“Derinat” is a broad-spectrum remedy for strengthening the immune system, used as a prevention and treatment for acute respiratory viral infections, as well as inflammations of the skin and mucous membranes. It is produced in the form of a solution, which is used for inhalation, irrigation, application and other methods.
Spray "Derinat": composition, description
This drug has a pronounced immunomodulatory effect. It accelerates tissue restoration and metabolism, due to which harmful components leave the body naturally faster. The product also has antioxidant functions, strengthens cell membranes, and works as a cardioprotector.
The composition includes the active substance – the organic salt sodium deoxyribonucleate. Auxiliary components are table salt (sodium chloride) and water. Available in the form of a solution that is administered intramuscularly. It appears to be a clear liquid. Another form is a solution for external use (without injections).
It is advisable to store both solutions in the refrigerator or in a dark place indoors (up to 20°C). Must be protected from direct sunlight. Access for children is excluded. The shelf life in a closed container is 5 years, after opening – 2 weeks.
pharmachologic effect
Derinat is an immunomodulatory drug that accelerates the processes of tissue regeneration and repair, relieves inflammation, stimulates anti-cancer immunity, has an anti-allergic effect, stimulates the natural detoxification of the body with immobilization and reduction of toxin .
In addition, the drug exhibits lymphotropic, cardioprotective and anti-ischemic properties, antioxidant and membrane stabilizer properties, and has a weak anticoagulant effect.
Indications for use
The drug is used as a primary and additional medicine. In the first case, Derinat is used to treat infectious diseases (external use):
- ARVI (including for prevention purposes);
- inflammatory ophthalmological pathologies, including those with purulent discharge;
- inflammation of the oral mucosa.
The drug is also used as an additional remedy as part of the complex treatment of such pathologies (external use):
- inflammatory processes (chronic);
- gynecological infections of a bacterial or fungal nature;
- acute and chronic pathologies of the nasal sinuses, including sinusitis, rhinitis;
- wounds and ulcers that do not go away for a long time, including due to the development of diabetes mellitus;
- gangrene;
- burns of varying degrees;
- haemorrhoids;
- partial death of the skin or mucous membrane;
- frostbite.
Injections are given for the treatment of a number of diseases of the cardiovascular, digestive and other organ systems:
- ulcers in the gastrointestinal tract;
- IHD;
- OSC (stages of development: I, II);
- long-lasting wounds, burns and other skin damage;
- dysfunction of hematopoiesis;
- radiation injuries;
- myelodepression;
- stomatitis of various nature;
- rheumatoid type arthritis;
- endometritis;
- COPD;
- prostatitis;
- bacterial infections of the genitourinary system, including chlamydia, ureaplasmosis.
Dezrinit
As with any treatment, patients using mometasone nasal spray dosage form for several months or longer should be periodically examined by a doctor for possible changes in the nasal mucosa.
It is necessary to monitor patients receiving intranasal corticosteroids for a long time. Possible development of growth retardation in children. If growth retardation is detected in children, it is necessary to reduce the dose of intranasal corticosteroids to the lowest that allows for effective control of symptoms. In addition, the patient should be referred to a pediatrician for consultation.
If a local fungal infection of the nose or pharynx develops, it may be necessary to discontinue therapy with mometasone in dosage form - dosed nasal spray and carry out special treatment. Irritation of the mucous membrane of the nose and pharynx that persists for a long time can also serve as a basis for discontinuing treatment with mometasone in dosage form - dosed nasal spray.
In placebo-controlled clinical studies in children, when mometasone in dosage form - nasal spray was used in a daily dose of 100 mcg for a year, no growth retardation was observed in children.
With long-term treatment with mometasone in the dosage form - nasal spray, no signs of suppression of the function of the hypothalamic-pituitary-adrenal system were observed.
Patients who switch to treatment with mometasone in dosage form - a dosage nasal spray after long-term therapy with systemic glucocorticosteroids require special attention. Withdrawal of systemic corticosteroids in such patients can lead to adrenal insufficiency, the subsequent recovery of which may take up to several months. If signs of adrenal insufficiency appear, systemic corticosteroids should be resumed and other necessary measures taken.
When using intranasal corticosteroids, systemic side effects may develop, especially with long-term use in high doses. The likelihood of developing these effects is much less than with the use of oral corticosteroids.
Systemic side effects may vary in individual patients and depending on the glucocorticosteroid drug used. Potential systemic effects include Cushing's syndrome, characteristic Cushingoid signs, adrenal suppression, growth retardation in children and adolescents, cataracts, glaucoma, and less commonly a number of psychological or behavioral effects including psychomotor hyperactivity, sleep disturbance, anxiety, depression, or aggression (especially in children).
During the transition from treatment with systemic glucocorticosteroids to treatment with mometasone nasal spray, some patients may experience initial symptoms of systemic glucocorticosteroid withdrawal (for example, joint and/or muscle pain, fatigue and depression), despite a decrease in the severity of symptoms. associated with damage to the nasal mucosa. If these signs appear, you should resume taking systemic glucocorticosteroids and take other necessary measures. Switching from systemic to topical glucocorticosteroids may also reveal pre-existing allergic diseases such as allergic conjunctivitis and eczema that were masked by systemic glucocorticosteroid therapy.
Patients treated with glucocorticosteroids have a potentially reduced immune responsiveness and should be warned of their increased risk of infection if exposed to patients with certain infectious diseases (eg, chickenpox, measles), as well as the need for medical advice if such exposure occurs .
If signs of a severe bacterial infection appear (for example, fever, persistent and sharp pain on one side of the face or toothache, swelling in the orbital or periorbital area), immediate medical consultation is required.
When using mometasone in dosage form - dosed nasal spray for 12 months, there were no signs of atrophy of the nasal mucosa. In addition, mometasone furoate tended to promote normalization of the histological picture when examining biopsy specimens of the nasal mucosa.
The effectiveness and safety of mometasone have not been studied in the treatment of unilateral polyps, polyps associated with cystic fibrosis, and polyps that completely occlude the nasal cavity.
If unilateral polyps of an unusual or irregular shape are detected, especially those that are ulcerated or bleeding, additional medical examination is necessary.
Visual disturbances have been reported with systemic and topical corticosteroid use. If a patient develops symptoms such as blurred vision or other visual disturbances, consider referring the patient to an ophthalmologist to evaluate possible causes, which may include cataracts, glaucoma, or rare diseases such as central serous chorioretinopathy (CSCR).
Contraindications and side effects
The drug has no contraindications, with the exception of individual intolerance to the components that make up it.
Side effects occur infrequently, but are not excluded:
- rejection of dead tissue during gangrene;
- painful sensations in the area where the injection was given (go away on their own);
- hypoglycemia (patients with diabetes should monitor sugar levels);
- short-term increase in body temperature to 37.5-38.0°C.
Most of the described consequences go away on their own and do not require treatment. But if they do not disappear within the first day, it is recommended to consult a doctor.
Pharmacodynamics and pharmacokinetics
The action of Derinat is aimed at stimulating cellular and humoral immunity, which in turn optimizes inflammatory reactions and acquired immunity (specific immune response) to foreign substances of bacterial, fungal and viral origin.
The immunomodulatory effect of the drug is determined by its ability to stimulate the activity of T- and B-lymphocytes and activate cells of the monocyte-macrophage series .
Derinat induces intracellular energy metabolism , and DNA synthesis . Due to the activation of the cellular immune response, the ability of natural killer cells (NK cells) to act on cells affected by viruses and bacteria increases.
While using the medication:
- reparative and regenerative processes are activated in the body;
- the condition of tissues and organs is normalized during dystrophic processes caused by vascular disorders;
- the susceptibility of cells to the damaging effects of chemotherapy and radiation therapy ;
- the body's resistance to various types of infections increases;
- the detoxification function of the lymphatic system is stimulated;
- indicators of myocardial contractile function improve;
- the death of cardiac muscle cells, cardiomyocytes ;
- physical performance increases.
Derinat helps remove free radicals from the body, accelerates the healing of wounds (including purulent and infected wounds), deep burns (while improving the dynamics of regeneration, epithelization and scarring of tissue), trophic ulcers.
Under the influence of the drug, scarless restoration of the mucous membranes occurs during the restoration of ulcerative defects.
Derinat does not cause any disturbances in intrauterine development or morphological abnormalities in the fetus. It also does not have a carcinogenic effect.
When used as a local remedy, it is quickly absorbed. The main route of transport of the active substance in organs and tissues is endolymphatic. At the stage of intensive entry of sodium deoxyribonucleate into the bloodstream, in parallel with metabolism and excretion, redistribution occurs between erythrocytes , leukocytes , platelets and plasma .
Metabolization occurs in the body. Metabolites are excreted partly with the intestinal contents, and mainly according to a biexponential dependence in the urine.
Instructions for use "Derinat"
The product is used in different ways:
- applications;
- irrigation;
- nasal drops;
- eye drops;
- microenemas;
- rinsing;
- injections.
Rinsing, irrigation, applications and microenemas are given 4, 5 or 6 times a day for 5-10 days in a row. To treat gynecological pathologies, it is necessary to perform an intravaginal microenema. To carry out one procedure, you will need to measure 5 ml of solution. 2 injections are made per day, the cycle is 10-14 days.
In the case of hemorrhoids, microenemas are placed directly in the rectal area. The solution is measured in an amount of 15-40 ml. The total duration is 4-10 days.
For eye diseases manifested by inflammatory processes, the product is instilled into the eyes (1-2 drops in each) 2-3 times a day for 15 days in a row.
To treat necrosis and other skin lesions, take sterile gauze, fold it twice, apply the solution and apply the application. The procedure is repeated up to 4 times a day until complete recovery, which can take several weeks or even up to 3 months.
"Derinat" is also used for instilling drops into the sinuses. Each turn gives 2 drops. The procedure is repeated 2-4 times a day for 7-14 days in a row.
To treat ARVI, the solution is also injected into the nasal passages (2-3 drops). Therapy continues for 7-14 days (every day 4, 5 or 6 times).
Injections are given intramuscularly, measuring 5 ml of solution. The frequency and dosage are determined by the doctor. They depend on the diagnosis, for example:
- IHD – 10 injections in 2-3 days;
- gastrointestinal ulcers - 5 injections with a break of 2 days;
- oncological pathologies - 3-10 injections with a break of 1-3 days;
- prostatitis, gynecology - 10 injections each with the same interval.
Interaction
When applied topically, the drug is not compatible with hydrogen peroxide and fat-based ointments.
The use of the drug in combination with the main therapy increases the therapeutic effect and reduces the duration of treatment. This also makes it possible to reduce the doses of antibiotics and antiviral drugs.
Against the background of using Derinat:
- the effectiveness of therapy with antitumor anthracycline antibiotics and cytostatic drugs increases;
- the effect of basic therapy prescribed to patients with peptic ulcer ;
- The iatrogenicity of drugs prescribed for the treatment of rheumatoid arthritis (up to 50-70%, which is also accompanied by an improvement in a number of complex indicators of disease activity).
In cases where a surgical infection provokes the development of sepsis , the introduction of Derinat into combination therapy allows:
- reduce the level of intoxication in the body;
- increase the activity of the immune system;
- normalize hematopoietic function;
- improve the performance of organs involved in removing toxins from the body.
Derinat's analogs
Level 4 ATC code matches:
Epobiocrine
Recormon
Epocrine
Erythropoietin
Structural analogues of Derinat are drugs:
- Panagen
- Deoxynate
- Sodium deoxyribonucleate
There are a huge number of drugs on the market that have an effect similar to Derinat:
- Grippferon
- Anaferon
- Viferon
- Orvirem
- Oscillococcinum
Derinat or Grippferon - which is better?
This question often arises for many mothers who are trying to protect their children from influenza and ARVI . The drugs are incomplete analogues, but at the same time they are very similar in therapeutic effect and indications.
The composition and origin of the drugs vary greatly, however, biologically active proteins in both Grippferon and Derinat have immunomodulatory, antiviral and anti-inflammatory effects.
Some are inclined to consider Derinat a slightly more effective medicine than Grippferon , it is a stronger immunomodulator and has a wider spectrum of action. This explains the presence of Derinat in a dosage form for intramuscular injection ( Grippferon is available only in the form of drops and nasal spray).
It should be remembered that in cases where health is involved, self-medication is unacceptable, and the final decision on prescribing a particular drug is made by the attending physician, because the same drug can act differently on different patients.
