Pharmacodynamics and pharmacokinetics
Mig 400 tablets contain ibuprofen , which is an analgesic with antipyretic and anti-inflammatory properties. It indiscriminately inhibits COX-1 and COX-2 , as well as prostaglandin .
The analgesic properties of the drug are most pronounced in cases of inflammatory pain. The analgesic effect is not of the narcotic type.
After taking the tablets orally, the medicine is well absorbed from the gastrointestinal tract. The maximum plasma concentration of the active ingredient is reached approximately 120 minutes after taking tablets at a dosage of 400 mg.
99% bound to plasma The active component is slowly distributed in the synovial fluid . It is biotransformed in the liver through carboxylation and hydroxylation of the isobutyl group. Pharmacologically inactive metabolites .
Plasma half-life is 2-3 hours. in the form of metabolites and their conjugates . A small part of the drug is excreted unchanged in urine and bile.
How Mig works
The action of the drug is based on ibuprofen. This substance is from the group of non-steroidal anti-inflammatory drugs of the first group. Mig relieves pain well, especially pain in bones and joints, as well as headaches and toothaches, so it is often chosen as a painkiller for fractures and dislocations.
At the same time, due to its ability to relieve inflammation, Mig can be used as an analgesic for pain of inflammatory etiology.
An excellent antipyretic, Mig effectively reduces body temperature when needed. Acting directly on the thermoregulation center, it restores the processes of heat production and release. If you take a headache pill when your body temperature does not exceed normal values, the drug will not affect the thermometer readings.
It is important to remember that taking antipyretics is indicated only when the body temperature has risen above 38.5℃. Exceptions may be cases when the patient experiences febrile convulsions even at a value of 37℃.
Indications for use
The drug is indicated for use for:
- headache;
- toothache;
- pain in muscles and joints;
- fever due to colds and flu ;
- migraine;
- neuralgia;
- menstrual pain.
If you need to find out why Mig 400 tablets will help in each specific case, it is advisable to consult a doctor.
Contraindications
This product is prohibited for use when:
- hemorrhagic diathesis;
- hypersensitivity to the components of the drug;
- erosive and ulcerative lesions of the gastrointestinal tract;
- hemophilia and other bleeding ;
- pregnancy;
- under 12 years of age;
- breastfeeding;
- history of a negative reaction to acetylsalicylic acid and other NSAIDs ;
- aspirin asthma;
- bleeding;
- deficiency of glucose-6-phosphate dehydrogenase ;
- diseases of the optic nerve.
The medicine should be used with caution in the elderly, as well as in cases of arterial hypertension , liver or kidney failure , hyperbilirubinemia , gastritis , colitis , heart failure , liver cirrhosis with portal hypertension , nephrotic syndrome , gastric and duodenal ulcers (including a history ), enteritis , blood diseases.
Using the drug for a hangover
The reason for the hangover syndrome is that when drinking alcoholic beverages, the body is poisoned by toxins and alcohol, the water-salt balance is disturbed, which results in swelling and severe thirst. A person suffers from a lack of fluid.
Using the drug for a hangover is strictly prohibited, since the reaction may be unexpected. Ibuprofen, which is included in the composition, when combined with alcohol, will lead to irritation of the gastrointestinal tract and disruption of the liver.
As a result, neurotoxic complications due to ethanol will occur. The patient may also experience visual hallucinations.
To treat a hangover, it is recommended to drink mineral water, sweet tea, and pickled cucumber brine. Simple liquids will help replenish micronutrient deficiencies and improve liver detoxification. A contrast shower with a combination of hot and cold water will improve the condition of blood vessels.
Adsorbent is taken from hangover tablets. It absorbs liquid and removes harmful components. Activated carbon is the most effective. It is taken at the rate of 2 tablets per 10 kg of weight.
Side effects
The use of Mig 400 can lead to the following adverse reactions:
- Gastrointestinal tract: vomiting, pain in the abdomen, loss of appetite , nausea, flatulence , heartburn , diarrhea , constipation ;
- sensory organs: dry or irritated eyes, decreased hearing, toxic damage to the optic nerve, ringing or noise in the ears, blurred or double vision, swelling of the conjunctiva and eyelids;
- CVS: heart failure , high blood pressure , tachycardia ;
- allergies : rash, Quincke's edema , dyspnea , anaphylactic shock , erythema multiforme , eosinophilia , itching , anaphylactoid reactions , bronchospasm , fever , Lyell's syndrome , rhinitis ;
- changes in laboratory parameters: increased serum creatinine concentration , increased bleeding time, decreased hemoglobin , decreased creatinine clearance liver transaminase activity serum glucose , decreased hematocrit ;
- respiratory organs: shortness of breath , bronchospasm ;
- CNS: insomnia , headache , nervousness, psychomotor agitation , depression , hallucinations , dizziness , anxiety, irritability, drowsiness , impaired consciousness ;
- urinary system: allergic nephritis , acute renal failure , cystitis , nephrotic syndrome , polyuria ;
- hematopoietic system: thrombocytopenic purpura , anemia , leukopenia , thrombocytopenia , agranulocytosis .
In rare cases, ulceration of the gastrointestinal mucosa, pain in the mouth, aphthous stomatitis , hepatitis , irritation or dryness of the oral mucosa, ulceration of the gum mucosa, pancreatitis , and aseptic meningitis .
With prolonged use of the drug in high doses, the likelihood of ulceration of the gastrointestinal mucosa, visual impairment, and bleeding increases.
Top 10 drugs incompatible with alcohol
Why paracetamol, ibuprofen and antigrippin require an exclusively sober lifestyle
It has long been known that alcoholic beverages are not friendly with many medications. But information about which drugs should not be combined with alcohol “in the same glass” is often contradictory and confusing. As part of self-education and preparation for the “generous” Russian holidays - New Year and Christmas - we will fill the gaps in knowledge and determine the list of the most common medications that require an exclusively sober lifestyle.
Let’s say right away that “combining” does not mean washing down the drug with a glass of champagne or wine. The half-life of drugs can reach 10–12 hours, so when you take the medicine in the morning and “on the chest” in the evening, you also combine it with alcohol.
Paracetamol
Few people know that one of the most popular antipyretic and painkillers can be dangerous if combined with alcoholic beverages. In the presence of alcohol, paracetamol is metabolized in the body to form toxic substances that can cause liver damage. The danger is greatest if you combine long-term alcohol intake (for example, 90 ml of vodka or more per day for several days) with high doses of paracetamol (3000 mg or more).
Antiallergic and anti-cold medications
Alcohol consumed on the same day with some antihistamines, including the popular cetirizine and loratadine, increases the effects of the drugs on the central nervous system. This is manifested by increased drowsiness, lethargy and decreased motor activity. It should be borne in mind that many combined anti-cold medications include antiallergic components and, by the way, paracetamol.
Read also: Antibiotics and alcohol: consequences
Be sure to give up alcohol if you are taking Antigrippin (paracetamol + chlorphenamine + ascorbic acid), AntiFlu or Coldact Flu Plus (paracetamol + phenylephrine + chlorphenamine).
Nonsteroidal anti-inflammatory drugs
They are popular and sometimes almost irreplaceable. Ibuprofen, ketoprofen, naproxen, diclofenac and other NSAIDs are taken for toothaches, headaches, severe arthritis or muscle inflammation. And often consumers do not suspect that alcohol taken during treatment with NSAIDs greatly increases the risk of gastrointestinal bleeding. Let me remind you that drugs in this group are already not very friendly to the digestive tract and can cause gastropathy - stomach diseases. Alcohol can turn NSAIDs into aggressive substances that threaten real disaster.
Antitussives
Treatment with widely used medications for dry cough, including dextromethorphan, which is part of complex antitussives (Terasil-D), as well as drugs with codeine (Terpinkod) in combination with alcohol can lead to drowsiness, dizziness and weakness.
Instructions for use Mig 400 (Method and dosage)
The medicine is used internally. For those who take Mig 400 tablets, the instructions for use indicate that dosages are set individually depending on the indications.
Usually start taking the medicine with 200 mg every day 3-4 times. If necessary, the dosage can be increased to 400 mg, which are taken 3 times a day. When the therapeutic effect is achieved, the daily dosage is reduced to 600-800 mg.
The instructions for use of Mig 400 advise that this product should not be taken for more than a week or in higher dosages without consulting a specialist.
In case of , heart or liver dysfunction, the dose is reduced.
Composition and release form
The active substance in Mig is ibuprofen. One tablet contains 400 mg of it. The auxiliary elements are:
- magnesium stearate;
- corn starch;
- silica;
- sodium carboxymethyl starch.
The drug is available in tablets. Each has an elongated oval shape. It is convex on both sides and has a score in the middle, which can be used to divide a single dose in half. The tablets are packaged in blisters. A cardboard box may contain 1 or 2 blisters.
Overdose
When using the drug in doses above normal, abdominal pain , vomiting, drowsiness , headaches, metabolic acidosis , acute renal failure , bradycardia , atrial fibrillation , nausea, lethargy, depression , tinnitus, coma , marked decrease in blood pressure, tachycardia , respiratory arrest are possible. .
If less than 60 minutes have passed since the overdose, gastric lavage . In addition, alkaline drinking, taking Activated Carbon , and forced diuresis . Treatment is symptomatic.
Interaction
When taking Mig 400, the effect of Furosemide and thiazide diuretics , which can be caused by sodium retention due to inhibition of prostaglandin .
In addition, the active ingredient of the drug may enhance the effect of oral anticoagulants . Taking them together is not advisable.
Ibuprofen also reduces the antiplatelet effect of acetylsalicylic acid and reduces the effectiveness of antihypertensive drugs.
Mig 400 should be used with caution in combination with NSAIDs and corticosteroids , as this can lead to adverse reactions from the gastrointestinal tract.
The drug also provokes an increase in the level of Methotrexate in the blood plasma .
In HIV-infected patients with hemophilia, the combination of ibuprofen with zidovudine increases the risk of hemarthrosis .
Combination with Tacrolimus increases the likelihood of nephrotoxicity due to inhibition of prostaglandin .
Under the influence of the drug Mig 400, the hypoglycemic properties of oral hypoglycemic drugs and Insulin are enhanced. Dosage adjustments may be necessary.
Compatibility of Mig and alcohol
? NSAIDs are taken for diseases of the musculoskeletal system, as an analgesic and antipyretic. The compatibility of the drug and alcohol leads to various negative consequences.
Mig is absolutely incompatible with alcoholic drinks. When present, the drug is converted into toxic substances that can cause enormous damage to the liver. The risk increases if you combine about 90 ml of vodka and 3000 mg of the drug for a long time.
Alcohol, which has a negative effect on the medication:
- beer;
- vodka;
- wine;
- cocktails;
- champagne;
- cognac.
Even one dose of alcohol affects the medication. Alcohol and painkillers are classified as antidepressants that depress the central nervous system. The double effect inhibits the processes of the nervous system and reduces the supply of oxygen to the body.
Alcohol and drugs are broken down in the liver, so the simultaneous intake of both components forces the nephrons to function at an increased rate. Their decay negatively affects the excretory system.
