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Rotadon powder for the preparation of solution for oral administration 1500 mg 20 pcs.

pharmachologic effect

Anti-inflammatory, antirheumatic.

Composition and release form Rotadon powder for the preparation of solution for oral administration 1500 mg 20 pcs.

Powder - 1 g:

Active ingredient: glucosamine sulfate (in the form of potassium glucosamine sulfate) 1500 mg;
Excipients: sorbitol, aspartame, anhydrous citric acid, macrogol 4000;

20 sachets of 1500 mg. in cardboard packaging.

Characteristic

Relieves pain and increases joint mobility.

Directions for use and doses

1 sachet per day. The course of therapy is no less than 4 and no more than 12 weeks. If indicated, the course of therapy can be repeated after 8 weeks.

It is advisable to take the prepared solution at the same time, 30 minutes before lunch or dinner.

Pharmacokinetics

Rapidly absorbed in the small intestine. Bioavailability is 25-26%. After tissue distribution, the highest concentrations are observed in the synovium, cartilage, liver and kidneys. Metabolized in the liver to form urea, water and carbon dioxide. It is excreted unchanged mainly in the urine, and to a very small extent in feces. The half-life is 68 hours.

Indications for use Rotadon powder for the preparation of solution for oral administration 1500 mg 20 pcs.

Inflammatory joint diseases;
Osteoarthritis;
Arthrosis of the knee and hip joints;
Dystrophic diseases of the spinal column;
Humeroscapular periarthritis;
Joint damage;
Chondromalacia patella;
Recovery period after joint injuries and operations;

Contraindications

Individual intolerance;
The patient's age is up to 12 years;
Functional kidney disorders;
Pregnancy and breastfeeding;
Phenylketonuria;

Effect on the body

Relieves pain and increases joint mobility.

Application Rotadon powder for the preparation of solution for oral administration 1500 mg 20 pcs. during pregnancy and breastfeeding

Contraindicated.

special instructions

Before use, consult a specialist.

Side effects Rotadon powder for the preparation of solution for oral administration 1500 mg 20 pcs.

Flatulence, diarrhea, constipation, epigastric pain;
Hives, itching;

Drug interactions

When used in combination, the absorption of tetracyclines reduces penicillins and chloramphenicol. The drug is compatible with non-steroidal anti-inflammatory drugs and glucocorticoids. When used together with non-steroidal anti-inflammatory drugs, it enhances the anti-inflammatory and analgesic effect of the latter.

Rotadon 1500 mg No. 20 pack.

ROTADON I ROTADON Rotadon Instructions for use of a biologically active food supplement Composition 1 sachet contains the active substance - glucosamine sulfate (in the form of potassium glucosamine sulfate) 1500 mg. excipients: sorbitol E420, aspartame E951, anhydrous citric acid EZZO, macrogol 4000. Description Granular powder of white or almost white color, odorless. Glucosamine sulfate is a salt of the natural aminomonosaccharide glucosamine, physiologically present in the human body. Glucosamine is used in the body by chondrocytes as a starting material for the synthesis of proteoglycans, glycosaminoglycans and hyaluronic acid in synovial fluid. It has a beneficial effect on cartilage metabolism - enhances anabolic and weakens catabolic processes, increases the permeability of the joint capsule, restores enzymatic processes in the cells of the synovial membrane and articular cartilage. Rotadon stimulates the synthesis of proteoglycans and collagen, increases the production of extracellular matrix components, while the properties of glycosaminoglycans and proteoglycans are close to physiological. An increase in the synthetic activity of chondrocytes is accompanied by inhibition of chondrolysis due to inhibition of the activity of chondrolytic proteinases (collagenases, etc.), which is the basis of chondroprotective and osteotropic effects. Glucosamine exhibits a moderate anti-inflammatory effect, which is not associated with suppression of prostaglandin synthesis, but is realized due to antioxidant activity (by blocking the formation of superoxide radicals) and suppression of the activity of lysosomal enzymes. Glucosamine initiates the process of sulfur fixation in the synthesis of chondroitinsulfuric acid and promotes normal calcium deposition in bone tissue; prevents the damaging effect of corticosteroids on chondrocytes and the disruption of glycosaminoglycan synthesis induced by NSAIDs. Sulfo groups also take part in the synthesis of glycosaminoglycans and the metabolism of cartilage tissue, and sulfoesters of side chains in the composition of proteoglycans, promoting water retention - in maintaining the elasticity of the cartilage matrix. Rotadon stops the destruction of cartilage and reduces symptoms of osteoarthritis. Indications - prevention of inflammatory and initial manifestations of degenerative-dystrophic diseases of the joints of the extremities (osteoarthrosis (osteoarthritis) of various localizations, including arthrosis of the knee and hip joints) - prevention of degenerative-dystrophic diseases of the spine (osteochondrosis, spondyloarthrosis, etc.) - prevention of chondromalacia patella - prevention of glenohumeral periarthritis - restoration of mobility and reduction of pain in case of damage to the articular-ligamentous apparatus - in the complex of rehabilitation measures after joint injuries. Side effects - flatulence, diarrhea, constipation, epigastric pain - urticaria, itching Contraindications - individual intolerance (including a history of hypersensitivity) to the components of the product - pregnancy and lactation - children under 1.2 years of age - severe impairment kidney function - phenylketonuria (contains aspartame) Method of administration and dosage For oral administration. Rotadon is prescribed to adults: 1 sachet (1500 mg) once a day, 20 minutes before meals. The contents of the sachet should be completely dissolved in a glass of warm water and drunk immediately after preparation. Duration of treatment is 4-12 weeks. If necessary, the course of treatment can be repeated at intervals of 2 months. Interactions When used in combination, the absorption of tetracyclines reduces penicillins and chloramphenicol. The Rotadon product is compatible with non-steroidal anti-inflammatory drugs and glucocorticoids. When used together with non-steroidal anti-inflammatory drugs, it enhances the anti-inflammatory and analgesic effect of the latter. Release form Powder for the preparation of a solution for oral administration in bags. 10 or 20 bags along with instructions in the state and Russian languages in a cardboard box. Storage Store at a temperature not exceeding 25° C. Keep out of the reach of children! Shelf life: 3 years Do not use after expiration date. Manufacturer The owner of the trademark and certificate of registration is GREAT BRITAIN. Made by K.O. Rompharm Company S.R.L., Otopeni, Eroilor street 1 A, Romania. Address of the organization that accepts claims from consumers regarding the quality of products (goods) of the Republic of Kazakhstan on the territory of the Republic of Kazakhstan, Almaty, st. Suyunbaya 222 B Tel/fax: +7 (7272) 529090 Not a medicine.

Rotadon 1500mg 4g No. 20 sachets

Rotadon 1500mg 4g No. 20 sachets

Composition 1 sachet contains the active substance - glucosamine sulfate (in the form of potassium glucosamine sulfate) 1500 mg. excipients: sorbitol E420, aspartame E951, anhydrous citric acid EZZO, macrogol 4000. Description Granular powder of white or almost white color, odorless. Glucosamine sulfate is a salt of the natural amino monosaccharide glucosamine, physiologically present in the human body. Glucosamine is used in the body by chondrocytes as a starting material for the synthesis of proteoglycans, glycosaminoglycans and hyaluronic acid in synovial fluid. It has a beneficial effect on cartilage metabolism - enhances anabolic and weakens catabolic processes, increases the permeability of the joint capsule, restores enzymatic processes in the cells of the synovial membrane and articular cartilage. Rotadon stimulates the synthesis of proteoglycans and collagen, increases the production of extracellular matrix components, while the properties of glycosaminoglycans and proteoglycans are close to physiological. An increase in the synthetic activity of chondrocytes is accompanied by inhibition of chondrolysis due to inhibition of the activity of chondrolytic proteinases (collagenases, etc.), which is the basis of chondroprotective and osteotropic effects. Glucosamine exhibits a moderate anti-inflammatory effect, which is not associated with suppression of prostaglandin synthesis, but is realized due to antioxidant activity (by blocking the formation of superoxide radicals) and suppression of the activity of lysosomal enzymes. Glucosamine initiates the process of sulfur fixation in the synthesis of chondroitinsulfuric acid and promotes normal calcium deposition in bone tissue; prevents the damaging effect of corticosteroids on chondrocytes and the disruption of glycosaminoglycan synthesis induced by NSAIDs. Sulfo groups also take part in the synthesis of glycosaminoglycans and the metabolism of cartilage tissue, and sulfoesters of side chains in the composition of proteoglycans, promoting water retention - in maintaining the elasticity of the cartilage matrix. Rotadon stops the destruction of cartilage and reduces symptoms of osteoarthritis. Indications - prevention of inflammatory and initial manifestations of degenerative-dystrophic diseases of the joints of the extremities (osteoarthrosis (osteoarthritis) of various localizations, including arthrosis of the knee and hip joints) - prevention of degenerative-dystrophic diseases of the spine (osteochondrosis, spondyloarthrosis, etc.) - prevention of chondromalacia patella - prevention of glenohumeral periarthritis - restoration of mobility and reduction of pain in case of damage to the articular-ligamentous apparatus - in the complex of rehabilitation measures after joint injuries.

Side effects - flatulence, diarrhea, constipation, epigastric pain - urticaria, itching Contraindications - individual intolerance (including a history of hypersensitivity) to the components of the product - pregnancy and lactation - children under 1.2 years of age - severe impairment kidney function - phenylketonuria (contains aspartame) Method of administration and dosage For oral administration. Rotadon is prescribed to adults: 1 sachet (1500 mg) once a day, 20 minutes before meals. The contents of the sachet should be completely dissolved in a glass of warm water and drunk immediately after preparation. Duration of treatment is 4-12 weeks. If necessary, the course of treatment can be repeated at intervals of 2 months. Interactions When used in combination, the absorption of tetracyclines reduces penicillins and chloramphenicol. The Rotadon product is compatible with non-steroidal anti-inflammatory drugs and glucocorticoids. When used together with non-steroidal anti-inflammatory drugs, it enhances the anti-inflammatory and analgesic effect of the latter.