Biorevitalization of the face: what kind of procedure is it, the after effect and contraindications

On the path to restoring their former beauty and youth, women encounter many procedures and medications. Thus, one of the most popular procedures - the injection of Botox - leaves many patients confused: what is the difference in the use of Botox, Dysport, Xeomin and others? Which one is better/worse, more expensive or cheaper? Let's try to deal with these issues once and for all.

Botulinum toxin type A has been used in cosmetology for several decades. Its task is to eliminate facial wrinkles due to muscle fiber relaxation, as well as correct hyperhidrosis. The toxin blocks neuromuscular transmission, thereby relaxing the muscle.

The most well-known drugs today are the following: Botox, Dysport, Xeomin, Lantox, Relatox. These products are certified and approved for use in the Russian Federation.

We will analyze and compare the composition of the most common botulinum toxins type A, and also try to compare them based on the analysis of this data.

What explains the effectiveness of the method

The condition of the skin is largely determined by the activity of special cells - fibroblasts. Their main function is to produce structural protein components (elastin and collagen). They form an elastic frame that supports all layers of skin tissue.

The effect of biorevitalization of the skin of the face and neck depends on hyaluron. The branched structure of the molecule helps to retain a large amount of water, thanks to which turgor (elasticity) is maintained, which serves to prevent the formation of wrinkles.

Improvement occurs after the first session and consists of:

• Normalization of moisture levels.
• Activation of the production of scaffold proteins.
• Acceleration of regeneration (renewal of cellular composition).

There is also stimulation of the natural synthesis of hyaluron, which significantly enhances and prolongs the rejuvenating properties of the technique.

PREPARATION FOR THE PROCEDURE

The day before the procedure you cannot:

1. Drink alcohol;
2. Perform any work while bending over, even simple actions such as trying on shoes, washing floors, etc.;
3. Attend massage sessions during which you will have to lie face down.

It is imperative to stop taking antibiotics and, if possible, anticoagulants.

Antibiotics and Botox are combined in the body, but can mutually influence the severity of each other's effects. Thus, tetracycline antibiotics can reduce the effect of Botox, while aminoglycosides increase the severity of muscle paralysis.

Anticoagulants can cause hematomas to form at injection sites. It is not life-threatening, but the bruising may limit the patient's normal activities and communication with other people for some time.

When is biorevitalization needed?

The procedure can be performed between the ages of 25 and 50 years. The maximum result can be achieved up to forty - the older the patient, the lesser the effect of the drug will be. This is due to the depletion of resources for the synthesis of elastic proteins and a decrease in the number of fibroblasts. To compensate for them, you will need to use additional rejuvenation products.

Let's consider the indications for when facial biorevitalization can be done:

• To compensate for natural dry skin or caused by harmful factors (smoking, ultraviolet rays, negative temperatures).
• With pronounced pigmentation. It may occur as a result of congenital characteristics, exposure to sunlight, or metabolic disorders.
• With age-related skin changes.
• To correct puffiness and drooping eyelids.
• For spider veins on the face and neck. Usually the reasons for their appearance are disturbances in blood circulation and vascular tone.
• For recovery after plastic surgery, laser resurfacing.

What effect will be achieved after biorevitalization depends solely on the cause of cosmetic problems. For example, tissue injury, excessive work of the sebaceous glands, and other skin disorders are successfully eliminated with the help of revitalization. If acne appears as a result of hormonal imbalance, and dull complexion is the result of metabolic disorders, then the benefits of the procedure will be much lower.

Super thin injection needles Nanoneedle

Kurasen dermal biocorrector

Nanoneedles with ultra-thin walls 30G

Nanoneedles with ultra-thin walls 33G

Nanoneedles with ultra-thin walls 34G

History of Botox

Botulinum toxin is the substance that forms the basis of Botox. It is produced by the bacteria Clostridium botulinum. Initially, the substance was used to solve other problems. This is how people with facial nerve neurosis were treated. Muscle tension forms on the face due to nervous tension and psychological problems. A person does not fully control his muscles, and they are constantly in good shape due to psychological pressures. Botulinum toxin was used to relax them.

Doctors noticed that after administering the drug, the network of wrinkles on the face completely disappears. And deep wrinkles become barely noticeable. This is how Botox was discovered as a cosmetic product.

Advantages of the method

The main advantages of this method of rejuvenation include:

• The ability to correct the oval of the face, smooth out fine wrinkles, and activate the process of cell renewal.
• No need for lengthy preparation.
• The total duration is less than an hour.
• Minimal discomfort.
• Preservation of the result for a long time (subject to the doctor’s recommendations).

Facial biorevitalization also has disadvantages and contraindications:

• allergy to the components of the drug;
• presence of neoplasms;
• severe chronic and autoimmune diseases;
• diabetes mellitus in the last stages;
• active phase of the inflammatory process.

Relative ones include pregnancy, the period of breastfeeding, and the use of anticoagulants.

INDICATIONS FOR ADMINISTRATION

Elimination and smoothing of wrinkles:

1. Horizontal wrinkles on the forehead;
2. Vertical wrinkles between the eyebrows;
3. Oblique wrinkles on the bridge of the nose (they are also called “rabbit wrinkles”);
4. Wrinkles at the outer corner of the eye;
5. Upturned or low eyebrows;
6. Pronounced nasolabial folds;
7. Vertical and horizontal neck wrinkles;
8. Treatment of hyperhidrosis, severe sweating of the palms, feet, and armpits;
9. Non-surgical face lift, the so-called Botox lift.

Kinds

Hyaluronic acid can be administered in different ways. Depending on the method of administration, the cost and other features will differ. The simplest type of revitalization is injection. The degree of injury is minimal and affects only the superficial layers.

Injection biorevitalization

Revitalization is carried out under sterile conditions using modern proven drugs. The injection is administered deep into the dermis using a syringe equipped with a thin needle. Most often, a point technique is used (punctures follow each other at a distance of up to 1.5 cm).

Since the procedure is traumatic, it is performed in combination with local anesthesia. Together with a cosmetologist, it is important to choose in advance the correct method of how to do facial biorevitalization in order to eliminate contraindications and choose the best option. There are two main ones:

1. Manual. The specialist personally performs the injections, thereby reducing the amount of damage.
2. Hardware. The substance is administered with a special device. It has a more aggressive effect, the cosmetic product is distributed as evenly as possible.

Recovery takes 1-3 days, after this period the effect becomes clearly visible.

Non-injection biorevitalization

In this case, hyaluronic acid is introduced using auxiliary technologies. The risk of complications is minimal and no recovery is required after the session. The technique is divided into several varieties:

• Cryo-biorevitalization. Involves the use of liquid nitrogen.
• Ultraphonophoresis. The drug enters the skin under the influence of ultrasound.
• Iontophoresis. The substance penetrates the dermis due to galvanic current. It also stimulates metabolic processes and regeneration.
• Magnetophoresis. Hyaluronic acid is injected using magnetic waves.

Any of these options can be used if there are certain contraindications or for clients who are afraid of injections.

Laser biorevitalization

It is placed in a special category, since in addition to the drug, the laser radiation itself also has an effect. Due to this, it is possible to obtain the following results:

1. Improving microcirculation of blood and lymph. This provides an additional flow of oxygen and nutrients.
2. Reducing inflammation.
3. Increased production of scaffold proteins.
4. Correction of uneven microrelief and microscars from acne.

Using a laser, cosmetologists introduce low molecular weight varieties of hyaluronic acid. It penetrates the skin better and has an increased stimulating effect on fibroblasts.

Overdose

Symptoms

overdoses appear some time after the injection. If the drug is accidentally administered or ingested, the patient should be under medical supervision for several days to identify clinical manifestations and symptoms of general weakness or muscle paralysis.

Patients with symptoms of botulinum toxin A poisoning (general weakness, ptosis, diplopia, difficulty swallowing and speech impairment or respiratory muscle paresis) should be hospitalized. A case of severe generalized muscle paralysis due to an overdose of the drug has been described.

In case of paralysis of the respiratory muscles, intubation and transfer to artificial ventilation are required until the patient's condition improves.

Treatment:

constant monitoring of the dynamics of symptoms is necessary; prescription of anticholinesterase drugs, if necessary, resuscitation measures are carried out. The introduction of a specific antitoxin (anti-botulinum serum type A) in accordance with the instructions for use is effective within 30 minutes after the injection of botulinum toxin.

Injection biorevitalization of the face

The technique can be divided into three stages. Before using it, you should definitely consult a specialist to exclude contraindications. For example, the technique cannot be used during pregnancy or in the presence of acute inflammatory diseases.

All stages take about 30-40 minutes, in some cases up to 1 hour. Moreover, most of the time (15-20 minutes) is spent waiting for the anesthetic to take effect. The injections themselves are performed in 10-15 minutes.

Preparation for the procedure

During the consultation process, cosmetologists conduct an external examination of the skin and interview the patient. Then the area of ​​influence, the optimal drug, and the method of its administration are selected. CURACEN has proven itself well - it is a multi-component product that has a complex restorative effect - reducing the rate of skin aging, preventing the appearance of wrinkles, preventing and treating pigmentation.

Progress of the procedure

Before visiting a specialist, you should avoid stress and alcohol consumption, and also not smoke a couple of hours before the session. Before biorevitalization and before injecting the substance, cosmetologists follow the following algorithm:

• Removing makeup from the client's face.
• Treat the skin with an antiseptic solution and mark the area where the composition is introduced.
• Application of local anesthetic.
• Injections of the drug are performed using Japanese NANONEEDLE needles. They make the procedure less painful and traumatic. This means that the rehabilitation period will go faster.

For women, it is advisable to carry out manipulations after the 14th day of the menstrual cycle. This is due to increased pain sensitivity and significant hormonal changes that are observed in most clients before this time.

Consolidate the result

After the end of the session, medicinal cosmetics with a soothing and anti-inflammatory effect are applied to the skin, and in the summer, cream with SPF. Next, the cosmetologist evaluates the patient’s condition and makes recommendations for further home care.

special instructions

Botox injections

must be carried out by a highly qualified doctor with special training and permission from the manufacturer. Injections can be performed on an outpatient basis in a treatment room.

Botox is dispensed, stored and used exclusively in specialized medical institutions. The drug is stored in a separate closed, labeled box in the refrigerator.

Immediately after the injections, the solution remaining in the vial or syringe should be inactivated with a sodium hypochlorite solution (containing 1% active chlorine). All auxiliary materials that have been in contact with the drug must be disposed of in accordance with the rules for the destruction of biological waste. Spilled drug solution should be wiped with an absorbent cloth soaked in a diluted sodium hypochlorite solution.

Impact on the ability to drive vehicles and operate machinery

There was no effect of the drug on the ability to engage in potentially hazardous activities that require increased attention and speed of psychomotor reactions.

Botox is not available for free sale through the pharmacy chain and is released only to specialized medical institutions.

Carrying out

Injections can be performed using several (different) methods; the type is selected by the cosmetologist depending on the area and condition of the skin.

Papular technique

The drug is injected into the middle and superficial layers of the dermis. The needle is placed at an acute angle (about 15 degrees) and held with the cut facing upward. Small elevations form on the surface of the skin - papules, filled with the injected substance, which is gradually distributed in the surrounding tissues. When using products based on synthesized hyaluronic acid, the recovery process can take up to 3 days. When using the drug CURACEN - from 20 to 60 minutes. The consequences of such a cosmetic procedure are positive; biorevitalization is characterized by long-term preservation of the effect due to the slow resorption of the drug.

The average size of the tubercles is about 4 mm. In particularly delicate areas (around the eyes and lips), smaller papules are created, up to 2 mm in diameter.

Tubercular or micropapular technique

Injections are made with a 4 mm long needle at an angle of 45 degrees. Due to this, the active substances penetrate into the deepest layers of the dermis. Externally, the skin remains smooth, only traces of injections are visually visible.

Linear-retrograde technique

The essence of the technique is to introduce the composition with a long needle (up to 13 mm), which, after puncture, is carried parallel to the surface of the skin through the middle layers. On the reverse movement of the syringe, the active substance is injected.

By using this technique, specialists are able to reduce the number of injections, and the deep penetration of the needle additionally stimulates the regenerative processes of the skin. How long the effect of facial biorevitalization in this way will last largely depends on the skill of the cosmetologist, the individual characteristics of the patient and home care. On average, this period ranges from 6 months to 1 year.

pharmachologic effect

Muscle relaxant. The botulinum toxin type A molecule consists of two chains: a heavy chain (with a molecular weight of 100,000 Daltons) and a light chain (with a molecular weight of 50,000 Daltons), connected by a disulfide bond.

The heavy chain has a high affinity for specific receptors localized on the surface of target neurons. The light chain is characterized by Zn2+-dependent protease activity. It is specific for the cytoplasmic regions of the synaptosomal associated protein with a molecular weight of 25,000 Daltons (SNAP-25), which is involved in the processes of exocytosis.

First stage

The action of botulinum toxin type A is the specific binding of the molecule to the presynaptic membrane.

Second stage

— penetration of the bound toxin into the cytoplasm of neurons by endocytosis.
Inside the cell, the light chain exhibits Zn2+-dependent protease activity, selectively destroying SNAP-25, which in the third stage
leads to blockade of acetylcholine release from the presynaptic terminals of cholinergic neurons.

The end result

is prolonged chemodenervation.

Clinically, there is a pronounced relaxation of the muscles into which the injection was made. In denervated muscles, the process of reinnervation occurs due to the formation of lateral processes of nerve endings 12 weeks after injection, which leads to the restoration of muscle contractions. However, the processes are partially effective and subsequently regress while primary neuromuscular transmission is activated.

Why is capillary mesotherapy needed?

This is a good way to prepare for revitalization and other cosmetic procedures, allowing you to significantly increase microcirculation, accelerate lymph flow, increase blood flow, and reduce swelling. It is prescribed for:

• Severe sagging skin (ptosis).
• Severe swelling.
• Large-scale age-related changes.

For capillary mesotherapy, cosmetologists use vascular preparations. They are introduced first into the cervical-collar region, slowly moving towards the earlobes, collarbones, and submandibular area. Next, injections are made along the tension lines. Usually 1-2 sessions are enough, but their number can increase to 4-5 if problems in this area are severe.

How effective is it?

In the photo above you can see the effect of facial biorevitalization before and after the procedure. It lasts quite a long time, the specific period depends on the condition of the client’s skin, the severity of the problems, heredity, lifestyle and other factors. On average, one session lasts 6-12 months. To improve the results, you can carry out additional manipulations, their number will depend on the goal:

• Preventive – 1-2 sessions are enough.
• Medicinal – less than 5 is required.

The interval between them is determined by a specialist, usually the interval is about 1 month. How often biorevitalization is done after the main cycle again depends on the recommendations of a specialist. Usually one procedure is prescribed every six months, this allows you to maintain youthful skin for a long period.

What you need to know about drugs

The exchange of hyaluron occurs quite quickly; without additional stabilization, it is absorbed in 1-2 days. If you give it a gel-like consistency, it will be possible to form a depot in the tissues, which will significantly prolong its resorption. To further increase the period of exposure, the substance is subjected to chemical stabilization, which significantly lengthens the decomposition time.

What facial biorevitalization gives depends on the type of drug used in cosmetology. There are two of them:

1. Low molecular weight. It retains less water, but small molecules act as signals, stimulating the work of fibroblasts and accelerating the natural regeneration of the skin. Significantly improves the overall condition of the skin and has an increased anti-aging effect.
2. High molecular weight. Provides a high degree of moisture retention, significantly increases turgor, and promotes rapid smoothing of shallow wrinkles.

Depending on the composition of the drugs, they are divided into:

• Monocomponent. Contains one active ingredient (hyaluron). Inexpensive, well suited for slowing down age-related changes under the age of 35, in the absence of other health problems. Allows you to normalize the level of moisture in tissues and eliminate fine wrinkles.
• Combined. They contain vitamins, microelements, and other useful compounds. Well suited for women 35-45 years old who do not have serious skin health problems. The drugs eliminate pigmentation and reduce the degree of photoaging.
• Powerful biorevitalizants. They contain many active components, such as peptides, various growth factors, amino acids.

Among the drugs is CURACEN from the Japanese manufacturer Japan Bio Products. It allows you to significantly reduce the rate of cellular aging, compact and even out the surface layers of the epidermis. This is achieved by enhancing the synthesis of its own structural proteins, such as collagen and elastin.

When choosing a suitable product, be sure to consult a cosmetologist. Cosmetologist specialists can correctly assess the condition of your body, indicate indications and choose the most effective and safe product.

Anti-age drugs

Bb Laboratories – Hyaluron-elastin-collagen extract

Laennec – solution for injection

Curacen Essence (20 fl x 2 ml)

Two-phase placental serum concentrate

Comparative table of botulinum toxin composition

Activity units reflect the dosage of drugs. One unit of activity corresponds to the average lethal dose (LD50) for female mice of average weight. Methods for determining activity units are individual and are not disclosed by manufacturers, so they are not equivalent to each other. It has been roughly established that 1 unit of Botox is almost equal in activity to 1 unit of Xeomin, Lantox, Neuronox and Relatox, and 3 units of Dysport. But once again I will emphasize that the equal sign cannot be used in this case. In practice, with equivalent administration of different drugs, different severity of effect and duration of action will be observed. This is also due to the fact that each batch of the drug may differ in activity by +/- 10%, which is reflected in the certificates provided by the manufacturer with each batch of toxins. Botulinum toxins are a biological product, which makes it difficult to standardize and store.

The particle size (molecular weight) of botulinum toxins will also differ (see table). The smaller the particle size, the greater the diffusion of the drug, the larger the area that can be “covered” with one injection. A high degree of diffusion in the hands of an inexperienced practitioner can lead to unwanted side effects due to the spread of the drug to adjacent muscles. On the other hand, this property provides a more uniform effect on the muscle, a “stronger” and faster effect.

Albumin is the main stabilizing substance. The functions of this protein are to bind botulinum toxin, limit the diffusion of the drug, and also limit its activity. The more albumin, the more subtly the drug works, and the “softer” its effect.

Excipients and their effect on the stability, diffusion and activity of drugs, unfortunately, are not described in the literature, which does not allow us to evaluate and accurately compare drugs with each other.

Complications and precautions

Side effects for this technique are uncharacteristic and are observed extremely rarely. They usually appear as:

• Allergies to anesthesia or drug components.
• Microhematoma. The number of subcutaneous hemorrhages depends on the characteristics of the skin, the condition of the capillaries and microarteries.

There are also cases of infection penetrating into the dermis. Such situations arise when aseptic rules are not observed during the procedure or subsequent care is improper. If all standards and recommendations are followed, the likelihood of infection is zero. A consultation with a specialist dermatologist will help you decide whether biorevitalization is worth doing.

Avoiding negative consequences is quite easy. To do this, strictly follow medical recommendations, including:

• Do not touch your face for 24 hours after the session.
• Do not wear makeup for 48 hours.
• Avoid physical and mental stress, stress for 2 weeks, avoid going to the bathhouse or public swimming pools.
• Avoid drinking alcohol.

When washing, you need to use gentle cleansers that do not dry out the skin. It is also necessary to use an antiseptic recommended by a doctor, regularly treating the dermis until the injection marks are completely healed, and drink the recommended amount of water.

Now you know the basic information about facial biorevitalization and understand that this procedure helps get rid of wrinkles, significantly slowing down age-related changes in the skin. To avoid negative consequences, it is important to use certified drugs. Entrust the care of your health to specialists.

Side effects

As a rule, adverse reactions appear during the first days after injection and are transient. In rare cases, the duration of adverse reactions may be several months or more.

Local muscle weakness reflects the expected pharmacological effect of botulinum toxin on the muscle. However, large doses may cause weakness in muscles other than those directly at the injection site.

Dysphagia following injections in areas other than the neck muscles has been reported. If there is a problem with swallowing, speech or breathing, the patient should immediately consult a doctor.

As with any injection, local soreness and/or bruising may occur at the injection site. An increase in temperature and the occurrence of a flu-like syndrome have been described.