Compound
The tablets contain the active substance cefpodoxime , as well as a number of auxiliary components: iron oxide, croscarmellose sodium, Opadry OY-L white, microcrystalline cellulose, magnesium stearate , sodium starch glycolate , sodium lauryl sulfate , silicon dioxide .
The composition of the powder from which the suspension is prepared includes the active substance cefpodoxime , as well as additional ingredients: simethicone emulsion , sodium saccharin , carboxymethylcellulose , hydroxypropylcellulose , xanthan dextrin , citric acid , corn starch , microcrystalline cellulose , vanillin flavor , sucrose , silicon dioxide , flavoring .
pharmachologic effect
Cefodox is a semisynthetic antibiotic that belongs to the third generation of cephalosporin drugs. Its bactericidal effect on the body is determined by the ability to acetylate membrane transpeptidases of the cell walls of microorganisms. As a result, the disruption of the formation of microbial cell walls is eliminated.
High sensitivity to Cefodox is observed in many gram-negative microorganisms (Escherichia coli, Klebsiella spp., Proteus mirabilis, Haemophilus influenzae, Serratia spp., Providencia spp., Pseudomonas spp., Citrobacter spp.), as well as in some gram-positive microorganisms . Low sensitivity to the drug is observed in insensitive anaerobes. The active substance of the drug has no effect on most strains of clostridia , enterococci , legionella , mycoplasma , chlamydia , as well as methicillin-resistant strains of staphylococci .
Pharmacological properties of the drug Cefodox
cefpodoxime (1-(isopropoxycarbonyloxy)ethyl (6R, 7R)-7-[2-(2-amino-4-thiazolyl)-(z)-2-(methioxyimino)acetamido]-3-methoxymethyl-3-cephem- 4-carboxylate) is a cephalosporin antibiotic. Active against many gram-positive and gram-negative microorganisms: Staphylococcus aureus (including penicillinase-forming, but not methicillin-resistant strains), Staphylococcus saprophyticus, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus spp. (groups C, F, G), Escherichia coli, Haemophilus influenzae (including strains producing β-lactamases), Klebsiella pneumoniae, Moraxella catarrhalis, Neisseria gonorrhoeae (including penicillinase-producing strains), Proteus mirabilis, Citrobacter diversus, Haemophilus parainfluenzae, Klebsiella oxytoca, Proteus vulgaris, Providencia rettgeri, anaerobes ( Peptostreptococcus magnus ). Cefpodoxime proxetil is absorbed in the digestive tract and deesterified to form cefpodoxime. After taking a dose of 100 mg, 50% is absorbed, the maximum concentration in the blood serum is reached after 2-3 hours and is 1.4 mcg/ml. Simultaneous ingestion of food increases the maximum concentration, but does not increase the time to achieve it when using tablets and increases the time to achieve it, but not the maximum concentration when using a suspension. Binds to plasma proteins (20–30%). Penetrates into liquids and tissues (including tonsils and lungs), forming in them a concentration exceeding MIC50 for most microorganisms. The half-life is 2.09–2.84 hours. About 30–35% of the dose is excreted unchanged in the urine within 12 hours. If renal function is impaired, excretion decreases: with a creatinine clearance of 50–80 ml/min, the half-life is 3. 5 hours, 30–49 ml/min – 5.9 hours, 5–29 ml/min – 9.8 hours.
Indications for use
The drug is used for infectious diseases that are caused by microorganisms that are highly sensitive to Cefodox:
- tonsillitis , sinusitis , laryngitis , otitis media , pharyngitis ;
- bronchitis , pneumonia ;
- pyelonephritis , cystitis (mild or moderate disease);
- infectious lesions of joints, skin, soft tissues, bone tissue;
- proctitis , urethritis , cervicitis , which is of gonococcal origin.
Instructions for use of Cefodox (Method and dosage)
The instructions for Cefodox stipulate that the antibiotic is taken by adults and adolescents over 12 years of age at a dose of 200-400 mg.
Instructions for use of Cefodox 200 stipulate that for infectious diseases of the human genitourinary system and upper respiratory tract, the daily dose is 200 mg of the drug, for bronchitis or pneumonia - 400 mg of the drug. Depending on the dosage, tablets are taken 1-2 times a day. The duration of treatment depends on the characteristics of the disease and is determined by a specialist. Elderly people do not need to adjust the daily dose of Cefodox.
To prepare the suspension, you must initially shake the bottle thoroughly, then add cold, boiled water until the liquid reaches the mark indicated on the bottle. You need to add water in two steps, shaking the bottle periodically so that the mass becomes homogeneous. A homogeneous suspension can be used five minutes after its preparation. Each time before taking, you need to thoroughly shake the bottle of suspension.
If Cefodox 100 suspension is prescribed, the instructions indicate that the drug should be taken simultaneously with food. The interval between doses should be 12 hours. The suspension is prescribed to children from the age of five months, with the daily dose of the drug being 10 mg of suspension per 1 kg of the child’s weight. The maximum dose per day is 400 mg. The drug must be taken in two doses, since the largest single dose is 200 mg.
Use of the drug Cefodox
Orally, for adults and children over 12 years of age for tonsillitis/pharyngitis - 200 mg/day in 2 divided doses, for acute and chronic bronchitis in the acute phase - 400 mg/day in 2 divided doses, for pneumonia - 400 mg/day in 2 divided doses , for infections of the skin and soft tissues - 800 mg / day in 2 doses, uncomplicated urinary tract infections - 200 mg / day in 2 doses, uncomplicated acute gonorrhea - 200 mg once. To prepare the suspension, invert and shake the bottle to fluff the powder. Add boiled cold water in 2 additions, shaking the bottle each time until a homogeneous suspension is formed. The suspension can be taken no earlier than 5 minutes after preparation. The suspension is intended for use in pediatrics. Children aged 5 months to 12 years are prescribed a dose of 10 mg/kg/day in 2 divided doses; the maximum single dose is 200 mg, the maximum daily dose is 400 mg.
special instructions
People who are allergic to other cephalosporins should be aware of the possibility of developing a cross-allergy to cefpodoxime. If there is a history of hypersensitivity to cephalosporins, the drug should not be prescribed, as the reaction can be severe and sometimes fatal.
For people suffering from gastrointestinal diseases, antibiotics should be prescribed with caution, since microflora disturbances can provoke the development of diarrhea.
With long-term treatment with cefpodoxime, there may be an excessive increase in resistant microorganisms.
During antibiotic , dizziness may periodically occur, which, in turn, can affect the ability to drive and operate major machinery.
Cefodox tablets 200 mg, 10 pcs.
Approximately 5-10% of patients with a penicillin allergy have a cross-reaction to cephalosporins, so before prescribing cephalosporins, it is necessary to determine the patient's possible allergy to penicillin and ensure careful medical supervision from the first day of cefpodoxime use. At the first signs of an anaphylactic reaction, you should stop using the drug.
Cefpodoxime is not recommended for use in patients with hypersensitivity to cephalosporin antibiotics. Allergic reactions (especially anaphylaxis) that occur with beta-lactam antibiotics can be severe and, in rare cases, fatal.
At the first signs of an allergic reaction when using the drug, you should stop taking it and consult a doctor.
If exudative erythema multiforme, Stevens-Johnson syndrome, or Lyell's syndrome appear, the drug should be discontinued.
Cefpodoxime is not an antibiotic for the treatment of staphylococcal pneumonia, and it should not be used to treat atypical pneumonia caused by Legionella, Mycoplasma and Chlamydia microorganisms.
When using the drug, adverse reactions from the digestive tract are possible, including nausea, vomiting, abdominal pain, so cefpodoxime should be prescribed with caution to patients with a history of gastrointestinal diseases, especially colitis. The use of cefpodoxime may lead to the development of diarrhea, antibiotic-associated colitis and pseudomembranous colitis. These adverse reactions, which may occur more frequently in patients treated with large doses of cefpodoxime for a long time, should be considered potentially severe.
It is necessary to conduct a test for the presence of Clostridium difficile. If colitis occurs, treatment with cefpodoxime should be stopped immediately, sigmoidoscopy should be performed and, if further treatment is necessary, appropriate therapy (vancomycin) should be prescribed. Foods that cause constipation should be avoided. Although any antibiotic can cause pseudomembranous colitis, the risk is greater with broad-spectrum drugs such as cephalosporins.
When using beta-lactam antibiotics, neutropenia and agranulocytosis may develop, especially during long-term treatment. If the drug is used for more than 10 days, blood tests should be monitored, and if neutropenia develops, treatment with cefpodoxime should be discontinued.
When treated with cefpodoxime, a positive Coombs test and, very rarely, hemolytic anemia may occur. In these reactions, there is cross-resistance between cephalosporins and penicillins.
Changes in renal function have been observed with simultaneous use with aminoglycosides or strong diuretics, in which case monitoring of renal function is necessary.
Long-term use of cefpodoxime may lead to overgrowth of non-susceptible microorganisms. If superinfection occurs, it is necessary to assess the patient's condition and prescribe appropriate treatment.
This medicine contains lactose. If the patient has an intolerance to certain sugars, a doctor should be consulted before taking this medicine.
Analogues of Cefodox
Level 4 ATC code matches:
Cephosin
Lendatsin
Medakson
Loprax
Ceftriaxone
Cefixime
Lorakson
Sulperazon
Cefoperazone
Rocephin
Tsedex
Fortum
Ceftazidime
Cefotaxime
Cefix
Ceforal Solutab
Pantsef
Claforan
Suprax Solutab
Similar drugs are medicines that contain the same active substance. In pharmaceutical networks you can buy analogues of Cefodox - the drugs Doccef , Cefpotek , Axef , Zinacef , Zocef , etc. However, you should not independently replace the drug prescribed by your doctor with its analogues.
Reviews of Cefodox
Adult patients, as well as parents who have used Cefodox for children, leave mostly positive reviews online. In particular, the drug has a rapid effect on infectious diseases of the upper respiratory tract, as well as bronchitis and other infections. The reviews talk about the rapid disappearance of symptoms - high temperature, pain, etc.
Side effects after taking the drug are very rare. The inconvenience of using the suspension bottle and dispenser is noted as a negative impression.
Cefodox powder for oral suspension 100 mg/5 ml for children, 50 ml
The following classification of the frequency of adverse reactions is used: very often (≥ 1/10), often (≥ 1/100, < 1/10), infrequently (≥ 1/1000, < 1/100), rarely (≥ 1/10000, < 1/1000), very rare (<1/10000).
Infections and infestations: rarely - superinfection caused by certain fungi of the genus Candida, insensitive to cefpodoxime; very rarely - colitis associated with the use of antibiotics.
From the blood and lymphatic system: rarely – eosinophilia; very rarely - leukopenia, hemorrhage, neutropenia, thrombocytopenia, thrombocytosis, agranulocytosis, serum sickness, decreased hematocrit, decreased hemoglobin concentration, hemolytic anemia, prolongation of thrombin and prothrombin time, leukocytosis, leukocytosis.
From the immune system: rarely - hypersensitivity, anaphylactic reactions, angioedema.
From the side of metabolism, metabolism: rarely - dehydration, gout, peripheral edema, weight gain.
From the musculoskeletal system and connective tissue: rarely – myalgia, arthralgia.
From the nervous system: infrequently – cephalalgia; rarely – vertigo; very rarely - dizziness, unsteady gait, headaches, weakness, insomnia, drowsiness, sleep disturbance, neurosis, irritability, nervousness, anxiety, unusual dreams, blurred vision, confusion, night terrors, paresthesia.
From the respiratory system, chest organs and mediastinum: rarely - asthma, bronchitis, cough, nosebleeds, sneezing, rhinitis, wheezing, suffocation, bronchospasm, sinusitis, pleural effusion, pneumonia.
From the digestive tract: rarely – abdominal pain, nausea; rarely - diarrhea, feeling of thirst, tenesmus, bloating, vomiting, dyspepsia, dry mouth, decreased appetite, feeling of pressure/fullness in the stomach, constipation, candidal stomatitis, toothache, anorexia, belching, gastritis, mouth ulcers, pseudomembranous colitis .
From the hepatobiliary system: rarely - cholestatic liver damage, increased levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, bilirubin.
From the skin and subcutaneous tissue: rarely - rash, redness, itching, urticaria, increased sweating, macular rash, fungal dermatitis, desquamation, dry skin, hair loss, vesicular rash, solar erythema, purpura syndrome, Johnson bule), toxic epidermal necrolysis, erythema multiforme.
From the urinary system: rarely - hematuria, urinary tract infections, metrorrhagia, dysuria, frequent urination, nocturia, infections of the male genital organ, proteinuria, pain in the vagina, vaginal candidiasis. In rare cases, renal dysfunction has been observed.
From the cardiovascular system: rarely - congestive heart failure, palpitations, vasodilation, hematoma, migraine, arterial hypertension or hypotension.
From the organs of vision: eye irritation.
On the part of the hearing and vestibular apparatus: tinnitus.
General disorders: rarely - discomfort, fatigue, asthenia, chills, drug-induced fever, chest pain (pain may radiate to the lower back), fever, generalized pain, localized edema, localized pain, impaired taste, abscess, allergic reaction, candidiasis, bacterial infections, parasitic infections
Biochemical tests: hyper- or hypoglycemia, hypoalbuminemia, hypoproteinemia, hyperkalemia, hyponatremia.
Laboratory characteristics: increased urea and creatinine levels, pseudo-positive Coombs test.
Cefodox price, where to buy
The price of Cefodox 200 (14 pcs.) in Russia is about 1600-1700 rubles. The price of Cefodox 100 in Ukraine (Kyiv, Kharkov, Dnepropetrovsk, etc.) averages 130-150 UAH. Powder for preparing a 100 mg suspension can be purchased for an average of 150 UAH.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
LuxPharma* special offer
- Cefodox (Cefpodoxime) tab.
200 mg No. 6 1990 rub. order
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Pharmacy24
- Cefodox 100mg/5ml 50 ml powder Pharma International, Jordan
266 UAH order - Cefodox 50 mg/5 ml 50 ml powder for oral suspension Pharma International, Jordan
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- Cefodox 100 mg No. 10 tablets Pharma International, Jordan
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- Cefodox 200 mg No. 10 tablets Pharma International, Jordan
343 UAH. order
