Compound
1 ampoule of the drug with a volume of 2.2 ml contains a complex of active ingredients in homeopathic dilution (D).
The mass fraction of each ingredient is 22 mg. The main substances are:
Ubichinon, Anthrachinonum, Para-Benzochinonum, Naphthochinonum, Acidum acetylsalicylicum, Histaminum, Trichinoylum, Adenosinum triphosphoricum, Coenzymum A, Nadidum, Magnesium gluconicum (diluted D10).
Natrium diethyloxalaceticum, Sulfur, Hydrochinonum, Manganum phosphoricum, Acidum alpha-liponicum (diluted D8).
Nicotinamidum, Pyridoxinum hydrochloricum, Thiaminum hydrochloricum, Galium aparine, Natrium riboflavinum phosphoricum, Acidum ascorbicum, Acidum sarcolacticum (diluted D6).
Hydrastis Canadensis, Podophyllum peltatum, Vaccinium myrtillus, Colchicum autumnale, Conium maculatum (diluted D4).
Until the volume reaches 2.2 ml, sodium chloride and water for injection are added as additional ingredients.
Pharmacodynamics and pharmacokinetics
The drug solution takes an active part in the processes of activation and regulation of enzyme systems of the human body.
It has a beneficial effect on cellular respiration , exhibits immunostimulating, anti-inflammatory, antioxidant, metabolic, detoxification activity, based on stimulation of the body's defense systems and restoration of its impaired functions, thanks to the mineral and herbal ingredients included in the drug.
What is Coenzyme Q10 and what is it used for?
Coenzyme Q10 or ubiquinone (ubiquinol, in supplements) is a fat-soluble vitamin-like compound from the group of coenzymes. It is found in all organisms. The scientific concept “ubiquinone” is translated as “ubiquitous quinone,” which fully corresponds to its role.
In the body, the substance is synthesized from:
- Vitamin C;
- B vitamins;
- Folic acid;
- Tyrosine;
- Pantothenic acid.
The process of producing coenzyme is incredibly complex. It occurs using several enzyme systems at once.
If there is a lack of any substances that take part in the synthesis of coenzyme Q10, as well as if there is a violation in the production of necessary enzymes, its basic production will decrease. As a result, it will not provide all the needs of the body, which will lead to a number of disorders. Ubiquinol is extremely needed by the body, which is why obtaining it from food sources or supplements is considered necessary.
Coenzyme Q10 is concentrated primarily in mitochondria, especially in all vital organs. One of the key functions of ubiquinone is its participation in the process of respiration. The substance transports electrons between membrane dehydrogenases and cytochromes.
The average level of ubiquinone in the blood is about 1 mg per 1 ml. To increase the concentration to 2 mg, which is considered the optimal norm for obtaining a noticeable effect from taking it, you need to consume about 100 mg of the substance per day. This is very difficult to achieve with regular food, which makes supplements almost indispensable.
A little confusion may occur in determining the name of a substance. Therefore, it is important to understand the difference between ubiquinone and ubiquinol. Ubiquinone is the name of a compound more commonly known as coenzyme Q10. By itself, it has low bioavailability. To improve absorption, two more hydrogen atoms are added to the substance molecule, as a result of which two ketone groups are converted into hydroxyl groups. This significantly increases its bioavailability when taken orally. That is, ubiquinone or ubiquinol is the same substance, but with a slightly modified molecular composition to improve absorption. Therefore, using different names is not a mistake. Coenzyme Q10, ubiquinone or ubiquinol, all these names are used for the same active substance.
Indications for use
Homeopathic intramuscular solution Ubiquinone Compositum is indicated for use in complex treatment for:
- degenerative chronic painful conditions of internal systems and organs;
- intoxication syndrome (including infectious diseases with fever, cachexia);
- metabolic disorders in the body (including gout, gallstones and kidney stones , atherosclerosis );
- relative or absolute deficiency of vitamins and/or enzymes ;
- conditions associated with hypoxia due to various diseases, mental and/or physical stress ;
- consequences of radiation therapy and/or chemotherapy .
Coenzyme Q10 (Ubiquinone)
CAS number:
303-98-0
Gross formula:
C59H90O4
Appearance:
yellow to orange crystalline powder, tasteless and odorless
Chemical name and synonyms:
Ubidecarenone, Ubiquinone 10;
, Co-Q-10, CoQ-10, CO Q10, Q10, Vitamin Q101-3 Physicochemical properties:
Almost insoluble in water.
Molecular weight 863.36 g/mol Melting point 48-52 ° C Stable under recommended storage conditions. Description:
The structure of Coenzyme Q10 consists of a quinone ring attached to an isoprene side chain. It contains 82.08% carbon, 10.51% hydrogen and 7.41% oxygen. It has a molecular weight of 863.37 and a formula of C59H90O4. It was first isolated from bovine heart mitochondria in 1957 at the University of Wisconsin. Chemical structure identification and synthesis were completed by 1958. Research conducted in the 1960s and 1970s showed that CoQ10 acts as an antioxidant and plays a central role in mitochondrial oxidative phosphorylation.
The term "coenzyme" means that it is an organic, non-protein molecule. The designation “Q” refers to the quinoid chemical group, and “10” indicates the number of isoprenyl groups contained in the molecule.
Structurally, the coenzyme Q group is very similar to members of the vitamin K group and tocopheryl quinones, which are derived from tocopherols (vitamin E), as they all have a quinone ring attached to a long hydrocarbon tail. The Coenzyme Q series quinones found in different species differ only slightly in chemical structure and form a group of related 2-3-dimethoxy-5-methylbenzoquinones with a polyisoprenoid side chain at position 6 that varies in length from 30 to 50 carbon atoms. Since each isoprenoid unit in the chain contains five carbon atoms, the number of isoprenoid units in the side chain varies from 6 to 10. The different numbers of groups have been indicated by a subscript after Q to indicate the number of isoprenoid units in the side chain, as in Q10. The difference in properties is due to the difference in side chain length. Members of the group known to occur in nature are Q6-Q10. Coenzyme Q acts as an agent to carry out oxidation and reduction in cells.
In humans, CoQ10 is found in relatively higher concentrations in cells with high energy needs, such as the heart, liver, muscle and pancreas. Normal blood levels range from 0.7 to 1.0 mcg/ml. Human cells synthesize CoQ10 from the amino acid tyrosine in an eight-step aromatic pathway that requires adequate levels of vitamins such as folic acid, niacin, riboflavin and pyridoxine. A deficiency in any of these nutrients can lead to CoQ10 deficiency.
Coenzyme Q10 (or ubiquinone) is a substance found in every cell of the animal body and many bacteria, the main function of which is to participate in the process of ATP production by mitochondria. However, some bacteria and lower organisms do not contain coenzyme Q. It has been shown that many of these organisms contain vitamin K instead and that this quinone functions in electron transport in much the same way as coenzyme Q. Likewise, plant chloroplasts do not contain coenzyme Q, but contain plastoquinones, which are structurally related to coenzyme Q. The functions of plastoquinone are participation in the process of electron transport involved in photosynthesis. In some organisms, Coenzyme Q is present along with other quinones such as vitamin K, tocopheryl quinones, and plastoquinones; and each type of quinone can perform different parts of the electron transport functions.
Coenzyme Q-10 in its action is a vitamin-like compound that is found in the cells of the body.
Application:
Coenzyme Q10 is not a drug, but is a component of dietary supplements, food additives, sports nutrition, used in the cosmetic industry, etc. Coenzyme is part of supplements used in the complex therapy of many diseases, such as cardiovascular diseases, and is prescribed for neurodegenerative processes in the body and for the purpose of their prophylaxis, as well as for oncological and immunosuppressive conditions. .Coenzyme Q10 is widely used in cosmetics; it is included in creams, ointments, masks, balms and many others.
Receipt:
There are methods for stereospecific synthesis of coenzyme Q10, ubiquinone; a semi-synthetic procedure using solanesol derived from tobacco waste as a starting material. The method leads to high yields of isometrically useful compositions containing optically pure isomers.
Solanezol is obtained by taking one kg of tobacco dust and shaking it with 41 hexane for 1.5 hours. The solid was collected by filtration and extracted with a total of 2.4 L of hexane. The combined extracts are evaporated. To the resulting residue add 140 ml of 2 N KOH in ethanol and 2 g of pyrogallol. The resulting mixture is heated for 1 hour (at reflux) under a nitrogen atmosphere. It is then quickly cooled, 400 mg of a 9:1 mixture of ethanol and water is added and this mixture is extracted with hexane (4 x 400 ml). The extract is dried with sodium sulfate and chromatographed on a column with 300 g of aluminum oxide. After elution with 9:1 hexane/ether and evaporation, 5 g of solanesol are obtained.
Effect on the body:
Coenzyme Q-10 is synthesized in the body. It can also be obtained from food products of animal and plant origin (such as meat, vegetable oils, vegetables and fruits, seafood, etc.) Everything living, or once living, contains coenzyme Q10.
Inside the cell, CoQ-10 is mainly present in the mitochondria (40-50%). It is an acceptor for the mitochondrial electron transport chain. It is also a cofactor used in the processes of aerobic respiration, aerobic metabolism, oxidative metabolism and cellular respiration. The main function of coenzyme Q10 is as an antioxidant, membrane stabilizer and production of adenosine triphosphate (ATP) in oxidative respiration. As an antioxidant and its role in ATP, CoQ10 has many therapeutic benefits.
A lack of coenzyme Q10 may occur in the body due to several main factors: rapid consumption of coenzyme by the body, as well as slow production (biosynthesis). Biosynthesis occurs in most human tissues. There are three main stages:
Creation of benzoquinone structure (using phenylalanine or tyrosine)
Creation of an isoprene side chain (using acetyl-CoA)
Attachment or condensation of the above two structures
The first two reactions occur in mitochondria, the endoplasmic reticulum (ER) and peroxisomes, indicating multiple sites of synthesis in the cells of the body. An important enzyme in this pathway is HMG-CoA reductase.
Elimination of Coenzyme Q10 occurs in bile and feces. Normal blood and tissue levels of CoQ10 have been well established by numerous researchers around the world. Significantly reduced levels of CoQ10 have been noted in a wide variety of diseases in both animal and human studies. Insufficient CoQ10 in the diet, impaired CoQ10 biosynthesis, excessive use of CoQ10 by the body, or any combination of these can cause CoQ10 deficiency. Reduced dietary intake is suggested in chronic malnutrition and cachexia.
The relative contribution of biosynthetic CoQ10 versus dietary CoQ10 is under investigation. Karl Folkers believes that the main source of CoQ10 in humans is biosynthesis. This complex 17-step process, requiring at least seven vitamins (vitamin B2 - riboflavin, vitamin B3 - niacinamide, vitamin B6, folic acid, vitamin B12, vitamin C and pantothenic acid) and several micronutrients, is very fragile in nature. Karl Folkers argues that suboptimal nutrient intake in humans is almost universal and that there is a secondary disturbance in CoQ10 biosynthesis. This would mean that average or “normal” CoQ10 levels are indeed suboptimal, and the very low levels seen in advanced disease states represent just the tip of the deficiency “iceberg.”
HMG-CoA reductase inhibitors, used to treat elevated blood cholesterol levels by blocking cholesterol biosynthesis, also block CoQ10 biosynthesis. The resulting decrease in blood CoQ10 levels is due in part to the common biosynthetic pathway of CoQ10 and cholesterol. In patients with heart failure, this is more than laboratory observation. It has significant harmful effects that can be reversed by oral CoQ10.
Increased body uptake of CoQ10 is the suspected cause of low blood CoQ10 levels observed during excessive exercise, hypermetabolism, and states of acute shock. It is likely that all three mechanisms (insufficient dietary CoQ10, impaired CoQ10 biosynthesis, and excessive CoQ10 utilization) are operative to varying degrees in most cases of observed CoQ10 deficiency.
Toxicological data:
Acute oral toxicity (LD): >4000 mg/kg [Mouse];
Acute oral toxicity (LD): >4000 mg/kg [rat].
Instructions for use Ubiquinone Compositum
The instructions for Ubiquinone Compositum recommend the use of a single dose for patients over 12 years of age in a volume of 2.2 ml (1 ampoule). Children's (from 6 to 12 years old) single dosage is 1.5 ml.
Administration of the solution (to patients over 12 years of age) is assumed in the form of intramuscular, intradermal or subcutaneous injections, with a frequency of 1-3 times every 7 days.
Injections into acupuncture points or taking the solution orally (inside) are also possible, for which you need to mix a dose of the solution with 5-10 ml of water, pour the resulting liquid into your mouth and drink after a few seconds.
When treating children (from 6 to 12 years old), the contents of the ampoule should be drawn into an insulin syringe . An age-specific single dosage can be used subcutaneously and intramuscularly, as well as instilled into the mouth, having previously dissolved it in 5 ml of water.
Excess solution can be stored in a syringe at room temperature in a dark place and subsequently taken orally at the indicated time.
As a rule, the course of treatment takes from 2 to 5 weeks.
special instructions
During therapy with homeopathic medicines, a temporary exacerbation of existing symptoms . In this case, it would be advisable to interrupt treatment and consult with your doctor.
If you detect any negative effects that are not listed in the instructions, you should consult a doctor.
It is possible to change the duration of therapy and the method of application of the solution, based on the individuality of the patient’s body and the course of the disease.
The drug should be administered with caution if the patient is hypersensitive ( previously observed) to B vitamins.
How to take ubiquinol
Coenzyme Q10 does not require a prescription and is classified as a supplement. But before taking ubiquinone or ubiquinol, it is better to consult with your doctor. There is also an age recommendation. Up to 30 years of age, taking the substance is indicated only for athletes due to the strong impact of physical activity on the body. For preventive purposes, the supplement is recommended to be taken after 30-35 years, when there is a gradual decrease in the production of coenzyme in the body.
Dosages typically used in studies ranged from 50 to 200 mg and are generally considered safe. Exceeding the daily dose over 300 mg is strictly not recommended, as this may lead to side effects. The standard dosage for people under 40 years of age ranges from 90 to 120 mg per day. At the age of 40-50 years, the daily norm can increase to 150 mg. At a more mature age, dosages of 200 mg are used, but only as prescribed by a doctor.
It is recommended to take the daily dose in the morning or lunchtime. Evening intake is not advisable, as it can cause a surge of energy and cause insomnia. You can use ubiquinol on an ongoing basis, but every 2-3 months it is recommended to take a break between courses for 3-5 weeks.
Analogs
Level 4 ATC code matches:
Cystamine
Neovasculgen
Lymphomyosot
Galium-Hel
Spascuprel
Ammonia
Mucosa Compositum
Coenzyme Compositum
Dimephosphone
Oscillococcinum
Dantinorm Baby
Coryzalia
Longidaza
Homeovox
- Actinohyal;
- Strumel T;
- Berberis-Homaccord;
- Gepar Compositum;
- Homeovox;
- Carmolis;
- Coenzyme Compositum;
- Lidaza;
- Mucosa Compositum;
- Cerebrum Compositum;
- Cystamine;
- Momordica compositum;
- Laprote;
- Neovasculgen , etc.
Reviews for Ubiquinone Compositum
On many professional and user forums you can often find real disputes about homeopathic remedies from the company Heel (Heel) and in particular the drug Ubiquinone .
What it is, what effects they have, what they are intended for and whether these drugs help at all are the most asked questions among patients trying to understand such drugs.
It is worth noting that the medicinal products of the Heel company are a kind of attempt to combine homeopathic remedies with the usual way of using medicines for people.
It is quite difficult to judge their effectiveness, especially since doctors’ opinions on this matter are divided from extremely positive to completely negative.
Reviews for Ubiquinone Compositum are also ambiguous and cannot lead to a clear positive or negative assessment of the drug. Some patients are absolutely satisfied with its effect and note a positive trend in their health after using the drug, while others, on the contrary, do not find any positive changes in themselves.
In fairness, it should be noted that neither one nor the other noted any side effects of the drug, so even if the drug does not help you, it most likely will not harm you.
Best CoQ10 Supplements
For a long time, coenzyme Q10 was considered a hard-to-find and expensive supplement. Now many popular brands are engaged in its production, which allows it to be accepted on an ongoing basis.
Among the main supplements that enjoy positive reviews and a reliable reputation are:
- NOW Ubiquinol is the most versatile supplement from a world-renowned brand. Each capsule contains 100 mg, which corresponds to the average daily value. After 40 years of age, 2 capsules per day may be required;
- Ubiquinol Reduced CoQ-10 from Solgar is a supplement from one of the most famous and high-quality brands. Also includes 100 mg per serving. The only drawback compared to NOW is the higher price;
- Ubiquinol from Doctor's Best is another popular option. It has different dosage options, available in the form of 100 and 200 mg per serving.
Ubiquinone Compositum price, where to buy
In Russian pharmacies, the price of Ubiquinon Compositum No. 5 ranges from 550 to 750 rubles; No. 100 from 6500 to 9000 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Ubiquinone compositum solution for in.
2.2 ml 100 pcs Biologische Heilmittel Heel GmbH RUR 11,133 order - Ubiquinone compositum solution d/in. 2.2ml 5 pcs Biologische Heilmittel Heel GmbH
RUR 977 order
Pharmacy Dialogue
- Ubiquinone Compositum ampoules 2.2ml No. 5Biologische Heilmittel Hell
RUR 579 order
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Pharmacy24
- Ubiquinone Compositum 2.2ml No. 5 injection solution Biologische Heilmittel Heel GmbH, Nimechtina
387 UAH.order
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