Pharmacodynamics and pharmacokinetics
The therapeutic effect is achieved through the interaction of Flukold's components.
Paracetamol inhibits cyclooxygenase, which leads to decreased production of prostaglanins , arachidonic acid, thromboxane and prostacyclins . It is a non-narcotic analgesic . It has a slight anti-inflammatory effect, but a pronounced antipyretic and analgesic effect. Reduces the level of prostaglandins in the central nervous system, in the thermoregulation center of the hypothalamus.
Phenylpropanolamine and chlorpheniramine eliminate swelling of the nasal mucosa, fight rhinorrhea and facilitate breathing through the nose.
Chlorpheniramine blocks H1-histamine receptors and has an anticholinergic and sedative effect.
Caffeine is an antipsychotic ; it enhances the therapeutic effect of NSAIDs, improves memory, attention, improves performance, and stimulates the activity of the central nervous system.
Flukold is absorbed into the gastrointestinal tract, metabolites are excreted in the urine. The components of the drug pass through the hematoplacental and blood-brain barriers and enter breast milk.
Flucoldex 100ml syrup for children nabros pharma
pharmachologic effect
Combined drug.
Paracetamol blocks COX only in the central nervous system, affecting the centers of pain and thermoregulation. The lack of influence of paracetamol on the synthesis of prostaglandins in peripheral tissues determines the absence of a negative effect on water-salt metabolism (retention of sodium and water ions) and the gastrointestinal mucosa.
Chlorphenamine is a histamine H1 receptor blocker. Prevents the development and facilitates the course of allergic reactions. It has antiallergic, antipruritic, antiexudative effects. Reduces capillary permeability, prevents the development of tissue edema, relieves spasm of smooth muscles. Has a suppressive effect on the central nervous system.
Composition and release form Flucoldex 100ml syrup for children nabros pharma
Syrup - 5 ml: paracetamol 125 mg, chlorphenamine maleate 2 mg.
100 ml - polymer bottles (1) complete with a measuring cup - cardboard packs.
Directions for use and doses
Inside.
Indications for use Flucoldex 100ml syrup for children nabros pharma
Feverish syndrome (colds and infectious diseases); pain syndrome (mild and moderate severity): arthralgia, myalgia, neuralgia, migraine, toothache and headache, algodismenorrhea; pain from injuries, burns; sinusitis; rhinorrhea (acute rhinitis, allergic rhinitis).
Contraindications
Hypersensitivity; deficiency of glucose-6-phosphate dehydrogenase; liver and/or kidney failure. With caution Congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), alcoholism, angle-closure glaucoma, prostatic hyperplasia, pregnancy, lactation; old age, children's age (up to 12 years).
Use of Flucoldex 100ml syrup for children nabros pharma during pregnancy and breastfeeding
With caution: during pregnancy and lactation (breastfeeding).
Use in children
With caution: children's age (up to 12 years).
special instructions
For hyperthermia lasting more than 3 days and pain lasting more than 5 days, consult a doctor.
Paracetamol distorts laboratory results when quantifying the content of sugar and uric acid in plasma.
During the treatment period, it is necessary to refrain from drinking ethanol (hepatotoxic effects may develop).
Impact on the ability to drive vehicles and machinery
During the treatment period, it is necessary to refrain from driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Side effects of Flucoldex 100ml syrup for children nabros pharma
Systemic reactions: allergic reactions (skin rash, itching, urticaria, angioedema),
From the digestive system: nausea, epigastric pain, dry mucous membranes of the mouth, nose, throat.
From the organ of vision: mydriasis, paresis of accommodation, increased intraocular pressure.
Laboratory parameters: hemolytic anemia, aplastic anemia, methemoglobinemia, thrombocytopenia, agranulocytosis, pancytopenia.
From the urinary system: nephrotoxicity (renal colic, glycosuria, interstitial nephritis, papillary necrosis), urinary retention.
Drug interactions
Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxications even with a slight overdose.
Long-term use of barbiturates reduces the effectiveness of paracetamol.
Ethanol contributes to the development of acute pancreatitis.
Microsomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxicity.
Paracetamol reduces the effectiveness of uricosuric drugs and increases the effect of indirect anticoagulants.
Long-term combined use of paracetamol and other NSAIDs increases the risk of developing “analgesic” nephropathy and renal papillary necrosis, and the onset of end-stage renal failure.
Simultaneous long-term administration of paracetamol in high doses and salicylates increases the risk of developing kidney or bladder cancer.
Diflunisal increases the plasma concentration of paracetamol by 50% - the risk of developing hepatotoxicity.
Myelotoxic drugs increase the manifestations of hematotoxicity of the drug.
Side effects
Flukold is well tolerated. Side effects are rare.
Gastrointestinal tract: dyspeptic disorders, epigastric pain, dry mouth , stool disorders.
Cardiovascular system: Increased blood pressure, thrombocytopenia, leukopenia, cardiac arrhythmia, neutropenia, methemoglobinemia .
Central nervous system: limb tremor , migraine , increased excitability, sleep disturbance, emotional lability, dizziness.
Allergy.
Pharmacological properties of the drug Flucoldex
Flucoldex is a combination drug. The analgesic effect of paracetamol includes effects on the central and peripheral nervous system. The antipyretic effect is mediated by the effect on the regulatory centers of the hypothalamus. Caffeine has a stimulating effect on the central nervous system, mainly on the cerebral cortex, respiratory and vasomotor centers, increases mental and physical performance, reduces drowsiness, a feeling of fatigue and weakens the effect of central nervous system depressants. Caffeine has a pronounced effect on the cardiovascular system: it increases strength and increases heart rate, blood pressure during hypotension, and has a moderate diuretic effect. Increases the secretion of gastric glands. Phenylpropanolamine hydrochloride, an α-adrenergic active compound without irritating effects on the central nervous system, has a predominantly direct effect on adrenergic receptors. Often included in combination medications to reduce the severity of cold symptoms. Chlorpheniramine maleate is an antiallergic agent, a blocker of histamine H1 receptors. Shows a moderate sedative effect and has antimuscarinic activity. Flucoldex is a multicomponent drug. The effect of the drug is the cumulative effect of its components, so pharmacokinetic observations are impossible; the dynamics of all components cannot be studied using markers or biological methods.
Instructions for use of Flukold (Method and dosage)
Flukold N tablets, instructions for use
Do not chew the Flucold tablet, swallow it whole, and wash it down with water.
The drug is taken three times a day, 1 tablet.
At least 4 hours should pass between doses.
No more than 4 tablets per day, no longer than a week.
Flukold sachets, instructions for use
The contents of the sachet are dissolved in water.
Take three times a day, but not more than once every four hours.
No more than 4 sachets per day.
The course of treatment should be no more than 3 days.
Flukold-N tablets for colds and flu, 12 pcs.
Symptoms of paracetamol overdose. Pallor, nausea, vomiting, anorexia and abdominal pain appear in the first 24 hours. When taking large doses, disorientation, agitation, dizziness, sleep disturbances, heart rhythm disturbances and pancreatitis may occur. In rare cases, acute renal failure with tubular necrosis has been reported, manifested by lumbar pain, hematuria, proteinuria; nephrotoxicity (renal colic, interstitial nephritis).
In severe poisoning, liver failure can progress to encephalopathy, hemorrhage, hypoglycemia, coma, and death.
Use of 10 g or more of paracetamol in adults, especially simultaneously with alcohol, and more than 150 mg of paracetamol per 1 kg of body weight in children can lead to hepatocellular necrosis with the development of encephalopathy, hepatic coma and death. The first clinical signs of hepatonecrosis may appear 12-48 hours after an overdose. Impaired glucose metabolism and metabolic acidosis may occur.
Cardiac arrhythmia and pancreatitis were also noted.
With long-term use of the drug in large doses, the hematopoietic organs may develop aplastic anemia, pancytopenia, agranulocytosis, neutropenia, leukopenia, thrombocytopenia. When taking large doses, the central nervous system causes dizziness, psychomotor agitation and disorientation; from the urinary system - nephrotoxicity (renal colic, interstitial nephritis, capillary necrosis).
In case of overdose, emergency medical care is required. The patient should be taken to hospital immediately, even if there are no early symptoms of overdose. Symptoms may be limited to nausea and vomiting or may not reflect the severity of overdose or the risk of organ damage. Treatment with activated charcoal should be considered if an excessive dose of paracetamol has been taken within 1 hour. Plasma concentrations of paracetamol should be measured 4 hours or later after administration (earlier concentrations are not reliable). Treatment N-acetylcysteine can be applied within 24 hours after taking paracetamol, but the maximum protective effect occurs when it is used within 8 hours after administration. The effectiveness of the antidote decreases sharply after this time. If necessary, the patient should be administered N-acetylcysteine intravenously according to the established list of doses. In the absence of vomiting, oral methionine can be used as an appropriate alternative in remote areas outside the hospital.
In case of an overdose of phenylephrine hydrochloride, hyperhidrosis, psychomotor agitation or depression of the central nervous system, headache, dizziness, drowsiness, impaired consciousness, arrhythmias, tremor, hyperreflexia, convulsions, nausea, vomiting, irritability, anxiety, and arterial hypertension occur.
In case of an overdose of chlorpheniramine maleate, atropine-like symptoms may be observed: mydriasis, photophobia, dry skin and mucous membranes, increased body temperature, intestinal atony. CNS depression is accompanied by respiratory disorders and disturbances in the functioning of the cardiovascular system (decreased heart rate, decreased blood pressure to vascular insufficiency).
Large doses of caffeine can cause pain in the epigastric region, vomiting, diuresis, rapid breathing, extrasystole, tachycardia or cardiac arrhythmia, effects on the central nervous system (dizziness, insomnia, nervous agitation, irritability, state of passion, anxiety, tremor, convulsions). Clinically significant symptoms of caffeine overdose are also associated with liver damage from paracetamol.
Treatment. During the first 6 hours after a suspected overdose, it is necessary to perform gastric lavage followed by hospitalization of the patient.
During the first 8 hours after an overdose - the use of methionine orally or the introduction of cysteamine or N-acetylcysteine; symptomatic therapy; for severe arterial hypertension - the use of α- and β-blockers.
Interaction
Ascorbic acid, codeine , propyphenazone , scopolamine enhance the therapeutic effect of the drug Flukold.
Ethanol, sedatives, tricyclic antidepressants, barbiturates increase the half-life of the drug.
It is not recommended to combine with drugs that contain paracetamol.
Flukold's analogs
Level 4 ATC code matches: Phenacetin
Combiflu
Chlorphenamine
Coldflu
Calpol
Fervex
Panadol Extra
Panadol for children
Panadol
Solpadeine
Efferalgan
Milistan
Coldrex Maxgripp
Coldrex Hotrem
Coldrex
AntiGrippin
Unispaz
Pentalgin Plus
Rapidol
Maxicold
Analogs include: Coldrex , Adjicold , Lorcold , Neogrip , Radicold .
Flukold price, where to buy
200 tablets of Flukold N cost about 450 hryvnia in Ukraine.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
ZdravCity
- Flucoldex forte tab.
12 pcs Nabros Pharma Pvt Ltd RUB 135 order
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Pharmacy24
- Flukold-N No. 200 tablets Nabros Pharma Pvt. Ltd., India
741 UAH order
