Among the effective antipyretic and painkillers, the drug “Upsarin Upsa” stands out. This is a fast-acting medicine based on acetylsalicylic acid. Eliminates pain in the head, joints, teeth, muscles, helps normalize body temperature. Approved for use by adults and children over 15 years of age. The medicine is inexpensive and accessible; you can buy it at any pharmacy; you don’t need to present a prescription.
Effervescent “Aspirin Upsa”: composition, pharmacology
The drug is produced in the form of tablets, highly soluble in water. They are called effervescent because when mixed with liquid they actively release bubbles of carbon dioxide. The active component of the product is organic acetylsalicylic acid. The following are used as excipients: aspartame, sodium in the form of anhydrous carbonate and bicarbonate, citric acid, sulfur in the form of dioxide and others.
The drug acts as an analgesic and antipyretic, inhibits inflammatory processes. It dissolves in water, resulting in the formation of a buffer solution that does not precipitate in the highly acidic environment of gastric juice.
Tablets are stored in a temperature range from 15 to 25 degrees Celsius, excluding access to sunlight. Must be kept away from children. The general shelf life is 3 years from the date of production.
General description:
Helps quickly against colds, headaches and fevers - with extra vitamin C.
Whether your pain is due to a cold, headache or fever, you will get help quickly ASPIRIN plus C forte Thanks to the fast-dissolving effervescent tablets, the active ingredient is activated in water and can quickly and effectively combat pain and fever.
Aspirin Plus C Forte contains twice the active ingredient compared to regular Aspirin Plus C. You can fight pain even more effectively! Thanks to its effervescent composition, the active ingredients of Aspirin Plus C Forte can be absorbed very quickly by the body, ensuring a rapid onset of action.
The vitamin C contained in Aspirin Plus C Forte may help strengthen the immune system and support the body's defenses. The body's defenses require ascorbic acid to effectively fight pathogens such as viruses. Therefore, vitamin C stimulates the formation of special protective cells and increases their activity.
In addition, Aspirin Plus C forte contains so-called buffer substances, which are guaranteed to improve the solubility of the active ingredient.
Result: recovery is much faster!
For use for pain in the neck, head and limbs
Indications and contraindications
Tablets are indicated for use in the presence of the following diseases and disorders:
- pain in muscle tissue;
- joint pain;
- toothaches;
- headaches;
- symptoms of neuralgia;
- pain during menstruation;
- sharp pain in the thoracic spine;
- migraine;
- high body temperature (the medicine is used to treat adults and children over 15 years of age).
In some cases, taking Upsarin Upsa is contraindicated:
- children under 14 years of age inclusive;
- hypersensitivity to any drug substances;
- bronchial asthma;
- pregnancy (during the 1st and 3rd trimesters);
- breastfeeding (entire period);
- ulcers of the digestive system (exacerbation period);
- internal bleeding in the stomach and/or intestines;
- malabsorption of galactose, glucose;
- lack of vitamin K;
- combination with drugs such as methotrexate and oral anticoagulants.
Take pills with caution in the following cases:
- gout;
- ulcerative formations in the digestive organs;
- urate type nephrolithiasis;
- allergies to medications;
- pregnancy at the stage of the second trimester;
- combination with other drugs containing acetylsalicylic acid or methotrexate;
- hypermenorrhea;
- simultaneous combination with anticoagulants.
In these cases, a preliminary consultation with a doctor is indicated. If side effects occur, a change in therapy may be necessary.
Indications:
Mild to moderate pain, such as: headache, toothache, menstrual pain, pain symptoms associated with colds (for example, sore throat, head and limbs), fever.
- Treats severe colds (sore throat, head and body) and fever
- Has anti-inflammatory properties
- High dose of vitamin C
Thanks to the effervescent composition, the active ingredients are released in a short time and are quickly absorbed by the body - this is a necessary condition for a rapid onset of action.
Side effects
Side effects are rare; they can occur in different organ systems:
- nausea, vomiting;
- bleeding in the stomach and/or intestines;
- painful sensations in the abdomen;
- diarrhea;
- loss of appetite;
- ulcers in the stomach;
- headaches;
- tinnitus;
- dizziness;
- skin rashes;
- bronchospasm;
- attack of bronchial asthma;
- bleeding in the gums;
- slowing down blood clotting processes;
- nasal polyposis.
Is it safe to take aspirin every day?
The US Food and Drug Administration (FDA) does not recommend using aspirin every day to prevent heart attacks and strokes. However, in some cases, the risk of heart attack and stroke may be much greater than the risk of side effects associated with aspirin use.
But in any case, you need to discuss the consequences of taking this drug with your doctor.
Recent changes to the USPSTF guidelines state that patients should decide to take aspirin only after discussing the benefits and risks of the drug with their doctor. The organization suggests that taking low-dose aspirin as a measure to prevent cardiovascular disease may have a negative effect on people of a certain age.
Taking aspirin daily as a preventative measure may not be effective in those aged 40–59 years.
One study also suggests that one-time use of the drug may be as effective as regular use.
Thus, a 2021 study published in the European Journal of Clinical Research analyzed the effects of aspirin when taken regularly and intermittently for the prevention of cardiovascular disease. The study included 1,720 pairs of patients who took aspirin daily or occasionally between 1997 and 2000. Scientists recorded 25 cases of bleeding and 67 cases of stroke in volunteers who regularly took the drug, while in patients of the second group the number of cases was 69 and 100, respectively.
At the same time, the researchers monitored the development of cancer in the experiment participants. In those who periodically took aspirin, 32 cases of cancer were identified, and in patients who constantly took the drug, 26 cases were recorded. The scientists concluded that long-term, regular use of aspirin was not significantly more effective than intermittent use of the drug in preventing heart attack and stroke.
Those who take aspirin for preventive purposes have something to think about. Is Aspirin Really Necessary for Your Health? Will it do more harm than good?
Instructions for use "Upsarin Upsa"
You need to take 1 or 2 tablets at a time, dissolving them completely in a glass/half glass of water. Dosage depends on age:
- Children over 15 years of age and adults take 1 tablet up to 6 times a day. If the temperature is high or the pain is severe, take 3 tablets at a time up to 3 times a day. In this case, a minimum interval between procedures of 4 hours is required.
- Elderly patients take 1 tablet up to 4 times daily. If the pain is severe or there is a high temperature, take 2 tablets at a time. In this case, a minimum interval of 4 hours must also be maintained. Moreover, for elderly patients the maximum daily dose of the drug is 4 tablets.
Acetylsalicylic acid + Ascorbic acid (Acidum acetylsalicylicum + Acidum ascorbinicum)
Acetylsalicylic acid
Absorption is complete and fast. During absorption, it undergoes presystemic elimination in the intestinal wall and in the liver (deacetylated). The half-life of the drug is 15-20 minutes; it is quickly hydrolyzed to salicylates (in the gastrointestinal tract, liver and blood). It circulates in the body (75-90% in connection with albumin) and is distributed in tissues in the form of salicylic acid anion. Cmax is reached in approximately 2 hours. During biotransformation in the liver, metabolites are formed that are found in many tissues and urine. Excretion of salicylates occurs primarily through active secretion in the renal tubules in unchanged form and in the form of metabolites. The excretion of unchanged substances and metabolites depends on the pH value of urine (with alkalinization of urine, the ionization of salicylates increases, their reabsorption worsens and excretion increases significantly).
Ascorbic acid
When administered orally, it is rapidly absorbed, sufficient concentration in the blood is observed after 30 minutes, maximum after 2 hours. Part of the drug is absorbed in the stomach, most of it in the small intestine. With an increase in dose to 200 mg, up to 140 mg (70%) is absorbed; with a further increase in dose, absorption decreases (50-20%). Communication with plasma proteins - 25%. The normal concentration of ascorbic acid in plasma is approximately 10-20 mcg/ml, and body stores are about 1.5 g when taking daily recommended doses and 2.5 g when taking 200 mg per day. TCmax after oral administration is 4 hours.
Easily penetrates into leukocytes, platelets, and then into all tissues; the highest concentration is achieved in the glandular organs, leukocytes, liver and lens of the eye; deposited in the posterior lobe of the pituitary gland, adrenal cortex, ocular epithelium, interstitial cells of the seminal glands, ovaries, liver, spleen, pancreas, lungs, kidneys, intestinal wall, heart, muscles, thyroid gland; penetrates the placenta.
Metabolized primarily in the liver into deoxyascorbic acid and further into oxaloacetic and diketogulonic acids.
It is excreted by the kidneys, through the intestines, with sweat, and breast milk in the form of unchanged ascorbate and metabolites.
When high doses are prescribed, the rate of elimination increases sharply. Smoking and drinking ethanol accelerate the destruction of ascorbic acid (conversion into inactive metabolites), sharply reducing reserves in the body.
Excreted during hemodialysis.
Absorbed in the duodenum, partially in the ileum (absorption decreases with increasing dose). F - 20-50% (when taking a dose exceeding 200 mg). Reserves in the body are about 1.5 g. Depot: leukocytes, platelets, endocrine glands, liver, ocular epithelium, lungs, kidneys, intestinal wall, heart, muscles. Communication with plasma proteins - 25%. Biotransformation in the liver. Elimination by the kidneys (in the form of metabolites).
special instructions
With long-term use of Upsarin Upsa, the development of Reye's syndrome is possible. It is accompanied by liver failure, severe vomiting, liver distention and acute encephalopathy. It is worth considering that acetylsalicylic acid delays the excretion of uric acid. Therefore, in some cases, an attack of gout cannot be ruled out.
After long-term treatment with the drug, it is recommended to donate blood and feces for general tests. If surgery is planned, stop taking Upsarin Upsa a week before.
What is aspirin?
Aspirin was discovered in 1853; until 1897, it was used for medical purposes only in powder form. In 1915, the small white aspirin tablets that we still use today were introduced.
The active component in aspirin, acetylsalicylic acid, was originally isolated from the bark of the willow tree. Did you know that this same ingredient is present in beans, peas, jasmine and clover?
In ancient Egypt, willow bark was used to relieve pain long before the benefits of acetylsalicylic acid were discovered.
Other ingredients in aspirin include cornstarch, hypromellose, cellulose powder, triacetin (a solvent), and carnauba wax.
Taking aspirin regularly is recommended for three reasons:
- to relieve pain and inflammation
- to prevent heart attack and stroke
- to fight fever
Data suggest that aspirin as a preventive therapy may be indicated for people with a medical history of heart attack, chest pain, and ischemic stroke. Aspirin is also used to reduce the risk of developing cancer, particularly colorectal cancer.
The production of this drug amounts to about 120 billion tablets per year, making it one of the most popular drugs in the world.
You might be wondering why so many people take aspirin regularly? The study suggests that regular aspirin use is often recommended for men aged 45 to 79 and women aged 55 to 79 to prevent heart attacks and strokes.
Aspirin reduces the amount of prostaglandins, hormone-like substances that control the body's inflammatory responses and processes such as blood flow and blood clot formation. Thus, the drug reduces the risk of heart attack and stroke, which are often the result of a blood clot in the coronary arteries or vessels.
Taking aspirin irregularly will not help to cope with this problem, but using the medicine every day for a long time can cause many side effects and complications.
Cases of overdose
The main symptoms of overdose include:
- severe pain in the head;
- hearing and vision problems;
- dizziness;
- nausea and vomiting;
- respiratory failure;
- depressed state of consciousness, rarely - coma.
Symptomatic treatment is indicated; in extreme cases, you should immediately seek emergency medical help.
Interaction with other drugs
If you regularly take aspirin, it is important to consult your doctor about possible drug interactions with other medications, vitamins, or dietary supplements.
The way aspirin works can be affected by:
- arthritis medications
- medications to treat symptoms of chronic gout
- drugs to normalize blood pressure
- medications that thin the blood and fight blood clots
- steroids
- anticonvulsants
Some people are more sensitive to complications associated with long-term use of aspirin. For this reason, they should not take this drug daily, especially in large quantities. People at risk of developing complications include people who suffer from the following diseases:
- heart failure
- kidney and liver diseases
- asthma
- stomach ulcers
- bleeding, bleeding disorders, blood clots
- uncontrolled hypertension
- diabetes
People who are allergic to aspirin or other NSAIDs, and people who have asthma with nasal polyps and rhinitis should never take aspirin. An allergic reaction to aspirin typically results in a rash, facial swelling, wheezing, and even anaphylactic shock.
It should also be avoided if you drink more than three alcoholic drinks a day. The medicine is not recommended for women during pregnancy and breastfeeding without a doctor's recommendation.
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