Efficacy of amoxicillin dispersible tablets in the treatment of acute bacterial lower respiratory tract infections

What are dispersible tablets?

Most medications in tablet form are intended to be taken orally and must be swallowed and washed down with water. Dispersed tablets are distinguished by the fact that they dissolve in the mouth without additional effort. That is, you just need to put them under your tongue and wait a little, and everything else will happen on its own.

According to regulatory documents, the dissolution rate of dispersible tablets should be no more than 30 seconds.

For the first time, such a drug was developed in 1996 by American scientists, and replaced buccal (cheek) tablets, which had many disadvantages. The product consists of molecules and filler, which form a special microsphere, and under the influence of saliva break down into microscopic components.

The filler retains the active substance and protects it from the destructive effects of hydrochloric acid. They pass through the digestive tract and enter the duodenum, from where the active component penetrates the blood and immediately begins to act.

Benefits of the drugs

Due to the special release form and mechanism of action, dispersed tablets have advantages over conventional preparations for oral use.

1. Increased bioavailability
   . Dispersed tablets, unlike conventional drugs, are fast-acting. They are not subject to the destructive effects of hydrochloric acid and are better absorbed into the blood.

2. Minimal number of side effects
   . The drugs do not irritate the gastrointestinal mucosa, so they do not have a negative effect on the stomach.
3. Pronounced effect
   . The effectiveness of treatment with dispersible tablets is not inferior to therapy with injection solutions.
4. Ease of use
   . To take medications you do not need to constantly carry water with you, and the pleasant taste completely eliminates discomfort.

Dispersible drugs can be taken by any category of patients. These include young children, people who have problems swallowing (dysphagia), patients with mental disorders, kidney dysfunction, paralysis, etc. For infants, tablets can be dissolved in water or breast milk.

Who are they for?

The doctor prescribed dispersible tablets to his patient. What does this mean? Experts recommend medications in this form to those who, for whatever reason, refuse to use their usual medications. A similar tablet is also needed for those for whom taking a pharmacological agent in this form will become as comfortable as possible. In addition, people suffering from dysphagia (swallowing dysfunction) are also prescribed dispersible tablets. What does this invention mean to them? This is an alternative form of taking medications that allows the patient to complete the necessary course of treatment. It is worth noting that patients with dysphagia occur in all age groups. According to US medical statistics, swallowing disorders occur in 35% of the country's residents. It affects 60% of elderly people. Dysphagia is also observed in 18-22% of patients in inpatient medical institutions.

Dispersible tablets do not need to be taken with water. This is why they are great for those who are paralyzed and bedridden. Busy people and travelers prefer these products. After all, both of them don’t always have a glass of water at hand.

Dispersible tablets are also important in the treatment of children. How to take this drug? The tablet can be swallowed whole or dissolved in any amount of water. And for infants, the medicine can be given along with mother's milk. This is an optimal, convenient and excellent solvent for infants.

Initially, the creators of such tablets thought about the convenience of treating children. However, the dispersible form turned out to be very versatile. And today it is not considered only as a children's room. Everyone should have convenience and comfort during treatment.

How to take medications?

Taking dispersible drugs does not cause difficulties for patients. They need to be dissolved in any liquid (tea, milk, juice, etc.) or simply placed under the tongue.

The amount of liquid varies from 50 ml to 1-2 glasses, depending on the content of the active substance. Eating usually does not affect the absorption and bioavailability of the drug, but it is better to clarify this point in the manufacturer’s instructions.

"Amoxiclav"

Let's consider the effect of dispersible agents using the example of tablets that are a combination of clavulanic acid and amoxicillin. This is the drug "Amoxiclav", which is a semi-synthetic penicillin, that is, an antibiotic.

A drug is being produced that allows patients to obtain a dosage form with maximum availability. The drug "Amoxiclav" has all the registered indications characteristic of conventional tablets. Its use allows for an effective course of treatment of chronic and acute sinusitis, otitis media, various types of infections and retropharyngeal abscess.

A similar form of the drug “Amoxicav” is also prescribed to patients in a state of moderate severity. Dispersible tablets are an excellent help for them. How to take usual remedies if you have difficulty swallowing? Difficult! And here the dispersible form of the drug “Amoxicav” is simply irreplaceable. In addition, in addition to all the advantages of dispersible tablets, this product is created taking into account the dose of the active substance required for the patient. Treatment becomes more effective and does not require correction.

Amoxiclav dispersible tablets dissolve perfectly in water, tea or juice. As a result, the patient receives a medicinal suspension. For one tablet you need 1-2 glasses of liquid, but not less than 30 ml. Before administration, the solution is thoroughly mixed. Amoxiclav dispersible tablets can be simply dissolved in the mouth. No pre-dissolution is required.

The packaging of the drug is also very convenient. The tablets are placed in a blister with an easy access system. In other words, the medicine will not need to be taken out of the package. One blister contains two tablets. This amount corresponds to the daily dosage.

List of dispersible drugs

Most often, antibiotics, vitamins and painkillers are produced in the form of dispersible tablets, but their list is constantly growing. Recently, pharmaceutical companies have begun to produce anxiolytic and antiparkinsonian drugs, as well as ACE inhibitors, in a similar form.

They are used in certain categories of patients who may have difficulty taking medications, and with the advent of drugs in dispersed form, therapy is greatly facilitated.

Antibacterial drugs

Antibacterial agents based on amoxicillin and azithromycin are produced in the form of dispersible tablets, which include:

• Flemoklav Solutab;
• Flemoxin;

• Amoxiclav Quiktab;
• Sumamed.

Antibiotics from this list are used to treat respiratory infections, ENT organs, skin, soft tissues, and genitourinary tracts. They have a wide spectrum of activity and rarely cause side effects - the most common are headaches and digestive system disorders. The dosage depends on the clinical course of the disease, the severity of symptoms, age and characteristics of the patient’s body. No dose adjustment is required in the elderly, as well as in patients with mild to moderate hepatic and renal dysfunction.

Anxiolytic Phenazepam

The anxiolytic drug Phenazepam is considered the most common drug used to treat neurological and psychoemotional disorders, depression, anxiety, etc. It has pronounced therapeutic activity and quickly eliminates unpleasant symptoms.

The key advantage of Phenazepam is that it causes virtually no drowsiness, so it can be used during the daytime.

Phenazepam dispersible tablets can be taken anywhere and at any time if you need to quickly stop a panic attack.

The disadvantage of the oral form of the drug is that it began to act only 1-2 hours after administration. This caused some inconvenience to patients, especially those suffering from panic attacks. After the appearance of Phenazepam in the form of lozenges, this drawback was eliminated - the therapeutic effect of the drug appears 15-20 minutes after administration.

Madopar tablets

Madopar is another popular drug used to treat Parkinson's disease and restless legs syndrome.

It contains the active substance levodopa, which has pronounced therapeutic activity. People diagnosed with Parkinson's disease often suffer from dysphagia and akinesia, conditions that make it difficult to take oral tablets and suspensions.

In addition, most of them are in old age, when the absorption and digestibility of the active components slows down. Madopar in the form of dispersible tablets makes treatment effective and comfortable - the patient does not have to make an effort to swallow the medicine, and the therapeutic effect appears faster and lasts longer.

Prestarium drug

The drug Prestarium belongs to the category of ACE inhibitors, has a vasodilator and hypotensive effect. It is used for chronic heart failure, coronary heart disease and arterial hypertension of any severity.

The active ingredient in perindopril, arginine, lowers blood pressure, normalizes the functioning of the heart and blood vessels, and reduces the load on the myocardium.

Prestarium is recommended for use in patients who suffer from paresis, paralysis and other disorders after strokes to prevent relapses.

Prestarium dispersible tablets are taken once a day, preferably in the morning before meals. You just need to put them on your tongue, wait until they dissolve, and swallow them with saliva. The therapeutic effect begins 15-20 minutes after administration, reaches a maximum after an hour and lasts about a day.

Nise remedy

Nise dispersible tablets are a non-steroidal anti-inflammatory drug based on the active substance nimesulide. It has a pronounced antipyretic, analgesic and anti-inflammatory effect, and is used for any diseases accompanied by fever and pain. Unlike other NSAIDs, Nise does not destroy the gastric mucosa, so it can be used with caution in diseases of the gastrointestinal tract, kidneys and liver. The dosage is prescribed individually, the course of treatment is no more than 7-10 days.

Free drug table:

Despite the fact that dispersible tablets have advantages over traditional drugs, it is better to consult a doctor and study the instructions before use.

Each drug has contraindications and side effects that should be considered before taking. It is especially important to exercise caution when using medications in certain categories of patients - children, pregnant women, people with chronic diseases.

"Nise"

This effective medicine is familiar to many of us. Its use helps relieve pain and relieve fever.

Today you can find dispersible tablets “Nise” in the pharmacy. Each of them contains 50 mg of the active element - nimesulide. The blister contains 10 tablets.

The innovative product must be dissolved in water before use. Moreover, 1 teaspoon of liquid is taken per tablet.

It is especially convenient to give the dispersed drug “Nise” to young patients.

Regular tablets or dispersible

Dispersible preparations are easy to use, have high bioavailability and a pronounced therapeutic effect. They are recommended for use in the treatment of children, people with mental illness, dysphagia, paralyzed patients and those who suffer from serious chronic pathologies.

Despite the fact that their cost is higher than that of conventional tablets, they have advantages and cause less harm to the body. If your doctor recommends taking dispersible agents, it is better to pay more but reduce the likelihood of discomfort during treatment and the development of side effects.