OMNADREN amp 250mg 1ml N1

July 31, 2018
Sports nutrition
Ulyana Romanova

Omnadren 250 is a powerful anabolic steroid that accelerates protein synthesis inside cells. It became widespread among bodybuilders, but in 2014 it was banned, so now to purchase it you must present a prescription form in form N 148-1/у-88. In this regard, the price for it increased 7 times.

What kind of drug is this? What is its composition, principle of application, and effectiveness? What is the opinion of men themselves about this substance? This and much more will be discussed now.

Pharmacodynamics

Stimulates protein synthesis, retaining the necessary potassium, sulfur, and phosphorus ions, enhances calcium fixation in bones, and increases muscle mass. Affects the development and function of the external genitalia, prostate gland, seminal vesicles, secondary sexual characteristics (voice, hair). Determines body constitution and sexual behavior, activates libido and potency, stimulates spermatogenesis. It is an antagonist of female sex hormones - estrogens. Reduces the negative manifestations of menopause.

Expert opinion

The reviews left about Omnadren are mostly positive. Experts say that this is a unique drug that is one of the most effective for building muscle mass and increasing strength. In powerlifting, as well as other strength sports, this is not only in demand, but necessary.

However, some criticize this drug for its side effects. It also cannot be called affordable, which is also a disadvantage - you can only get it with a prescription.

But it has a nice price. "Omnadren" costs only 600-700 rubles per pack. Unfortunately, some men often exceed recommended dosages precisely because of the price. It is strictly not recommended to do this. Eliminating side effects and long-term treatment will cost much more.

Side effects

From the gastrointestinal tract: cholestatic jaundice, increased aminotransferase activity.

From the genitourinary system: peripheral edema, fluid retention in the body, bleeding from the genital tract, oligospermia, increased libido in men, impaired spermatogenesis.

Allergic reactions: pain, itching, redness at the injection site.

Other: acne, phlebothrombosis, hypercalcemia, bone pain; extremely rarely - increased sensitivity to insulin in patients with hypoglycemia. Women may experience symptoms of masculinization after prolonged use.

Feature of the drug

The specificity of this medication lies in its unique composition. The mixture of esters has impressive power, and they all influence each other. It is the joint action that determines the effectiveness of Omnadren. Therefore, it is injected not only by athletes who want to “pump up” quickly, but also by serious bodybuilders and powerlifters.

The active components begin to work not together, but one by one. It is due to this that the level of testosterone in the body is at a constantly high level. This fact determines the pharmacological effectiveness of the drug.

Also, the mixture of esters has a different effect. The components influence the joints, facilitating their movements. This occurs due to moderate fluid retention in the body.

In addition, the use of Omnadren 250 accelerates tissue restoration processes, which is the most important nuance for professional athletes. The medication also stimulates appetite. This is also necessary for people whose lives revolve around regular high-intensity training.

Directions for use and doses

IM, deep into the gluteal muscle. The dose is set individually depending on the indications and the patient’s response.

For primary male hypogonadism: depending on the degree of insufficiency of the gonads (according to clinical assessment and laboratory test results), initially it is administered once every 1-2 weeks, after achieving a therapeutic effect - once every 3 weeks.

For menopause in men: once every 2 weeks, after achieving a therapeutic effect - once every 3 weeks.

For infertility in men (azospermia, oligospermia): 2 ml 1 time every 2 weeks (if a painful erection of the penis appears, treatment is stopped).

For menopausal syndrome in women: 1 ml once every 2–3 weeks.

For breast and ovarian cancer: 1–2 ml every 1–2 weeks, long-term treatment.

Reviews from athletes: advantages

Their study should also be given attention. There are a lot of reviews about Omnadren, and here are the advantages of this drug that athletes talk about:

The efficiency is truly impressive. The vast majority of analogues are much inferior according to this criterion.
The price-quality ratio is the best in the entire market.
Athletes of average build gain weight intensively. If you believe some reviews, Omnadren is capable of giving about 5-6 kilograms in the first week with an injection of 500 mg.
“Advanced” athletes experience a stable increase in weight from 5 to 10 kg.
The drug significantly affects potency and libido. In a good way, of course. By the way, the medication also affects the quality of sex.
After completing the course, the results are obvious - both strength and external. What is important is that they last even after the injections stop.
It is muscle mass that is gained. Of course, “water” is also present, but in adequate quantities.
On thin men, the effect is noticed faster. If you train conscientiously, giving your all in the gym, then even within a month or a month and a half you will see a visible effect.
Thin girls who take this drug in order to gain weight and acquire appetizing shapes claim that already on the 2nd day after the first injection their appetite noticeably increases. If you go to the gym, you will see an increase in muscle mass (not body fat) literally before your eyes. In simple words, what will grow is that the girl starts pumping.

In general, Omnadren is popular in bodybuilding. And the effect will be exactly as described in the instructions. The most important thing is not to exceed the dosage.

Artificial testosterone "Omnadren 250"

It is one of the most affordable drugs. The product “Omnadren 250” receives quite specific reviews from doctors and athletes. But before moving on to them, let's look at the drug itself.

The drug "Omnadren 250" is an anabolic steroid; in its pharmacological properties it is almost identical to the drug "Sustanon". Their differences are just one testosterone ester. The drug is produced in cardboard packages that contain five ampoules of one milliliter each.

The drug contains four types of testosterone:

30 mg testosterone propianate;
60 mg testosterone phenylpropionate;
60 mg testosterone isocapronate;
100 mg testosterone decanoate.

As excipients, the drug contains a softening agent for injections - peanut oil, and a preservative - benzyl alcohol.

Recommendations from athletes

Having decided to start taking Omnadren, you should contact a qualified specialist responsible for training athletes. He will prescribe an individual regimen for using the drug.

Also, in order for its effect to be maximum and the harm to be minimal, it is necessary to follow certain rules, which are the basics of strength sports. That is, you need to eat well, work out in the gym (at least 3 times a week), and also sleep 7-8 hours a day.

This is really important. Because many people overestimate the role of pharmaceutical support. “Omnadren” is a powerful medicine, but if a person does nothing himself, then there will be little benefit from it.

Modern view on the problem of age-related androgen deficiency in men

It is traditionally believed that men are the stronger sex. However, the facts prove the opposite: in the modern world, men are inferior to women not only in quality of life, but also in its duration (in Russia, the difference in life expectancy between men and women is dramatic and amounts to 13 years!). Men have a significantly higher prevalence of cancer and cardiovascular diseases. Alcohol consumption and smoking in Russia are significantly higher than in the West, which leads to the early onset of erectile dysfunction, which negatively affects the quality of life of both the couple as a whole and the woman.

Thus, the facts demonstrate some weakness of men. Is it possible to somehow influence their weaknesses? Is it possible to change the quality of a man's life and increase its duration? Over the past 10 years, a real “testosterone revolution” has occurred; we no longer ask the question whether age-related androgen deficiency is a myth or reality, since the presence of age-related androgen deficiency is a scientifically proven fact. Moreover, today we know that testosterone levels determine the functioning of almost all organs of the male body. Testosterone is a kind of protective hormone against the development of a number of age-associated diseases. Men with low testosterone levels have a lower life expectancy than men with normal testosterone levels. Back in 1983, Dilman V.M. wrote that “one of the mandatory conditions for cancer prevention is maintaining hormonal and metabolic indicators at the level that the body reaches at the age of 20–25 years...”. Today, the dreams of scientists of the last century are feasible, since we have effective and safe drugs for this, but, unfortunately, they are practically not used.

Despite the fact that somatic diseases lead to androgen deficiency, which aggravates their course, the determination of testosterone has not become routine practice. Replenishing androgen deficiency increases the effectiveness of treatment of erectile dysfunction with phosphodiesterase type 5 inhibitors (PDE-5), urinary disorders with alpha-blockers, diabetes mellitus with hypoglycemic drugs, and promotes weight loss - the main component of metabolic syndrome.

An age-related decrease in testosterone secretion in men begins at age 30, and the rate of decrease in free testosterone exceeds the rate of decrease in total testosterone (due to increased synthesis of sex steroid-binding globulin (SHBG) with age). Every year in patients 30–40 years old, the decrease in testosterone is about 0.7–1.0% of total testosterone and 1.2–1.4% of its free fraction. In the literature, this syndrome has received many names: “andropause”, “male menopause”, male menopause. Currently, the above terms are considered inaccurate and are practically not used. In the literal sense, menopause (translated from Greek - step, ladder) is not observed in men with age. However, there is a gradual decline in sexual and hormonal functions, although their complete shutdown is not observed until old age.

The following terms are used in modern literature:

age-related androgen deficiency (AAD) - in the domestic literature;
Late On-set Hypogonadism (LOH) - late-onset hypogonadism;
Partial AnrogenoDeficit at Alding Men (PADAM) - partial androgen deficiency in aging men;
Testosterone Deficit Syndrome (TDS) is a term recommended by the European Association for the Study of the Health of Older Men (AMS).

VAD is a clinical and biochemical syndrome associated with aging. It is characterized by typical symptoms of chronic deficiency of systemic testosterone and is manifested by dysfunction of various organs and systems, and also reduces the quality of life (Nieschlag E., Swerdloff R. et al., 2005).

Timing of onset and prevalence of VAD. The timing of the onset of clinically significant VAD is individual and depends on the level of testosterone at the peak of its secretion at 20–30 years of age: the higher its content, the later its decrease will occur, beyond the normative values (Fig. 1).

Any chronic somatic disease negatively affects the secretion of testosterone, leading to an acceleration of the onset of androgen deficiency, and therefore the prevalence of androgen deficiency in chronic somatic diseases is extremely high. According to our data, the prevalence of VAD in type 2 diabetes mellitus is 68% (

), and for ischemic heart disease - 60% (Fig. 3).

The level of SHBG, on the contrary, increases with aging, so the content of the free fraction of testosterone further decreases. In men without somatic diseases, the prevalence of VAD increases with age and averages 30% in the population of men over 50 years of age (

Age-related changes in the secretion of other hormones combined with VAD. The aging process occurs in almost all organs of the endocrine system, including the adrenal glands. The changes that occur in them with age are called adrenopause. This term describes a decrease in the levels of dehydroepiandrosterone (DHEA) and DHEA sulfate in the adrenal glands, while the secretion of corticotropin remains unchanged for a long time. Lack of DHEA leads to decreased mood, libido, weakened potency, osteopenia, decreased muscle mass and strength, impaired immunity, and the appearance of insulin resistance.

During the aging process, the production of the second important anabolic hormone, growth hormone, decreases (somatopause). According to a number of authors, there is an age-related decrease in melatonin levels (melanopause). A deficiency of this hormone is associated with an imbalance in the sleep-wake system.

Although aging does not lead to complete hormonal deficiency, medical intervention in the processes of andro-, somato-, melano- and adrenopause is possible in order to delay some manifestations of the aging process (Laurent O. B., Segal A. S., 1999).

The clinical picture of VAD is presented in

The photo shows a clinical example of VAD. Note the increase in the amount of adipose tissue (abdominal obesity), decrease in muscle mass, sagging skin, decrease in hair growth on the torso, limbs, and pubis.

Diagnosis of VAD

Stages of VAD diagnosis

stage - clinical examination and filling out questionnaires.
stage - determination of the level of total testosterone (determination of luteinizing and follicle-stimulating hormones (LH and FSH) is only necessary to clarify the type of hypogonadism).
stage - determination of the level of SHBG (sex-steroid-binding globulin - SSGG) (only in men with clinical VAD and normal levels of total testosterone).
stage - if low testosterone levels are detected, it is advisable to confirm laboratory measurements and exclude other causes of decreased testosterone secretion (thyroid-stimulating hormone (TSH), prolactin, the presence of severe somatic diseases).

Categories of patients with an increased risk of VAD, in whom hormonal screening is absolutely necessary:

men with erectile dysfunction;
men with decreased libido;
men with an unexplained decrease in physical activity;
men receiving glucocorticoids for a long time;
men with chronic systemic diseases (diabetes mellitus, coronary artery disease);
men with new-onset gynecomastia;
men who abuse alcohol and drugs;
obese men (waist circumference more than 94 cm);
men with metabolic syndrome.

Categories of patients with an increased risk of developing VAD, in whom hormonal screening is advisable:

men with an increase in body mass index (BMI over 23);
men with dyslipidemia;
men with depression;
men with anemia.

Establishing diagnosis. It is generally accepted that total testosterone and SHB levels are examined to confirm VAD. Blood sampling should be carried out in the morning between 7.00 and 11.00 hours. If the level of total testosterone is above 12 nmol/l (3.46 ng/ml), in the presence of a clinical picture of androgen deficiency, then it is necessary to calculate the level of free testosterone using the formula. If the level of total testosterone is below 12 nmol/l (200 pmol/l), it is necessary to determine TSH, prolactin, evaluate liver and kidney function, the state of carbohydrate and lipid metabolism to exclude induced hypogonadism by other diseases. VAD should be a diagnosis of exclusion, i.e. it is established only after excluding all possible causes of hypogonadism, including drug-induced hypogonadism (

The role of VAD in the development of obesity and metabolic syndrome (MS) in men. As has been established in a number of studies, one of the determining factors in the development of obesity, insulin resistance and MS in men is a deficiency of sex hormones and, in particular, testosterone. Thus, Simon D. et al. in TELECOM-Study, when examining 1292 men, they revealed a clear negative relationship between testosterone levels and insulin levels (Simon D.). Chen RY et al. showed that the level of total testosterone in men with MS is significantly lower than in healthy people. At the same time, an inverse correlation was found between the concentration of testosterone and waist circumference, as well as the level of low-density lipoprotein cholesterol. At the same time, this study did not reveal a causal relationship between low testosterone levels and the development of type 2 diabetes mellitus (Chen RY). However, an earlier large-scale study, the Massachusetts Male Aging Study, shows a strong correlation between low free testosterone levels and the risk of developing insulin resistance and type 2 diabetes (Stellato RK).

Thus, low testosterone levels in men should be considered as one of the components of MS along with insulin resistance, hyperinsulinemia, obesity, dyslipidemia, arterial hypertension, impaired glucose tolerance and disorders in the blood coagulation system.

Treatment of VAD

Androgen replacement therapy has a 60-year history, thanks to Thomas HB, Hill RT, who in 1940 first successfully used Testosterone propionate to treat androgen deficiency in men. For a long time, the indications for use remained the classical forms of hypogonadism, namely congenital or acquired hypogonadism (mainly of a tumor or traumatic nature). Recently, the indications have expanded significantly and androgen therapy is becoming increasingly popular and widespread in the treatment of VAD.

VAD therapy is aimed at replenishing androgen deficiency. The stumbling block to widespread use of testosterone therapy is still safety in relation to the prostate gland. For a long time it was believed that androgens are stimulators of tumorigenesis in the prostate gland. However, research in recent years has refuted this opinion, based on isolated observations of increased acid phosphatase levels in patients with prostate cancer during the use of testosterone drugs conducted in the last century. Today it has been proven that androgen therapy is not only safe for the prostate gland, but, moreover, hypogonadism is considered a factor associated with a more severe and aggressive course of prostate cancer. Recent studies conducted in Europe and the USA have shown that the incidence of prostate cancer during androgen therapy does not exceed the incidence of prostate cancer in the population of men not receiving testosterone therapy (Morgentaller A., 2006), and low testosterone levels are associated with more aggressive forms of prostate cancer.

Currently, there is a wide selection of drugs to compensate for androgen deficiency (Table 3). In men with preserved secretory ability of Leydig cells, both therapy with exogenous drugs and stimulating therapy with human chorionic gonadotropin can be used. Stimulation therapy should be the method of choice in patients planning to have children, since exogenous drugs, especially injectable forms, have a negative effect on spermatogenesis.

In men with an increase in LH levels, which is a marker of Leydig cell damage, continuous androgen therapy is necessary, and the dose of the drug should be selected under the control of LH, which, with the correct dose, should be within normal limits.

Currently, there is a fairly wide range of testosterone preparations for androgen therapy, including oral forms, oil solutions for intramuscular injections, as well as transdermal gels and patches. Since all testosterone preparations have their own advantages and disadvantages, when choosing a method of hormonal therapy, it is necessary to be guided by the principles of effectiveness, safety and ease of use. As a rule, when starting androgen therapy for VAD, the drugs of choice are non-invasive forms - transdermal gels, which are represented on the Russian market by the drug "Androgel".

Testosterone in the form of a gel is absorbed from the surface of the skin and enters the bloodstream, with a constant concentration in the plasma observed within 24 hours. Its only drawback is the possibility of contact of the gel with the partner’s skin.

In case of severe androgen deficiency, accompanied by an increase in LH levels, it is better to use long-acting testosterone preparations.

Previously, 2 androgenic drugs with a relatively long-term effect were registered in our country - Sustanon-250 and Omnadren 250, injections of which must be done 2-3 times a month. These drugs are a mixture of four testosterone esters - testosterone capronate, isocapronate, propionate and phenylpropionate, which are characterized by different pharmacokinetics. Testosterone propionate begins to act quickly, but by the end of the first day its effect practically ceases, phenylpropionate and isocapronate begin to act in about a day, the effect lasts up to two weeks, and the longest-acting one is capronate, its effect can last up to 3-4 weeks. A significant drawback of these drugs is fluctuations in the concentration of testosterone in the blood from supra- to subphysiological, which is felt by a number of patients. In addition, supraphysiological increases in testosterone levels in some cases lead to an increase in hematocrit, which not only requires monitoring of the blood condition, but also in some cases requires discontinuation of the drug. In 2005, for patients with androgen deficiency, a new testosterone drug with a truly long-term effect became available - testosterone undecanoate (Nebido®) in the form of an oil solution, which is recognized throughout the world as the drug of choice for long-term hormone replacement therapy for hypogonadism of any origin and, including VAD. Nebido® not only maintains serum testosterone at a physiological level for a long time, which makes it possible to reliably and effectively eliminate and prevent symptoms of testosterone deficiency, but is also significantly better tolerated by patients compared to the previously mentioned intramuscular drugs, since after Nebido® injection the testosterone level increases within 12 weeks is maintained within physiological limits, without sudden increases or decreases. Patients require only 4–5 injections per year. However, given the fairly large volume of the oil solution of the drug - 4 ml, and the need for slow intramuscular administration of the drug, we recommend administering the drug under the supervision of a physician to avoid the possible occurrence of abscesses.

Side effects of androgen therapy

Androgen therapy for VAD is a replacement therapy, i.e., testosterone levels are normalized, therefore, with the correct dose, i.e., at a dose at which the testosterone level is within normal physiological limits and there can be no side effects from the therapy.

If the dose is exceeded, side effects associated with androgen overdose may develop:

polycythemia;
a sharp increase in sexual desire;
priapism;
fluid retention, swelling;
acne, seborrhea, baldness.

Androgen drugs combine well with hypoglycemic agents, including insulin therapy and metformin, as well as with antihypertensive and lipid-lowering therapy, which allows their widespread use in the complex treatment of MS in men with VAD.

S. Yu. Kalinchenko , Doctor of Medical Sciences, Professor of RUDN University , Moscow

Post cycle therapy

Proviron product. The most popular hormonal drug taken after a course of steroids. The active ingredient is masterolon. Helps avoid aromatization of steroids and their conversion into estrogens. Prevents the appearance of gynecomastia. Take 50 mg per day, it is advisable to split the dose into two 25 mg doses. The course lasts approximately 3-5 weeks. It is better to purchase the drug in advance so that there are no problems later, because the body needs help after taking potent steroids. It also eliminates excess water in the body and removes fat deposits on the body.

The drug "Tamoxifen". The most affordable and effective anti-estrogen. It is taken during courses of steroids at 20-40 mg per day. The drug Tamoxifen fights the aromatization of steroids, eliminates the accumulation of excess water in the muscles, and fights the appearance of acne, which is important when taking Omnadren 250. Unlike the drugs "Proviron", "Tamoxifen" only prevents aromatization, and does not fight the appearance of its signs, so you can start taking it immediately after leaving the course.

Reviews from athletes: cons

The drug works 100%, but, nevertheless, everything has its drawbacks. Here are the specific disadvantages of this drug that you can learn from the reviews left about Omnadren:

The skin condition is deteriorating. Many people develop a rash, especially on the back, shoulders and chest. This side effect can be minimized if you sunbathe in a solarium (or on the beach, if you have the opportunity). Reducing the intake of fatty foods and simple carbohydrates also works.
The endogenous test is recovering slowly after discontinuation of the course.
After the injection, many people develop bumps. Athletes recommend rubbing and warming the injection site. Then the oil dissolves and the lump goes away.
Injections are difficult to give. The liquid is tight, stringy and oily. It is drawn into the syringe slowly; you have to shake it frequently to remove air bubbles. After all, if they get into a muscle, they can cause an abscess. The injection itself is also administered slowly. Because of this, many people have skin pain later.
For some, the body takes a long time to get used to the drug. This is manifested by increased sweating, irritability, anxiety and lethargy.
Girls taking the drug experience deepening of their voices. He becomes hoarse. An acne rash that is difficult to remove also appears, and aggressiveness also increases.

And many are also upset by the fact that Omnadren 250 (5 ampoules) cannot be bought everywhere without a prescription. However, athletes simply order the drug and it is delivered to them. But it is better and safer, of course, to take it in pharmacies.

Health effects

Like all steroids, the main negative effect of Omnadren 250 is on the hormonal system, temporarily reducing the production of your own testosterone and aromatizing it. It also leads to excessive accumulation of water in the muscles and disruption of the sebaceous glands of the skin, which often causes rashes and acne to appear after taking it. All this can be completely avoided by following the instructions described in the paragraph “Post-course therapy”.

results

Let's look at the results of taking the drug Omnadren 250. Feedback from specific people allows us to draw a conclusion about the difference in the initial data and results.

For example, an athlete weighing 95 kilograms gains ten kilograms over a course of 5 weeks on a high-protein diet. The course includes:

— The drug “Omnadren 250”. There is a 7 day difference between the first two injections. Then, every four days, an injection of 250 mg of the substance, that is, one milliliter of the drug.

- Proveron product. Its course begins with the last injection of the previous one. 50 mg per day for three weeks.

- The drug Tamoxifen. 20 mg per day, ends with the course of Proveron.

After leaving the course, the athlete weighs 102 kg.

Strength indicators increase as follows:

Bench press – 130, after the course 145.

Squat – 140, after the course 155.

Deadlift – 155, after the course 180.

This is an example of how the drug “Omnadren 250” works for the first course. With its help, you can achieve much greater results, especially if you take other anabolic agents at the same time.