Glucose (for injection), 40%, solution for intravenous administration, 10 ml, 10 pcs.

pharmachologic effect

Glucose enhances redox processes in the body, improves the antitoxic function of the liver, and covers part of the body’s energy costs, as it is a source of easily digestible carbohydrates. Entering the tissues, it is phosphorylated, turning into glucose-6-phosphate, which is actively involved in many parts of the body’s metabolism.

A 40% solution is hypertonic. When a hypertonic solution is injected into a vein, the osmotic pressure of the blood increases, the contractile activity of the heart muscle increases, blood vessels dilate, the detoxification function of the liver improves, and diuresis increases.

Why is a glucose drip needed?

Glucose droppers

(from the Latin “glucos” - “sweet”) have been used for medicinal purposes for a long time. Glucose is healthy; it is a very nutritious simple carbohydrate for humans, which is easily digestible and provides a large amount of energy for various biochemical processes.

More specifically, the substance adenosine triphosphate (ATP) is released from glucose, which is a kind of “generator” for cells and tissues. Note that athletes often use glucose during the training process. They know from their own experience how quickly this carbohydrate restores the body’s energy balance. In addition, research shows that glucose helps relieve stress.

Glucose is excreted in the usual way, through the genitourinary system.

Two types of glucose solutions

There are two types of glucose solutions: isotonic and hypertonic.

The use of a dropper involves slowly introducing the drug into the blood. And this is true if a sharp one-time intake of the solution is not recommended. In this case, thanks to the dropper, the solution enters directly into the vein. And, for example, when taken orally, the solution must still pass through the digestive system, and, therefore, it will not act immediately.

The procedure for instilling glucose can take from forty minutes to an hour and a half.

The glucose dropper is used for the following purposes:

• to improve blood pressure inside blood vessels;
• to activate the liver (it begins to cope better with toxic substances);
• to normalize and improve general metabolism;
• to stimulate the contractility of the heart muscle.

Glucose droppers may also be indicated by doctors:

• with general physical exhaustion;
• with a strong decrease in blood sugar;
• in case of kidney dysfunction;
• in a state of shock;
• with a sharp drop in blood pressure;
• In case of poisoning with drugs and alcoholic beverages.

A glucose drip is prescribed even to pregnant women. The use of glucose has a positive effect on the condition of the mother and the weight of the unborn baby.

Contraindications for glucose drip

There are not only numerous indications for a glucose drip, but also contraindications. It cannot be assigned:

• chronically ill patients with diabetes mellitus;
• suffering from hyperglycemia (high serum glucose syndrome) and hyperlactic acidemia (high lactic acid syndrome).

Plus, a person may have individual intolerance to glucose or low tolerance to it.

Of course, glucose drips should be administered by professionals to avoid overdose and other negative consequences. You will be given high-quality glucose droppers at the medical office. Come!

You may also be interested in information about Cerebrolysin drips.

Indications for use

Hypoglycemia, carbohydrate deficiency, toxic infection, intoxication due to liver diseases (hepatitis, liver dystrophy and atrophy, including liver failure), hemorrhagic diathesis; intoxication (poisoning with drugs, hydrocyanic acid and its salts, carbon monoxide, aniline, arsenic hydrogen, phosgene, etc.); collapse, shock.

As a component of various blood replacement and anti-shock fluids; for the preparation of drug solutions for intravenous administration.

Glucose (for injection), 40%, solution for intravenous administration, 10 ml, 10 pcs.

Since glucose (dextrose) tolerance may be impaired in patients with diabetes mellitus, renal failure, or those in acute critical condition, their clinical and biological parameters should be especially carefully monitored, in particular the concentration of electrolytes in the blood plasma, including magnesium and phosphorus, the concentration blood glucose. If hyperglycemia is present, the rate of drug administration should be adjusted or short-acting insulin should be prescribed.

During episodes of intracranial hypertension, careful monitoring of blood glucose concentrations is necessary.

The use of dextrose solutions can lead to hyperglycemia. Therefore, they are not recommended for administration after acute ischemic stroke, since hyperglycemia is associated with increased ischemic brain damage and impedes recovery.

Particularly careful clinical monitoring is required when starting intravenous administration of the drug. Carbohydrate solutions without sufficient electrolytes cannot be used for rehydration therapy as this may lead to significant decreases in serum electrolyte concentrations, particularly severe hyponatremia and hypocalcemia, with potentially harmful consequences for the patient, such as brain damage or heart disease. In particular, children, elderly and debilitated patients are at risk. In case of electrolyte deficiency, such as hyponatremia or hypokalemia, the solution should not be used without proper electrolyte replacement.

It is necessary to monitor the concentration of glucose and electrolytes in the blood, water balance, as well as the acid-base balance of the body.

The administration of hyperosmolar glucose solutions can lead to an increase in intracranial/intraspinal pressure in patients with impaired integrity of the blood-brain barrier.

Various conditions accompanied by metabolic disturbances (for example, after surgery or after injury, with hypoxia or organ failure) can slow down the oxidative metabolism of glucose and lead to metabolic acidosis.

Hyperglycemia should be appropriately monitored and, if necessary, controlled with short-acting insulin. Insulin administration leads to additional movement of potassium into the cells and, therefore, can cause or worsen hypokalemia.

In newborns, especially those born prematurely or with low body weight, the risk of developing hypo- or hyperglycemia is increased, therefore, during the period of intravenous administration of dextrose solutions, careful monitoring of blood glucose concentrations is necessary to avoid long-term undesirable consequences. Hypoglycemia in newborns can lead to prolonged seizures, coma, and brain damage.

Hyperglycemia has been associated with intraventricular hemorrhage, delayed bacterial and fungal infections, retinopathy of prematurity, necrotizing enterocolitis, bronchopulmonary dysplasia, prolonged hospitalization, and death.

To avoid potentially fatal overdose of intravenous drugs in neonates, special attention must be paid to the route of administration. IV infusion devices and other drug administration equipment should be monitored regularly.

Impact on the ability to drive vehicles and machinery

The use of the drug does not affect driving or engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Glucose solution for intravenous administration 400 mg/ml in 5 ml ampoules No. 10

Name

Glucose.

Release form

Solution for intravenous administration.

Dosage

400 mg / 1 ml 5 ml Pack quantity: 10 pcs.

Manufacturer

Borisovsky ZMP.

INN

Dextrose.

FTG

Carbohydrate food.

Description

Transparent colorless or slightly yellowish liquid.

Compound

One ampoule (5 ml) contains: active ingredient: glucose in the form of anhydrous glucose – 2000 mg; excipients: concentrated hydrochloric acid, sodium chloride, water for injection.

Pharmacotherapeutic group

Solutions for intravenous administration. Solutions for parenteral nutrition. ATX code: B05BA03.

Indications for use

- hypoglycemia; - as a source of carbohydrates (alone or as part of parenteral nutrition if necessary).

Contraindications

- hyperglycemia, diabetes mellitus, postoperative disorders of glucose utilization; - hyperlactic acidemia, hyperosmolar coma; - overhydration, cerebral and pulmonary edema, acute left ventricular failure; - hypersensitivity to the drug; - circulatory disorders that threaten cerebral and pulmonary edema; - hemorrhages in the brain and spinal cord (except for conditions accompanied by hypoglycemia); - childhood.

Directions for use and doses

A hypertonic solution of 400 mg/ml is administered intravenously at a rate of up to a maximum of 30 drops/min (1.5 ml/min), which corresponds to approximately 48 ml/hour. The maximum daily dose for adults is 250 ml. The maximum daily dose is 15 ml/kg/day, which corresponds to 6 g/kg/day. The maximum infusion rate is 0.62 ml/kg/h, which corresponds to 0.25 g/kg/h. For a patient weighing 70 kg, the maximum infusion rate is 43 ml/h (glucose - 17.5 g/h). The drug can be administered intravenously as a bolus to relieve hypoglycemic coma. When diluted to 200 mg/ml of solution, the maximum infusion rate is up to 30-40 drops/min; the maximum daily dose for adults is 500 ml. When diluting the solution to 100 mg/ml, the maximum infusion rate is up to 60 drops/min; volume of administration – 500 ml/day. When diluted to 50 mg/ml of solution, the maximum infusion rate is up to 150 drops/min; volume of administration – up to 2 l/day. In adults with normal metabolism, the daily dose of administered glucose should not exceed 1.5-6 g/kg/day (if the metabolic rate decreases, the daily dose is reduced), while the daily volume of administered fluid is 30-40 ml/kg.

Precautionary measures

The drug should not be administered quickly or for a long time. If shivering occurs during administration, administration should be stopped immediately. To prevent thrombophlebitis, it should be administered slowly through large veins. Monitor water and electrolyte balance and serum glucose levels. With long-term intravenous use of the drug, control of blood sugar levels is necessary. For better absorption of glucose in normoglycemic conditions, it is advisable to combine the administration of the drug with the administration of (subcutaneous) short-acting insulin at the rate of 1 unit per 4-5 g of glucose (dry matter). The drug is used with caution in acute cerebrovascular accidents, as it can increase damage to brain structures and worsen the condition of the disease, except in cases of correction of hypoglycemia. In case of hypokalemia, the administration of the drug must be combined with the correction of potassium deficiency due to the risk of increased hypokalemia; for hypotonic dehydration - simultaneously with the introduction of hypertonic saline solutions. Do not use the solution subcutaneously or intramuscularly. The contents of the ampoule can only be used for one patient. After breaking the seal of the ampoule, the unused part of the contents of the ampoule should be thrown away.

Use in pediatrics

It is not recommended to use the drug Glucose, a solution for intravenous administration of 400 mg/ml in doses of more than 1 ml/kg of weight in newborns and premature infants, since there is a high risk of developing encephalopathy caused by the administration of a hypertonic solution. In case of renal failure, decompensated heart failure, hyponatremia. In case of renal failure, decompensated heart failure, hyponatremia, special care is required when prescribing glucose and monitoring central hemodynamic parameters.

Use during pregnancy and breastfeeding

The drug should be prescribed with caution to women during pregnancy and lactation. The use of the drug during pregnancy and breastfeeding is possible only as prescribed by a doctor, if the intended benefit to the mother outweighs the potential risk to the fetus or child. Use of the drug by pregnant women with normoglycemia can cause fetal hyperglycemia and metabolic acidosis. The latter is important to consider, especially when fetal distress or hypoxia is already caused by other perinatal factors.

Impact on the ability to drive a car and work with moving machinery

Glucose solutions have no or negligible effect on the ability to drive a car or use other machinery.

Side effect

Adverse reactions (HP) are grouped by systems and organs in accordance with the MedDRA dictionary and the WHO classification of the incidence of HP development: very often (≥1/10), often (≥1/100 to

Interaction with other drugs

Insulin (3 units per 1 g of glucose) and potassium salts improve the absorption of glucose by tissues. When used together with sodium chloride solution, it has an additive effect on the osmolarity of the solution. Glucose solution should not be mixed with alkaloids (their decomposition occurs), with general anesthetics (decreased activity), with sleeping pills (decreased their activity). Glucose weakens the activity of analgesics and adrenomimetic drugs, inactivates streptomycin, and reduces the activity of nystatin. Due to the fact that glucose is a fairly strong oxidizing agent, it should not be administered in the same syringe with hexamethylenetetramine. Under the influence of thiazide diuretics and furosemide, glucose tolerance decreases. Insulin promotes the entry of glucose into peripheral tissues, stimulates the formation of glycogen, the synthesis of proteins and fatty acids. The drug reduces the toxic effect of pyrazinamide on the liver. The administration of a large volume of the drug contributes to the development of hypokalemia, which increases the toxicity of simultaneously used digitalis drugs. Glucose is incompatible in solutions with barbiturates, erythromycin, aminophylline, hydrocortisone, warfarin, kanamycin, soluble sulfonamides, cyanocobalamin. When combined with other drugs, it is necessary to clinically monitor their possible incompatibility (invisible pharmaceutical or pharmacodynamic incompatibility is possible). Glucose solution should not be administered in the same infusion system with blood due to the risk of nonspecific agglutination. Since glucose solution for intravenous infusion is acidic (pH

Overdose

Symptoms. When high doses are administered, hyperglycemia may develop, accompanied by thirst, polyuria, polydipsia, and in severe cases, the development of acute left ventricular failure. Treatment. Measures of assistance: discontinuation of the drug, administration of insulin at the rate of 3 units per 1 ml of administered glucose in the form of an intravenous drip infusion under glycemic control. Symptomatic therapy.

Package

5 ml in glass ampoules. 10 ampoules along with the package insert are placed in a cardboard box (No. 10). 10 ampoules, together with a leaflet, are placed in a cardboard pack with one or two cardboard inserts for fixing the ampoules (No. 10).

Storage conditions

At temperatures between 5°C and 30°C. Keep out of the reach of children.

Best before date

5 years. Do not use after expiration date.

Conditions for dispensing from pharmacies

On prescription.

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Glucose 10% 400ml 15 pcs. solution for infusion

pharmachologic effect

Rehydration and detoxification product.
An isotonic dextrose solution (5%) is used to replenish the body with fluid. In addition, it is a source of valuable nutrients that are easily absorbed. When glucose is metabolized in tissues, a significant amount of energy is released, which is necessary for the functioning of the body.

With the intravenous administration of hypertonic solutions (10%, 20%, 40%), the osmotic pressure of the blood increases, the flow of fluid from tissues into the blood increases, metabolic processes increase, the antitoxic function of the liver improves, the contractile activity of the heart muscle increases, blood vessels dilate, and diuresis.

Composition and release form Glucose 10% 400ml 15 pcs. solution for infusion

Solution for infusion 10% - 100 ml: dextrose 10 g.

400 ml - bottles for blood and blood substitutes (15) - cardboard packs.

Directions for use and doses

Dextrose solutions are administered intravenously.

5% solution: maximum up to 150 drops/min, maximum daily dose for adults - 2 l;

10% solution: maximum up to 60 drops/min, maximum daily dose for adults - 500 ml;

20% solution: maximum up to 40 drops/min, maximum daily dose for adults - 300 ml;

40% solution: maximum up to 30 drops/min, maximum daily dose for adults - 250 ml.

Pharmacokinetics

Dextrose, entering tissues, is phosphorylated, turning into glucose-6-phosphate, which is actively involved in many parts of the body's metabolism. Excreted by the kidneys.

Indications for use Glucose 10% 400ml 15 pcs. solution for infusion

Compensation for the lack of carbohydrates in the body. Correction of dehydration due to vomiting, diarrhea, in the postoperative period. Detoxification infusion therapy. Collapse, shock (as a component of various blood-substituting and anti-shock fluids). Used for the preparation of drug solutions for intravenous administration.

Contraindications

Hyperglycemia, diabetes mellitus, hyperhydration, postoperative disorders of glucose utilization, hyperosmolar coma, hyperlactic acidemia.

With caution - severe heart failure, pulmonary edema, oliguria, anuria, hyponatremia.

Application Glucose 10% 400ml 15 pcs. solution for infusion during pregnancy and lactation

It is possible to use dextrose during pregnancy and lactation (breastfeeding) according to indications.

Side effects Glucose 10% 400ml 15 pcs. solution for infusion

Fever, hypervolemia, development of infection and thrombophlebitis at the site of glucose administration, extravasation.