Pharmacodynamics and pharmacokinetics
This combined agent exhibits a high antitussive and bronchodilator effect. Its action is determined by its constituent components.
Glaucine hydrobromide is able to suppress the cough center without causing respiratory depression , drug dependence , the development of constipation and other undesirable effects.
Taking ephedrine leads to dilation of the bronchi, helps stimulate breathing, exhibiting a vasoconstrictor effect, which helps eliminate swelling of the mucous membranes of the bronchi.
Basil oil has some sedative, antimicrobial and antispasmodic effects.
Once in the body, the drug undergoes good absorption from the gastrointestinal tract, showing maximum effect after 1.5 hours. The metabolic takes place mainly in the liver, and is excreted from the body in urine.
What is Broncholitin?
Broncholitin is a branded pharmaceutical drug.
A combined antitussive, bronchodilator and antispasmodic drug, which contains two active ingredients: glaucine hydrobromide 5.75 mg/ml and ephedrine hydrochloride 4.6 mg/ml. Glaucine hydrobromide - suppresses the cough center, but does not inhibit the breathing process. Glaucine is close in structure to such well-known substances as morphine and codeine, but at the same time, it is not a narcotic substance, and therefore does not cause addiction.
Ephedrine hydrochloride is a sympathomimetic, eliminates swelling of the mucous membrane, stimulates the respiratory process. Ephedrine also has a bronchodilator effect, and helps with difficulty in clearing phlegm from the bronchial mucosa.
Indications for use
The drug Bronholitin is a cough syrup, which is recommended for use as part of complex therapy for diseases of the respiratory system accompanied by dry cough , for example, with:
- acute inflammation of the upper respiratory tract;
- tracheobronchitis;
- acute and chronic forms of bronchitis;
- bronchial asthma;
- pneumonia;
- bronchiectasis;
- whooping cough
Application
Bronholitin cough syrup is used orally after meals.
Adults and children over 10 years old are prescribed 10 ml of syrup 3-4 times a day, children 5-10 years old - 5 ml 3 times a day.
Broncholithin for children 3-5 years old is used in a dose of 5 ml, but first the dose of the drug should be diluted in 10 ml of water, drunk 3 times / day.
Adults take 1tb tablets 2-3r/day. If necessary, the dosage is increased to 2tb per dose. Bronholitin for children over 4 years old is prescribed 10 mg 2-3 times a day. The maximum daily dose for this age category is 40 mg (1tb). The course of treatment is 5 days. Use of Broncholitin in higher doses only under medical supervision.
Contraindications
Taking the drug is contraindicated if:
- arterial hypertension;
- IHD;
- severe forms of organic heart disease;
- pheochromocytoma;
- heart failure;
- thyrotoxicosis;
- early pregnancy ;
- insomnia;
- prostatic hyperplasia , which is accompanied by clinical manifestations;
- lactation;
- patients aged less than 3 years;
- angle-closure glaucoma;
- sensitivity to the drug.
Caution is necessary if you are prone to drug addiction. Since the drug contains ethanol, caution is required when prescribing to children, patients with liver disease, epilepsy, chronic alcoholism, and brain disorders.
Side effects
When treated with Bronholitin, side effects may occur that affect the functioning of the cardiovascular, nervous, digestive, endocrine, urinary and other systems. In this case, undesirable effects often occur in the form of: tachycardia, extrasystole , increased blood pressure , tremor , agitation, insomnia , dizziness , nausea , vomiting, anorexia , constipation , increased libido, dysmenorrhea , difficulty urinating and others.
It is also possible that vision impairment, the development of dermatological reactions, tachyphylaxis , and so on.
Bronholitin syrup, instructions for use (Method and dosage)
This drug is intended to be taken orally after eating. As the instructions for use of Broncholitin for children indicate, it can be used from 3 years of age.
In this case, the daily dosage for children 3-10 years old is 5 ml for 3 times a day. For adult patients and children over 10 years of age, the instructions recommend taking the syrup in a daily dosage of 10 ml 3-4 times.
The duration of therapy is on average 5-7 days, and reviews for children show that this time is quite enough for a complete recovery.
Pharmacological properties of the drug Bronholitin
Pharmacodynamics . A combined drug with antitussive, bronchodilator and bronchoseptic effects. The complex effect of the drug is due to the properties of its main components: glaucine hydrobromide and ephedrine hydrochloride. Glaucine hydrobromide inhibits the cough center without having a depressing effect on the respiratory center. It has a mild analgesic, bronchospasmolytic and anti-inflammatory effect. Ephedrine is a mixed-action sympathomimetic that excites α- and β-adrenergic receptors and causes the release of norepinephrine from the depot. Moderately inhibits MAO activity. Reduces swelling of the bronchial mucosa, causes constriction of arterioles and increases blood pressure; improves atrioventricular conduction; enhances cardiac activity. Activates excitation processes in the central nervous system and stimulates the respiratory center. Experimental pharmacological studies of the action of Broncholitin syrup show that it reduces the spastic effect of histamine on the bronchi. Two main components act on the cardiovascular system - ephedrine and glaucine, which exhibit the opposite effect. Ephedrine increases heart rate and blood pressure, and glaucine reduces the value of both indicators. Facilitation of sputum production and reduction of bronchial obstruction are due to the bronchodilator effect of ephedrine. Pharmacokinetics. When administered orally, glaucine hydrobromide is rapidly absorbed from the gastrointestinal tract. The time to reach the maximum level in blood plasma is about 1.5 hours after administration. Metabolized in the liver and excreted primarily in the urine. Ephedrine hydrochloride is well absorbed from the gastrointestinal tract. The half-life is 3–6 hours. It is eliminated in the urine mainly unchanged.
Interaction
This drug contains ephedrine, which can reduce the effectiveness of hypnotics and opioid analgesics.
Concomitant use with cardiac glycosides, tricyclic antidepressants and Quinidine can lead to the development of arrhythmias .
Combination with Reserpine or MAO inhibitors significantly increases blood pressure, and with non-selective beta-blockers reduces the bronchodilator effect of the drug.
Interactions of the drug Broncholitin
Bronholitin can be prescribed simultaneously with antibiotics and other antimicrobials, antipyretics and vitamins. Considering the properties of the active substance - ephedrine - it is necessary to take into account its drug interactions:
- with guanitidine - displacing it from binding to α-adrenergic neurons and enhancing its direct α-adrenomimetic effect;
- with reserpine - a decrease in the effect of ephedrine due to depletion of norepinephrine depots;
- with tricyclic antidepressants - increased pressor effects of direct and indirect action sympathomimetics due to blocking the accumulation of catecholamines in adrenergic nerve endings;
- with propranolol - a decrease in the bronchodilator effect of ephedrine.
Ephedrine is an antagonist of non-narcotic analgesics and drugs that inhibit the central nervous system. There are no known adverse interactions of glaucine with other drugs.
special instructions
You should know that one measuring spoon or glass, the volume of which is 5 ml, contains about 0.069 g of 96% ethanol.
When driving vehicles and operating machinery, dizziness may occur and vision may be impaired, so you need to be careful when performing work that requires high attention and quick psychomotor reactions.
Treatment of patients with impaired liver function also requires extreme caution when choosing a therapeutic regimen and course duration.
Special instructions for the use of the drug Broncholitin
Bronholitin contains up to 1.7 vol.% ethanol. Each dose (1 scoop) contains up to 0.069 g of alcohol. This can be dangerous for patients with alcoholism, epilepsy, patients with liver disease, brain damage or disease, as well as for pregnant women and children. This medicine may change or enhance the effects of another medicine. Excipients may lead to allergic reactions. The drug should be used with caution when driving vehicles or operating machinery due to the possibility of dizziness and visual impairment.
Broncholitin analogs
Level 4 ATC code matches:
Bronchoton
Pectolvan Stop
Glycodin
The main analogues of Broncholitin, similar in mechanism of action: Bronchocin, Broncholin sage, Bronchoton, Codipront, Tussin Plus, Tedein, Alex Plus, Tercodin, Glycodin . If the patient has a problem, what to replace the drug with is better to discuss this with the attending physician.
Bronholitin for weight loss
Quite often, this drug is taken by women who want to quickly and completely lose weight. In this case, a special scheme for weight loss is used, including: Caffeine , Broncholithin, Aspirin , which are taken in certain dosages.
Reviews about this method of losing weight vary and are not always positive. For many people, this results in serious health problems, but this stops few people. Also, regimens using this drug are used in bodybuilding, when it is necessary to influence the development of muscle mass and body structure.
Reviews about Bronholitin
In most cases, reviews about Broncholitin are found on medical forums, but users also leave opinions about this drug on other resources. However, they are not always related to its intended use.
Unfortunately, many reports concern how to obtain ephedrine for use as a narcotic substance. There are also many schemes for using the drug in combination with other drugs.
It is not surprising that all this causes a storm of indignation. Many users sincerely do not understand how they can buy this highly effective drug, which helps patients with bronchial asthma , only to knock out the ephedrine and use it for other purposes. Usually such experiments end in serious complications. As a result, the health of the liver and kidneys, cardiovascular and other body systems suffers.
You can also find reviews of Broncholitin for children, when this drug was used in the treatment of bronchial asthma, obstructive bronchitis and other diseases. The treatment usually goes well, but some mothers are interested in whether Bronholitin is available in pharmacies by prescription or not? As you know, it is almost impossible to buy this drug without a prescription. Moreover, syrup is not at all easy to purchase in pharmacies, even with a prescription, so some patients prefer tablets, which are more affordable.
Thus, reports regarding the use of the drug according to its indications indicate its high effectiveness. Cases of side effects have not been described. But still, it is not recommended to take this medicine without a doctor’s prescription.
Note!
The description of the drug Bronholitin on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
Bronholitin price, where to buy
The price of syrup in Russian pharmacies starts from 95 rubles. You can also buy Bronholitin with delivery, after finding out how much the drug costs by phone or on the company’s website.
The price of Bronholitin in Ukraine varies between 60-70 UAH.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Broncholitin syrup 125gSopharma AD
RUB 203 order
Pharmacy Dialogue
- Bronholitin (vial 125g)Sopharma
186 RUR order
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Pharmacy24
- Bronholitin 125 ml syrup AT "Sopharma", Bulgaria
99 UAH. order - Broncholitin 40 mg No. 20 tablets AT "Sopharma", Bulgaria
103 UAH order
PaniPharmacy
- Bronholitin liquid Bronholitin syrup 125ml Bulgaria, Sopharma
113 UAH order
- Bronholitin tablets Bronholitin tablets. 40 mg No. 20 Bulgaria, Sopharma
107 UAH order
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