Pharmacological properties of the drug Thiogamma
α-lipoic (thioctic) acid is synthesized in the body and acts as a coenzyme in the oxidative decarboxylation of α-keto acids; plays an important role in the process of energy production in the cell. Helps reduce blood glucose levels and increase the amount of glycogen in the liver. Deficiency or metabolic disorder of α-lipoic acid due to intoxication or excessive accumulation of certain breakdown products (for example, ketone bodies) leads to disruption of aerobic glycolysis. α-Lipoic acid can exist in two physiologically active forms (oxidized and reduced), which have antitoxic and antioxidant effects. α-Lipoic acid affects cholesterol metabolism, takes part in the regulation of lipid and carbohydrate metabolism, improves liver function due to its hepatoprotective, antioxidant and detoxification effects. In terms of pharmacological properties, α-lipoic acid is similar to B vitamins. It has a beneficial effect on tissue regeneration processes. Pharmacokinetics. After oral administration, α-lipoic acid is rapidly and almost completely absorbed from the gastrointestinal tract. It is excreted by the kidneys, mainly in the form of metabolites. The formation of metabolites occurs due to side chain oxidation and conjugation. The half-life from serum is 10–20 minutes.
Thiogamma Turbo 12 mg/ml 50 ml No. 10 solution d/in.
Instructions for medical use of the drug Tiogamma® Turbo Trade name Tiogamma® Turbo International nonproprietary name No Dosage form Solution for infusion, 12 mg/ml Composition 50 ml of solution contain the active substance - thioctic acid meglumine salt - 1167.70 mg (equivalent to 600 mg thioctic acid), excipients: meglumine 5.0 - 25.0 mg, macrogol 300 - 4000.0 mg, water for injection 45557.3 - 45577.3 mg. Description Transparent solution of yellowish or yellowish-green color. Pharmacotherapeutic group Other drugs for the treatment of gastrointestinal diseases and metabolic disorders. Various other drugs for the treatment of gastrointestinal diseases and metabolic disorders. Thioctic acid. ATC code A16AX01 Pharmacological properties Pharmacokinetics After intravenous administration of 200 mg of thioctic (alpha-lipoic) acid, the maximum plasma concentration (Cmax) was 7.3 μg/ml, the time to reach the maximum concentration (tmax) was 19 minutes, and the area under the concentration-time curve (AUC) 2.2 µg/ml/hour. After intravenous administration of thioctic acid at a dose of 600 mg, Cmax was 31.7 μg/ml, tmax was 16 minutes, and AUC was 2.2 μg/ml/hour. At the end of the 30-minute infusion of the 600 mg vial, the plasma level is approximately 20 mcg/min. Thioctic acid undergoes a first-pass effect through the liver. The formation of metabolites occurs as a result of oxidative reduction of the side chain (β oxidation) and conjugation and/or S-methylation of the corresponding thiols. The half-life in blood plasma is 25 minutes, the total plasma clearance is 10-15 ml/min/kg. It is excreted mainly by the kidneys, 80-90% in the form of metabolites. Pharmacodynamics Thioctic (alpha-lipoic) acid is an endogenous antioxidant and acts as a coenzyme in the oxidative decarboxylation of alpha-keto acids. As a result of hyperglycemia caused by diabetes mellitus, there is an accumulation of glucose on the matrix proteins of blood vessels and the formation of so-called “advanced glycation end products”. This process results in decreased endoneural blood flow and endoneurial hypoxia/ischemia, which is associated with increased production of free oxygen radicals that damage peripheral nerves. Depletion of antioxidants such as glutathione has also been found in peripheral nerves. Thioctic acid interacts with the biochemical processes caused by diabetes by reducing the formation of advanced glycation end products, improves endoneurial blood flow, increases physiological levels of the antioxidant glutathione, and acts as an antioxidant of oxygen free radicals in “diabetic” nerves. Thiogamma® Turbo helps reduce blood sugar and increase glycogen content in the liver, as well as overcome insulin resistance. Changes the concentration of pyruvic acid in the blood. Thiogamma® Turbo is similar in pharmacological properties to B vitamins. Participates in the regulation of lipid and carbohydrate metabolism, stimulates cholesterol metabolism, and improves liver function. It has hepatoprotective, hypolipidemic, hypocholesterolemic, hypoglycemic effects. Improves trophism of neurons. Indications for use: peripheral (sensory-motor) diabetic polyneuropathy. Method of administration and dosage. The daily dose is 1 bottle of Thiogamma® Turbo (600 mg/day) for 2-4 weeks daily, intravenously, drip, in the initial phase of treatment. The drug should be administered slowly over at least 30 minutes, not more than 50 mg per minute (equivalent to 1.7 ml of infusion solution). The maximum daily dose is 600 mg. Thiogamma® Turbo infusions are made directly from the vials using the included hanging light-protective cases. The bottle with the drug is removed from the box immediately before use and immediately covered with the supplied light-protective case, since thioctic acid is sensitive to light. Further treatment should include daily administration of 600 mg of thioctic acid in the form of oral tablets. Side effects - allergic reactions on the skin in the form of urticaria, itching, eczema, skin rash - systemic allergic reactions, up to the development of anaphylactic shock - urticaria or eczema at the injection site - hemorrhagic rash (purpura), thrombophlebitis - hypoglycemic symptoms (dizziness, sweating, headache and visual disturbances) due to decreased blood sugar levels - increased intracranial pressure and dyspnea with rapid intravenous administration - nausea, vomiting, abdominal pain, diarrhea Rarely - changes or disturbances in taste Contraindications - hypersensitivity to the components of the drug - gastric ulcer, hyperacid gastritis - decompensated form of diabetes mellitus - pregnancy, lactation - childhood and adolescence up to 18 years of age Drug interactions A decrease in the effectiveness of cisplatin was noted when prescribed simultaneously with Thiogamma® Turbo. The drug should not be prescribed simultaneously with iron, magnesium, potassium supplements; the time interval between doses of these drugs should be at least 5 hours. Since the hypoglycemic effect of insulin or oral antidiabetic agents may be enhanced, regular monitoring of blood sugar is recommended, especially at the beginning of therapy with Thiogamma® Turbo. To avoid symptoms of hypoglycemia, blood glucose levels must be carefully monitored. Thioctic (alpha-lipoic) acid forms poorly soluble complex compounds with sugar molecules (for example, levulose solution). Thiogamma® Turbo is incompatible with glucose solution, Ringer's solution and solutions that react with SH groups or disulfide bridges. When prescribing Thiogamma® Turbo as an infusion, if necessary, only physiological saline solution should be used as the main vehicle. Special instructions During treatment with the drug, the use of alcohol is contraindicated. Alcohol consumption during therapy with Thiogamma® Turbo reduces the therapeutic effect and is a risk factor contributing to the development and progression of neuropathy. In isolated cases, patients with decompensated and adequately uncontrolled diabetes, as well as in cases of severe general poor health, may develop serious anaphylactic reactions associated with the use of Thiogamma® Turbo. In patients with diabetes mellitus, constant monitoring of blood glucose concentration is necessary, especially at the initial stage of therapy. In some cases, it is necessary to reduce the dose of insulin or oral hypoglycemic drug to avoid the development of hypoglycemia. If symptoms of hypoglycemia occur (dizziness, increased sweating, headache, visual disturbances, nausea), therapy should be stopped immediately. Pregnancy and lactation Pregnant and breastfeeding women can undergo treatment with thioctic acid only if the doctor determines that the need for treatment is strictly life-saving. Features of the effect of the drug on the ability to drive a vehicle and potentially dangerous mechanisms Care should be taken when driving vehicles and potentially dangerous mechanisms. Overdose Symptoms of probable intoxication with Thiogamma® Turbo (more than 6000 mg in an adult or more than 50 mg per kilogram of weight in a child): generalized convulsive seizures, clouding of consciousness, severe disturbances of the acid-base balance leading to lactic acidosis, severe bleeding disorders. Treatment: Treatment of generalized seizures, lactic acidosis and other life-threatening consequences should be carried out in accordance with the principles of modern intensive care, according to symptoms. The benefits of using hemodialysis, hemoperfusion, or filtration as methods of forced elimination of thioctic acid have not been convincingly proven. Release form and packaging 50 ml are bottled in brown hydrolytic glass type II bottles, sealed with a pink rubber bromobutyl stopper, rolled with an aluminum cap and a polypropylene ring. 1 bottle or 10 bottles with hanging light-protective cases according to the number of bottles, made of black polyethylene, together with instructions for medical use in the state and Russian languages, are placed in cardboard boxes with cardboard partitions. Storage conditions Store at a temperature not exceeding 25 °C. Protect from light. Keep out of the reach of children! Shelf life: 5 years Do not use after expiration date. Conditions for dispensing from pharmacies By prescription Manufacturer/Packager Solyufarm Pharmaceutical Erzeugnisse GmbH, Germany Registration certificate holder Wörwag Pharma GmbH and Co. KG, Calver Strasse 7, 71034 Böbligeng, Germany Address of the organization that accepts claims from consumers regarding the quality of products (products) in the territory of the Republic of Kazakhstan: Representative office of Wörwag Pharma GmbH and Co. KG in the Republic of Kazakhstan and Central Asia, 050000, Almaty, st. Bogenbai batyr 148, off. 303 tel./fax, 311 67 99, e-mail
Use of the drug Thiogamma
Prescribed for adults. The tablets are taken orally whole with a sufficient amount of water. The daily dose is 1 tablet of Thiogamma, which corresponds to 600 mg of α-lipoic acid, which should be taken as a single dose approximately 30 minutes before the first meal. Duration of treatment is 1–4 months. The tablet is swallowed whole with a sufficient amount of liquid, regardless of meals. In case of severe sensory impairment caused by diabetic polyneuropathy, it is advisable to begin treatment with parenteral administration of Tiogamma Turbo for infusion. In the future, you should continue taking Thiogamma tablets at a dose of 600 mg/day. Concomitant food intake may slow down the absorption of the drug. The drug is administered parenterally as an intravenous infusion in an isotonic solution of sodium chloride, at a dose of 600 mg/day. To do this, the contents of one ampoule (which corresponds to 600 mg of α-lipoic acid) are diluted in 50–250 ml of sodium chloride solution. IV administration should be carried out slowly - no faster than 50 mg of α-lipoic acid (which corresponds to 1.7 ml of solution for infusion) per minute, over 20-30 minutes. The prepared solution should be used immediately; when administering it, a light-protective case should be used.
Contraindications to the use of the drug Tiogamma
Hypersensitivity to α-lipoic acid or other components of the drug; hereditary galactose intolerance, lactase deficiency, malabsorption syndrome, that is, impaired absorption of glucose and galactose; period of pregnancy and lactation, childhood and adolescence (up to 18 years). Due to insufficient clinical data, it is not recommended to use the drug during pregnancy and lactation, as well as in children and adolescents. Severe liver and kidney dysfunction, acute and decompensated cardiac and respiratory failure, acute phase of myocardial infarction, acute cerebrovascular accident, dehydration, chronic alcoholism and other conditions that may contribute to the development of lactic acidosis (when using the injection form of the drug).
Side effects of the drug Thiogamma
Isolated reports of gastrointestinal disorders have been received: nausea, vomiting, pain in the stomach and intestines, diarrhea. In some cases, allergic reactions: skin rash, urticarial rash and itching. There are also cases of symptoms similar to hypoglycemia with vertigo, excessive sweating, headache and blurred vision. When taken orally, due to improved glucose utilization, a decrease in blood glucose levels may be noted. In isolated cases, dyspepsia and allergic skin reactions may develop. When administered parenterally, the following side effects are possible: from the nervous system and sensory organs: very rarely - convulsions, diplopia; from the blood coagulation system: possible hemorrhagic rash (purpura), thrombophlebitis; allergic reactions: urticaria or eczema at the injection site, systemic allergic reactions, up to anaphylactic shock; other: as with oral administration, a decrease in blood glucose levels may be observed due to improved glucose utilization. After rapid administration of the drug, a feeling of squeezing in the head and respiratory depression may occur, but these phenomena disappear spontaneously.
Special instructions for the use of the drug Tiogamma
During therapy with Thiogamma in patients with diabetes mellitus, due to improved glucose utilization, a decrease in blood glucose levels may be noted. Therefore, regular monitoring of blood glucose levels is necessary. In some cases, it is necessary to reduce the dose of hypoglycemic agents to prevent the development of hypoglycemia. You should refrain from drinking alcohol, as the latter reduces the therapeutic activity of α-lipoic acid. Use during pregnancy or breastfeeding. There is insufficient data regarding the use of the drug, therefore its use during pregnancy and lactation is not recommended. Children. The effectiveness and safety of the drug in children have not been established. Influence on reaction speed when driving vehicles or other mechanisms. There are no special precautions.
Cosmetologists care about results
Of course, as is usually the case with such videos, I foresee reviews like:
You are deceiving us! It is simply not profitable for you cosmetologists when women use cheap products from the pharmacy. I use Tiogamma and even with the mistakes you are talking about here, I see excellent results!
I will immediately respond to such comments.
You can use whatever you want as long as you believe it helps you. My goal is not to dissuade anyone. I shoot videos, write articles and books for my subscribers who doubt the effectiveness of such drugs and who are interested in my opinion and the opinion of experts in the field of cosmetic chemistry.
You shouldn’t think that cosmetologists are not interested in inexpensive but effective products. Very interesting. And I am sure that many cosmetologists read this article with curiosity.
However, cosmetologists are primarily interested in the result - otherwise clients will no longer come to them. And if the effectiveness of the product is in great doubt, cosmetologists are not interested in such a drug.
Interactions of the drug Thiogamma
in vitro, α-lipoic acid reacts with ionic metal complexes, such as cisplatin, so the effectiveness of the latter may be reduced. α-lipoic acid forms poorly soluble complexes with sugar molecules, therefore its solution is incompatible with glucose solution, Ringer's solution and solutions that can react with SH groups or disulfide bonds. α-Lipoic acid is a metal chelator and therefore cannot be used in conjunction with metals (for example, iron, magnesium preparations). If the total daily dose of Thiogamma is taken 30 minutes before the first meal, iron and magnesium supplements should be taken during lunch or in the evening. When used simultaneously, α-lipoic acid enhances the effect of insulin and oral hypoglycemic agents.
Cosmetics are still more effective
Even if we assume that you can meet all the conditions and alpha-lipoic acid retains its properties, the effectiveness of the pharmaceutical drug will still be several times lower than that of a cosmetic product.
The point is not only that in cosmetics alpha-lipoic acid is hidden in some kind of delivery system, for example, in a liposome.
There is another important nuance - alpha-lipoic acid works better in combination, so in cosmetics it is often used together with vitamins C and E, coenzyme Q10 and squalene.
In other words, it takes a whole team to achieve a good result! And the effectiveness of the cosmetic product is achieved not only due to the presence of alpha-lipoic acid, but thanks to a complex of components that work together much better.
For example, alpha lipoic acid extends the antioxidant life of vitamins C and E, making the cream or serum more effective.
Therefore, to say that a pharmaceutical drug will not only be cheaper, but also no worse than a cosmetic product, is, to put it mildly, naive.
Alpha lipoic acid works better when combined!
