptions when a pediatrician can prescribe Dioxidin to a child. In this case, the expected benefit should be many times higher than the possible threat. When prescribed to children, constant medical supervision is required.
The medicine can be prescribed for ENT diseases, in particular rhinitis and sinusitis. Also, the drug in the form of an ointment and solution can be used to treat affected areas of the skin.
Composition of Dioxidine
The main active component of the drug is hydroxymethylquinoxaline dioxide. It is also called quinoxaline. This is a strong antimicrobial drug (antibiotic), in case of overdose it has a toxic effect on the body's cells.
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A solution of Dioxidin 0.5% contains 5 mg of the substance per 1 milliliter. A 1% solution of the drug contains 10 mg of the active ingredient per 1 ml of the drug. The only auxiliary component is sterile water.
100 grams of medicine contains 5 grams of quinoxaline. The ointment contains monoglycerides, nipazole, macrogol, nipagin.