Tizin Expert/Xylo Bio spray nas.dose.vial with dose.0.05% 10ml No.1

According to statistics, vasoconstrictor nasal sprays and drops are the most popular means for treating a runny nose. These medications are available and can be purchased at any pharmacy without a doctor's prescription. Most patients consider rhinitis to be a banal ailment and limit themselves to the recommendations of pharmacists who select nasal drops without taking into account the diagnosis, severity and form of the disease, and the presence of complications.

Often the patient violates the recommended dosage regimen and duration of treatment. As a result of such “active” therapy, drug dependence on intranasal drugs develops. It is very difficult for a person to refuse drops, despite the fact that they only temporarily relieve swelling of the nasopharynx and do not allow them to cope with rhinitis.

At CELT you can consult an otorhinolaryngologist.

• Initial consultation – 3,000
• Repeated consultation – 2,000

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Pharmacological properties of the drug Tizin

Pharmacodynamics. Tetrizoline hydrochloride is a sympathomimetic that stimulates α-adrenergic receptors of the sympathetic nervous system and has virtually no effect on β-adrenergic receptors. When applied to the mucous membrane of the nasal cavity as a sympathomimetic amine, it has a vasoconstrictor and anti-edema effect, leading to a narrowing of small arterioles, a decrease in swelling of the mucous membrane of the nasal passages and a decrease in secretion. Pharmacokinetics. The vasoconstrictor effect of tetrizoline and the reduction in swelling of the nasal mucosa under its influence begins approximately 1 minute after application and lasts for 4–8 hours. When applied topically in recommended doses, tetrizoline is practically not absorbed from the mucous membrane, but the possibility of systemic absorption in patients cannot be ruled out with damage to the epithelium of the mucous membrane.

Surgical methods of treatment:

• Laser bloodless operation (vaporization), in which altered mucous membranes are removed by evaporation.
• Radio wave thermal reduction.
• An ultrasonic waveguide makes it possible to reduce the volume of blood vessels, after which healthy capillaries are formed in their place and nasal breathing is restored.
• Submucosal vasotomy, conchotomy.

Long-term use of vasoconstrictor drugs leads to serious consequences. Addiction will not go away on its own; specialist help is needed. You can get the necessary treatment at the CELT clinic. Here are high-quality diagnostics and effective therapy. Make an appointment with an ENT doctor right now.

Use of the drug Tizin

0.1% Tizin solution is instilled into adults and children over 6 years of age, 2–4 drops into each nasal passage. 0.05% Tizin solution for children is instilled into children aged 2–6 years, 2–3 drops. Use Tizin as needed, but not more than once every 4 hours. Tizin drops are used at large intervals (up to 8 hours). The use of drops before bedtime does not cause insomnia due to the lack of central action. Tizin should not be used for 5 days; re-use is possible only after a few days.

Causes of drug-induced rhinitis

Infectious or allergic rhinitis is manifested by inflammatory reactions, one of the symptoms of which is swelling of the nose. The body tries to cope with this process, and blood circulation increases in the nasal passages. As a result, an increase in the size of blood vessels contributes to the development of nasal congestion. Nasal breathing becomes difficult, the sense of smell is lost, the person rushes to get rid of these unpleasant symptoms with the help of decongestants (vasoconstrictor drops - vasoconstrictors).

From vasoconstrictor drops, blood vessels narrow, swelling quickly subsides, breathing through the nose is restored, and the sense of smell is normalized. The therapeutic effect of decongestants lasts 4-12 hours, after this period the lumen of the blood vessels increases again, swelling and congestion of the nasal passages returns. The patient knows how to get rid of the unpleasant condition and again uses vasoconstrictor drops.

If nasal vasoconstrictor drops are used correctly, addiction does not occur. The recommended period of use of the drugs is 3-7 days. Dependence manifests itself if the patient neglects the instructions for use and violates the frequency and duration of therapy. This is due to the fact that tachyphylaxis develops when the body’s response to repeated use of medications decreases. A person uses the same nasal remedies, but the vessels react poorly to them. To achieve a therapeutic effect, decongestants must be instilled more often.

The main active components of the drugs are substances such as nasazoline, oxymetazoline, xylometazoline, phenylephrine. Violation of the frequency and duration of therapy leads to the fact that the own regulation of capillary tone suffers. Up to the complete destruction of reflex regulation. The capillaries get used to narrowing from nasal drops and wait for the arrival of active components from the outside.

The longer a person uses vasoconstrictor drops, the stronger the addiction and the less chance of restoring their own regulation. You can only get rid of addiction to nasal drops with the help of an ENT specialist.

Contraindications to the use of the drug Tizin

Hypersensitivity to tetrizoline or other components of the drug, dry rhinitis. Tizin drops 0.1% are not prescribed to children under 6 years of age. Tizin drops 0.05% are not prescribed to children under 2 years of age. Tizin should not be prescribed for severe forms of cardiovascular diseases (coronary heart disease, hypertension (arterial hypertension), pheochromocytoma), with metabolic disorders (hyperterosis, diabetes), as well as for patients receiving treatment with MAO inhibitors and other drugs that can increase blood pressure; patients with glaucoma.

Features of the drug

Tizin spray belongs to the group of topical nasal preparations. The active component in the drug is xylometazoline. This substance has vasoconstrictor properties. It quickly reduces tissue swelling and mucus secretion. When treating rhinitis, it is possible to quickly remove nasal congestion and restore nasal breathing.

Tizin nasal spray is a very convenient form of release of a remedy for the runny nose. Manufacturers produce the drug containing 0.1% and 0.05% of the active substance.

When using a spray, which is a clear liquid with a slight specific odor, maximum comfort is guaranteed. The drug can be used in any position and, if necessary, even during movement. In addition, its use has a targeted effect on the inflamed areas of the mucous membrane.

Tizin spray is equipped with a special sprayer that provides precise dosage with fine spraying. Its design guarantees coverage of a wide area of ​​the mucous membrane.

Side effects of the drug Tizin

Reactive hyperemia and swelling of the mucous membrane, burning sensation or dryness of the mucous membrane, chronic swelling during long-term therapy. Sometimes systemic side effects are observed (tachycardia, headache, tremor, general weakness, sweating, increased blood pressure). Frequent use of the drug in high doses can cause a burning sensation and dryness in the nasal cavity, as well as the development of drug-induced rhinitis. Long-term use of imidazole derivatives can cause damage to the epithelium of the nasal cavity with the development of dry rhinitis.

What are the dangers of abusing decongestants?

Uncontrolled use of vasoconstrictor drops leads to the fact that the capillaries are constantly in spasm. They stop functioning normally, blood flow is disrupted, and nearby tissues suffer because they do not receive the required amount of oxygen and nutritional components.

Systematic drying of the mucous membranes and disruption of its restoration threatens the development of malnutrition and the formation of drug-induced rhinitis. In an effort to get rid of seasonal runny nose as quickly as possible, a person acquires an illness that requires serious treatment.

The next danger is psychological addiction. A reflex is formed in the brain that normal breathing can only be restored with the help of medications. Using vasoconstrictor drops makes a person feel better; he does not think about the alarming consequences for his own health. Improper use of decongestant drops harms the entire body. Violation of the dosage regimen is especially dangerous in childhood. There are cases when a child has to be hospitalized because the mother intensively instilled drops into his nose. The danger is that vasoconstrictor drugs enter the general bloodstream and negatively affect all tissues and organs. Arterial hypertension may develop, shortness of breath, headache, insomnia, etc. may appear.

Most often, dependence on nasal drops is formed due to illiteracy of the population. Not everyone knows that harmless medications can cause intoxication of the entire body. If dangerous symptoms are detected, it is important to immediately seek medical help and receive timely treatment.

Special instructions for the use of the drug Tizin

The drug should be prescribed with extreme caution and after assessing the degree of possible risk to patients with severe forms of cardiovascular diseases (coronary artery disease, hypertension (arterial hypertension)), metabolic disorders (hyperthyroidism, diabetes mellitus). In patients with glaucoma (especially angle-closure) it is used with caution and only under medical supervision. During pregnancy and breastfeeding. Since there is a possibility of developing systemic side effects, the use of the drug during pregnancy and lactation is possible only after careful comparison of the possible benefits to the mother and the risk to the fetus or infant. Ability to drive vehicles and operate machinery. Caution should be exercised with long-term use of the drug, since systemic effects from the cardiovascular system may develop, which have a negative impact on the ability to drive vehicles or work with potentially dangerous mechanisms.

Contraindications and side effects

You should not use Tizin spray, the instructions emphasize this, if you are hypersensitive to the active substance and auxiliary components in its composition. The drug is not prescribed to children under 12 years of age. The following pathologies are contraindications to the nasal spray:

• Arterial hypertension, which is associated with a constant increase in blood pressure.
• Atrophic rhinitis, characterized by thinning of the mucous membrane.
• Tachycardia, a characteristic feature of which is an increase in heart rate.
• Atherosclerosis with severe symptoms.
• Glaucoma accompanied by increased eye pressure.

Tizin spray cannot be used during pregnancy. This is due to the fact that the necessary studies on the effect of the active substance on the fetus have not been carried out. For the same reason, the nasal remedy should not be used during lactation.

With long-term or frequent use of the drug, there is a risk of irritation or increased dryness in the nose. If you do not stop taking the drug, there is a risk of mucosal atrophy. Chronic rhinitis may also develop. It is characterized by hypersecretion and sneezing, which indicates dependence on the drug.

Adverse reactions include the sensation of a strong heartbeat and irregular heart rhythms. While taking the drug, an increase in blood pressure is sometimes observed. Sometimes nausea and vomiting occur when using the spray. In this case, you should stop using the drug, after which the unpleasant symptoms disappear. Very rarely, when using Tizin spray, the following body reactions were observed:

• Dizziness.
• Skin rash.
• Impaired vision clarity.
• Insomnia.
• Inner restlessness.
• Arrhythmia.

In case of overdose, as well as in case of accidental ingestion of the drug, dilation of the pupils is observed. Additionally, severe dizziness and headache occur. These symptoms are accompanied by nausea and vomiting. Fever and shortness of breath may also occur. In severe cases, blood pressure also decreases. This can cause loss of consciousness, seizures and even coma.

In case of overdose, if the medicine gets inside, you should immediately perform gastric lavage and take absorbents. In severe cases, resuscitation with a ventilator may be necessary. You also need to take medications to stabilize blood pressure.

Overdose of the drug Tizin, symptoms and treatment

Manifested by mydriasis, nausea, cyanosis, fever, fasciculation, tachycardia, arrhythmia, asystole, hypertension (arterial hypertension), pulmonary edema, respiratory disorders, mental disorders. In some cases, the absorption of imidazole derivatives with α-sympathomimetic activity may be accompanied by CNS depression, which is manifested by drowsiness, hypothermia, bradycardia, collapse, apnea and coma. There is no specific antidote for tetrizoline. The use of stimulant drugs is contraindicated. Although the symptoms of a Tizin overdose are quite alarming, they usually disappear quickly. If necessary, oxygen therapy is carried out and anticonvulsants are used. To reduce blood pressure, 5 mg of phentolamine is administered in an isotonic saline solution intravenously slowly or prescribed at a dose of 100 mg orally. In case of arterial hypotension, vasoconstrictor drugs are contraindicated. When anticholinergic symptoms develop, physostigmine is used as an antidote.

Treatment of addiction to nasal drops

The first stage is awareness of the problem. It is necessary to accept that an addiction to nasal drops or sprays has formed. Addiction worsens the quality of life and threatens serious complications.

The next step is to seek help from a competent ENT doctor. A specialist will help distinguish medicinal rhinitis from seasonal or allergic rhinitis, decide how serious the complications are, and select adequate treatment to restore nasal breathing. The sooner the patient contacts the doctor, the more successfully vascular function will be restored.

Drug addiction sometimes takes years to form, so you can’t get rid of it in a couple of days. Nasal breathing improves gradually. Medicines, physiotherapy methods and surgical interventions are used. To make you feel better, the doctor prescribes intranasal anti-inflammatory drugs containing synthetic glucocorticosteroids. The drugs improve the condition of the mucous membrane, facilitate the discharge of mucus, and relieve the symptoms of inflammation. The therapy is complemented by physiotherapeutic procedures - laser treatment, medicinal extracts (herbal medicine), the use of ultraviolet irradiation, tube quartz treatment, etc.

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