Instructions for use of DONA® (DONA) solution for intramuscular administration

Compatibility of Dona and alcohol

? Alcohol in combination with Dona inhibits its effectiveness. A small portion of alcohol will not cause significant harm to health. In most cases, neither local nor systemic adverse reactions develop. The result of such a combination will be the absence of a positive outcome of therapy.

And the medicine is intended for long-term course treatment for six months or more. Its active ingredient gradually exhibits therapeutic effects.

Only after creating a certain concentration of the drug in the body, joint pain and inflammation recede. Even a single dose of alcohol will lead to undesirable consequences - the symptoms of diseases of the musculoskeletal system will return.

Top 10 drugs incompatible with alcohol

Why paracetamol, ibuprofen and antigrippin require an exclusively sober lifestyle

It has long been known that alcoholic beverages are not friendly with many medications. But information about which drugs should not be combined with alcohol “in the same glass” is often contradictory and confusing. As part of self-education and preparation for the “generous” Russian holidays - New Year and Christmas - we will fill the gaps in knowledge and determine the list of the most common medications that require an exclusively sober lifestyle.

Let’s say right away that “combining” does not mean washing down the drug with a glass of champagne or wine. The half-life of drugs can reach 10–12 hours, so when you take the medicine in the morning and “on the chest” in the evening, you also combine it with alcohol.

Paracetamol

Few people know that one of the most popular antipyretic and painkillers can be dangerous if combined with alcoholic beverages. In the presence of alcohol, paracetamol is metabolized in the body to form toxic substances that can cause liver damage. The danger is greatest if you combine long-term alcohol intake (for example, 90 ml of vodka or more per day for several days) with high doses of paracetamol (3000 mg or more).

Antiallergic and anti-cold medications

Alcohol consumed on the same day with some antihistamines, including the popular cetirizine and loratadine, increases the effects of the drugs on the central nervous system. This is manifested by increased drowsiness, lethargy and decreased motor activity. It should be borne in mind that many combined anti-cold medications include antiallergic components and, by the way, paracetamol.

Read also: Antibiotics and alcohol: consequences

Be sure to give up alcohol if you are taking Antigrippin (paracetamol + chlorphenamine + ascorbic acid), AntiFlu or Coldact Flu Plus (paracetamol + phenylephrine + chlorphenamine).

Nonsteroidal anti-inflammatory drugs

They are popular and sometimes almost irreplaceable. Ibuprofen, ketoprofen, naproxen, diclofenac and other NSAIDs are taken for toothaches, headaches, severe arthritis or muscle inflammation. And often consumers do not suspect that alcohol taken during treatment with NSAIDs greatly increases the risk of gastrointestinal bleeding. Let me remind you that drugs in this group are already not very friendly to the digestive tract and can cause gastropathy - stomach diseases. Alcohol can turn NSAIDs into aggressive substances that threaten real disaster.

Antitussives

Treatment with widely used medications for dry cough, including dextromethorphan, which is part of complex antitussives (Terasil-D), as well as drugs with codeine (Terpinkod) in combination with alcohol can lead to drowsiness, dizziness and weakness.

Antibiotics

Contrary to popular belief, not all antibacterial drugs are categorically incompatible with alcohol, but only some of them, in particular:

• Cefamandole
• Cefoperazone
• Chloramphenicol (chloramphenicol)
• Metronidazole
• Ornidazole
• Isoniazid (anti-tuberculosis drug)
• Sulfomethoxazole (Biseptol) and some other, rarer drugs.

When these antibiotics are used in combination with alcohol, the enzyme responsible for the decomposition of toxic acetaldehyde is blocked. The latter, when accumulated, causes difficulty breathing, tachycardia, feelings of fear, chills or fever, a drop in blood pressure, and vomiting. By the way, this is exactly how drugs that are used for “coding” against alcoholism work, in particular, disulfiram (Teturam).

Drugs for the treatment of type 2 diabetes mellitus

Diabetics generally need to be extremely careful with alcohol, as it increases blood sugar levels. Moreover, if you lean heavily on alcohol while taking glucose-lowering medications, in particular metformin (the “gold standard” for the treatment of diabetes): the risk of an extremely dangerous complication – lactic acidosis – sharply increases. It is characterized by increased levels of lactic acid in the blood, which is fatal in almost 50% of cases.

Medicines that lower blood pressure

Hypertensive patients who try to control their blood pressure with the help of medications and at the same time do not deny themselves a glass or two also risk falling victim to the incompatibility of drugs with alcohol. Doctors do not recommend combining quinapril, verapamil, doxazosin, prazosin, clonidine (Clonidine), losartan, amlodipine, lisinopril, enalapril and hydrochlorothiazide with alcoholic beverages. Otherwise, dizziness, drowsiness, fainting, and cardiac dysfunction, including arrhythmia, may occur.

Medicines that lower blood cholesterol levels

Drugs intended to normalize the content of lipoproteins (cholesterol) in the blood should also not be combined with alcoholic beverages to avoid liver damage. You should avoid drinking alcohol if you are taking statins - first-line drugs to combat dyslipidemia, namely atorvastatin, lovastatin, rosuvastatin, simvastatin.

Antidepressants

Patients with depression who are receiving drug treatment should approach alcoholic libations with extreme caution. Tricyclic antidepressants (for example, amitriptyline) in combination with alcohol produce a powerful sedative effect. The combination of small doses of alcohol with modern serotonin reuptake inhibitors (for example, paroxetine, fluoxetine, escitalopram, etc.) can still pass with impunity for the drinker. However, regular alcohol loads against the background of antidepressant therapy threaten to worsen the condition: increased anxiety and feelings of hopelessness, decreased motor functions.

Sedatives

Alcohol has a sedative, i.e., calming effect. If you take sedatives and at the same time allow yourself to “take it on your chest,” rest assured: the effect of sedatives under the influence of doses of ethanol will certainly increase, which will manifest itself as lethargy, decreased motor activity, drowsiness and loss of concentration. Therefore, it is categorically not recommended to indulge in the green snake for those who are treated with sleeping pills (zolpidem, zopiclone, doxylamine), sedatives (including herbal ones, for example, the same valerian extract), and especially tranquilizers (phenazepam, diazepam, etc.). ).

Brief characteristics of the drug

The medicine is included in the clinical-pharmacological group of stimulants of fibrous, hyaline cartilage. It is their destruction that provokes the appearance of acute or aching pain in the joints, spine, crunching, crackling, clicking while walking, bending or turning the body. The drug is intended for the gradual restoration of cartilage tissue.

Orthopedists, neurologists, and rheumatologists prescribe it to patients for the treatment of the following diseases:

• cervical, thoracic, lumbosacral osteochondrosis;
• ankylosing spondylitis;
• gouty attacks;
• rheumatoid, psoriatic arthritis;
• epicondylitis lateral, medial;
• deforming osteoarthrosis, including gonarthrosis, coxarthrosis;
• intervertebral hernia;
• tendonitis, tendovaginitis;
• bursitis, synovitis.

Taking the medication is indicated in the postoperative period after installation of endoprostheses. Its active ingredient - glucosamine - accelerates the healing of torn muscles, ligaments, and tendons.

Use of the drug for alcoholism

The medicine has no direct effect on strong physical and psychological alcohol dependence. But it is often used in therapy to eliminate complications that arise from long-term alcohol abuse. Ethanol is toxic to all vital systems of the body.

Alcoholics have the following signs of damage to the joints and spine:

• lack of adequate nutrition of cartilage due to narrowing of blood vessels, coarsening of their walls;
• development of sluggish inflammatory processes against the background of decreased immunity.

In patients with chronic alcoholism of 2-3 degrees of severity, osteoarthritis is often diagnosed. To prevent its progression, doctors include it in treatment regimens. The disease stops spreading to neighboring joints, and the cartilage layers are partially restored.

Risk group for spinal diseases

I often heard from friends that they play sports and eat normally, so they cannot get all kinds of arthritis and arthrosis. To be honest, for some time I thought that the risk of illness depended only on lifestyle. It turned out that everything was completely wrong. Of course, if you eat only fast food and don’t get off the couch, then the probability of bone deformation is close to 100%, but everyone is at risk! Athletes, vegetarians and doctors also get sick, and quite often.

How did I understand that I needed to start taking pills and why Dona?

I won’t delve into the detailed history of my own life, I’ll just write that after 40 I began to periodically complain of headaches, chronic fatigue, crunching in the limbs and numbness in the fingers. At first I suspected a problem with the blood vessels. I thought the blood was not circulating well. I went to the cardiologist. The doctor listened to me and referred me to a surgeon.

“You have cervical osteochondrosis in the initial stage.
Most likely, the disease developed due to low mobility, plus some bad habits played a role. It's okay - everything can be fixed. You need to start taking medications, do special gentle exercises and sign up for physical therapy. Let’s start therapy with Don’s tablets and look at the results...” Roman Igorevich, surgeon, chiropractor, Murmansk

I thought, but I really worked as a driver for many years (low mobility, poor posture), I live far from a southern resort (frequent hypothermia), I smoke, sometimes drink (bad habits), and there is often stress - predisposing factors are obvious. I decided that I would start treatment without delay.

Using the drug for a hangover

During a hangover, migrating joint or muscle pain often occurs. Especially in the feet and fingers. The reason for their appearance is the removal of most of the calcium from the body. Without this macroelement, the full functioning of the musculoskeletal system is impossible.

Treating a hangover with a drug makes no sense. Glucosamine has an analgesic effect only after 2-3 weeks of its course of administration.

In this case, to improve the person's well-being, the use of analgesics, for example, non-steroidal anti-inflammatory drugs, is required.

Consequences of drinking alcohol

Alcohol neutralizes all therapeutic effects. Due to its powerful diuretic properties, it excretes its active ingredient in the urine. And it took about a month to accumulate it. Therefore, 2-3 days after drinking alcohol, the joints hurt again, the skin over them swells, turns red, and the range of movements decreases.

In clinical practice, there have been cases and developments of adverse reactions when combining alcohol and medication. Ethanol enhanced all the negative effects of the drug, causing a false overdose.

It manifests itself with the following symptoms:

• flatulence;
• stomach pain;
• diarrhea or constipation;
• nausea;
• headaches and dizziness.

The drug is available in 3 dosage forms - capsules, powder and solution for parenteral administration. The latter contains the anesthetic lidocaine, which is absolutely incompatible with alcohol.

If after the injection a person immediately drinks alcohol, the consequences are unpredictable. Usually these are vomiting, drowsiness, diplopia, numbness of the mucous membrane of the mouth and tongue, tremor, disorientation, and cardiac conduction disturbances.

Organs affected by the toxin

The combined use of pharmacological agents and alcohol has a toxic effect on the internal organs and environments of the body. Alcohol, entering into a chemical reaction with a medicine, leads to poisoning, disrupts physiological processes, enhances or weakens the healing properties of drugs.

The liver suffers more than other organs. She gets hit twice. Many medications have a side effect - hepatotoxicity, destroy cells, and disrupt the physiology of the organ. In the liver, alcohol breaks down to ethanal, a substance 20-30 times more toxic than ethanol, which causes the death of hepatocytes.

Dangerous groups of drugs for the organ in combination with alcohol:

• anti-inflammatory;
• hormonal;
• antibacterial;
• antifungal;
• glucose control agents for diabetes mellitus;
• anti-tuberculosis;
• cytostatics (chemotherapy drugs);
• tranquilizers (anti-epileptic, psychotropic).

In second place among the internal organs exposed to the harmful effects of alcohol together with medications are the heart and vascular system. Strong drinks during drug therapy constrict blood vessels and increase blood pressure. The simultaneous intake of alcohol and chemical substances leads to failure of the myocardium and increases the risk of developing an attack of angina pectoris and a heart attack.

A mixture of ethanol and pharmaceuticals disrupts the quality of the blood and reduces clotting. This is dangerous due to internal bleeding and strokes.

Top 10 drugs incompatible with alcohol

Why paracetamol, ibuprofen and antigrippin require an exclusively sober lifestyle

It has long been known that alcoholic beverages are not friendly with many medications. But information about which drugs should not be combined with alcohol “in the same glass” is often contradictory and confusing. As part of self-education and preparation for the “generous” Russian holidays - New Year and Christmas - we will fill the gaps in knowledge and determine the list of the most common medications that require an exclusively sober lifestyle.

Let’s say right away that “combining” does not mean washing down the drug with a glass of champagne or wine. The half-life of drugs can reach 10–12 hours, so when you take the medicine in the morning and “on the chest” in the evening, you also combine it with alcohol.

Paracetamol

Few people know that one of the most popular antipyretic and painkillers can be dangerous if combined with alcoholic beverages. In the presence of alcohol, paracetamol is metabolized in the body to form toxic substances that can cause liver damage. The danger is greatest if you combine long-term alcohol intake (for example, 90 ml of vodka or more per day for several days) with high doses of paracetamol (3000 mg or more).

Antiallergic and anti-cold medications

Alcohol consumed on the same day with some antihistamines, including the popular cetirizine and loratadine, increases the effects of the drugs on the central nervous system. This is manifested by increased drowsiness, lethargy and decreased motor activity. It should be borne in mind that many combined anti-cold medications include antiallergic components and, by the way, paracetamol.

Read also: Antibiotics and alcohol: consequences

Be sure to give up alcohol if you are taking Antigrippin (paracetamol + chlorphenamine + ascorbic acid), AntiFlu or Coldact Flu Plus (paracetamol + phenylephrine + chlorphenamine).

Nonsteroidal anti-inflammatory drugs

They are popular and sometimes almost irreplaceable. Ibuprofen, ketoprofen, naproxen, diclofenac and other NSAIDs are taken for toothaches, headaches, severe arthritis or muscle inflammation. And often consumers do not suspect that alcohol taken during treatment with NSAIDs greatly increases the risk of gastrointestinal bleeding. Let me remind you that drugs in this group are already not very friendly to the digestive tract and can cause gastropathy - stomach diseases. Alcohol can turn NSAIDs into aggressive substances that threaten real disaster.

Antitussives

Treatment with widely used medications for dry cough, including dextromethorphan, which is part of complex antitussives (Terasil-D), as well as drugs with codeine (Terpinkod) in combination with alcohol can lead to drowsiness, dizziness and weakness.

Antibiotics

Contrary to popular belief, not all antibacterial drugs are categorically incompatible with alcohol, but only some of them, in particular:

• Cefamandole
• Cefoperazone
• Chloramphenicol (chloramphenicol)
• Metronidazole
• Ornidazole
• Isoniazid (anti-tuberculosis drug)
• Sulfomethoxazole (Biseptol) and some other, rarer drugs.

When these antibiotics are used in combination with alcohol, the enzyme responsible for the decomposition of toxic acetaldehyde is blocked. The latter, when accumulated, causes difficulty breathing, tachycardia, feelings of fear, chills or fever, a drop in blood pressure, and vomiting. By the way, this is exactly how drugs that are used for “coding” against alcoholism work, in particular, disulfiram (Teturam).

Drugs for the treatment of type 2 diabetes mellitus

Diabetics generally need to be extremely careful with alcohol, as it increases blood sugar levels. Moreover, if you lean heavily on alcohol while taking glucose-lowering medications, in particular metformin (the “gold standard” for the treatment of diabetes): the risk of an extremely dangerous complication – lactic acidosis – sharply increases. It is characterized by increased levels of lactic acid in the blood, which is fatal in almost 50% of cases.

Medicines that lower blood pressure

Hypertensive patients who try to control their blood pressure with the help of medications and at the same time do not deny themselves a glass or two also risk falling victim to the incompatibility of drugs with alcohol. Doctors do not recommend combining quinapril, verapamil, doxazosin, prazosin, clonidine (Clonidine), losartan, amlodipine, lisinopril, enalapril and hydrochlorothiazide with alcoholic beverages. Otherwise, dizziness, drowsiness, fainting, and cardiac dysfunction, including arrhythmia, may occur.

Medicines that lower blood cholesterol levels

Drugs intended to normalize the content of lipoproteins (cholesterol) in the blood should also not be combined with alcoholic beverages to avoid liver damage. You should avoid drinking alcohol if you are taking statins - first-line drugs to combat dyslipidemia, namely atorvastatin, lovastatin, rosuvastatin, simvastatin.

Antidepressants

Patients with depression who are receiving drug treatment should approach alcoholic libations with extreme caution. Tricyclic antidepressants (for example, amitriptyline) in combination with alcohol produce a powerful sedative effect. The combination of small doses of alcohol with modern serotonin reuptake inhibitors (for example, paroxetine, fluoxetine, escitalopram, etc.) can still pass with impunity for the drinker. However, regular alcohol loads against the background of antidepressant therapy threaten to worsen the condition: increased anxiety and feelings of hopelessness, decreased motor functions.

Sedatives

Alcohol has a sedative, i.e., calming effect. If you take sedatives and at the same time allow yourself to “take it on your chest,” rest assured: the effect of sedatives under the influence of doses of ethanol will certainly increase, which will manifest itself as lethargy, decreased motor activity, drowsiness and loss of concentration. Therefore, it is categorically not recommended to indulge in the green snake for those who are treated with sleeping pills (zolpidem, zopiclone, doxylamine), sedatives (including herbal ones, for example, the same valerian extract), and especially tranquilizers (phenazepam, diazepam, etc.). ).

Rules for taking medications and alcohol

Drinking alcohol during treatment minimizes the clinical effect of therapy and creates a risk of developing complications of the disease.

If this cannot be avoided, follow the rules of behavior that will reduce the occurrence of negative consequences:

1. Do not drink strong drinks (vodka, cognac, whiskey), choose dry wine (100-150 ml), beer (no more than 300 ml). Don't drink alcohol on an empty stomach.
2. The interval between taking the medicine and alcohol should be at least 2 hours.
3. To reduce the toxic effect, take medications that protect the liver (hepatoprotectors), pancreas (pancreatin), and stomach (antacids ─ Rennie, Almagel).

If a person takes antiviral medications for colds, anti-inflammatory drugs, alcohol in moderation does not pose a threat to the body.

Alcoholic drinks during treatment are strictly contraindicated in cases of liver cirrhosis, severe infectious diseases, and during a course of chemotherapy.

"Dona": instructions for use

The drug is taken 1 tablet orally in the morning and evening, preferably during a meal, with a sufficient amount of water. In the first days the effect is unnoticeable, which is normal. The first results appear after a 2-3 week continuous course. In this case, the minimum duration of therapy is from 4 to 6 weeks; tablets are often taken for several months.

After this, a break is taken for 1.5-2 months, then the cycle is repeated. The dosage, as well as the duration of therapy and the general regimen depend on the age, condition of the patient, chronic diseases and other factors.

In the case of powder, the contents of 1 sachet must be dissolved in 1 glass of water (200-250 ml) and drunk with meals. Reception is carried out only once a day. In this case, the total duration of the course is determined by the same rules as in the case of tablets.

Medicines, alcohol and chronic diseases

If a person has chronic diseases, simultaneous use of alcohol and medications is potentially dangerous for the functioning of vital organs. Since patients systematically take prescribed medications, the influence of alcohol can lead to negative consequences.

People with chronic heart disease (angina pectoris, heart defects) develop arrhythmias of varying severity. Heart attacks with severe pain syndrome develop, which is not relieved by Nitroglycerin, and the risk of developing myocardial infarction increases significantly.

In case of chronic liver diseases (viral hepatitis, hepatosis), alcohol during treatment can become a trigger in the development of cirrhosis and hepatocellular carcinoma (cancer).

Drinking alcohol during cirrhosis leads to the following consequences:

• bleeding into the abdominal cavity;
• liver decomposition, infection, peritonitis;
• hepatic coma;
• death.

If a person is on long-term treatment with sedatives, psychotropic drugs, tranquilizers, he is contraindicated in drinking alcohol. This leads to severe depression and the appearance of obsessive states (hallucinations, phobias). Suicidal feelings develop. Such a patient needs constant monitoring and assistance from a psychiatrist.

“Don” tablets

I always suspected that I would develop some kind of bone disease. I have bad heredity and a lot of bad habits (for example, I like to crunch my fingers). That is why, after the onset of discomfort in the spine, I immediately went to see a doctor. I know that you need to start treatment as early as possible. The doctor prescribed me Don tablets (I ordered them on the online pharmacy website) and a special set of exercises. Now, after the first course of the drug, it has become much easier and it makes me happy! In general, I briefly described the situation to you, now I’ll try to go through the points in more detail)))

The most dangerous combinations and consequences

The combination of alcohol and chemical-based drugs can lead to serious disorders in the body, and in some cases to fatal consequences.

List of medications and their side effects in combination with alcohol:

Why did the doctor prescribe Don's tablets?

On the way home from the hospital, I went to the pharmacy and asked for a medicine for joint pain. To my surprise, the pharmacist named several drugs, but Don’s tablets were not on the list. I thought that the doctor prescribed me some unnecessary dietary supplement. I decided to double-check the information and started surfing the World Wide Web.

I shouldn't have thought badly about the specialist! The doctor ordered it correctly. Osteochondrosis can only be defeated with special chondroprotectors. I read that if it hurts a lot, you need to take antispasmodics and anti-inflammatory substances. In my case (the initial stage), there is no need to destroy the liver with such heavy pills.

Dona is a relatively safe remedy, with a small list of side effects. So the doctor thought about my health.