Compound
Drops for oral use 0.75% contain the active component: sodium picosulfate - 7.5 mg/ml and additional substances: sorbitol, hydrochloric acid, sodium methylhydroxybenzoate and purified water.
One tablet contains the active substance: sodium picosulfate in terms of 100% anhydrous substance, 5 mg or 7.5 mg, as well as auxiliary components: lactose monohydrate, corn starch and pregelatinized 1500, magnesium stearate, colloidal anhydrous silicon dioxide.
Pharmacodynamics and pharmacokinetics
When treated with Picolax inside the body, its active component sodium picosulfate has a beneficial effect on the large intestine. Under the influence of bacterial flora, the drug is broken down, resulting in the formation of the active form - free diphenol.
Then the sensitive nerve endings of the intestinal mucosa are stimulated, enhancing its motility. Taking this drug does not lead to tenesmus and intestinal spasms. The development of the laxative effect occurs 6-12 hours after using one dose.
During the treatment of infants, insufficient effectiveness of the drug was noted, since they have a small amount of bacterial flora that produces sulfatases .
Pharmacological properties
Pharmacodynamics.
sodium picosulfate, the active ingredient of the drug picolax, is a local laxative of the triarylmethane group. sodium picosulfate, after bacterial breakdown in the colon, stimulates its mucous membrane, accelerating peristalsis, and promotes the accumulation of water and electrolytes in the lumen of the colon. the result is stimulation of defecation, reduction of transit time and softening of the feces. Pharmacokinetics. Following oral administration, sodium picosulfate reaches the large intestine without significant absorption. The active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane is formed after bacterial breakdown in the colon; the onset of action of Picolax usually occurs 6–12 hours after dosing, depending on the release of the active metabolite. After oral administration, a small amount of the drug can be detected in the organs and systems of the body.
The laxative effect of the drug does not correlate with the level of the active metabolite in the blood plasma.
Indications for use
Picolax is prescribed to patients in the following cases:
- atonic constipation caused by changes in diet, prolonged immobilization, severe general condition, fever , metabolic disorders and diseases of the cardiovascular system;
- preparation for surgical and gynecological operations, as well as instrumental studies;
- stool adjustments for hemorrhoids and fissures in the anus .
Contraindications for use
It is not recommended to use the medicine in any form if:
- increased individual sensitivity to the drug;
- obstructive intestinal obstruction , nausea , vomiting , abdominal pain of unknown etiology and complicated dehydration;
- acute surgical pathologies of the abdominal organs and after surgical interventions on the gastrointestinal tract.
- lactation, pregnancy.
Picolax drops are not prescribed for:
- fructose intolerance.
Tablets are contraindicated in patients suffering from:
- lactase deficiency, galactosemia and glucose-galactose malabsorption ;
- under the age of 10 years.
Caution must be exercised when treating patients suffering from hypokalemia , hypermagnesemia and elderly patients.
* Attention! Product packaging may differ from that shown in the photo.
Product description
Picolax (Picolaх) Composition of the medicinal product: active ingredient: sodium picosulfate; 1 tablet contains sodium picosulfate in terms of anhydrous substance 7.5 mg; excipients: lactose, monohydrate; potato starch; povidone; magnesium stearate. Dosage form. Pills. Tablets are white or almost white, with a biconvex surface. Name and location. Ukraine, 61105, Kharkov, st. Newton, 3. Pharmacotherapeutic group. Laxatives. Contact laxatives. Sodium picosulfate. ATC code A06A B08. Contact laxative. The active form of the drug, diphenol, is formed due to the biotransformation of sodium picosulfate in the large intestine under the influence of bacterial sulfotransferases. Stimulates receptors of the mucous membrane of the intestinal wall, enhances intestinal motility, accelerates the movement of intestinal contents. The use of the drug is not accompanied by tenesmus and intestinal spasms. After oral administration, it reaches the large intestine without significant absorption and does not undergo enterohepatic circulation. The laxative effect develops 6–12 hours after administration. A small amount of diphenol is detected in the systemic circulation and urine. The severity of the laxative effect does not correlate with the concentration of active diphenol in the blood plasma. Indications for use. Constipation or situations requiring easier bowel movements. Contraindications. Hypersensitivity to the components of the drug, obstructive intestinal obstruction, abdominal pain of unknown origin, nausea and vomiting of unknown origin, acute surgical pathology of the abdominal organs (acute appendicitis, ulcerative colitis, etc.), condition after surgery on the gastrointestinal tract, severe dehydration, pregnancy, breastfeeding, children under 10 years of age. Appropriate safety precautions for use. Like other laxatives, Picolax should not be taken daily for long periods of time. If you need to take laxatives every day, you should find out the cause of constipation. Long-term use of laxatives can lead to electrolyte imbalance and hypokalemia, as well as cause addiction and constipation due to the rebound effect. Special precautions. The drug contains lactose, which should be taken into account by persons with hereditary lactose intolerance. Use during pregnancy and lactation. The use of the drug during pregnancy is not recommended. During treatment with the drug, breastfeeding should be stopped. The ability to influence the reaction rate when driving a vehicle or working with other mechanisms. Does not affect. Children. The use of the drug in this dosage form is not recommended for children under 10 years of age. Method of administration and dose. Prescribed orally for adults and children over 10 years of age, 1 tablet (7.5 mg) in the evening before bed or in the morning. For severe and persistent constipation, adults are recommended to take 2 tablets (15 mg). The duration of treatment is determined individually and usually should not exceed 10 days. Overdose. Symptoms. Intestinal colic, diarrhea, water and electrolyte imbalance (hypokalemia, loss of other electrolytes and fluids), muscle weakness. Treatment. Discontinuation of the drug, gastric lavage, symptomatic therapy aimed at normalizing water and electrolyte balance and maintaining vital functions, antispasmodics if indicated. Side effects. With long-term use, the following are possible: abdominal pain, dyspeptic symptoms, diarrhea, development of dehydration and electrolyte imbalance. Interaction with other drugs and other types of interactions. When used simultaneously with diuretics and glucocorticoids, the risk of water and electrolyte disturbances, in particular hypokalemia, increases. Possible deterioration of tolerance to cardiac glycosides. Broad-spectrum antibiotics can reduce the laxative effect of sodium picosulfate. Best before date. 3 years. Do not use the drug after the expiration date indicated on the package. Storage conditions. Store in a dry place at a temperature not exceeding 25 ºС. Keep out of the reach of children. Package. 10 tablets in a blister; 1 or 3 blisters included in a pack.
Side effects
As clinical practice shows, Picolax is well tolerated by patients of various age groups. However, one should not exclude the development of such side effects as: indigestion, diarrhea , vomiting , nausea , intestinal colic , flatulence, pain in the anal area.
Also possible: headaches, sleep problems, cramps, severe fatigue, tremors, various allergic manifestations , and so on.
Long-term use of the drug contributes to addiction and the development of constipation , which causes a “ricochet” effect. To avoid the development of unwanted symptoms, it is recommended to take this drug once or for a short time.
Note!
Description of the drug Picolax table. 7.5 mg No. 10 on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
Instructions for Picolax (Method and dosage)
It should be noted that Picolax drops, instructions for use recommend taking them in the evening. For young patients, this form of the drug can be added to food. For precise dosing of the drug there is a special dispenser on the bottle. The duration of treatment and dosage are determined by the attending physician for each patient, taking into account his individual characteristics. As a rule, for adult patients and adolescents from 10 years of age, a daily dose of 13-27 drops is prescribed. Children aged 4-10 years are prescribed an average daily dosage of 7-13 drops of the drug. When treating children under 4 years of age, the dosage of the drug is calculated according to a special formula of 250 µg/kg per total weight of the child, that is, 2 drops of Picolax for every 3 kg of body weight - once a day.
For patients with cancer who are receiving treatment with opioid analgesics, the dosage of the drug is also calculated by the attending physician. In any case, it is not recommended to take the drops for more than 3 days in a row.
It is recommended to swallow Picolax tablets whole with liquid. The drug is prescribed for use in the morning or evening. The duration of the course of therapy and the dose of the drug are determined by the attending physician for each individual patient. For adult patients and adolescents over 10 years of age, the average daily dosage is 1 tablet. If necessary, the dose is increased to 2 pieces per day. The therapeutic course can last no more than 10 days.
Picolax drops for oral administration 7.5 mg/ml 30 ml No. 1
Name
Picolax drops daily approx. 7.5 mg 1 ml in 30 ml bottle in pack No. 1
Description
Transparent, colorless or yellowish, slightly viscous solution.
Main active ingredient
Sodium picosulfate
Release form
drops
Dosage
30ml
Pharmacological properties
Laxative medicine. The laxative effect develops after 6–12 hours.
Indications for use
For short-term use for constipation and diseases requiring relief of bowel movements.
Directions for use and doses
Adults. It is recommended to start taking the drug with a dose of 12-13 drops of Picolax® in water. If the effect is excessive, the dose must be reduced. If the laxative effect is insufficient, the dose can be increased. In cases of constipation, a dose of up to 24–32 drops of Picolax® (corresponding to 7.5–10 mg sodium picosulfate) in water is recommended. Children over 4 years of age should take 8–16 drops of Picolax® (corresponding to 2.5–5 mg sodium picosulfate) in water once a day. It is advisable to take Picolax® in the evening; the effect occurs the next morning. It is necessary to take enough fluid. Do not exceed the recommended dose. The optimal dose is the minimum dose sufficient to obtain the desired effect. Laxatives should be used as rarely as possible and for no more than seven days in a row. Prescribing laxatives for a longer period of time is possible only after a doctor has assessed the specific clinical situation.
Use during pregnancy and lactation
There are no clinical data on the use of sodium picosulfate during pregnancy. Since sodium picosulfate is a stimulant laxative, it is recommended for safety reasons not to use the drug during pregnancy. If you need to use the drug Picolax® during lactation, you should first consult with your doctor to assess the benefit/risk ratio.
Precautionary measures
Like all laxatives, Picolax® should not be prescribed daily or over a long period. Long-term or excessive use of the drug can lead to imbalance of fluid and electrolytes in the body and to hypokalemia. Patients taking Picolax® have reported dizziness and/or fainting. However, available information from such cases suggests that the fainting episodes were caused by straining to defecate or abdominal pain due to constipation, but were not associated with sodium picosulfate. Abuse of laxatives (private or long-term use or in excessive doses) can cause chronic diarrhea with subsequent loss of water, mineral salts (especially potassium) and other essential nutrients. In severe cases, dehydration or hypokalemia may develop, which can lead to cardiac dysfunction or neuromuscular diseases, especially in the case of concomitant use of cardiac glycosides, diuretics or corticosteroids. Abuse of laxatives, especially contact laxatives, can cause dependence (and therefore the need to gradually increase the dosage), chronic constipation and disruption of normal bowel function (intestinal atony). Treatment of chronic or recurrent constipation always requires consultation with a doctor for diagnosis, prescription of medications and monitoring during therapy. Consultation with a doctor is also necessary if there is a change in the frequency and other characteristics of bowel movements that last more than two weeks, and if there is no effect from the use of laxatives. Elderly patients or patients with underlying medical conditions should also consult a doctor before using the drug. The drug contains sorbitol and is not recommended for patients with hereditary fructose intolerance. Use in children The drug is contraindicated in children under 4 years of age. In children aged 4 to 12 years, the drug can be used only after consultation with a doctor. Effect of the drug on the ability to drive a car and use machinery. No studies have been conducted to assess the effect of the drug on the ability to drive a car or use machinery. Patients should be informed that they may experience dizziness or fainting during a parasympathetic vascular response (eg, abdominal cramps). If patients experience abdominal cramps, they should avoid potentially hazardous activities such as driving or operating machinery.
Interaction with other drugs
Broad-spectrum antibiotics, affecting the intestinal microflora, reduce the effectiveness of Picolax®. When used simultaneously with diuretics or corticosteroids, the likelihood of electrolyte disturbances increases. Electrolyte imbalance that occurs when taking Picolax® in large doses can lead to a deterioration in the tolerability of cardiac glycosides. Milk and antacids may alter the effect of the laxative: you should leave a gap of at least one hour before taking the laxative. Laxatives may reduce the absorption of other concomitantly taken orally administered drugs. The simultaneous use of laxatives and other medications is not recommended: after taking the drug, you must wait at least 2 hours before taking the laxative. Picolax® may increase the effect of oral anticoagulants and alter glucose tolerance.
Contraindications
Hypersensitivity to sodium picosulfate, triarylmethane derivatives or other components of the drug; narrowing of the intestinal lumen with impaired passage of intestinal masses, intestinal obstruction, acute abdominal conditions (for example, appendicitis); acute inflammatory diseases of the gastrointestinal tract; acute abdominal pain, accompanied by nausea and vomiting, as these symptoms may be manifestations of the above acute diseases; for diseases associated with water-electrolyte imbalance (for example, severe renal failure), the drug can only be used under medical supervision; children under 4 years of age; severe dehydration; pregnancy.
Compound
1 ml (24 drops) contains 7.5 mg of sodium picosulfate as an active ingredient. Excipients: sorbitol non-crystallizing solution, propylene glycol, purified water.
Overdose
Symptoms When taking the drug in large doses, watery stools (diarrhea), abdominal cramps, and clinically significant loss of potassium and other electrolytes may occur. When taking doses of the drug that are much higher than those recommended for normal constipation, ischemia of the colon mucosa may occur. As with any laxative, Picolax® may cause chronic diarrhea, abdominal pain, hypokalemia, secondary hyperaldosteronism and kidney stones when taken in high doses over a long period of time. Chronic and long-term use of laxatives causes renal tubular damage, metabolic alkalosis, and muscle weakness due to hypokalemia. Treatment In case of acute overdose within a short time after administration, absorption of the drug can be reduced or prevented by inducing vomiting or gastric lavage. If necessary, measures are taken to replace fluid losses and restore electrolyte balance. In some cases, it may make sense to use antispasmodics.
Side effect
The incidence of adverse reactions is indicated as: very often (? 1/10); often (from ? 1/100 to
Storage conditions
Store in a place protected from light at a temperature not exceeding 25 °C. Keep out of the reach of children.
Overdose
In case of an overdose of Picolax, patients may develop: diarrhea, pain in the abdomen, a decrease in the level of potassium in the blood and other disturbances in water and electrolyte balance.
Ischemia of the mucous membranes of the large intestine is also possible. If the drug is used in high dosages for a long time, patients may experience: chronic diarrhea, intestinal colic, hypokalemia , renal dysfunction, secondary hyperaldosteronism , urolithiasis and metabolic acidosis . Hypokalemia can lead to muscle weakness.
In such cases, gastric lavage, enterosorbents are usually prescribed, and further symptomatic therapy is carried out.
Reviews of Picolax
This drug is very popular among patients of various age groups. Therefore, reviews of Picolax can be found on medical forums where problems of digestion and gastrointestinal tract are discussed. In addition, users often say that they use this medicine to treat children. It is successfully used in the treatment of constipation during dysbacteriosis and other problems. Many people note its high effectiveness, which relieves intestines in a short time.
Quite often, this drug is used by patients suffering from chronic digestive disorders . Unfortunately, they often experiment with dosage or introduce additional agents. As a result, they develop side effects, mainly in the form of diarrhea. Therefore, experts recommend abandoning self-medication and strictly adhering to doctor’s prescriptions.
Picolax® (drops)
Features of application
Patients suffering from chronic constipation should undergo a complete diagnosis and determine the cause of constipation.
Prolonged and excessive use of the drug can lead to fluid and electrolyte imbalances and hypokalemia.
Discontinuation of Picolax may result in a return of symptoms. If Picolax has been used for chronic constipation for a long time, any return of symptoms may be more severe.
Cases of dizziness and/or syncope have been reported concurrently with the use of sodium picosulfate. Available information suggests that these phenomena are consistent with syncope during defecation (associated with the Valsalva maneuver) or are associated with a vasovagal response to abdominal pain.
Patients with rare hereditary fructose intolerance should not take this medicine because it contains sorbitol.
This medicinal product contains less than 1 mmol/dose sodium, which means it is practically sodium-free.
This medicinal product contains 2 mg sodium benzoate per 1 ml (30 mg sodium benzoate per 15 ml bottle, 60 mg sodium benzoate per 30 ml bottle).
Use during pregnancy or breastfeeding.
Pregnancy
No adequate clinical studies have been conducted in pregnant women. Animal studies have demonstrated reproductive toxicity of the drug when used in daily doses of 10 mg/kg and above. For safety reasons, Picolax should not be used during pregnancy if possible.
Breastfeeding period
Clinical data show that neither the active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM) nor its glucuronides are excreted in breast milk. Thus, Picolax can be used during breastfeeding.
Fertility
Clinical studies to evaluate the effect of the drug on fertility in humans have not been conducted.
Animal studies have shown no effect of the drug on fertility.
The ability to influence the reaction rate when driving vehicles or other mechanisms.
Studies of the effect on the ability to drive a car and operate other mechanisms have not been conducted. However, patients should be warned about the possibility of developing adverse reactions such as dizziness and/or syncope as a result of a vasovagal reaction (in particular abdominal spasm). If abdominal spasm occurs, the patient should avoid potentially hazardous activities such as driving or operating other machinery.
Picolax price, where to buy
In Moscow, the price of Picolax tablets starts from 49 rubles.
The drug in drops can be purchased at a price of 185 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
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