Interaction
Paracetamol reduces the effectiveness of uricosuric drugs.
The simultaneous use of paracetamol in high doses increases the effect of anticoagulants (decreased synthesis of procoagulant factors in the liver).
Inducers of microsomal liver enzymes, ethanol and hepatotoxic drugs increase the production of hydroxylated metabolites of paracetamol, which makes it possible to develop severe intoxications even with a small overdose.
Long-term use of barbiturates reduces the effectiveness of paracetamol.
When used simultaneously with ethanol, the risk of developing acute pancreatitis increases.
Myelotoxic drugs enhance the hematotoxicity of paracetamol.
Caffeine is an adenosine antagonist (larger doses of adenosine may be required). With the simultaneous use of caffeine and inducers of microsomal liver enzymes, it is possible to enhance metabolism and increase the clearance of caffeine; inhibitors of microsomal liver enzymes - decreased metabolism of caffeine in the liver. Mexiletine reduces caffeine excretion by up to 50%; Nicotine increases the rate of caffeine elimination.
Monoamine oxidase inhibitors, furazolidone, procarbazine and selegiline - large doses of caffeine can cause the development of dangerous cardiac arrhythmias or severe. increased blood pressure.
Caffeine reduces the absorption of calcium from the gastrointestinal tract; reduces the effect of narcotic and sleeping pills; increases the excretion of lithium drugs in the urine; accelerates absorption and enhances the effect of cardiac glycosides, increasing their toxicity.
Concomitant use of caffeine with beta-blockers may; lead to mutual suppression of therapeutic effects; with β-adrenergic agonists - to additional stimulation of the central nervous system and other additive: toxic effects.
Caffeine may decrease the clearance of theophylline and possibly other xanthines, increasing the potential for additive pharmacodynamic and toxic effects.
Propyphenazone may enhance the effect of oral hypoglycemic agents, sulfonamide drugs, anticoagulants, the ulcerogenic effect of glucocorticosteroids, and reduce the effectiveness of potassium-sparing diuretics.
Absorption of the components of the drug may be reduced when used simultaneously with cholestyramine, m-anticholinergics, and antidepressants.
NOVALGIN (tablets)
age.
These tablets can cope with various types of pain, but the manufacturer focused specifically on pain during menstruation. Like “female” pills, the packaging is decorated with butterflies and made in pink tones. It turned out to be quite difficult not to attract attention. During recess I wanted to take a pill unnoticed, my classmates immediately pestered me, “Show me and show me!” Once the guy had a headache, I offered him a Novalgin tablet. So he turned out to be so suspicious. He says: “What kind of pills are these?” This isn’t for men, why am I going to drink it?’” In fact, the medicine can be used at high temperatures, since paracetamol is present, which brings it down; for headaches and toothaches, for joint pain, muscle pain. Novalgin belongs to the category of non-steroidal anti-inflammatory drugs. These medications say that you can take them 1-2 days before the onset of pain. I drank directly when the pain came over me, and in the full sense of the word. The medicine for acute pain should be taken once in the amount of one tablet. The maximum daily dose for an adult is 3 tablets per day. I don’t know why I should take this medicine in advance. I noticed that it stops working after 10-12 hours. I have so. If I drink it within a day, it probably won’t do anything for me.
According to the instructions, its effect should begin in 15-30 minutes. By and large, this is how it turns out. With severe pain, time drags on, but these pills really work quickly and gradually it becomes much easier.
Like many other medications, Novalgin has a decent list of side effects. It can cause nausea, an allergic reaction, insomnia (probably due to caffeine) and increase blood pressure. In case of an overdose, you can get the opposite reaction: drowsiness, increased excitability, as well as blurred vision, vomiting and even convulsions.
Since the component of the medicine is caffeine, you need to give up alcohol and coffee. Interestingly, non-drug methods for treating PMS suggest giving up coffee altogether so that emotional lability, increased breast sensitivity and anxiety do not worsen.
One article says that non-steroidal anti-inflammatory drugs have the “plus” of reducing blood loss. This was absolutely not noticed. Those who have stomach problems need to be careful, as this medicine has a bad effect on the mucous membrane. If you have an ulcer, then Novalgin is definitely not for you. The cause of menstrual pain is an excessive amount of prostaglandins that are produced in the uterus. It is because of them that it contracts and causes painful spasms. There is no way to reduce their production. You can only relieve pain; for this, non-steroidal anti-inflammatory drugs, such as Novalgin, are the best.
Apparently this is my case, I almost always had pain on the 1st day of menstruation. Only at the age of 14, when my periods began, did my stomach not hurt for the first six months. And it has been hurting ever since: the pain is aching, severe, accompanied by chills and mild nausea. That's why I take pills. Sometimes I tried to endure it, but I realized that it was not worth it.
Inside the cardboard box there is also a cardboard case.
The shelf life of such tablets is 3 years.
The tablet is white, slightly bitter. It has never been difficult for me to swallow any tablet; this one is medium in size. It needs to be washed down with water.
In addition to Novalgin, there are other medications that contain a combination of caffeine + paracetamol + propyphenazone. These are Saridon, Koffedon, Safiston, Gevadal, etc. It is quite possible that if you set a goal, you can find an analogue of Novalgin and even cheaper.
Novalgin quickly and effectively relieves menstrual pain, does not cause adverse reactions, I can afford to buy such a medicine myself. Be sure to study the instructions, as there are a lot of aspects that should be taken into account individually. For example, tablets should not be taken by people under 12 years of age, elderly people, pregnant women, breastfeeding women, people with diabetes, or epilepsy.
There is a package of 120 tablets, it costs about 200 hryvnia. But if you are going to take Novalgin for such a long time, you should consult your doctor again.
Overdose
For paracetamol
Symptoms:
during the first 24 hours after administration - pallor of the skin, nausea, vomiting, anorexia, abdominal pain; metabolic disorder, metabolic acidosis. Symptoms of impaired liver function may appear 12-48 hours after an overdose. In case of severe overdose - liver failure with progressive encephalopathy, coma, death (10 g in terms of paracetamol or 50 tablets of the drug); acute renal failure with tubular necrosis (including in the absence of severe liver damage); arrhythmia, pancreatitis.
Treatment:
administration of SH-group donors and precursors for the synthesis of glutathione - within 8-9 hours after an overdose and acetylcysteine - within 8 hours. The need for additional therapeutic measures (further administration of methionine, intravenous administration) is determined depending on the concentration of paracetamol in the blood, and also on the time elapsed after taking it.
For caffeine
Symptoms:
gastralgia, agitation, anxiety, motor restlessness, confusion, delirium, dehydration, tachycardia, arrhythmia, hyperthermia, frequent urination, headache, increased tactile or pain sensitivity, tremor or muscle twitching; nausea and vomiting, sometimes with blood; ringing in the ears, convulsions (in case of acute overdose - tonic-clonile).
Caffeine in doses of more than 300 mg/day (including against the background of coffee abuse - more than 4 cups of natural coffee, 150 ml each) can cause anxiety, tremor, headache, confusion, and extrasystole.
Treatment:
gastric lavage if caffeine was taken in the last 4 hours at a dose of more than 15 mg/kg and there was no vomiting caused by caffeine; taking activated carbon, laxatives; for hemorrhagic gastritis - administration of antacids, gastric lavage with an ice-cold 0.9% solution; maintaining pulmonary ventilation and oxygenation; for seizures - intravenous diazepam, phenobarbital or phenytoin; maintaining fluid and salt balance.
