Meloxicam is a non-steroidal anti-inflammatory drug with analgesic and antipyretic effects. It is used as injections (deep intramuscular), tablets (orally) and suppositories (rectally). The medicine is affordable and gives a quick effect. Used only in consultation with a doctor, dispensed from pharmacies with a prescription.
"Meloxicam" is a drug with the active ingredient of the same name. It is a non-steroidal anti-inflammatory drug. It has antipyretic, analgesic and analgesic effects.
Available in 3 dosage forms:
- solution in ampoules;
- pills;
- suppositories (candles).
The active component of Meloxicam is a derivative of organic enolic acid. It inhibits the activity of the enzyme cyclooxygenase-2 and slows down the formation of prostaglandins. As a result, inflammatory processes are stopped, the lesion is reduced, resulting in an analgesic effect.
The drug is released only with a prescription. It can be stored at room temperature (no more than 25 degrees) out of the reach of children. The shelf life is 2 years from the date of production.
Contraindications and side effects
The drug should not be used if there are such contraindications:
- intolerance to pyrazolone and its derivatives;
- allergic reactions, hypersensitivity to acetylsalicylic acid;
- recurrent nasal polyposis;
- severe kidney damage;
- peptic ulcers of the gastrointestinal tract;
- bronchial asthma;
- period of pregnancy, as well as lactation (at any stage);
- older people take the drug with caution.
Meloxicam suppositories are not allowed to be used in the presence of diseases of the rectum, anal region, if they are chronic. Other contraindications are possible, so be sure to consult a doctor before starting use.
In some cases, side effects are observed:
- exacerbation of stomach and intestinal ulcers;
- vomiting, nausea;
- belching;
- bloating;
- constipation;
- diarrhea syndrome;
- headaches;
- dizziness;
- drowsy state;
- leukopenia;
- anemia;
- increased blood pressure;
- skin rashes, itching, other forms of allergies;
- swelling;
- high urea level;
- blood rush to the chest, face, neck.
Meloxicam solution for intramuscular administration 15 mg/1.5 ml in ampoules 1.5 ml No. 10
Name
Meloxicam solution for intramuscular injection, 15 mg 1.5 ml per amp. 1.5ml pack No. 10
Release form
Solution
Description
transparent green-yellow solution.
Compound
one ampoule (1.5 ml) contains: active ingredient – meloxicam – 15 mg; excipients: meglumine, tetraglycol-glycofurol, poloxamer 188, sodium chloride, glycine, sodium hydroxide, water for injection.
INDICATIONS FOR USE
Short-term symptomatic treatment of exacerbation of rheumatoid arthritis or ankylosing spondylitis if it is impossible to use the drug orally or rectally
CONTRAINDICATIONS
- hypersensitivity to meloxicam or auxiliary components of the drug. There is a possibility of cross-sensitivity to acetylsalicylic acid and other NSAIDs. Should not be prescribed to patients with symptoms of bronchial asthma, nasal polyps, angioedema or urticaria after taking acetylsalicylic acid or other NSAIDs in history;
- history of gastrointestinal bleeding or gastrointestinal perforation associated with previous NSAID therapy;
- active phase or recurrent course of ulcers (bleeding from the gastrointestinal tract) (two or more separate episodes with confirmed presence of ulcers or bleeding);
- severe liver failure;
- severe renal failure without dialysis;
- gastrointestinal bleeding, cerebrovascular bleeding or an established diagnosis of diseases of the blood coagulation system;
- severe heart failure;
- children and adolescents under 18 years of age;
- III trimester of pregnancy and breastfeeding;
- hemostasis disorders or simultaneous treatment with anticoagulants (contraindication for this method of administration).
METHOD OF APPLICATION AND DOSES
The solution should be administered slowly by injection into the upper outer quadrant of the buttock, observing the rules of asepsis. In case of repeated administration, it is recommended to alternate injections on the left and right. Before insertion, you must ensure that the tip of the needle does not enter a blood vessel. In case of severe pain during injection, administration should be stopped immediately. If you have a hip prosthesis, it is recommended that the injection be performed in the other buttock. You can only use a clear solution without any inclusions. It is administered deeply intramuscularly once a day. The recommended dose is 15 mg 1 time per day. Treatment is usually limited to one injection; in exceptional cases (when oral or rectal administration is not possible), the duration of treatment with this dosage form can reach 2-3 days. The patient's need for the drug to relieve symptoms and response to therapy should be periodically assessed. Since the potential risk of adverse reactions depends on the dose and duration of treatment, use the minimum effective dose for the shortest period of time necessary to control symptoms. The maximum recommended daily dose is 15 mg. Elderly patients and patients at increased risk of adverse reactions The recommended dose for elderly patients is 7.5 mg per day. Patients with an increased risk of adverse reactions should begin treatment with a dosage of 7.5 mg per day (1/2 ampoule containing 1.5 ml). Hepatic impairment: No dose reduction is required in patients with mild to moderate hepatic impairment (see Contraindications for recommendations for patients with severe hepatic impairment). Renal impairment: In patients with severe renal failure on hemodialysis, the dose should not exceed 7.5 mg per day. No dose reduction is required in patients with mild to moderate renal impairment (creatinine clearance greater than 25 mL/min) (for recommendations regarding patients with severe renal impairment not undergoing dialysis, see section "Contraindications"). Children and adolescents Meloxicam injection solution 15 mg/1.5 ml is contraindicated in children and adolescents under 18 years of age.
PACKAGING AND CONDITIONS OF DISCHARGE FROM PHARMACIES
In ampoules of 1.5 ml in packaging No. 10, No. 10x1, No. 5. On prescription.
Instructions for use of Meloxicam tablets and suppositories
Tablets are taken once a day in an amount of 7.5-15 mg with meals. This dosage is intended for adults and adolescents. In this case, the tablets can only be used for the first few days, after which it is possible to replace them with another drug.
If the patient is on hemodialysis and has severe kidney pathologies, he can use no more than 7.5 mg per day. However, daily and single dosages of other drugs in the same series (for example, Meloxicam Prana) may differ. The norm depends on the person’s age, condition, concomitant diseases and other factors.
Suppositories are administered rectally once a day - regardless of the time of day or meal. One suppository corresponds to a daily dosage of 15 mg.
Attention!
In case of overdose, the side effects described above may occur. Immediate gastric lavage is indicated; treatment is symptomatic. A specific antidote for Meloxicam has not been developed.
Meloxicam
Meloxicam is a representative of the most popular class of non-steroidal anti-inflammatory drugs. NSAIDs today have firmly established themselves at the top of the pharmacological charts in terms of frequency of prescription by doctors and sales volumes from pharmacies. And this is absolutely justified: they allow you to achieve the desired therapeutic effect in the shortest possible time - and this is exactly what both patients and doctors themselves expect from the drug. The mechanism of action of NSAIDs is associated with the suppression of the activity of cyclooxygenase, or, as it is abbreviated in the specialized literature, COX. For reference: this is an enzyme that promotes the reproduction of prostaglandins, mediators of pain and inflammation. There are (in any case, their presence has been established for certain) two forms of COX. COX-1 saturates most organs and tissues and is in a constantly activated form. It is involved in the synthesis of normal, “non-extreme” prostaglandins, which regulate the normal routine functioning of cells, expressed in the formation of gastrointestinal mucus, suppression of the secretion of hydrochloric acid in the stomach, influence on platelet aggregation, blood supply to the kidneys and other completely ordinary, but necessary processes for the body. Another thing is COX-2: this enzyme is activated only in response to any anti-inflammatory stimuli. That is why it is believed that the unwanted side effects of NSAIDs on the digestive tract and kidneys are associated with the suppression of COX-1, and the therapeutically significant anti-inflammatory effect is associated with the inhibition of COX-2.
The effect of early generations of NSAIDs could be compared to carpet bombing: they indiscriminately “turned off” both COX-1 and COX-2. In contrast, meloxicam is a selective COX-2 inhibitor, which avoids negative reactions with a compatible or higher therapeutic effect compared to the same diclofenac or naproxen. The main purpose of meloxicam is to suppress pain and inflammatory reactions in osteoarthritis and rheumatoid arthritis, although the drug can be used to relieve pain of other origins.
Today in Russian pharmacies you can find three dosage forms of meloxicam: tablets, solution for intramuscular administration and rectal suppositories. The tablets are taken orally once a day with meals. For osteoarthritis, the recommended (also maximum) daily dose for all forms of the drug is 15 mg, for rheumatoid arthritis - 7.5 mg. Injections are made only intramuscularly, observing the required injection depth. The suppositories are inserted as deep as possible into the anus. If the patient has an increased risk of developing negative side effects, then the daily dose should be halved.
Drug interactions
Combined use with myelotoxic drugs increases the side effects of Meloxicam on the blood. If you take the drug together with non-steroidal anti-inflammatory medications, the risk of bleeding in the stomach and intestines, as well as exacerbation of ulcers, increases.
If you take Cholestyramine, the drug promotes the rapid elimination of Meloxicam. When using Heparin, Ticlopidine, drugs to lower blood pressure, and indirect anticoagulants, the risk of bleeding increases. When taken together with Cyclosporine, the likelihood of kidney-related side effects increases.
MELOXICAM (solution)
a day a day.
This is the usual box that contains the drug Meloxicam. It is written that it is dispensed with a prescription and as prescribed by a doctor, but in our pharmacies this drug is sold freely.
Here is the back side of the box, it describes in detail what is included in this drug. There is only one active substance - meloxicam. And several auxiliary components, of which the most well-known substance for me is glycine.
I considered the cost for three ampoules of the medicine quite acceptable - one hundred and fifteen rubles. If it should help in just three days, then the price is a pittance.
The manufacturer was not familiar to me. This drug is produced by Slavic Pharmacies LLC, Vladimir Region. That is, the drug is domestic. To be honest, I trust imported anti-inflammatory drugs more. But the pharmacist highly recommended this product.
The box contains detailed instructions, printed small, but you need to read it. I tried to photograph all the instructions. Meloxicam, as I thought, is an anti-inflammatory non-steroidal drug. Moreover, the active substance (meloxicam) has an analgesic effect, relieves inflammation, and is antipyretic. Well, this drug has so many side effects. that you get tired of listing. Almost all systems of the body can be negatively affected - the nervous system, the digestive system, the circulatory system, the immune system, the genitourinary system...
I was confused, besides such a huge number of side effects, that the drug is intended only for the symptomatic treatment of pain. I always don’t like this, because I still want to not only relieve the symptoms, but also at least slightly remove the cause, in this case, relieve inflammation.
The instructions also describe the symptoms of a drug overdose. However, with only three ampoules in the box, I think it’s difficult to get an overdose. Unless you give several injections in one day.
Interactions with other drugs have also been described. In general, the instructions contain all the information the consumer needs, there are no complaints.
The ampoules were not standard glass, but rather small plastic vials.
Here in the photo are two vials, or ampoules. In this version, there is no need to break anything off like with glass ampoules; there is a small plastic cap on top of the bottle. Here in the photo it is on the left, next to the ampoules. The ampoule is opened very easily; no special equipment is needed. On the front side of the box there is a picture of how to open the ampoule.
The ampoule has a label with basic information about the drug.
I forgot to take a photo of the full ampoule, here’s just a photo of the empty bottle. Meloxicam solution is light yellow in color. I liked the plastic ampoules, they are convenient to use, they are not scary to drop, they won’t break and you won’t have to clean up the fragments.
The Meloxicam injection seemed completely painless to me. I pierced as recommended, one injection for three days, intramuscularly. I used 5 ml syringes (like these), I always take large syringes even for 1 or 2 mg injections, five milliliter syringes have a thin and long needle, which may also be why the injections are not painful. Unfortunately, I didn’t notice any effect from this drug. There was no complete relief of the pain syndrome. Well, I felt better, of course, but I can’t say that much. Although my mother believes that the drug helped her. I don’t know, I didn’t notice any special effect from three injections either immediately or after a couple of days. I probably won’t buy or use this drug again. I don’t like that a medicine with so many side effects stated in the instructions and only promising pain relief has no obvious effect. True, I must say that I didn’t have any side effects either.
Perhaps before using this medicine you should still consult a competent neurologist who will prescribe treatment taking into account the specifics of the situation. But I haven’t gone to the clinic for back pain for a long time. I had to return to the proven remedies that always helped me and get injections of nicotinic acid. It always helps me with noise in the head and back pain in combination with B vitamins, and unfortunately I couldn’t do without Diclofenac ointment. This course, although it didn’t take three days, helped me.
I will not recommend the drug Meloxicam without consulting a competent doctor; there are many stated side effects, but little effect.
Be healthy always and everywhere, thank you everyone for your attention!
Meloxicam solution (10 mg/ml)
Pharmacodynamics
Non-steroidal anti-inflammatory drug (NSAID), has anti-inflammatory, antipyretic, analgesic effects. Belongs to the class of oxicams; enolic acid derivative. The mechanism of action is inhibition of prostaglandin (Pg) synthesis as a result of selective suppression of the enzymatic activity of cyclooxygenase 2 (COX2). When prescribed in high doses, long-term use and individual characteristics of the organism, COX2 selectivity decreases. Suppresses Pg synthesis in the area of inflammation to a greater extent than in the gastric mucosa or kidneys, which is associated with relatively selective inhibition of COX2. Less commonly causes erosive and ulcerative diseases of the gastrointestinal tract (GIT).
Pharmacokinetics
Meloxicam is completely absorbed after intramuscular administration. Relative bioavailability compared to oral bioavailability is almost 100%. After intramuscular administration of the drug at a dose of 5 mg, the maximum concentration in the blood is 1.62 mcg/ml and is achieved within approximately 60 minutes.
Meloxicam binds well to plasma proteins, especially albumin (99%). Penetrates into synovial fluid. The concentration in synovial fluid is approximately 50% of the plasma concentration. The volume of distribution is on average 11 liters. Interindividual deviations are 30-40%.
Meloxicam is almost completely metabolized to 4 pharmacological inert metabolites. The main metabolite, 5-carboxymeloxicam (60% of the dose), is formed by oxidation of the intermediate metabolite 5-hydroxymethylmeloxicam. In vitro studies have shown that the CYP2C9 isoenzyme plays an important role in this metabolic transformation; the CYP3A4 isoenzyme is of additional importance. Peroxidase, the activity of which can vary individually, takes part in the formation of the other two metabolites (constituting 16 and 4% of the drug dose, respectively).
Meloxicam is excreted, predominantly in the form of metabolites, in equal amounts in urine and feces. Less than 5% of the daily dose is excreted unchanged in feces. In urine, unchanged drug is found only in trace amounts. The average half-life is about 20 hours. Plasma clearance is an average of 8 ml/min.
Meloxicam exhibits linear pharmacokinetics in doses of 7.5-15 mg when administered intramuscularly.
