Hemorrhoidal disease often becomes a serious cause of deterioration in quality of life. A sedentary lifestyle, excessive stress, constant constipation, obesity, poor circulation, pregnancy - all these factors sooner or later lead to the development of the first stage of hemorrhoids. In the absence of adequate treatment, the disease progresses to the second stage, which often requires surgical intervention. Ultraproct ointment has proven itself as a remedy for hemorrhoidal disease. However, in recent years, patients have complained that the ointment is rarely available in pharmacies. There are several analogues of Ultraproct ointment, the effect of which is no worse.
Compound
1 gram of Ultraproct ointment includes 945 mcg of fluocortolone hexonate ; 918 mcg fluocortolone pivalate ; 5 mg cinchocaine hydrochloride .
Additionally: castor oil; 2-octyldodecanol; macrogol-400-monoricinoleate; hydrogenated castor oil; lemon pink scent.
1 Ultraproct suppository includes 630 mcg of fluocortolone hexonate ; 612 mcg fluocortolone pivalate ; 1 mg cinchocaine hydrochloride .
Additionally: 1797.758 mg of solid fat (vitepsol W35).
Pharmacodynamics and pharmacokinetics
Ultraproct in any of its pharmacological forms is a local combined medicinal drug used in proctology and, due to the effects of its active ingredients, has local anesthetic , antipruritic , anti-inflammatory and antiallergic effects.
The two forms of fluocortolone included in the drug are characterized by a rapid onset of action and its significant duration. In the case of topical application, the effectiveness of these active ingredients is aimed at preventing the marginal concentration of neutrophils (as a result of which there is a decrease in the production of lymphokines and the level of inflammatory exudate ), slowing down the migration of macrophages and weakening the processes of granulation and infiltration .
The local anesthetic - cinchocaine - provides an analgesic effect, which is achieved by inhibiting the occurrence and conduction of nerve impulses through depolarization of sodium channels.
Due to the different molecular weight and lipophilicity fluocortolone preparations , different rates of absorption are noted, which leads to a rapid onset of drug effectiveness and a long duration of action.
Hydrolysis of the drug occurs with the help of enzymes of the inflammatory focus - esterases , with the release of fluocortolone , trimethylacetic acid and 11-ketofluocortolone .
After rectal administration, T1/2 of fluocortolone is 1.3 hours, its metabolic are about 4 hours. Excretion is carried out primarily by the kidneys in the form of metabolites .
Proctosedyl ointment: instructions and description
“Proctosedil” is an Indian-made ointment for hemorrhoids with an anesthetic, antipruritic and antiseptic local effect. The main active ingredient is benzocaine. The composition also includes components:
- butamben;
- hydrocortisone;
- framycetin sulfate;
- heparin sodium.
Together, all these components ensure the fast and effective action of the drug. Reviews of Proctosedyl report that the use of the ointment brings relief from exacerbation of hemorrhoids already on the third or fourth day of use. Pain and severe itching go away after the first or second use. The duration of therapy using Proctosedyl is at least a week. More accurate information about the frequency of use and duration of treatment can be obtained from a proctologist after the stage of hemorrhoidal disease has been established.
Contraindications
The use of Ultraproct is contraindicated in:
- manifestations of syphilis , tuberculosis in the area where the drug is used;
- pregnancy (in the first trimester);
- manifestations of diseases of viral etiology (including chickenpox , response to vaccination ) in the area where the drug is used;
- increased personal sensitivity to fluocortolone , cinchocaine or other drug ingredients.
Also, Ultraproct is not recommended for use in childhood and adolescence (due to the lack of reliable clinical data).
The effect of Neo-Anuzol ointment on hemorrhoids
"Neo-Anuzol" is a Russian analogue of the "Ultraproct" ointment. It contains several active ingredients - zinc oxide, vitepsol, tannin, iodine, resorcinone. Release form: ointment and rectal suppositories. Alas, the ointment is not always available in pharmacies. "Neo-Anuzol" is a cheap and effective remedy for hemorrhoids, which has an analgesic, disinfectant, antispasmodic, and mild antipruritic effect. A contraindication to the use of Neo-Anuzole is hypersensitivity to any of the components in the composition.
The instructions for "Neo-Anuzol", depending on the severity of the condition and age, recommend daily use of 1-3 suppositories. As a rule, the course of local therapy takes 7-10 days.
Instructions for use of Ultraproct (Method and dosage)
Ointment or suppositories should be used after defecation and anal hygiene .
As a rule, improvement in the painful condition occurs quite quickly, however, even if negative symptoms completely disappear, to prevent possible relapses , it is recommended to continue therapy for at least another 7 days, while reducing the frequency of use of the drug to 1 time per day for ointment and 1 time every 48 hours for suppositories. It is better to limit the total duration of treatment to 4 weeks.
Ultraproct ointment, instructions for use
The drug in the form of a rectal ointment is usually prescribed for use twice every 24 hours. On the first day of the course of therapy, you can use the ointment up to 4 times to quickly relieve negative symptoms.
Correct use of the ointment involves distributing a small amount (about the size of a pea) around the anus and further introducing it into the anus , using the tip of a finger (comfortable for the patient), in order to overcome the resistance of the anal sphincter . Then, by lightly pressing the tube with the supplied tip pre-screwed onto it, squeeze out a sufficient (recommended by the doctor) amount of ointment directly into the rectum .
Ultraproct suppositories, instructions for use
Suppositories should be administered into the rectum , placing the suppository in it as deeply as possible. The treatment course usually involves the use of 1 suppository every 24 hours. In case of a severe course of the painful condition, on the first day of therapy, 2-3 suppositories can be administered at an equal interval of time.
If the patient has painful, severely inflamed hemorrhoids, it is recommended to begin therapy with the use of ointment, for which the prolapsed hemorrhoids are thickly lubricated with ointment and gently pressed back with a finger.
Analogue of Ultraproct ointment in composition
There is only one complete analogue in composition - this is Fluocortolone ointment. Indications for use of ointment:
- contact dermatitis;
- various forms of eczema in children and adults (contact, dyshidrotic, anal, seborrheic, accompanying varicose veins);
- neurodermatitis of various etiologies (atopic dermatitis, endogenous eczema);
- psoriasis in children and adults;
- lichen planus;
- erythroderma;
- first degree burns (ointment is used for faster healing of the skin);
- discoid lupus erythematosus;
- mild sunburn;
- itching of the anus and vulva, caused by hemorrhoids or thrush.
“Fluocortolone” is an analogue of “Ultraproct” ointment in composition, since in both drugs the main active ingredient is fluocortolone. But there is a significant difference, since Ultraproct also contains cinchocaine and fluocortolone pivalate. Reviews from patients with hemorrhoids report that if you compare Ultraproct ointment with the analogue Fluocortolone, the second one largely loses. It does not have a pronounced anesthetic effect. Also, unlike Ultraproct, Fluocortolone does not help reduce hemorrhoids, which develop in almost all patients at the second stage of the disease.
Overdose
The results of studies of the possibility of acute toxicity with a single perianal or rectal use of fluocortolone and cinchocaine , even in excessive doses, showed a low probability of such an event occurring.
In case of accidental oral administration (swallowing) of any of the dosage forms of the drug, the formation of negative symptoms of a somatic nature, inherent primarily to cinchocaine and depending on the dose taken, is possible. Such negative phenomena can be manifested by disturbances in the activity of the central nervous system , including the occurrence of convulsions and respiratory depression until it stops, or severe cardiovascular disorders , characterized by a decrease in cardiac activity and even possible cardiac arrest .
special instructions
If the patient has a concomitant fungal infection, he should be prescribed additional antimycotic therapy .
When using any of the dosage forms of the drug, it is necessary to exclude the possibility of contact with the eyes and/or ingestion.
After using suppositories or ointments, the patient is advised to wash their hands with special care.
To give the candles their previous solid form, lost under the influence of heat, the suppositories in the package must be immersed in cold water.
Analogs
Level 4 ATC code matches:
Betiol
Olestesin
Proctosedyl
Relief
Anuzol
Posterisan Forte
Posterisan
Bezornil
Procto-Glyvenol
Glivenol
Proctosan
Hepazolon
Analogues of Ultraproct are represented by local drugs of other groups used in proctology for the treatment of similar pathological conditions:
- Anuzol;
- Bezornil;
- Gepatrombin G;
- Betiol;
- Hemorol;
- Doloproct;
- Posterisan;
- Neo-Anuzol;
- Procto-glivenol;
- Baliz;
- Proctosan;
- Relief;
- Proctosedyl;
- Symetrid , etc.
During pregnancy (and lactation)
A number of epidemiological studies involving pregnant women receiving glucocorticoids (including fluocortolone ) in the first trimester of pregnancy found an increased risk of cleft palate . reliable data on the effects of glucocorticoids during pregnancy ; however, in this case, the likelihood of a negative effect of the treatment on the fetus is very low, since the local use of drugs implies their extremely low bioavailability.
Based on the above, it is prohibited to prescribe Ultraproct in the first trimester of pregnancy ; its use in the second and third trimesters is permissible only in extreme cases for a short period of time and with extreme caution.
nursing women require careful prescribing and a minimum period of use of Ultraproct .
Reviews about Ultraprokt
Reviews of Ultraproct ointment, as well as reviews of Ultraproct suppositories, are either positive or neutral. In other words, the effectiveness of the drug receives either a positive assessment (including the rapid onset of action of the drug and long-term remission of the disease), or indifferent (including insufficient or zero effectiveness of treatment ). In both cases, mentions of any side effects are extremely rare.
Such a discrepancy in assessing the effectiveness of the drug most likely arises due to the formation of proctological pathologies ( anal fissures , hemorrhoids , etc.) for various reasons and due to various external or internal influences ( traumatic injuries , poor nutrition metabolic disorders , etc. .). In this regard, there is no single effective treatment that alleviates the patient’s painful condition. If treatment is necessary, the patient should consult a proctologist to find out the exact reasons for the development of the pathology observed in him and to select an effective therapeutic agent in this case.
The effect of Posterizan ointment on hemorrhoids
"Posterizan" is an ointment for hemorrhoids produced by a German pharmaceutical company. Release form: rectal suppositories, ointment, cream. The main active ingredient is an aqueous suspension of hydrocortisone. Also contains glycerin, lanolin, phenol, soft paraffin.
For hemorrhoids, Posterizan has a mild analgesic and antiseptic effect. Patients report that it is most effective to use not only ointment, but also suppositories. Compared to Ultraproct, Posterisan loses: patient reviews indicate that the former is much more effective in combating the symptoms of hemorrhoidal disease.
Ultraprokt price, where to buy
The average price of Ultraproct ointment 10 grams varies around 550 rubles, the average price of Ultraproct in suppositories No. 10 is 620 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in KazakhstanKazakhstan
LuxPharma* special offer
- Ultraproct candles 12 pcs
2200 rub. order - Ultraproct ointment 30g
2150 rub. order
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The use of "Heparin ointment" for hemorrhoidal disease
“Heparin ointment” is a Russian analogue of “Ultraproct” ointment for hemorrhoids. The main advantage of the drug is its low cost. The main active ingredient is heparin sodium. It accelerates local blood circulation, as a result of which the pain becomes less pronounced and the hemorrhoids decrease in size.
Reviews of Heparin Ointment report that the product is quite safe and very rarely causes allergic reactions. Effective in the initial stages of hemorrhoids, in later stages it may be too weak. The main advantage of “Heparin Ointment” over “Ultraproct” is its several times lower cost, which is why hundreds of thousands of patients choose it.
