Colon cleansing with an aqueous solution of magnesium: all the nuances of carrying out

6.1. Dosage.

6.2. Procedure.

6.3. After the procedure.

1. Cleansing with magnesium and mineral water.
2. How often can you cleanse your intestines with an aqueous solution of magnesium?
3. Advantages of the procedure.
4. Disadvantages of colon cleansing with magnesium sulfate.

Colon cleansing with magnesium is an effective procedure that you can do yourself at home. To do this, you should study the indications and contraindications, methods of preparing the body and the rules for carrying out the purification process itself by drinking magnesia. We will consider all these nuances in the article.

Pharmacological properties

Pharmacodynamics Magnesium is predominantly an intracellular cation, reduces the excitability of neurons and neuromuscular transmission of excitation, and takes part in many enzymatic processes. Magnesium is an essential element of organs and tissues; half of the total amount of magnesium in the body accumulates in bone tissue. Serum magnesium levels: between 12 and 17 mg/L (1 - 1.4 mEq/L or 0.5 - 0.7 mmol/L): indicate mild magnesium deficiency below 12 mg/L (1 mEq/L or 0.5 mmol/l): indicates severe magnesium deficiency. The deficiency can be: primary, due to a congenital abnormality of metabolism (chronic congenital hypomagnesemia), secondary, due to: inadequate intake (severe malnutrition, alcoholism, exclusively parenteral nutrition); gastrointestinal absorption disorders (chronic diarrhea, gastrointestinal fistula, hypoparathyroidism); excessive excretion of magnesium by the kidneys (severe polyuria, abuse of diuretics, chronic pyelonephritis, primary hyperaldosteronism, treatment with cisplatin). Pyridoxine (vitamin B6) is involved in many metabolic processes and helps improve the absorption of magnesium from the gastrointestinal tract and its penetration into cells. Pharmacokinetics Gastrointestinal absorption of magnesium salts occurs partly through a passive mechanism in which the solubility of the salt plays a determining role. The degree of this absorption does not exceed 50%. In the body, magnesium is distributed mainly in the intracellular space (about 99%), of which approximately 2/3 is distributed in bone tissue, and a third is in smooth and striated muscle tissue. Excretion of magnesium occurs in the urine, at least 1/3 of the dose of magnesium taken. Pyridoxine is absorbed in the small intestine. Metabolized in the liver to form pharmacologically active metabolites (pyridoxal phosphate and pyridoxaminophosphate). Distribution is predominantly in muscles, liver and central nervous system. Penetrates through the placenta and into mother's milk. Excreted by the kidneys.

Release form, composition

• Dosage 100 mg/10 mg: film-coated tablets, white, oval, biconvex, scored.
• Dosage 50 mg/5 mg: film-coated tablets, white, round, biconvex in shape. Excipients: macrogol (6000), magnesium stearate, microcrystalline cellulose, lactose monohydrate, opadry II white (polyvinyl alcohol, titanium dioxide, polyethylene glycol, talc).
• Powder for preparing a solution for oral administration is white or almost white with a yellowish or gray tint, odorless; The presence of soft lumps is allowed. 1 package contains anhydrous magnesium citrate 618.4 mg, which corresponds to a magnesium content of 100 mg, as well as pyridoxine hydrochloride 10 mg. Excipients: anhydrous citric acid, sugar.

The main analogues are Magne B6, magvit.

Indications

Treatment of confirmed magnesium deficiency in the body, both isolated and associated with other deficiency conditions. A combination of a certain number of the following symptoms may indicate magnesium deficiency: nervousness, irritability, mild anxiety, transient fatigue, minor sleep disturbances; signs of anxiety, such as gastrointestinal cramps or rapid heartbeat (if your heart is healthy); muscle cramps, tingling sensation. Taking magnesium may help relieve these symptoms.

Advantages of the procedure

Using magnesium to cleanse the intestines has the following positive aspects for humans:

1. Magnesium sulfate cleanses even very polluted intestines.
2. The general condition of a person is stabilized and muscle tone increases.
3. The cleaning process does not take much time - about 5 hours.
4. The mucous membrane is not damaged due to the inability of magnesium to be absorbed by the intestinal walls.
5. Magnesium sulfate has a low cost, so colon cleansing will not cost much.

Directions for use and dosage

The use of Magnelek is possible only after consultation with a doctor!
The tablets should be taken whole with a glass of water. Adults: 3-4 tablets with a dosage of 100 mg/10 mg or 6-8 tablets with a dosage of 50 mg/5 mg per day, divided into 2-3 doses, with meals. Children over 6 years of age (body weight about 20 kg): 10-30 mg/kg/day (0.4-1.2 mmol/kg/day), i.e. 2-4 tablets with a dosage of 100 mg/10 mg or 4-6 tablets with a dosage of 50 mg/5 mg per day, divided into 2-3 doses, with meals. Typically the duration of treatment is one month. The score on the 100 mg/10 mg tablets is intended solely to facilitate the administration of one tablet (by breaking the tablet into two halves) and not to divide the tablet into two doses. Treatment should be discontinued when serum magnesium concentrations normalize. If you forget to take a medicine, do not take a double dose to make up for the missed dose! If you have any doubts or questions, contact your healthcare provider.

Preparing the body

Carrying out a cleansing procedure using magnesia will require preliminary preparation. It should be done according to two main recommendations:

1. For 7-14 days you should stop eating the following food groups - fatty, salty, canned and smoked. Also prohibited are meat, fish, pasta, bakery and confectionery products, alcoholic beverages, tea, coffee, spices and herbs. Instead of all the listed products, products of plant origin are introduced into the diet, which are consumed raw, boiled or steamed.
   

   Important! Vegetable products that are fried or cooked in the oven should not be consumed; oil is used in their preparation in any case. And even with a small amount, the finished product will fall into the category of fatty products.

2. During the period allotted for preparing the body, you should organize the correct drinking regime. The amount of water that needs to be consumed per day is calculated individually using the formula: for men - body weight x 0.035 l, for women - body weight x 0.031 l. In addition to water, you can only drink rosehip decoction.

Overdose

Oral overdose of magnesium usually does not cause toxic reactions if the kidneys are functioning normally. However, magnesium poisoning can develop in cases of kidney failure. Toxic effects depend on the level of magnesium in the blood. Symptoms: drop in blood pressure, nausea, vomiting, central nervous system depression, impaired reflexes, ECG changes, respiratory depression, coma, cardiac arrest and respiratory paralysis, anuric syndrome. Treatment: rehydration, forced diuresis. In case of renal failure, hemodialysis or peritoneal dialysis is necessary. Precautions In patients with severe magnesium deficiency, the use of the drug should be started by administering it intravenously. It is also indicated in patients with malabsorption. The drug should be used with caution in cases of moderate renal insufficiency, as there is a risk of developing hypermagnesemia. With concomitant calcium deficiency, magnesium deficiency in the body should be eliminated before taking calcium supplements. Because this drug contains sucrose, it is contraindicated in patients with fructose intolerance, glucose-galactose malabsorption syndrome, or sucrase-isomaltase deficiency. Use with caution for gastric and duodenal ulcers and coronary heart disease. In case of severe liver damage, pyridoxine in high doses can cause deterioration of liver function. When pyridoxine is used in high doses (>300 mg/day) for a long time (several months or in some cases years), sensory neuropathy may develop, accompanied by the following symptoms: numbness and vestibular disorders, tremor of the distal extremities and gradually developing sensory ataxia (impaired coordination of movements). These disorders are usually reversible and disappear after discontinuation of high doses of vitamin B.

Pregnancy and lactation

If you are pregnant or breastfeeding, think you may be pregnant, or think you might be pregnant, tell your doctor. Pregnancy. Limited data from clinical studies in animals did not reveal fetotoxic or embryotoxic effects of the drug. Thus, the use of magnesium during pregnancy is possible only if necessary after consultation with a doctor. Breastfeeding period. Each of the active ingredients of the drug (both magnesium and vitamin B6) is not contraindicated during this period. Given the limited evidence regarding the use of the maximum daily dose of vitamin B6 during breastfeeding, it is recommended to prescribe no more than 20 mg/day of vitamin B6.

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Interaction with other drugs

If you are currently or have recently taken other medications, tell your doctor. Phosphorus or calcium salts These drugs inhibit the absorption of magnesium from the intestines. Orally administered tetracyclines An interval of at least 2 hours should be observed between oral administration of tetracyclines and magnesium preparations due to the decreased absorption of tetracyclines in the gastrointestinal tract. Oral thrombolytic agents When used together, magnesium weakens the effect of these drugs Levodopa The activity of levodopa (if this drug is not combined with the use of peripheral dopa decarboxylase inhibitors) is inhibited by pyridoxine. Any use of pyridoxine should be avoided unless peripheral dopa decarboxylase inhibitors are prescribed concomitantly with levodopa. Hormonal contraceptives When used simultaneously, it is possible to increase the concentration of pyridoxine in the blood. Diuretics When used concomitantly, pyridoxine potentiates the effect of diuretics. Isonicotin hydrazide, penicillamine, cycloserine The effectiveness of pyridoxine may be reduced when used simultaneously with these drugs. Phenytoin, phenobarbital When used simultaneously, it is possible to reduce the plasma concentrations of phenytoin and phenobarbital.

Buy Magnesium sulfate powder for oral solution 25g in pharmacies

Instructions for use of Magnesium sulfate. size 25g

Dosage forms powder 25g Synonyms No synonyms. Group Peripheral vasodilators International nonproprietary name Magnesium sulfate Composition Active ingredient - magnesium sulfate. Manufacturers Vologda Pharmaceutical Factory (Russia), Krasnodar Pharmaceutical Factory (Russia), Tula Pharmaceutical Factory (Russia), Pharmaceutical Factory St. Petersburg (Russia), Chemical Plant named after. L.Ya. Karpova packaged Pharmaceutical factory of St. Petersburg (Russia) Pharmacological action Sedative, hypnotic, general anesthetic, anticonvulsant, antiarrhythmic, hypotensive, antispasmodic, laxative, choleretic, tocolytic. Magnesium is a physiological antagonist of calcium and is able to displace it from binding sites. Regulates metabolic processes, neurochemical transmission and muscle excitability, prevents the entry of calcium ions through the presynaptic membrane, reduces the amount of acetylcholine in the peripheral nervous system and the central nervous system. Relaxes smooth muscles, reduces blood pressure (mostly elevated). When administered by injection, it blocks neuromuscular transmission and prevents the development of seizures; in large doses it has curare-like properties. When taken orally, it is poorly absorbed (no more than 20%), increases osmotic pressure in the gastrointestinal tract, causes fluid retention and its release (along a concentration gradient) into the intestinal lumen, increasing peristalsis throughout its entire length, leading to defecation (after 4-6 hours) . Promotes the release of cholecystokinin, irritates the receptors of the duodenum, and has a choleretic effect. The absorbed portion is excreted in the urine, and diuresis increases; the rate of renal excretion is proportional to the plasma concentration. Systemic effects develop 1 hour after IM administration and almost immediately after IV administration. Their duration with intravenous administration is 30 minutes, with intramuscular administration - 3-4 hours. Passes through the BBB and placenta, creating concentrations in milk that are 2 times higher than concentrations in plasma. Side effects When administered by injection: bradycardia, conduction disturbances, diplopia, sensation of heat, sweating, hypotension, anxiety, weakness, headache, deep sedation, decreased tendon reflexes, shortness of breath, nausea, vomiting, polyuria. When taken orally: nausea, vomiting, acute inflammation of the gastrointestinal tract. Indications for use Injection: hypertensive crisis (including with symptoms of cerebral edema), myocardial infarction, eclampsia, encephalopathy, hypomagnesemia, incl. prevention (poor or unbalanced nutrition, taking contraceptives, diuretics, muscle relaxants, chronic alcoholism), increased need for magnesium (pregnancy, growth period, recovery period, stress, excessive sweating), acute hypomagnesemia (signs of tetany, myocardial dysfunction), convulsive syndrome (for example, in acute nephritis in children), complex therapy of premature birth, bronchial asthma, angina pectoris, cardiac arrhythmias (especially supraventricular and caused by therapy with antiarrhythmic or diuretic drugs, glucocorticoids or cardiac glycosides), poisoning with salts of heavy metals, arsenic, tetraethyl lead, soluble barium salts (antidote). Orally: poisoning, constipation, cholangitis, cholecystitis, bowel cleansing, before diagnostic procedures. Contraindications Hypersensitivity, severe bradycardia, AV block, impaired renal function, severe renal failure, myasthenia gravis, respiratory diseases, acute inflammatory diseases of the gastrointestinal tract, pregnancy, menstruation. Method of administration and dosage As a laxative - orally (at night or on an empty stomach) for adults - 10-30 g in 0.5 glasses of water, for children - at the rate of 1 g per 1 year of life. As a choleretic agent - orally, 1 tablespoon of a 20-25% solution 3 times a day or duodenal intubation with the introduction of 50 ml of a 25% solution or 100 ml of a 10% solution. Overdose Symptoms: disappearance of the knee reflex, nausea, vomiting, sharp decrease in blood pressure, bradycardia, respiratory depression and central nervous system. Treatment: calcium preparations (calcium chloride or calcium gluconate) are administered intravenously (slowly) as an antidote, artificial ventilation, peritoneal dialysis or hemodialysis, symptomatic agents. Interaction Enhances the effect of other CNS depressants. Digitalis glycosides increase the risk of conduction disturbances and AV block. Muscle relaxants and nifedipine enhance neuromuscular blockade. Barbiturates, narcotic analgesics, and antihypertensive drugs increase the likelihood of depression of the respiratory center. IV administration of calcium salts reduces the effect. Pharmaceutically incompatible (forms a precipitate) with calcium preparations, alcohol (in high concentrations), carbonates, bicarbonates and phosphates of alkali metals, salts of arsenic acid, barium, strontium, clindamycin phosphate, hydrocortisone sodium succinate, polymyxin B sulfate, novocaine hydrochloride, salicylates and tartrates . Special instructions During long-term treatment, monitoring of blood pressure, cardiac activity, tendon reflexes, renal function, and respiratory rate is recommended. If simultaneous intravenous use of magnesium and calcium salts is necessary, they should be injected into different veins. Storage conditions : Protected from light, at a temperature not exceeding 25°C.