What is the difference between the drug Liprimar and Atorvastatin and which one is better?

Prohibited during pregnancy

Prohibited during breastfeeding

Has restrictions for children

Allowed for older people

Has limitations for liver problems

Allowed for kidney problems

Cholesterol (CS) is a fat-like alcohol that performs many important functions in the human body. With its help, bile acids are produced, the stability and elasticity of cell membranes, the synthesis of steroidal and non-steroidal hormones, as well as vitamins D, A and E. Cholesterol is very beneficial for the body, but only if it does not exceed normal levels.

An increased cholesterol index in the blood leads to the development of systemic and cardiac diseases, and is also the main factor in the formation of atherosclerotic deposits inside the arterial membranes.

To lower your cholesterol index, you need to switch to a low-cholesterol diet, give up bad habits (alcohol and nicotine) and increase activity.

But non-drug control methods are not always effective; then, to reduce cholesterol, drugs from the statin group are prescribed, most often based on the active component atorvastatin. In this article we will figure out what is better to take for high cholesterol - Atorvastatin or Liprimar.

Comparison of the effectiveness of Atoris and Liprimar

The effectiveness of Atoris is quite similar to Liprimar - this means that the ability of the drug substance to provide the maximum possible effect is similar.
For example, if the therapeutic effect of Atoris is more pronounced, then using Liprimar even in large doses will not achieve this effect.

Also, the speed of therapy - an indicator of the speed of therapeutic action - is approximately the same for Atoris and Liprimar. And bioavailability, that is, the amount of a drug reaching its site of action in the body, is similar. The higher the bioavailability, the less it will be lost during absorption and use by the body.

Indications and contraindications

In accordance with the instructions for use, medications based on the active substance atorvastatin are prescribed for the following pathologies:

• primary form of genetic hypercholesterolemia;
• heterozygous and homozygous hypocholesterolemia in addition to dietary nutrition;
• combined hypercholesterolemia;
• dyslipidemia and dysbetalipoproteinemia in addition to an anti-cholesterol diet;
• hypertriglyceridemia in combination with an anti-cholesterol diet;
• hypertonic disease;
• low HDL fraction;
• systemic atherosclerosis.

Combined hypercholesterolemia

Medications are also prescribed in the following situations:

• with a hereditary predisposition of the body to the accumulation of lipids, regardless of the patient’s gender and age;
• IHD, unstable angina and other cardiac diseases;
• with coronary insufficiency;
• men over 45 years old;
• women during menopause;
• for patients with nicotine and alcohol addiction.

It is also relevant to use medications as preventive measures to prevent such pathologies:

• primary prevention of heart attack and stroke;
• post-infarction and post-stroke period;
• after vascular surgery.

Liprimar and Atorvastatin are not prescribed for the following disorders in the body:

• high sensitivity to the components of the drug;
• cirrhosis;
• liver failure;
• impaired malabsorption;
• increased transaminase levels;
• cataract;
• pregnancy and lactation;
• children under 18 years of age (Liprimar is not prescribed to children under 8 years of age).

Statins are prescribed very carefully for:

• low blood pressure index, as well as patients over 65-70 years old;
• hypothyroidism;
• chronic alcoholism;
• diabetes mellitus of the first and second types.

Symptoms of hypothyroidism

Atorvastatin crosses the placental barrier. Cholesterol is very important for the intrauterine development of the fetus, so statins have a detrimental embryonic effect on the fetus if a woman takes medications. For this reason, during pregnancy, women are prohibited from being prescribed HMG-CoA reductase inhibitors. Statins are also detected in breast milk, so therapy with statin drugs is also contraindicated for women during lactation.

Comparison of safety of Atoris and Liprimar

The safety of a drug includes many factors.

At the same time, in Atoris it is quite similar to Liprimar. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing metabolism in Atoris, as well as in Liprimar, we look at which organ is the metabolizing organ and how critical the effect on it is.

The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Atoris does not have any risks when used, just like Liprimar.

Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of using Atoris and Liprimar.

Interaction with other drugs and analogues

When statins are taken together with the drug Cyclosporine, myopathy and rhabdomyolysis develop, and the risk of developing these pathologies after Erythromycin also increases.

If you take Digoxin and statins at the same time, then the concentration of Digoxin increases. The concentration of oral contraceptives in the body increases when used together with statins. When taking Atorvastatin, or Liprimar and Warfarin, the prothrombin time decreases and must be constantly monitored.

It is also not recommended to take statin tablets and grapefruit juice.

Analogs of third-generation satins based on the active component atorvastatin are medications of this generation, as well as drugs based on simvastatin:

1. Atoris is effective for homozygous hypercholesterolemia and triglyceridemia.
2. Vasostat is a drug prescribed for systemic atherosclerosis and hypercholesterolemia of various etiologies, as well as for the prevention of cerebrovascular pathologies.
3. Zocor - the use of the drug reduces the risk of developing cardiac diseases and effectively reduces the cholesterol index.

Comparison of addiction between Atoris and Liprimar

Like safety, addiction also involves many factors that must be considered when evaluating a drug.

So, the totality of the values ​​of such parameters as “o syndrome” in Atoris is quite similar to the similar values ​​in Liprimar. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible. At the same time, at Atoris the meaning of the “syndrome” is quite small, however, the same as for Liprimar.

Main differences, effectiveness and safety

These medications do not have any special differences and are prescribed with the same dosage and can be substitutes for each other. Therefore, to the question of how Liprimar differs from Atorvastatin, we can answer that both medications belong to the same generation and have atorvastatin as the main component of the drug. The only difference is the price of the drugs. Liprimar costs 7-8 times more than Atorvastatin, because Liprimar is considered the original drug of this generation of drugs and is produced in the USA.

Both medications have an almost identical composition and the same active ingredient, but Liprimar is more effective as an original medication. The Russian analogue Atorvastatin is slightly inferior in this regard and has more negative effects on the body. In addition, Liprimar is used in pediatrics.

Statins have many side effects, but proper adherence to all doctor’s recommendations reduces the risk of developing negative reactions of the body to medications. The main side effects of drugs based on atorvastatin:

Comparison of side effects of Atoris and Liprimar

Side effects or adverse events are any adverse medical event that occurs in a subject after administration of a drug.

Atoris's state of adverse events is almost the same as that of Liprimar. They both have few side effects. This implies that the frequency of their occurrence is low, that is, the indicator of how many cases of an undesirable effect of treatment are possible and registered is low. The undesirable effect on the body, the strength of influence and the toxic effect of Atoris are similar to Liprimar: how quickly the body recovers after taking it and whether it recovers at all.

Instructions for use

According to the instructions, the tablets should be taken orally whole and not chewed, washed down with the required amount of water. The drugs must be taken at the same time. Medication regimen:

• before starting therapy, the patient must switch to an anti-cholesterol diet, and the entire course of therapy must take place in combination with dietary nutrition;

• 
  the dosage and medication are selected by the doctor personally and in accordance with the lipid spectrum indicators;

• the initial dose of both drugs is 10 mg, once a day;
• only the attending physician can increase the dosage or change the drug to an analogue after diagnosing cholesterol 14-30 days after taking it and assessing its effectiveness;
• maximum dosage per day – 80 mg;
• Maximum dosage therapy is recommended to be carried out in a hospital setting with constant monitoring of liver transaminases and cholesterol;
• Elderly patients do not need dosage adjustment.

From 8 to 17 years of age with heterozygous genetic hypercholesterolemia, statins are prescribed at a dosage of 10 mg. The maximum permissible dose for adolescents is 20 mg per day.

Comparison of ease of use of Atoris and Liprimar

This includes dose selection taking into account various conditions and frequency of doses. At the same time, it is important not to forget about the release form of the drug; it is also important to take it into account when making an assessment.

The ease of use of Atoris is approximately the same as Liprimar. However, they are not convenient enough to use.

The drug ratings were compiled by experienced pharmacists who studied international research. The report is generated automatically.

Last update date: 2020-12-04 13:44:18

Characteristics of drugs

Atoris was developed as an analogue of the German-made statin Liprimar. The latter was expensive and therefore was inaccessible to some patients. Atoris is almost identical to the original in composition and effectiveness in lowering cholesterol levels. Its active ingredient is atorvastatin.

While taking Atoris, the following happens:

• acceleration of blood flow;
• decrease in triglyceride levels in the blood;
• blood thinning;
• suppression of the production of substances that can accumulate on the intravascular wall;
• slowing down platelet pooling;
• restoration of blood movement through the vessels;
• prevention of rupture of cholesterol plaques.

Atorvastatin is a drug from the group of 3rd generation statins. It is produced by both Russian and Israeli pharmaceutical companies. This drug actively affects reductase, resulting in a decrease in cholesterol levels and a halt in atherosclerotic processes. Atorvastatin is available in three dosages - 10, 20 and 40 mg.

Atorvastatin is produced in Russia and is an analogue of Atoris

The excipient composition varies depending on the country in which it is produced and the specific pharmaceutical company. Among domestic manufacturers, Atorvastatin is produced by the following companies: Kanonpharma, Severnaya Zvezda, Vertex, Izvarino Pharma, Irbitsky HFZ. The cost of a Russian-made drug varies from 120 to 800 rubles, depending on the dosage and number of tablets in the package.

Atoris is produced by the Slovenian pharmaceutical company KRKA. The cost of the drug is higher than the price of Atorvastatin, and averages 600 rubles. Despite the different price categories, both drugs have a good therapeutic effect and can effectively reduce blood cholesterol levels.

How do drugs work?

Both drugs contain atorvastatin as the active ingredient. It prevents the synthesis of the HMG enzyme - Coa reductase and normalizes the production of mevalonic acid. It directly affects the synthesis of cholesterol in liver cells. Both Atorvastatin and Atoris reduce the amount of cholesterol produced, which triggers low-density lipoprotein receptors.

As a result of regular intake of drugs, the blood plasma is cleared of cholesterol. In addition, the active components of drugs suppress the production of very low density lipids, which leads to a decrease in the synthesis of triglycerides. In addition to reducing the level of bad cholesterol, the drugs in question have a positive effect on the lining of blood vessels, dilating them.

Blood viscosity is also reduced and the formation of atherosclerotic deposits is prevented. Taking such statins significantly reduces the risk of developing complications of atherosclerosis in the form of heart attack and stroke. If we compare how the pharmacokinetics of these drugs differ, we can see that these indicators for all 3rd generation statins are almost the same:

• the highest concentration is achieved 2 hours after taking the medicine;
• the effect of the drugs does not depend on the gender and age of the patient;
• there is a decrease in the absorption of statins if they were taken after meals;
• the active substances of the drugs are able to overcome the placental barrier and penetrate into breast milk;
• the bioavailability of each of them is 12%;
• metabolites formed in the liver provide protection for 30 hours;
• the components of the drugs are excreted from the body with bile and feces.