AnviMax, 6 pcs., 5 g, powder for oral solution, lemon with honey

Composition of AnviMax

Oral powder (the dosage of biologically active substances is calculated for 1 sachet for one-time use) consists of the following components:

• paracetamol – 360 mg;
• ascorbic acid – 300 mg;
• calcium gluconate monohydrate – 100 mg;
• rimantadine hydrochloride – 50 mg;
• rutoside trihydrate – 20 mg;
• Loratadine – 3 mg.

The following are used as excipients that allow the main components to have a more complete pharmaceutical effect:

• lactose monohydrate – 4.086 g;
• aspartame – 30 mg;
• colloidal silicon dioxide – 20 mg;
• hypromellose – 10 mg;
• food flavoring with the taste of lemon, honey, blackcurrant or raspberry – 21 mg.

Active components of capsule P:

• paracetamol – 360 mg;
• pregelatinized starch – 9 mg;
• colloidal silicon dioxide – 3 mg;
• lactose monohydrate – 4.2 mg;
• Magnesium stearate – 3.8 mg.

The P type capsule itself contains:

• gelatin – 94.795 mg;
• titanium dioxide (E171) – 1.94 mg;
• blue patent dye (E131) – 0.265 mg.

Composition of AnviMax in capsule P:

• ascorbic acid – 300 mg;
• calcium gluconate monohydrate – 100 mg;
• rimantadine hydrochloride – 50 mg;
• rutoside trihydrate in terms of pure rutoside – 20 mg;
• Magnesium stearate – 4.8 mg;
• loratadine – 3 mg;
• potato starch – 2.2 mg.

The type P capsule consists of the following components:

• gelatin – 94.064 mg;
• yellow dye iron oxide (E172) – 0.97 mg;
• crimson dye (Ponceau 4R) (E124) – 0.511 mg;
• red dye iron oxide (E172) – 0.485 mg;
• titanium dioxide (E171) – 0.97 mg.

Age restrictions.

Children from two years of age can take two medicines with paracetamol powders. The older they get, the more choices parents have.

Release form

The pharmaceutical drug can be found on pharmacy shelves in the following form:

• Powder used for solution and oral administration. Available in different flavors, for example, lemon, lemon with honey, blackcurrant, raspberry. The medicinal powder is placed in a heat-resistant bag, 3, 6, 12 or 24 pieces in a cardboard pack.
• Capsules for oral administration, 10 pieces in a cell package. A cardboard box contains 2 contour plates. Capsules can be of two types: marked P - hard, gelatinous, blue, the contents of which are a mixture of granules and white powder, sometimes with a creamy or pinkish tint; P-capsules are hard, gelatinous, red, containing a mixture of granules and yellow-green or milky-white powder.

pharmachologic effect

The drug has a wide range of pharmaceutical effects:

• antipyretic;
• analgesic (pain reliever);
• antihistamine;
• antiviral;
• interferonogenic;
• angioprotective.

AnviMax is a combination drug , as it contains several biologically active components. Thus, therapy with this drug is complex, even when only one position is included in the conservative treatment regimen, and therefore attention should be paid to the mechanisms of action of each component separately.

Ascorbic acid (a chemical analogue of natural vitamin C) – regulates the normal course of redox reactions, thereby helping to normalize the permeability of the capillary vascular bed . It has a stimulating effect on the body's immune systems and activates natural tissue regeneration. The acid also supports the normal functioning of the plasma coagulation system and the ability of platelets to coagulate.

Calcium gluconate acts as a donor of ions that are built into the wall of blood vessels. This prevents the development of increased permeability and fragility of the capillary bed. In this way, the hemorrhagic link of the inflammatory process during influenza or respiratory viral infection is eliminated.

Rimantadine is a substance with a high level of specificity of pharmaceutical action, the antiviral activity of which is aimed exclusively at the influenza virus type A. Thanks to its chemical properties, the M2 channels of the virus are blocked, which disrupts the ability of ribonucleoproteins to be released and further penetrate into the cell of a living organism. Thanks to such pharmaceutical abilities of Rimantadine, the main pathway of viral reproduction is inhibited, which has a beneficial effect on the state of the human macro organism. Also, the biologically active component induces the targeted production of alpha and gamma interferons , thereby stimulating the humoral component of immunity.

Loratadine is a typical H1 histamine receptor blocker . As an integral component of AnviMax, it prevents the development of edema of tissues adjacent to those affected by harmful microflora, as it prevents the generalized release of histamine (a biologically active amine that provides the main manifestations of the inflammatory process - swelling, redness, hyperthermia, and so on).

Rutoside is a pharmaceutical angioprotector , that is, the action of this substance is primarily aimed at maintaining the integrity of the vascular wall. To fulfill its task, the constituent component of the powder reduces the fragility and permeability of capillaries, inhibits the aggregation of red blood cells, and increases the degree of their deformation when passing through the microvasculature. It also relieves swelling and inflammation in the local area, which further strengthens the vascular wall.

Phoenix Health

Alcoholic drinks have a special effect on the human body and often suppress the effect of medications, so Anvimax and alcohol are not compatible. There are explanations for this. Firstly, the drug negatively affects liver function. Secondly, alcohol-containing drinks weaken the effect of the medication. Thirdly, it is strictly forbidden to drink alcoholic beverages for colds and other conditions for which the use of the drug is indicated. Fourthly, the components of the medicine are not compatible with ethyl alcohol. Numerous reviews speak about this.

Pharmacodynamics and pharmacokinetics

As with the pharmacological action, in order to understand the pharmacokinetic abilities of AnviMax, the metabolic pathways of each of the components of the combination drug should be traced.

Paracetamol is well absorbed from the gastrointestinal tract, the maximum plasma concentration is reached within half an hour after administration and is 4.8 mcg/ml. The substance is able to penetrate the blood-brain barrier and affect brain structures. The constituent component of AnviMax is metabolized in the liver, conjugating with sulfates, glucuronides or being oxidized by microsomal enzymes. Toxic intermediate metabolic products are formed only if paracetamol undergoes transformation through the third chemical pathway with the obligatory participation of glutathione , cysteine ​​and mercapturic acid . If there is an insufficient amount of cytochrome P450 enzymes, metabolites can have a damaging effect on hepatocytes , which leads to necrosis of liver cells. Metabolic products are excreted by the kidneys; the half-life is 2.8 hours, but with individual characteristics it can reach 3.5 hours. In old age, the clearance of the active substance decreases slightly, which is manifested by an increase in the half-life.

Ascorbic acid is absorbed mainly in the jejunum. Its absorption can be inhibited by diseases of the gastrointestinal tract, consumption of fresh fruits or vegetable juices, and copious amounts of alkaline drinks. The maximum concentration in blood plasma is reached after 4 hours from the moment of taking the drug and is approximately 10-20 mcg/ml. 25 percent of the acid binds to plasma proteins , the rest easily penetrates into blood cells, especially platelets and leukocytes. The chemical is deposited in the glandular organs, liver and lens of the eye. Ascorbic acid is able to penetrate the placental barrier and affect the fetus.

The active component is metabolized in the liver, excreted by the kidneys and through the intestines. Some of the acid may be excreted unchanged in sweat. The destruction of “ascorbic acid” is sharply accelerated due to smoking and excessive consumption of ethanol, which leads to a decrease in the physiological reserves of the body.

Calcium gluconate , like ascorbic acid, is absorbed primarily through the jejunum. Adsorption capacity depends on the acidity of the contents of the gastrointestinal tract and the presence of ergocalciferol . The ability to absorb calcium ions is greatly enhanced by their deficiency in the blood plasma. The active component is excreted 80 percent by the intestines and 20 percent by the kidneys.

Rimantadine is slowly absorbed from the digestive tract, its maximum concentration in the blood plasma is reached only 5-7 hours after taking the pharmaceutical drug. About 40 percent of a single dose taken after absorption is able to bind to plasma proteins, which ensures a constant concentration in the range of 50-80 ng/ml in the blood. Metabolized in the liver, after which more than 90 percent of the metabolic products are excreted by the kidneys over the next 72 hours. The half-life ranges from 20 to 45 hours. In old age, renal clearance of creatinine decreases, which contributes to the accumulation of rimantadine in toxic concentrations , therefore, the conservative treatment regimen in this age category should be strictly regulated taking into account individual metabolic parameters.

The metabolism of rutoside largely depends on the state of the gastrointestinal tract and the macroorganism as a whole. The time to reach its maximum concentration in plasma can range from 1 to 9 hours, and the half-life can range from 10 to 25 hours. The metabolic products of rutoside are excreted in the bile and, to a lesser extent, in the kidneys.

Loratadine is similar to ascorbic acid in its metabolic abilities. It is quickly and fairly completely absorbed from the intestine, which ensures its accumulation in the blood plasma within 2-4 hours after taking the drug. The maximum concentration is approximately 1-3 ng/ml, which is provided by 97 percent of a single dose due to binding to plasma proteins. Loratadine is not able to penetrate the blood-brain barrier, and accordingly, side effects of central origin should not be expected after taking it.

is metabolized in the liver under the influence of isoenzymes of the cytochrome . Excreted with bile or kidneys. The half-life is 5-15 hours, depending on the individual characteristics of the body. In patients with chronic renal failure or during hemodialysis, the pharmacokinetics of Loratadine do not change significantly. In older adults taking AnviMax, maximum plasma concentrations will increase by approximately 50 percent.

Can tablets be combined with alcoholic drinks?

Is it possible to take tablets at the same time as alcoholic drinks? Combining alcohol with treatment with any medications is definitely not beneficial. Absolutely all doctors agree on this opinion. To achieve successful results of therapy, of course, you should give up alcohol. It is better to preserve the body’s reserves to fight the disease and restore strength. And alcohol in itself does not contribute to recovery.

The risk of hepatotoxicity is greatest in people with alcohol-related liver damage. That is, a person who regularly drinks alcohol will certainly get side effects.

This liver damage is called alcohol syndrome. This combination is quite capable of leading to toxic hepatitis and subsequently to cirrhosis of the liver. Consequently, Paracetamol and alcohol together can cause damage to health, instead of improving it. This state of affairs is confirmed by many clinically established cases of toxic liver damage when using therapeutic doses in persons suffering from alcoholism.

Side effects are similar to the manifestations of alcohol poisoning. And Paracetamol and alcohol undergo their metabolism in the liver, which puts a double burden on this organ. A person who consumes such “cocktails” runs the risk of severe complications, even death. It is not for nothing that the combination of medicine with alcohol belongs to the fourth class of danger on a scale of five classes.

There is an opinion among people that paracetamol is quite good for helping with a hangover, it can alleviate the condition and relieve unpleasant symptoms such as headaches. However, this is unacceptable, since a certain concentration of ethyl alcohol remains in the body and its interaction with tablets will have the same negative consequences. Here the question arises - how long after drinking alcohol can you take medicine? At least 10-12 hours must pass after the last dose of alcohol before the combination of alcohol and Paracetamol becomes safe. In this case, it is better to take some kind of sorbent, the same Sorbex, activated carbon.

Indications for use

AnviMax serves as the main pharmaceutical drug that provides etiotropic treatment of influenza type A, that is, the drug provides conservative therapy aimed at eliminating the causative factors in the development of the nosological unit.

As a symptomatic treatment, AnviMax can be used in the following clinical situations:

• colds;
• acute respiratory viral infections;
• pathological conditions, the course of which is accompanied by fever, muscle pain, headache , and chills.

What do doctors say about the compatibility of Anvimax and alcohol?

Alcoholic drinks have a special effect on the human body and often suppress the effect of medications, so Anvimax and alcohol are not compatible. There are explanations for this. Firstly, the drug negatively affects liver function. Secondly, alcohol-containing drinks weaken the effect of the medication. Thirdly, it is strictly forbidden to drink alcoholic beverages for colds and other conditions for which the use of the drug is indicated. Fourthly, the components of the medicine are not compatible with ethyl alcohol. Numerous reviews speak about this.

Contraindications

• hypersensitivity , idiosyncrasy , acquired or hereditary intolerance to the constituent components of a pharmaceutical drug;
• pathologies of the gastrointestinal tract (especially in the acute stage);
• hemorrhagic diathesis;
• vitamin K deficiency ;
• hemophilia;
• portal hypertension ;
• thyroid diseases;
• insufficient platelet count;
• acute diseases of the liver and kidneys (glomerulonephritis, pyelonephritis, nephrourolithiasis , renal failure, hepatitis) or chronic pathologies in the acute stage;
• severe hypercalcemia and hypercalciuria ;
• chronic alcoholism;
• sarcoidosis;
• phenylketonuria;
• period of pregnancy and lactation (breastfeeding);
• lactose intolerance , malabsorption of glucose and galactose.

There are a number of diseases when, if there are absolute indications for the use of a pharmaceutical drug, it should be included in the conservative therapy regimen, but the drug must be taken under the supervision of qualified medical personnel (it is recommended to undergo treatment in a 24-hour hospital). Such pathologies include:

• epilepsy;
• cerebral atherosclerosis;
• diabetes;
• sideroblastic anemia;
• increased amount of oxalates in blood plasma;
• glucose-6-phosphate dehydrogenase deficiency;
• malabsorption syndrome;
• dehydration and exicosis;
• thalassemia;
• disturbances in the electrolyte composition of the blood;
• old age (especially with pathologies of the cardiovascular system accompanied by arterial hypertension ).

Side effects

Conservative treatment with AnviMax can cause the following undesirable consequences:

• From the central nervous system: drowsiness or increased excitability, tremor, excessive mobility ( hyperkinesia ), dizziness and headache, arterial hyperemia of the skin of the face.
• From the gastrointestinal tract: dyspeptic disorder, damage to the mucous membrane of the duodenum and stomach, dry mouth, flatulence (bloating due to intestinal gases), diarrhea, loss of appetite.
• Regarding the hematopoietic organs: changes in blood counts (regular diagnostic tests are required during conservative treatment).
• From other organ systems: – inhibition of insulin by b-cells of the pancreas, glucosemia , glucosuria and pronounced manifestations of diabetes mellitus , as a consequence. Also, the complex drug can cause allergic reactions, which manifest themselves in the form of skin itching, pigmented rashes, and urticaria.

Instructions for use of AnviMax (Method and dosage)

The drug is used, regardless of the pharmaceutical form, orally , that is, for oral administration.

If AnviMax is in powder form, then prepare a solution by adding half a glass (about 100 ml) of boiled warm water to the contents of the package and mix the contents. Consume orally immediately. Daily dosage – 1 sachet 2-3 times a day. It is recommended to take AnviMax after meals, since the adsorption capacity of the gastrointestinal tract is stimulated by the passage of the bolus. The course of treatment is usually about 5 days. It is strictly forbidden to prolong treatment on your own.

The instructions for AnviMax capsules require taking 1 capsule 2-3 times a day. Like the powder, you should take the medicine after meals, drinking plenty of water with the capsules. The therapeutic course is 5 days. If you do not feel better, you should stop treatment and contact your doctor or qualified pharmacist. Under no circumstances should you voluntarily prolong conservative rehabilitation.

How to avoid complications?

During treatment, it is important to be careful, because our health directly depends on it. And there is nothing more valuable than health. It is best when a specialist treats human diseases. If it is not possible to see a doctor, read the instructions for the drug before taking the pill.

It is worth remembering that paracetamol is part of many medications that have a wide variety of trade names:

And if you take into account that it is sometimes customary to treat an incipient cold with heated alcohol, be it mulled wine, heated wine, or a glass of strong alcohol, it is simply necessary to study the composition of such cold medicines. This will help you avoid harming yourself and keeping your liver healthy.

Everyone is responsible for their own health. The main principle in treatment is to do no harm! When deciding to resort to the help of the drug, the best choice would be to stop drinking alcohol. After all, the consequences can be unpredictable, and the complications of such a combination are irreversible.

Overdose

During the first 24 hours after taking an increased dose of AnviMax, the following symptoms of overdose :

• pale skin;
• dyspeptic syndrome (vomiting, nausea, pain in the epigastric region);
• arrhythmia type tachycardia;
• metabolic acidosis;
• exacerbation of concomitant chronic diseases.

In case of severe overdose, symptoms may appear 48 hours after taking the drug and be aggravated by liver failure with encephalopathy and even coma (due to the accumulation of metabolic products). , renal failure with necrosis of the tubular apparatus may develop .

The etiotropic treatment for increased concentrations of the active components of the drug is the introduction of sulfhydryl group donors and precursors for glutathione synthesis ( products containing methionine and acetyl cysteine ) during the first eight hours. As a symptomatic treatment, you can use gastric lavage or induce vomiting with medication. The need for additional therapeutic measures is determined by the attending physician.

Interaction

Paracetamol is an extremely active component of the drug AnviMax, which is why the list of positive and not so positive interactions of the biological drug covers such a wide range of drugs. First of all, the metabolism of Paracetamol is affected by inducers of microsomal oxidation in the liver, ethanol and hepatotoxic drugs . They significantly increase the production of hydroxylated metabolic products, which, if their elimination rate is insufficient, can cause the development of severe intoxication even with a small daily dosage. Inhibitors of microsomal oxidation act strictly opposite, reducing the risk of damage to liver cells and allowing the active component to circulate in the bloodstream for a longer period.

The concomitant use of Paracetamol and anticoagulants in complex therapy, which is often found in severe respiratory pathologies, increases the effectiveness of the latter, and accordingly, a lower dosage of drugs that affect the blood coagulation system is required.

Long-term treatment with barbiturates may reduce the effectiveness of Paracetamol. Simultaneous use with Metoclopramide increases the rate of its absorption.

Ascorbic acid is no less active than Paracetamol. Its chemical effects make it possible to accelerate the metabolic pathways of iron preparations . Thus, by reducing the valency from three to two, their absorption in the gastrointestinal tract is improved, and simultaneous use with Deferoxamine increases the rate of elimination of ferrum-based drugs.

When treated with alicylates and sulfonamide drugs, the risk of developing crystalluria increases, since the elimination of drugs and natural metabolites is accelerated by the alkaline reaction. Alkaloids , both plant and animal origin, are also more actively removed

Pharmacy textbooks describe a very complex interaction between ascorbic acid and ethanol . Their combination during conservative therapy is strictly contraindicated, since the concentration of the vitamin analogue in the blood decreases, and the renal clearance of ethanol, on the contrary, increases. This creates an additional load on the urinary apparatus of the kidneys, which can manifest itself as an increase in daily diuresis and nonspecific nephrotoxic effect , as a consequence. Barbiturates and Primidone also increase the excretion of ascorbic acid in urine .

Ascorbic acid reduces the blood concentration of oral contraceptives, which should be taken into account by women during active abstinence from pregnancy. However, it is also not recommended to increase the dose of drugs on your own; the best way out of this situation would be an additional consultation with your doctor.

Separately, it is worth noting the possibility of interaction between ascorbic acid and antipsychotic drugs . Neuroleptics, which make up the group of phenothiazine , reduce their therapeutic effects, which requires immediate intervention in the conservative treatment regimen for disorders of the central nervous system.

Rimantadine is not as chemically active a component of AnviMax as Paracetamol or Ascorbic acid. Of the clinically important interactions, only the increased stimulating effect of caffeine , brain stimulants, and the fact that cimetidine reduces the renal clearance of rimantadine by 18 percent should be noted. This can be used to reduce the daily dosage of the drug, so as not to once again induce increased liver function, thus avoiding possible hepatic effects.

Anvimax during pregnancy scheme

In a state of interesting situation, every woman wants to feel good due to excessive concern about the child. In this regard, there is a need to increase immunity and implement preventive measures against various diseases. And here a fair question arises: is Anvimax taken during pregnancy? We have already considered the facts of its negative impact on the body’s state, as well as a large number of side effects on all organs and systems. Due to this, its use is not possible.

Despite the immediate and high-quality therapeutic effect, the product is not used when a woman is in an “interesting position.” Moreover, it cannot be used not only in the early stages (1st trimester), but also later (2nd trimester and 3rd trimester). If you neglect this rule, the consequences for the expectant mother and child may be very disastrous. They consist of mental retardation, a set of congenital pathologies and involuntary miscarriage. The health condition of the mother herself may also worsen. If you are faced with the need to take the drug, you should contact a specialist who will prescribe an effective analogue.

Meanwhile, we are reviewing Anvimax, instructions for use, price, reviews, analogues.

special instructions

Paracetamol can have a damaging effect on the liver, therefore, if you have chronic diseases of this organ or people who are prone to drinking ethanol, you should definitely undergo additional consultation with your doctor before starting to take AnviMax.

The complex drug has no visible effect on the ability to concentrate, attention or the speed of psychomotor reactions, however, during the treatment period you should be careful when driving a vehicle or engaging in other potentially hazardous activities.

Use of the drug for alcoholism

Among the contraindications to treatment with the drug, the instructions attached to it indicate chronic alcoholism. For people suffering from alcohol addiction, violation of this prohibition will entail irreversible negative consequences.

Liver damage, characteristic of frequent consumption of alcohol in large quantities, leads to dangerous pathological changes in an organ that experiences incredible stress.

When paracetamol reacts with ethanol, it has a powerful inhibitory effect on liver cells. The consequences can be life-threatening.

Analogs

Level 4 ATC code matches:
Aflubin

Kofex

TeraFlu Bro

Suprima-Broncho

Sinupret

Bronchostop

Doctor Mom

Tonsilgon N

Pentaflucin

Tonsipret

Insti

Imupret

Antigrippin-Maximum

Antigrippin-ANVI

Atma

Viburkol

Travisil

RiniCold Broncho

Umkalor

Stodal

Antigrippin, Brustan, Voltaren Acti, GrippoFlu for colds and flu, Coldrex MaxGripp , Nalgesin forte, Tempalgin, Theraflu, Fervex.

Flavors

Reviews about AnviMax

There is a lot and often written about the drug on pharmaceutical forums and information sites. Reviews are predominantly positive, because the complex remedy allows you to eliminate the causative factors of pulmonary disease, also providing additional symptomatic therapy, effectively stopping the manifestations of pathology that reduce the quality of life during the period of illness. By destroying harmful microorganisms, AnviMax helps to cope with the flu in a short course of conservative sanitation, which is not the case with every pharmaceutical drug nowadays.

Reviews of AnviMax are rarely overshadowed by side effects. Many, of course, write about drowsiness, dizziness or headaches, but in the vast majority of these symptoms they are a derivative of the action of toxic substances of harmful microorganisms, and not an undesirable reaction due to treatment. Some patients treated with AnviMax report dyspeptic disorders, but the frequency of their manifestations barely exceeds even one-fifth of all those treated with this pharmaceutical drug, so you should not take them, as they say, to heart.

Qualified specialists are also satisfied with the complex drug. Both attending physicians and pharmacists unanimously recommend the active use of AnviMax, because such a wide range of active ingredients is not found in every drug, and the indications for the use of this particular set of biologically active substances are strictly absolute for influenza type A or acute respiratory disease caused by infectious microflora.

The most dangerous combinations and consequences

The combination of alcohol and chemical-based drugs can lead to serious disorders in the body, and in some cases to fatal consequences.

List of medications and their side effects in combination with alcohol:

About

AnviMax price, where to buy

The price of AnviMax in the Russian Federation ranges from 100 to 250 rubles.

The cost of the drug in Ukraine is about 50 hryvnia per package.

• Online pharmacies in RussiaRussia

ZdravCity

• Anvimax powder for pryg solution for internal use.
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