"Arthra" or "Arthra MSM Forte": the difference between the products and what to choose

Artra

The drug is available in tablets, which contain 500 mg of chondroitin sodium sulfate and glucosamine hydrochloride .

In addition to them, the medication contains the following inactive ingredients:

• MCC.
• E576.
• E468.
• E570.
• E341.

The shell is formed by the following components:

1. Titanium white.
2. E1518.
3. E464.

The drug is available in oval tablets, convex on both sides. They are covered with a white film shell, interspersed with a yellowish tint, and have the inscription “ ARTRA” . The tablets have a specific smell.

The drug activates the process of restoration of cartilage tissue and prevents its destruction. It takes part in the formation of connective tissue and has a moderate anti-inflammatory effect.

Glucosamine, taken orally, enhances the production of cartilage matrix and protects it from the negative effects of glucocorticoids and NSAIDs.

Chondroitin is the substrate from which healthy cartilage tissue is formed. It activates the formation of type II collagen fibers and proteoglycans. Chondroitin inhibits the activity of hyaluronidase and elastase, enzymes that break down the cartilage matrix. It is required for the viscosity of the synovium. It protects cartilage tissue from the dangerous effects of free radicals.

Chondroitin relieves symptoms of osteoarthritis and reduces the need to use non-steroidal anti-inflammatory drugs.

The bioavailability of glucosamine is only 25% . It quickly migrates to internal organs, most of all in the liver, kidneys and cartilage tissue. It is excreted primarily through urine; the half-life is 2 days 20 hours .

The bioavailability of chondroitin is 13% . Excreted by the kidneys. The half-life lasts 6 hours 10 minutes.

Description of the drug "Arthra"

The medication is available in tablet form. The composition of the drug includes:

• – sodium chondroitin sulfate (500 mg);
• – glucosamine hydrochloride.

The tablets have an oval shape, convex on the sides. There is a blotch on the white shell. Some tablets may have a yellowish color. On one side there is a stamp "ARTRA". The tablets also have a pleasant aroma.

The drug stimulates the restoration process in cartilage tissue and reduces the risk of its destruction. The active component stimulates the formation of tissue for compounds and has a moderate anti-inflammatory effect.

When glucosamine hydrochloride enters the body, it protects the cartilage matrix from the pathological effects of NSAIDs and glucocorticosteroids.

Chondroitin sulfate sodium is a substrate that is involved in the formation of healthy cartilage tissue. It stimulates the formation of collagen fibers and proteoglycans. It inhibits elastases, enzymes and hyaluronidases, which destroy the cartilage matrix. Chondroitin is needed to ensure synovial viscosity and protect tissues from the harmful effects of free radicals.

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The drug relieves the symptoms of osteoarthritis and reduces the need to use non-steroidal drugs with an anti-inflammatory effect.

The bioavailability parameters of glucosamine are 25%. Glucosamine quickly enters cartilage tissue, as well as internal organs (kidneys, liver). The medication is excreted through the bladder. It will take about 3 days for complete removal from the body.

The bioavailability parameters of chondroitin are 13%. The substance is excreted through the kidneys. The half-life is approximately 7 hours.

Artra MSM forte

Artra MSM Forte is available in tablets; their therapeutic effect is explained by the following medicinal components:

• Sodium hyaluronate contains 10 mg.
• Chondroitin sulfate sodium 400 mg.
• Glucosamine hydrochloride 500 mg.
• Methylsulfonylmethane (MSM) 1.3 g.

The medicine contains the following substances as additional components:

1. MCC.
2. Aerosil.
3. E576.
4. E341.
5. Stearic acid.
6. E468.

The shell includes the following components:

• E464.
• Titanium white.
• Syrup.
• E553b.
• E110.
• E1200.
• Medium chain triglycerides.

The drug is available in biconvex oval-shaped tablets, which are coated. Their color can vary from pale yellow-orange to dark orange. The drug has a specific smell.

The active substances of the drug slow down the progression of osteoarthritis , they suppress the destruction of cartilage tissue and promote its restoration. The medicine relieves pain and inflammation, improves blood supply to the subchondral bone plate.

Methylsulfonylmethane is an organic sulfur-containing compound. It is part of hormones and proteins such as collagen, elastin, keratin, and has an analgesic and anti-inflammatory effect.

Sodium hyaluronate is a homoglycoside from the group of acid glycosaminoglycans. It is part of the synovium; it is this substance that gives the viscoelastic properties of the synovial fluid. It forms a layer on the inner side that protects cartilage tissue and synovium from inflammatory mediators, free radicals and mechanical damage.

Comparison of addiction in Artra and Artra MSM forte

Like safety, addiction also involves many factors that must be considered when evaluating a drug.

So, the totality of the values ​​of such parameters as “o syndrome” in Arthra is quite similar to the similar values ​​in Artra MSM forte. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible. At the same time, in Artra the meaning of the “syndrome” is quite small, however, just like in Artra MSM fortya.

What do the drugs have in common?

There are many similarities between the drugs:

1. Both medications are used to treat osteoarthritis of the musculoskeletal system.
2. Medicines should be stored in a dry place, out of the reach of children, at a temperature of 10 to 30 degrees.
3. Both medications should not be taken if you are allergic to their composition, in patients under 15 years of age, in pregnant women or nursing children. They should be taken with caution if you are prone to bleeding, people with bronchial asthma and diabetes.
4. Both medications can cause allergies, bloating, indigestion, stool retention, and gastralgia.
5. Both chondroprotectors should be taken 1 tablet twice a day for 21 days, then 1 tablet once a day.
6. Medicines increase the absorption of tetracycline antibiotics, weaken the effect of semisynthetic penicillins, and can enhance the effect of fibrinolytic agents, indirect anticoagulants and antiplatelet agents.

How are the drugs similar?

The drugs "Arthra" and "Arthra MSM Forte" have common features:

• Medicines are prescribed to patients with osteoarthritis.
• It is recommended to store medications in a dry place. Temperature ranges from 10-30 degrees. Children should not reach the storage area.
• The drugs are not prescribed to patients with allergies to components, children under 14 years of age, pregnant and lactating women. If you have diabetes, bleeding, or asthma, special care must be taken.
• Medicines can provoke allergic reactions, diarrhea, constipation, and flatulence.
• Both drugs must be taken according to the same regimen. 1 tablet 2 times a day, then 1 tablet 1 time a day. The course of therapy is 21 days.
• Medicines stimulate the absorption of tetracycline-type antibacterial agents, inhibit penicillins of semi-synthetic origin, and enhance the effect of fibrinolytics, antiplatelet agents and anticoagulants.

Comparison and how they differ

Artra and Artra MSM forte have the following differences:

Both chondroprotectors can be purchased without a doctor's prescription, but self-medication with them is prohibited . Only the doctor must decide which medication is best individually for a particular patient, taking into account the severity of the pathological process and the presence of contraindications.

Medicine and healthComment

Results and discussion

Analysis of the results allowed us to establish a significant reduction in pain according to VAS in both groups (see figure, a). A decrease in pain intensity was noted by the end of the 1st month of therapy and persisted throughout the entire observation period. There were no differences between groups in WOMAC pain scores across visits.

Dynamics of pain assessment according to WOMAC (a) “get up and walk” test (b) and during treatment with ARTRA MSM and ARTRA.

Both drugs reduced stiffness after just 1 month of therapy; There were no differences in the dynamics of morning stiffness between the groups.

In terms of their effect on the functional state of the joints and the total WOMAC index, both drugs gave similar results: a decrease in indicators was noted in both groups from the second visit. The improvement was maintained in all components of the WOMAC index throughout the entire course of therapy, and the differences found within the groups were statistically significant.

Analysis of the “get up and go” test (time spent getting up from a chair and walking 5 m) showed a significant decrease in the time spent in both groups, however, in group M these differences reached statistical significance already on the second visit, and in group A - only on the third. Changes in this test already from the second visit in group M indicate a more rapid action of ARTRA MSM (see figure, b). This is confirmed by assessments of the effectiveness of treatment carried out by the patient and the doctor. These assessments, which were practically different and reflected a more rapid onset of a positive effect in group M: “significant improvement” and “improvement” were noted by 60% of patients already at the second visit, while in group A - only 38% of patients ( p

=0.02). From the third visit, there were no differences in the effectiveness of treatment between the groups.

When assessing EQ-5D, positive results were also obtained: a significant improvement in these indicators was observed from the third visit in both compared groups.

Tolerability of the drugs was very good, there were practically no adverse events.

Comparison of ease of use of Artra and Artra MSM forte

This includes dose selection taking into account various conditions and frequency of doses. At the same time, it is important not to forget about the release form of the drug; it is also important to take it into account when making an assessment.

The ease of use of Artra is approximately the same as Artra MSM Fortem. However, they are not convenient enough to use.

The drug ratings were compiled by experienced pharmacists who studied international research. The report is generated automatically.

Last update date: 2020-12-04 13:44:20

Comparison of side effects of Arthra and Arthra MSM forte

Side effects or adverse events are any adverse medical event that occurs in a subject after administration of a drug.

Arthra's state of adverse events is almost the same as Artra's MSM forte. They both have few side effects. This implies that the frequency of their occurrence is low, that is, the indicator of how many cases of an undesirable effect of treatment are possible and registered is low. The undesirable effect on the body, the strength of influence and the toxic effect of Artra are similar to Artra MSM Fortem: how quickly the body recovers after taking it and whether it recovers at all.