Composition and release form
The composition of the drug depends on the form of release of the drug. Eufillin is produced in the following versions:
- Pills. One piece contains the active substance - aminophylline (150 milligrams), as well as auxiliary components. The latter include calcium, stearic acid and potato starch.
- Ampoules (solution for injection). Aminophylline is also the main substance. Each ampoule contains 24 milligrams of the active ingredient. In addition to it, the composition also contains water for injection.
Pharmacological effects
The main effect of the drug is antispasmodic. However, it also has other effects on the human body, namely tocolytic, diuretic and bronchodilator.
According to the Vidal classifier, Eufillin is included in the pharmacological group of phosphodiesterase inhibitors.
What does Eufillin help with? Indications for use
Indications for use of the drug Eufillin may vary slightly depending on the form of release. Tablets are most often prescribed for:
- Bronchial asthma of varying severity.
- Chronic obstructive pulmonary disease.
- Paroxysmal attacks of apnea at night.
- Right ventricular heart failure.
- Emphysema.
The injection form of the drug is used for:
- Cerebrovascular insufficiency of the brain (the drug is used in combination with other drugs and helps reduce intracranial pressure).
- Pulmonary hypertension.
- Left ventricular heart failure (also used in combination with a number of other drugs).
- For diseases of the respiratory system accompanied by spasm and broncho-obstructive syndrome (COPD, emphysema, bronchial asthma).
Eufillin - indications for use
Eufillin
- a pharmacological drug that is a combination of theophylline and ethylenediamine. The drug relieves spasms in the bronchi, blood vessels, and bile ducts. Eufillin is available in two forms: tablets and liquid ampoules.
There are a number of indications for the use of Eufillin:
- bronchospasms, asthma;
- apnea (impaired breathing function) in infants;
- cerebrovascular accident;
- angina pectoris and other cardiovascular diseases;
- diuretic for edema.
Eufillin for bronchitis
First of all, Eufillin is used to treat diseases of the respiratory system: asthma, bronchitis, chronic cough, emphysema. The drug makes breathing easier by opening the airways and providing more oxygen. The use of Eufillin should occur under strict medical supervision, since as a result of exceeding the dose, convulsions and rapid heartbeat may occur, and an insufficient amount of medication can aggravate the course of asthmatic attacks.
Dosage of Eufillin tablets
The dose of the drug and the frequency of its use are determined by the attending physician.
For respiratory diseases, the average daily dose for an adult is 300 mg, divided into two doses.
Patients with diseases of the cardiovascular system and weighing more than 60 kg are usually prescribed 400 mg of Euphyllin per day. People who weigh less should take 200 mg per day.
The daily dose may be reduced in case of severe heart and liver diseases, as well as in some viral diseases.
Children weighing up to 30 kg are prescribed no more than 20 mg per 1 kilogram of weight per day, dividing the dose into two doses.
Children under 7 years of age can take no more than 0.1 g of Euphyllin per 24 hours.
Attention!
For children under 3 years of age, the drug is prescribed in exceptional cases. The drug should not be given to infants under 3 months of age! During pregnancy, Eufillin can be used for edema.
Features of using Eufillin tablets:
- the drug cannot be taken with other medications;
- the medicine is not used for caffeine allergies;
- tablets should be taken with plenty of liquid;
- between doses it is necessary to maintain a period of at least 12 hours.
Eufillin - instructions for use of ampoules
The medicine is used intramuscularly for asthma. It is recommended to inject into the upper quadrant of the gluteal muscle in the amount of 100–500 mg per day. In some situations, adults can administer Eufillin into a vein at the rate of 6 mg of solution per 1 kg of weight. In case of severe asthmatic attacks, the patient is given a dropper of a solution of the drug (no more than 750 mg).
The amount of medication administered to the child is calculated by a specialist, taking into account the weight, age of the child and the pathology of the disease.
Eufillin for cellulite
Another direction of use of Eufillin is getting rid of cellulite. It is easy to prepare an anti-cellulite composition at home. One tablet of Eufillin is ground and mixed with Vaseline or baby cream. The resulting mixture not only reduces the “orange peel” effect, but also softens the skin and eliminates irritation. You can enhance the effect by using any anti-cellulite cream as a basis.
Efullin is used to combat cellulite manifestations and in the form of a wrap. A liquid preparation or cream is rubbed into problem areas, and the body is wrapped in cling film. Visible results are achieved after two weeks if daily procedures are performed. To enhance the effectiveness of the wrap, a mixture of massage cream, essential citrus oil (or tea tree oil), Dimexide and Euphyllin is prepared.
Contraindications
Eufillin is not a completely safe drug and has a fairly wide list of contraindications for its use:
- Individual hypersensitivity to one or more components of the drug.
- Children under 3 years of age.
- From the cardiovascular system: acute period of myocardial infarction, acute and severe chronic heart failure, atherosclerosis, dissecting aortic aneurysm, hypertrophic cardiomyopathy, high-grade arterial hypertension, and low blood pressure.
- From the digestive tract: exacerbation of gastric or duodenal ulcer, GERD, decompensated liver failure.
- Hormonal disorders: hypothyroidism, thyrotoxicosis.
- From the blood system: coagulation disorders and spontaneous bleeding in the anamnesis.
- Acute infectious diseases, sepsis.
- Severe renal failure.
- Epilepsy.
Eufillin instructions for use, treatment, indications for use
EUPHYLLINE
Euphyllinum (CIS)
Synonyms of Eufillin. Aminophylline - Aminophyllinum; Diaphylline - Diaphyllin (Ven.); Novfillin - Novphyllin (Bol.); Syntophyllin - Synthophyllin (Czech).
Eufillin dosage forms.
Eufillin is a combination drug. Composition: theophylline - 80%, 1,2-ethylenediamine - 20%. Available in powders, tablets of 0.15 g in packs of 30 pieces, ampoules of 10 ml of 2.4% solution and 1 ml of 24% solution in packs of 10 pieces. The highest doses orally and into the rectum are: VRD - 0.5 g, VSD - 1.5 g.
Eufillin description of medicinal properties.
The drug has an antispasmodic and vasodilator effect. Eufillin lowers blood pressure, improves blood supply to the heart muscle and internal organs, stimulates cardiac activity and increases the heart's need for oxygen. The drug relieves muscle spasms of the bronchi, intestines, urinary and biliary tracts, has some diuretic effects, and somewhat stimulates the central nervous system. Eufillin can accumulate (cumulate) in the body.
Eufillin indications for use.
The drug is used for bronchial asthma, bronchospasms, pulmonary edema, cardiac asthma, angina pectoris, myocardial infarction, stroke accompanied by cerebral edema, edema of cardiac and renal origin, intestinal, renal and hepatic colic.
Eufillin instructions for use.
The drug is prescribed orally, into the rectum (rectally), intramuscularly and intravenously. The drug is not administered subcutaneously, as it causes severe tissue irritation. Take 1 tablet orally 2-3 times a day after meals. 0.3 g is administered into the rectum in suppositories or microenemas. Microenemas are prepared at the rate of 0.25-0.4 g per 20-25 ml of warm water. For children, the drug is prescribed in smaller doses, calculated according to an age scale or using special formulas.
Eufillin side effects and complications.
If taken orally, nausea, vomiting, diarrhea, and abdominal pain may develop. Headaches, increased excitability, anxiety, sleep disturbances, palpitations, decreased blood pressure (hypotension), and skin rashes may occur. When used in suppositories, irritation of the rectal mucosa is possible.
Eufillin contraindications.
The drug is not prescribed for low blood pressure, paroxysmal palpitations (paroxysmal tachycardia), and extraordinary contractions of the heart (extrasystoles). Eufillin should not be used in the acute period of myocardial infarction, with sclerosis of the heart vessels (coronary sclerosis), peptic ulcers associated with increased production of gastric juice. Eufillin is absolutely contraindicated for children under 6 months. The drug should be prescribed with caution to children under 14 years of age.
Storage of Eufillin.
The drug should be stored in a well-closed container, protected from light. The shelf life of the powder is 2 years, tablets - 5 years, ampoules of 2.4% solution - 2 years, ampoules of 24% solution - 1 year.
Side effects
When taking Eufillin, in addition to the main pharmacological action, side effects may also occur. Most often, patients develop insomnia, dizziness, weakness, tachycardia, arrhythmia, dyspeptic syndrome, allergic reactions, hypoglycemia, hypotension, increased sweating, pain in the head, chest and abdomen.
Against the background of a drug overdose, muscle cramps, increased body temperature, polyuria, hematuria, albuminuria and even disturbances of consciousness may occur.
To eliminate adverse symptoms, it may be necessary to reduce the dosage or stop taking the drug.
If the rules of asepsis and antisepsis are violated during injections of Eufillin, infectious complications sometimes develop.
Eufillin instructions for use
The single and daily dose of the drug is selected depending on the form of release, the disease and the age of the patient.
Adult patients are recommended to take 15 milligrams per kg of body weight 1 to 3 times a day. The pediatric dosage is 7-10 mg per kilogram of body weight 4 times a day. The course of treatment with tablets can vary from 3 days to several months.
When administered intravenously, the average daily dose ranges from 400 to 800 milligrams.
While taking the drug, it is necessary to monitor blood pressure, blood glucose and heart rate daily.
Eufillin
Theophylline with 1, 2-ethylenediamine. The content of theophylline is about 80%, ethylenediamine - 20%.
Synonyms: Aminocardol, Aminophyllinum, Ammophyllin, Diaphyllin, Genophyllin, Methaphyllin, Neophyllin, Novphyllin, Synthophyllin, Theophyllamin, Theophylline ethylendiamine, etc.
White or white with a yellowish tint crystalline powder with a faint odor of ammonia. Let's dissolve in water. Aqueous solutions (pH 9.0 9.7) are prepared aseptically.
The effect of aminophylline is primarily due to the content of theophylline in it. Ethylenediamine enhances antispasmodic activity and promotes dissolution of the drug. The molecular mechanism of action of aminophylline is basically similar to the mechanism of action of theophylline.
Important features of aminophylline are its solubility in water and the possibility of its parenteral (intravenous) administration.
Like theophylline, aminophylline relaxes the bronchial muscles, reduces blood vessel resistance, dilates coronary vessels, lowers pressure in the pulmonary artery system, increases renal blood flow, and has a diuretic effect associated primarily with a decrease in tubular reabsorption; causes an increase in the excretion of water and electrolytes, especially sodium and chlorine ions, in the urine.
The drug strongly inhibits platelet aggregation.
Eufillin is used for bronchial asthma and bronchiolospasms of various etiologies (mainly for the relief of attacks); hypertension in the pulmonary circulation, as well as in cardiac asthma, especially when attacks are accompanied by bronchiolospasm and Cheyne Stokes-type breathing disorders. It is also recommended for relieving cerebral vascular crises of atherosclerotic origin and improving cerebral circulation, reducing intracranial pressure and cerebral edema during ischemic strokes, as well as chronic cerebrovascular insufficiency. The drug improves renal blood flow and can be used if indicated.
Eufillin is prescribed orally, into muscles, veins and microenemas. Aminophylline solutions are not injected under the skin, as they cause tissue irritation.
The method of administration depends on the characteristics of the case: in acute attacks of bronchial asthma and strokes it is administered intravenously, in less severe cases - intramuscularly or orally.
Adults take 0.15 g orally after meals 1 to 3 times a day. Children are given orally at the rate of 7 - 10 mg/kg per day in 4 divided doses. The duration of treatment ranges from several days to several months.
Adults are administered slowly (over 4-6 minutes) 0.12 0.24 g (5 - 10 ml of 2.4% solution) into a vein, which is pre-diluted in 10 - 20 ml of isotonic sodium chloride solution. When palpitations, dizziness, nausea occur, the rate of administration is slowed down or switched to drip administration, for which 10 - 20 ml of a 2.4% solution (0.24 0.48 g) is diluted in 1OO - 150 ml of isotonic sodium chloride solution; injected at a rate of 30 - 50 drops per minute. If it is impossible to administer into a vein, 1 ml of a 24% solution is injected intramuscularly.
Eufillin is administered parenterally up to 3 times a day for no more than 14 days.
Children are administered intravenously at a single dose of 2 - 3 mg/kg. The drug is not recommended for children under 14 years of age (due to possible side effects).
You can prescribe aminophylline rectally in the form of microenemas. Dose for adults 1O - 20 ml of 2.4% solution in 20 - 25 ml of warm water; children less, according to age.
Higher doses of aminophylline for adults orally, intramuscularly and rectally: single 0.5 g, daily 1.5 g; into a vein: single 0.25 g, daily 0.5 g.
Higher doses for children orally, intramuscularly and rectally: single 7 mg/kg, daily 15 mg/kg; intravenously: single dose - 3 mg/kg.
When taking aminophylline orally (especially when taken on an empty stomach), dyspeptic symptoms associated with the irritating effect of the drug are possible; with rapid intravenous administration, dizziness, headache, palpitations, nausea, vomiting, convulsions, and a sharp decrease in blood pressure are possible.
Intravenous administration should be carried out under careful monitoring of the patient's blood circulation, breathing and general well-being.
With increased sensitivity to ethylenediamine, exfoliative dermatitis, febrile reaction and other side effects are possible; with intramuscular administration of aminophylline, pain at the injection site is possible.
When administered rectally, irritation of the rectal mucosa may occur.
The use of aminophylline, especially intravenously, is contraindicated in cases of sharply reduced blood pressure, paroxysmal tachycardia, extrasystole, and epilepsy. The drug should also not be used for heart failure, especially associated with myocardial infarction, when there is coronary insufficiency and heart rhythm disturbances.
Release forms: tablets of 0.015 g; 24% solution in ampoules for intramuscular administration and 2.4% solution in 10 ml ampoules for intravenous injection.
Storage: List B. In a well-closed container, protected from light.
Rр. Sol. Euphyllini 2.4% 10 ml
Dtd 3 in ampull.
S. Into a vein (dilute in 20 ml of isotonic sodium chloride solution).
Enter slowly!
Rр. Sol. Euphyllini 24% 1 ml
DtdN 6 in ampull.
S. 1 ml into the muscles 1 - 2 times a day
Reviews about the drug
Reviews of Euphylline, like any other medicinal drug, are very diverse on the Internet. However, most patients note its high effectiveness and rapid elimination of symptoms of the disease.
There are also negative reviews, but they are most often associated with the development of adverse reactions due to individual intolerance to a component of the drug or as a result of an incorrectly selected dosage.
Some patients use Eufillin in combination with Dimexide and a number of essential oils for weight loss and getting rid of cellulite. The effectiveness of the drug in this regard has not been proven, so it is impossible to objectively judge its effectiveness.
Attention! Before taking the medicine, consultation with a specialist is required. Only a doctor will be able to select the correct dosage of the drug, calculate the duration of the course of treatment and take into account all the indications and contraindications for taking Eufillin. Otherwise, there is a high risk of developing negative side effects.
