Pharmacodynamics and pharmacokinetics
This is a combined drug that has a vasodilator, analgesic and analgesic effect. A good antispasmodic, which determines the use of Andipal for blood pressure.
Metamizole sodium, which is part of the composition, reduces body temperature and relieves pain. Once in the gastrointestinal tract, the substance is well and quickly absorbed and blocks the prostaglandin system of arachidonic acid, increasing the sensitivity threshold of pain centers in the hypothalamus .
Papaverine hydrochloride dilates blood vessels (reduces the level of calcium in cells) located on the periphery and significantly reduces the overall tone of the smooth muscles of the surface of internal organs.
Bendazole is an antispasmodic, dilates blood vessels, stimulates the spinal cord, and restores nerve endings in the periphery.
Phenobarbital exhibits its sedative properties and enhances the effects of other components of the drug.
Pharmadynamics and pharmacokinetics
Andipal begins to act 15 minutes after administration. This is due to the fact that the active components of the drug are quickly absorbed into the blood. The condition of a person with high blood pressure is normalized by improving cerebral circulation and stopping the release of adrenaline.
Analgin, entering the body, helps reduce the pain symptoms of migraines. The substance also reduces the severity of swelling in soft tissues, which provokes an increase in body temperature.
Papaverine eliminates spasms of smooth muscles in the digestive organs and in the walls of blood vessels. By dilating the arteries, blood flow improves.
Dibazol reduces heart rate and normalizes breathing. Phenobarbital in the drug has a sedative effect on the cells of the central nervous system.
Indications for use of Andipal. What does it help with?
Andipal tablets, what are they for?
- Indications for the use of the drug are migraines of various types.
- Pain associated with spasms of cerebral vessels in the head.
- The medicine helps against pain caused by spasms of smooth muscles or internal organs of the gastrointestinal tract.
- For mild forms of hypertension, it can be used as blood pressure pills.
What blood pressure should I take the medicine for? For primary or secondary hypertension, Andipal can be taken for high blood pressure.
Contraindications to the use of Andipal
It is necessary to stop using the drug if you are prone to hypotension, habitual low blood pressure, individual intolerance to metamizole or other components, blood disorders, severe chronic liver diseases, cirrhosis, intestinal obstruction.
Andipal is prohibited for use during pregnancy and breastfeeding. It should not be given to children under 14 years of age.
Neglect of contraindications or overdose of the drug causes increased side effects and intoxication. Possible signs of poisoning:
- severe headache;
- impaired coordination of movements;
- nausea, vomiting, pain in the epigastric region;
- vascular collapse;
- angioedema;
- skin itching, urticaria.
Negative reactions are possible within a few minutes after taking the medicine or within several days while therapy is continued.
Contraindications
- Acute increased sensitivity to the constituent substances of the drug (especially pyrazolone).
- For glucose-6-phosphate dehydrogenase deficiency, various blood diseases, porphyria.
- Severe dysfunction of the kidneys and liver, tachyarrhythmia , angina pectoris, intestinal obstruction .
The use of the drug is contraindicated for children under 8 years of age during lactation.
Side effects
According to the annotation: constipation , nausea , various allergic reactions ( conjunctivitis , urticaria, Quincke's edema ), nephritis , red urine , drowsiness , increased sweating .
With long-term use, agranulocytosis , leukopenia , and thrombocytopenia .
Before use, you should consult your doctor.
Doctor's recommendations online
When taking Andipal for blood pressure, a rapid therapeutic effect is observed. Its effectiveness is evidenced by reviews from patients suffering from hypertension. Before using the product, you must ensure that there are no contraindications. If you take the medicine for hypotension or to relieve a hangover, you can get negative consequences in the form of nausea, weakness and an allergic reaction. The medication is suitable for one-time or short-term use. For course treatment, Andipal is taken only with the consent of the doctor, since it affects the composition of the blood and is addictive.
Instructions for use of Andipal (Method and dosage)
How to use the drug? Inside. Adults should take 1-2 tablets 2-3 times a day. The full course of treatment should take 7-10 days.
Before taking the medicine, consult your doctor. The course of treatment should be prescribed by a specialist, depending on the nature of the disease and its course. It is not recommended to take the drug for more than 10 days.
How to take if you have high blood pressure? Does Andipal increase or decrease blood pressure?
The drug has a hypotensive effect and is used for high blood pressure. Cannot be used for hypotension, this can lead to harmful changes in the brain.
At what pressure is the drug used?
Andipal can only be taken with high blood pressure. The drug does not treat hypotension and does not eliminate the causes of the pathology. The main effect of consuming the drug is a decrease in the intensity of symptoms accompanying high blood pressure. For this reason, Andipal is considered as an emergency drug.
The maximum level at which taking the medication is justified is 160 mmHg. At higher levels, it is not recommended to consume Andipal. This is due to the effect of bendazole in the tablets. The substance first increases blood pressure and then lowers it.
Interaction
The use of astringents, enveloping agents and activated carbon reduces absorption in the gastrointestinal tract.
When combined with other antispasmodics and sedatives, the hypotensive effect of the drug is enhanced. diabetes medications increases . Enhances the effect of glucocorticosteroids , Indomethacin and ethanol . Reduces the concentration of cyclosporine in the blood.
Inducers of microsomal liver enzymes ( barbiturate , phenylbutazone ), analeptics ( camphor , Cordiamin ), tonics ( Eleutherococcus , ginseng root) reduce the effectiveness of the drug.
Patient reviews
Alexander 34 years old . “The drug is well suited for slightly elevated blood pressure, but for people whose blood pressure rises to 200 mm Hg. he won't help. The product saves me from headaches and nausea that occurs after overwork or drinking coffee. I recommend that people who are taking medicine for the first time consult a doctor. The undeniable advantage of the medicine is its cost.”
Stanislav is 54 years old . “I took Andipal in the initial stages of the development of hypertension, when the pressure rose to 140-160 mm Hg. Art. Over time, the drug stopped helping, since the tablets only slightly lower blood pressure and are addictive if used frequently. I believe that the medicine is suitable for young people who do not suffer from chronic hypertension. For people with gastrointestinal diseases, it is better to give preference to other medications, since Andipal negatively affects the mucous membranes of the intestines and stomach.”
Elena is 41 years old . “My parents have been drinking Andipal since 2010. Recently, the drug has stopped helping due to the fact that addiction to its components has occurred. During treatment, parents noted a side effect – nausea.”
Svetlana, 36 years old . “I had to take Andipal while on vacation. After drinking whiskey I had a severe headache. I drank the drug at risk to my health, since the medicine is not compatible with alcohol. Fortunately, there were no adverse reactions. I advise anyone who is planning to undergo a course of medication to consult a doctor first. This medicine has many side effects."
Tatyana, 38 years old . To take the drug as an antipyretic or analgesic, it is necessary to control the blood pressure level. The product is not suitable for people suffering from low blood pressure. These tablets help me with hypertension associated with changing weather or stress. Among the main advantages I can note the low cost. The only drawback of the product is the lack of instructions for use.
special instructions
With long-term use of Andipal, the overall picture of peripheral blood should be monitored.
It is recommended to be careful and vigilant when working with mechanisms, due to the fact that the drug significantly affects the change in the reaction rate.
Does the medicine lower or increase blood pressure?
The medicine lowers blood pressure.
At what pressure should Andipal be taken?
With high blood pressure.
Andipal should be used as a medicine for blood pressure after consulting a doctor.
Adverse reactions
Therapy with Andipal can cause:
- allergic skin rashes;
- feelings of drowsiness;
- liver dysfunction.
After taking Andipal, it is not recommended to drive a vehicle or perform work that requires increased concentration.
Among the side effects of the drug are:
- blood thinning;
- development of a depressive state;
- depression of the nervous system;
- decreased motor activity.
Due to numerous adverse reactions, Andipal is not recommended for use as a pain reliever. For this purpose, drugs with a milder therapeutic effect are selected.
In case of an overdose of the drug, the following is observed:
- drowsiness;
- dizziness;
- collptoid state.
Analogues and substitutes
Level 4 ATC code matches:
Analdim
Reopirin
Tempalgin
Spazgan
Benalgin
Pentalgin ICN
Pentalgin N
Pentalgin
Analgin
Renalgan
Tetralgin
Spasmalin
Maxigan
Sedal-M
Piralgin
Baralgin M
Sedalgin Plus
Baralgetas
Revalgin
The drug has no analogues in terms of its main active ingredient.
Analogs for antispasmodic effect:
- Nomigren
- Papazol-UBF
- Papazole
- Urolesan
- No-Shpalgin
- Unispaz
- Teodibaverin
Price for Andipal
Andipal tablets in Russia will cost about 40 rubles per pack of 20 pieces.
In Kyiv pharmacies the price of tablets will be about 20 UAH. for 10 pcs.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Andipal Avexima tablets 10 pcs. UNDEFINED
63 rub. order - Andipal avexima tab. n20 LLC Avexima Siberia
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- Andipal tablets 20 pcs. PharmstandardPharmstandard-Leksredstva OJSC
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Pharmacy Dialogue
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- Andipal Avexima tablets No. 20 Anzhero-Sudzhensky chemical-f.z.
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Pharmacy24
- Andipal forte No. 100 tablets PAT Monfarm, Ukraine
154 UAH.order - Andipal V No. 10 tablets PAT Monpharm, Ukraine
16 UAH order
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17 UAH order
- Andipal-V No. 100 tablets PAT Monpharm, Ukraine
152 UAH order
PaniPharmacy
- Andipal tablets Andipal B tablet. No. 10 Ukraine, Monfarm JSC
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- Andipal-Forte tablets Andipal-Forte tablets. No. 10 Ukraine, Monfarm JSC
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Composition and release form
Andipal is available in the form of round tablets of white or yellowish color. There are distinctive marks on the surface of the tablets. At the pharmacy, the drug is sold in cardboard or paper packages containing 10 tablets of the drug.
1 pill contains the following active ingredients:
- analgin – 0.25g;
- dibazol – 0.02 g;
- papaverine – 0.02 g;
- Phenobarbital – 0.02 g.
Among the auxiliary components of the medication are:
- potato starch – 47.7 mg;
- talc – 9.25 mg;
- stearic acid – 2.9 mg.
