Buy Mezim forte 10000 film-coated tablets No. 20 in pharmacies

Compound

The active ingredient in Mezim Forte is pancreatin (powder from pork pancreas) in a concentration of 93.33 - 107.69 mg/tab. Minimum enzyme activity of the drug:

• amylase - 4.2 thousand euros. pharm. units;
• lipase - 3.5 thousand euros. pharm. units;
• protease - 250 euros. pharm. units

Auxiliary components: MCC, sodium starch glycolate (type A), anhydrous colloidal silicon dioxide, hypromellose, talc, Mg stearate, additives E122 (azorubine varnish) and E171 (titanium dioxide), simethicone emulsion, macrogol 6000, polyacrylate dispersion.

Composition of Mezim Forte 10000/Mezim 20000 tablets: powder from pork pancreas (concentration, respectively 125 mg/tablet/220–293.34 mg/tablet) with minimal lipolytic activity - 10/20 thousand euros. pharm. units, minimal amylolytic activity - 7.5/12 thousand euros. pharm. units, minimum proteolytic activity 375/900 euros. pharm. units

Auxiliary components: lactose monohydrate, MCC, anhydrous colloidal silicon dioxide, Mg stearate, crospovidone, methacrylic acid and ethyl acrylate copolymer (1:1 ratio), additives E122 (azorubic varnish) and E171 (titanium dioxide), hypromellose, triethyl citrate, simethicone emulsion , talc, polyethylene glycol 6000, polysorbate 80, sodium carmellose, sodium hydroxide.

Mezim forte 10,000 enteric-coated tablets No. 10x2

Name

Mezim forte 10000.

Description

Tablets, enteric-coated, pink, round, with biconvex surfaces, chamfered; Brown inclusions are possible on the fracture.

Main active ingredient

Pancreatin

Release form

Tablets, enteric-coated, pink, round, with biconvex surfaces, chamfered; Brown inclusions are possible on the fracture. 1 tab. Active substance: pancreatin 137.5 mg; with minimal enzymatic activity: lipase 10,000 units Ph.Eur; amylase 7500 units Ph.Eur; protease 375 units Ph.Eur; Excipients: lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, crospovidone, magnesium stearate. Shell composition: hypromellose, copolymer of methacrylic acid and ethyl acrylate (1:1) dispersion 30% (dry weight), triethyl citrate, titanium dioxide (E171), talc, simethicone emulsion 30% (dry weight), macrogol 6000, sodium carmellose, polysorbate 80 , azorubine varnish (E122), sodium hydroxide. 10 pieces. - blisters (1) - cardboard packs. 10 pieces. - blisters (2) - cardboard packs.

special instructions

In case of acute pancreatitis or exacerbation of chronic pancreatitis (at the stage of attenuation of exacerbation), during a restorative diet, it is advisable to prescribe Mezim® forte 10000 against the background of existing or remaining insufficiency of pancreatic function. Mezim® forte 10000, taking into account the solid indivisible dosage form, is contraindicated in children under 3 years of age. The effect of the drug on the ability to drive vehicles and operate machinery Mezim® forte 10000 does not affect the speed of psychomotor reactions and the ability to perceive or assess a situation.

pharmachologic effect

An enzyme preparation that improves digestion. Pancreatin is a powder from pork pancreas, which, along with the exocrine pancreatic enzymes - lipase, amylase, protease, trypsin and chymotrypsin, also contains other enzymes. Pancreatic enzymes included in the drug facilitate the breakdown of proteins, fats and carbohydrates, which leads to their more complete absorption in the small intestine. Trypsin suppresses stimulated pancreatic secretion, producing an analgesic effect. The maximum enzymatic activity of the drug is observed 30-45 minutes after oral administration.

Pharmacokinetics

Mezim® forte 10000 tablets are coated with an acid-resistant coating that does not dissolve under the action of stomach hydrochloric acid and thereby protects the enzymes contained in the drug from inactivation. Dissolution of the shell and release of enzymes occurs at a pH value close to neutral or slightly alkaline.

Indications for use

Replacement therapy for exocrine pancreatic insufficiency (including chronic pancreatitis, cystic fibrosis); chronic inflammatory-dystrophic diseases of the stomach, intestines, liver, gall bladder; conditions after resection or irradiation of the gastrointestinal tract, accompanied by impaired digestion of food, flatulence, diarrhea (as part of combination therapy); gastrointestinal disorder of a functional nature (with intestinal infectious diseases, irritable bowel syndrome, etc.); to improve food digestion in patients with normal gastrointestinal function in case of dietary errors; preparation for x-ray and ultrasound examinations of the abdominal organs.

Directions for use and doses

The dose of Mezim® forte 10000 is set individually depending on the severity of the disease and the composition of the food. Unless otherwise indicated, the average single dose for adults is 2-4 tablets. Mezim® forte 10000 per meal. It is recommended to take half or a third of a single dose at the beginning of a meal, and the rest during it. The drug is taken orally, without chewing and with a sufficient amount of liquid. It is possible to increase the dose, which should only be carried out under the supervision of a physician, focusing on the weakening of symptoms (for example, steatorrhea, abdominal pain). The maximum daily dose is 15,000-20,000 units Ph.Eur. lipase/kg body weight. For children, the dosage regimen is determined by the doctor depending on the severity of the disease and the composition of the food at the rate of 500-1000 units Ph.Eur. lipase/kg of child's body weight for each meal. The duration of treatment can vary from several days (for indigestion, dietary errors) to several months and even years (if constant replacement therapy is necessary).

Use during pregnancy and lactation

Due to the lack of sufficient data on the use of pancreatic enzymes in humans during pregnancy and lactation, the use of Mezim® forte 10000 is possible only if the expected benefit to the mother outweighs the possible risk to the fetus or child.

Precautionary measures

Contraindicated in children under 3 years of age (indivisible dosage form). For children, the dosage regimen is determined by the doctor depending on the severity of the disease and the composition of the food at the rate of 500-1000 units Ph.Eur. lipase/kg of child's body weight for each meal.

Interaction with other drugs

When taking medications containing pancreatin, the absorption of folic acid may be reduced. The effect of hypoglycemic drugs (acarbose, miglitol) may decrease when taken simultaneously with pancreatin. With the simultaneous use of pancreatin with iron preparations, the absorption of the latter may be reduced. The simultaneous use of antacids containing calcium carbonate and/or magnesium hydroxide may lead to a decrease in the effectiveness of the drug.

Contraindications

Acute pancreatitis; exacerbation of chronic pancreatitis; hypersensitivity to pancreatin or other components of the drug; hereditary galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome; children under 3 years of age (indivisible dosage form).

Compound

Active substance: pancreatin 137.5 mg; with minimal enzymatic activity: lipase 10,000 units Ph.Eur; amylase 7500 units Ph.Eur; protease 375 units Ph.Eur; Excipients: lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, crospovidone, magnesium stearate. Shell composition: hypromellose, copolymer of methacrylic acid and ethyl acrylate (1:1) dispersion 30% (dry weight), triethyl citrate, titanium dioxide (E171), talc, simethicone emulsion 30% (dry weight), macrogol 6000, sodium carmellose, polysorbate 80 , azorubine varnish (E122), sodium hydroxide.

Overdose

There are no data on cases of overdose and intoxication with the drug. Possible: hyperuricosuria. hyperuricemia, in children - constipation. Treatment: drug withdrawal, symptomatic therapy.

Side effect

No side effects or complications were detected even with long-term and regular use of the drug Mezim ® forte 10000 in patients with impaired pancreatic function. In some cases, after taking pancreatin, allergic reactions may develop; rarely - diarrhea or constipation, nausea, discomfort in the epigastric region. In isolated cases, in patients suffering from cystic fibrosis, with prolonged use of high doses of the drug, hyperuricosuria (increased levels of uric acid in the blood plasma) may develop, and strictures may form in the ileocecal region and ascending colon.

Storage conditions

The drug should be stored out of the reach of children at a temperature not exceeding 30°C.

Buy Mezim forte 10000 tablets p/enteric solution. about. in bl. in pack No. 10x2 in the pharmacy

Price for Mezim forte 10000 tablets p/enteric solution. about. in bl. in pack №10x2

Instructions for use for Mezim forte 10000 tablets p/enteric solution. about. in bl. in pack №10x2

Release form

• Mezim Forte film-coated tablets. The tablets are pink, flat, cylindrical in shape, with almost plane-parallel surfaces and a beveled edge. Available packaged in blister packs of 20 pieces, packaging No. 20 or No. 80.
• Tablets Mezim Forte 10000 in a red coating. The tablets are pink, film-coated, have almost flat-parallel surfaces and a beveled edge. Available packaged in blister packs of 10 pieces, packaging No. 20 or No. 50.
• Mezim 20000 tablets in a red coating. The tablets are round, biconvex, white (possibly grayish-white) in color, with a smooth surface, there may be brown inclusions on the break, and have a specific odor. Available packaged in blister packs of 10 pieces, packaging No. 10, No. 20 or No. 50.

Pharmacodynamics and pharmacokinetics

The basis of the multienzyme drug Mezim is pancreatin . Wikipedia states that the substance is a powder that is obtained from the pork pancreas (PG) by extraction.

The substance contains excretory enzymes of the pancreas (amylase, lipase, trypsin and chymotrypsin), which are necessary for the digestion of proteins, carbohydrates and fats.

Pancreatin is not absorbed, but is excreted with the contents of the intestine. Most of the dose taken is broken down and denatured in the digestive canal under the influence of bacteria and digestive juices.

The decisive factors for the effectiveness of the drug are the lipolytic activity of pancreatin, as well as the proportion of trypsin, while amylase activity is important only in patients with cystic fibrosis .

The drugs Mezim and Mezim Forte have differences. The coating of Mezim Forte tablets is not enteric-soluble, which is why the lipolytic activity of the drug is inactivated even when the pH value of the gastric juice is below 4.

Mezim Forte 10000 and Mezim 20000 tablets are coated with a red coating that does not dissolve under the influence of gastric juice and thus protects pancreatic enzymes from inactivation.

Dissolution of the membrane and release of enzymes occurs only in a neutral or slightly alkaline environment of the small intestine.

Peculiarities

Mezim Forte tablets, flat with beveled edges, are pink in color. Their peculiarity is that they have an enteric, dense shell. The tablets are packaged in blisters.

The active substance in the enzyme preparation is pancreatin, which is obtained from the pancreas of pigs. This component has a positive effect on the digestion process. When taking an enzyme preparation, the breakdown of fats, carbohydrates and proteins that enter the body with food improves.

The medication allows you to compensate for enzyme deficiency in a short time. This guarantees normalization of the digestion process and improvement of the overall functional state of the gastrointestinal tract.

When Mezim Forte tablets enter the stomach, they do not dissolve under the influence of gastric juice, but enter the intestines. When the active substance is mixed with intestinal contents, enzymes are distributed evenly. This guarantees the high effectiveness of the drug. Pancreatin is excreted in feces without having a systemic effect on the body.

Indications for use of Mezim

Indications for use Mezim Forte

The tablets are designed to improve digestion. Indications for their use are:

• dyspepsia;
• simultaneous consumption of fatty, difficult to digest, unusual foods;
• flatulence associated with these disorders ;
• functional disorders accompanied by accelerated transit of intestinal contents.

What do Mezim Forte 10000 tablets help with?

The drug is prescribed for:

• diseases accompanied by digestive disorders due to insufficient secretion of essential enzymes from the pancreas;
• conditions after simultaneous removal of sections of the small intestine and stomach;
• functional disorders accompanied by accelerated transit of intestinal contents;
• simultaneous consumption of fatty, difficult to digest, unusual foods; flatulence, intestinal disorders;
• preparation for ultrasound or x-ray diagnostic studies.

When is Mezim 20000 prescribed?

Mezim 20000 is effective for:

• insufficiency of exocrine function of the pancreas;
• chronic inflammatory-dystrophic diseases of the liver, intestines, gall bladder, stomach;
• conditions after irradiation or resection of the listed organs, if these conditions are accompanied by impaired digestion of food, diarrhea , flatulence ;
• to eliminate the consequences of dietary errors and improve digestion in patients with normal pancreatic function;
• preparing patients for ultrasound or x-ray diagnostic examinations;
• functional gastrointestinal disorders: infectious intestinal diseases, irritable bowel syndrome .

Indications

The drug Mezim Forte is indicated if replacement therapy is necessary due to the development of various pathological conditions. This:

• Chronic pancreatitis. It is characterized by the occurrence of pain in the left hypochondrium and various dyspeptic symptoms after eating a heavy meal.
• Cystic fibrosis. As a hereditary disease develops, various intestinal disorders occur.

The drug Mezim Forte is prescribed to stabilize the condition in the treatment of pancreatic cancer, as well as after surgery on the organ. The remedy is also indicated for other pathological conditions accompanied by pancreatic insufficiency. All of them are indicated in the instructions for use, but decisions about taking the drug should always be made by a doctor.

Short-term use of the drug is permitted in cases of relative enzyme deficiency. This occurs with functional disorders of the gastrointestinal tract, against the background of acute intestinal infections, and irritable bowel syndrome. A single dose of the drug is indicated after eating indigestible or fatty foods, as well as before X-ray and ultrasound examinations of the abdominal organs.

Contraindications

Contraindications for the use of Mezim Forte:

• hypersensitivity to pancreatin obtained from pig livestock, food additive E122 (synthetic food coloring azorubine), auxiliary components of tablets;
• acute pancreatitis;
• cases of exacerbation of chronic pancreatitis ;
• obstructive intestinal obstruction (occurs when a mechanical obstruction appears).

For pancreatitis, occasional use of the drug is possible during the period of restorative dietary nutrition when the exacerbation subsides.

Side effects

Side effects of Mezim Forte appear as:

• immediate hypersensitivity reactions (sneezing, lacrimation, skin rashes, bronchospasm );
• disorders of the digestive system, including nausea, diarrhea, abdominal pain, changes in bowel habits.

The additive E122 (azorubine varnish) contained in the tablets can also cause allergic reactions.

The annotation for Mezim Forte 10000 and Mezim 20000 indicates that in patients with cystic fibrosis , when using high doses of the drug, narrowing in the ileocecal region and in the ascending colon is sometimes possible.

Also, in patients with cystic fibrosis , the possibility of increased excretion of uric acid in the urine cannot be excluded, especially when taking high doses of pancreatin. To avoid the formation of uric acid stones in such patients, its concentration in the urine should be kept under control.

Buy Mezim forte 10000 film-coated tablets No. 20 in pharmacies

Instructions for use Mezim forte 10000 tab p.o No. 20

Dosage forms tablets Synonyms Gastenorm forte Gastenorm forte 10000 Creon 10000 Creon 25000 Creon 40000 Mezim 20000 Mezim forte Mikrasim Pangrol 10000 Pangrol 25000 Panzinorm 10000 Panzinorm forte 20000 Panzinorm forte-N Pancreazim Pancreatin Pancreatin forte Pancreatin-LekT Penzital Enzistal-P Ermital Group Enzyme products that improve digestive processes International nonproprietary name Pancreatin Composition Active ingredient - pancreatin. Manufacturers Berlin-Chemie AG (Germany), Berlin-Chemie AG/Menarini Group (Germany) Pharmacological action Replenishes the deficiency of pancreatic enzymes. Contains excretory pancreatic enzymes: lipase, alpha-amylase, trypsin, chymotrypsin, promotes the breakdown of proteins (to amino acids), fats (to glycerol and fatty acids) and starch (to dextrins and monosaccharides), normalizes digestive processes. The enzymes that make up pancreatin are released in the alkaline environment of the small intestine, because protected from the action of gastric juice by the membrane. Trypsin in the upper part of the small intestine inhibits stimulated pancreatic secretion, causing the analgesic effect of pancreatin. Side effects Symptoms of intestinal obstruction (formation of strictures in the ileocecal region and ascending colon) and immediate allergic reactions (with cystic fibrosis, especially in children). Indications for use Digestive insufficiency in violation of the exocrine function of the pancreas: cystic fibrosis, chronic pancreatitis, pancreatectomy, dyspepsia, Roemheld syndrome, flatulence; impaired digestion of food, intestinal infections, chronic diseases in the liver and biliary tract, intestinal degassing before diagnostic studies. Contraindications Hypersensitivity (including pork intolerance), acute pancreatitis, exacerbation of chronic pancreatitis. Method of administration and dosage : Orally, before meals, without chewing, with plenty of liquid (alkaline if possible: water, fruit juices). The dose is set individually, depending on the severity of the digestive disorder. In the usual dose - 1-2 tablets, if necessary, with meals, another 1-4 tablets. It is not recommended to exceed the daily dose of enzymes, which is 15,000-20,000 IU lipase/kg, especially in patients with cystic fibrosis. The duration of treatment can vary from several days (if the digestive process is disrupted due to errors in the diet) to several months and even years (if constant replacement therapy is necessary). Overdose No data available. Interaction Reduces iron absorption (especially with long-term use). Special instructions For long-term use, iron supplements should be prescribed. It is not recommended to exceed the daily dose, especially for patients with cystic fibrosis. Storage conditions: In a dry place, protected from light.

Instructions for use (Method and dosage)

Instructions for use Mezim Forte

Both adults and children over three years of age are prescribed to take one or two tablets with meals, without chewing and with a sufficient volume (about 200 ml) of liquid.

When carrying out enzyme replacement therapy, take two to four tablets of the drug.

The duration of the course is set individually.

Instructions for use Mezim Forte 10000

The dose of the drug depends on the deficiency of pancreatic enzymes in the duodenum and is selected individually.

In the absence of other recommendations, as well as in cases of consuming difficult-to-digest vegetable, unusual or fatty foods, an adult should take one or two tablets at each meal.

When carrying out enzyme replacement therapy, the recommended dose is two to four tablets. If necessary, it can be larger.

Increasing the dose to relieve symptoms (abdominal pain, steatorrhea) should be carried out under the supervision of a physician.

The permissible upper limit of the daily dose of lipase is 15-20 thousand euros. pharm. units/kg

The question of the dosage of the drug and the duration of the course of treatment is decided by the doctor.

How to take Mezim 20000?

The drug is taken with meals with plenty of warm water (the tablets are swallowed whole, without chewing).

The dose is set individually depending on the severity of the disease.

Unless otherwise directed, adults should take one or two tablets. Increase the dose, focusing on the weakening of symptoms, and only under the supervision of a doctor.

It is contraindicated to exceed a dose exceeding 15-20 thousand euros. pharm. units lipase/kg.

Treatment can last from several days (for dietary errors or digestive disorders) to several years (if it is necessary to prescribe enzyme replacement therapy to the patient).

Instructions for use of Mezim Forte for children

Mezim Forte is prescribed to children in a standard dosage - one or two tablets during meals with plenty of warm water.

For children under twelve years of age, Mezim Forte 10,000 is prescribed in a dose necessary to normalize bowel movements, but not exceeding 1.5 thousand euros. pharm. units lipase/kg. For adolescents 12-18 years old, the permissible upper limit of the daily dose of lipase is 15-20 thousand euros. pharm. units/kg

Mezim 20,000, in the absence of other recommendations, children are given at the rate of 1 thousand euros. pharm. units lipase/kg.

Recommendations

After agreeing on the use of the drug Mezim Forte with the doctor, the tablets should be taken in accordance with the instructions contained in the instructions for use in the appropriate section. The recommended dose with meals is 2-4 tablets. It can be changed by the doctor if necessary. In this case, an increase in dosage is possible in order to reduce the severity of symptoms in case of digestive disorders.

The instructions for use of the product do not prohibit the use of the drug during pregnancy. But at the same time, despite the absence of contraindications, Mezim Forte tablets should be taken during the critical period for a woman only with medical recommendations. You must strictly adhere to the recommended duration of treatment with the drug. This will eliminate the possible negative impact of the medication on the development of the fetus. A similar approach is required when taking the drug during lactation.

It is important to swallow Mezim Forte tablets whole. You need to wash them down with enough water or juice. When chewed, the effectiveness of the drug is significantly reduced, since the enzymes do not enter the intestines, but are absorbed in the stomach. In addition, if they enter the oral cavity, they can damage the mucous membrane.

The instructions for use do not contain any time restrictions on taking Mezim Forte tablets. The interval for using the product is determined by the doctor depending on the type of disease. To compensate for a missed dose, you should not take additional tablets. It is necessary to continue treatment in accordance with the recommended regimen.

Mezim Forte should be stored in a place where children do not have access. The temperature in it should not be higher than 30°C. The shelf life of the product is indicated by the manufacturer on the cardboard packaging. It is strictly prohibited to use the tablets after the end.

special instructions

There are no special instructions for the use of Mezim Forte.

Precautionary measures for Mezim Forte 10000 and Mezim 20000

Intestinal obstruction is a known complication in patients with cystic fibrosis , so if symptoms reminiscent of this condition appear, you should be aware of possible intestinal strictures.

The drug contains active enzymes that can damage the oral mucosa, even to the point of ulceration, so the tablets must be swallowed whole without chewing.

Patients with congenital galactose intolerance, lactase deficiency and or impaired absorption of glucose/galactose are contraindicated to take the drug.

There is no need to limit activities related to driving a car or dangerous machinery.

Analogues of Mezim Forte

Level 4 ATC code matches:
Digestin

Creon

Pancitrate

Festal

Pankreoflat

Pancreazim

Enterosan

Panzinorm Forte

Panzinorm

Micrasim

Enzistal P

Pancreatin

Penzital

Pangrol

Hermital

Abomin

• Pancreatin
• Biozyme
• Gastenorm
• Creon
• Micrasim
• PanziCam
• Pangrol
• Panzinorm
• Pankrenorm
• Penzital
• Pancitrate
• Uni-Festal
• Hermital

Cheap analogues of Mezim

As a more affordable substitute for the drug, Pancreatin (price from 20 rubles for package No. 20) or Penzital (price for package No. 20 - from 60 rubles, for package No. 100 - from 170 rubles) can be used.

Which is better: Festal or Mezim?

The active substances of the drug Festal are pancreatin, hemicellulose and bile components. The medicine is available in the form of enteric tablets.

The protective shell reduces the aggressive effects of acid, and also helps ensure that the active substances enter and begin to act in the intestines, where the help of enzymes is needed.

However, there are also disadvantages - the pills, like Mezim tablets, are taken during lunch, that is, they enter the intestines with food, and not necessarily with the first portion. The coating with which Mezim tablets are coated begins to dissolve in the stomach, due to which food enters the intestines with enzymes.

In Festal, one of the components that enhances its effect is bile, which facilitates the digestion of fats. And this is basically very good, but this effect is strictly contraindicated in patients with cholelithiasis .

Mezim or Creon - which is better?

Creon has an active ingredient identical to Mezim, but in the drug Creon it is contained in a much higher concentration.

However, this is not the main difference between the drugs. First of all, they are distinguished by the form of release. Creon is available in the form of capsules filled with minimicrospheres.

The unique dosage form of the drug ensures its higher effectiveness (including for severe digestive disorders) - the microcomponents of the capsules are mixed almost evenly in the stomach with food, due to which the medicine enters the intestines with each serving of food, and the food is digested much more evenly.

It has been proven that the use of pancreatin in the form of capsules filled with microspheres is much more effective than the use of conventional tablets and mini-tablets: during treatment with Creon, the patient’s digestive function is restored more quickly and completely, and the duration of the relapse-free period is increased.

The downside of the drug is its high content of active components - concentrated accumulations of enzymes can irritate the intestines. In addition, it is known that the supply of enzymes in large quantities from the outside can provoke a situation when the pancreas stops producing its own enzymes.

High doses of pancreatin are effective in the treatment of severe pathologies, however, when it comes to treating pregnant women or children, the low content of enzymes in Mezim is its advantage over its analogue.

Mezim neo 10,000, 20 enteric capsules 10,000 units

Registration Certificate Holder

BERLIN-CHEMIE/MENARINI PHARMA (Germany)

Dosage form

Medicine - Mezim® neo 10000 (Mezym neo 10000)

Description

Enteric capsules
1 cap.
pancreatin 10000 units

20 pcs. — polypropylene bottles (1) — cardboard packs. 50 pcs. — polypropylene bottles (1) — cardboard packs. 100 pieces. — polypropylene bottles (1) — cardboard packs.

Indications

Replacement therapy for exocrine pancreatic insufficiency in adults and children in the following conditions:

• chronic pancreatitis;
• cystic fibrosis;
• pancreas cancer;
• conditions after surgical interventions on the pancreas and stomach (complete or partial resection of the organ);
• after irradiation of the gastrointestinal tract, accompanied by impaired digestion of food, flatulence, diarrhea (as part of combination therapy);
• narrowing of the pancreatic duct (for example, due to a tumor or gallstones);
• Shwachman-Diamond syndrome;
• subacute pancreatitis;
• other diseases accompanied by exocrine pancreatic insufficiency.

Relative enzyme deficiency in the following conditions and situations:

• functional gastrointestinal disorders;
• for acute intestinal infections,
• with irritable bowel syndrome;
• consumption of indigestible plant or fatty foods.

Preparation for x-ray and ultrasound examinations of the abdominal organs.

Contraindications for use

• acute pancreatitis;
• exacerbation of chronic pancreatitis;
• hypersensitivity to porcine pancreatin or other components of the drug.

pharmachologic effect

The active ingredient of Mezim® neo 10000 is pancreatin, which is a powder from the pancreas of pigs. The enzymes that make up pancreatin help break down fats, carbohydrates and proteins coming from food. Pancreatin, having proteolytic, amylolytic and lipolytic effects, compensates for enzymatic insufficiency of the pancreas, improves the functional state of the gastrointestinal tract, and normalizes digestive processes.

Drug interactions

No interaction studies have been conducted.

Dosage regimen

The dose of Mezim® neo 10000 is selected individually depending on the severity of the disease, as well as the volume and composition of food taken.

Unless otherwise instructed, adults

It is recommended to take 2-4 caps. Mezim® neo 10000 during each meal, swallowing the capsules whole (do not chew) with a sufficient amount of liquid (for example, a glass of water).

If it is difficult for the patient to take a whole capsule (for example, in small children or elderly patients), you can pour its contents, for example, into a glass, opening the capsule by separating the cap from the body, and then take the contents (mini-tablets) with a small amount liquids or added to liquid foods that do not require chewing (such as applesauce or fruit juice). The mixture of mini-tablets with food or liquid cannot be stored (take immediately after preparation).

Increasing the dose of the drug should be carried out only under the supervision of a physician, focusing on the dynamics of symptoms (for example, a decrease in steatorrhea, easing abdominal pain).

It is not recommended to exceed the daily dose of enzymes, which is 15,000-20,000 lipase units/kg of body weight.

The duration of treatment is determined by the doctor and depends on the course of the disease.
For children,
the dosage regimen and duration of treatment are determined by the doctor depending on the severity of the disease and the composition of the food at the rate of 500-1000 lipase units. /kg of the child’s body weight for each meal.

For cystic fibrosis

The dose of Mezim® neo 10000 depends on body weight and at the beginning of treatment should be 1000 lipase units/kg at each meal for
children under 4 years of age
, and 500 lipase units/kg at each meal for
children over 4 years of age
. The dose of the drug should be selected individually depending on the severity of the disease, under the control of steatorrhea and the support of an optimal diet. For most patients, the dose should be no more than 10,000 lipase units/kg/day or 4,000 lipase units/g fat consumed.

Overdose

Symptoms:

the use of large doses of pancreatic enzymes may be accompanied by hyperuricosuria and hyperuricemia in patients with cystic fibrosis.

Treatment:

drug withdrawal, symptomatic therapy.

Side effect

Possible side effects are listed below in descending frequency of occurrence: common (> 1/100, < 1/10), uncommon (> 1/1000, < 1/100), rare (> 1/10000, < 1/1000), very rare (<1/10000), including isolated reports.
From the gastrointestinal tract:
often - nausea, vomiting and bloating. Gastrointestinal disorders are mainly associated with the underlying disease. The incidence of the following adverse reactions was lower or similar to those with placebo: very common - abdominal pain; often - diarrhea.

For the skin and subcutaneous tissues:

rarely - rash; There is not enough data to estimate the frequency of cases - itching, urticaria.

special instructions

In patients suffering from cystic fibrosis who received high doses of pancreatin preparations, strictures of the ileum, cecum and colon (fibrosing colonopathy) have been described.
As a precaution, if unusual symptoms appear or changes in the nature of the symptoms of the underlying disease, a medical examination is necessary to exclude damage to the colon, especially when using the drug at a dose of more than 10,000 lipase units/kg/day. Effect on the ability to drive vehicles and machinery
Mezim® neo 10000 does not affect the performance of potentially hazardous activities that require special attention and speed of reaction.

Storage conditions

The drug should be stored out of reach of children at a temperature not exceeding 25°C.

Best before date

Shelf life: 2 years.

Do not use after the expiration date stated on the package

Use during pregnancy and breastfeeding

Restrictions during pregnancy - With caution. Restrictions when breastfeeding - No restrictions.

There are no clinical data on the treatment of pregnant women with drugs containing pancreatic enzymes. Animal studies have not revealed the absorption of pancreatic enzymes of porcine origin, therefore toxic effects on reproductive function and fetal development are not expected.

The use of Mezim® neo 10000 during pregnancy is possible if the expected benefit to the mother outweighs the possible risk to the fetus.

Based on animal studies in which no negative effects of pancreatic enzymes were detected, no harmful effects of the drug on the child through breast milk are expected. You can take pancreatic enzymes while breastfeeding.

Use in children

Restrictions for children - With caution.

For children

The dosage regimen and duration of treatment are determined by the doctor depending on the severity of the disease and the composition of the food at the rate of 500-1000 lipase units. /kg of the child’s body weight for each meal.

Terms of sale

The drug is approved for use as a means of OTC.

Contacts for inquiries

BERLIN-CHEMIE/MENARINI PHARMA GmbH (Germany)

BERLIN-CHEMIE/A.MENARINI LLC

123317 Moscow, Presnenskaya embankment. 10 Business, Block B Tel.; Fax

Mezim during pregnancy and lactation

Is it possible to drink Mezim Forte during pregnancy?

Officially, there are no contraindications to the use of Mezim during pregnancy , but women still doubt whether pregnant women can take these pills and whether it will harm the unborn child.

The manufacturer indicates that Mezim tablets contain enzymes identical to those produced in the human body. Lipase acts on fats, amylase breaks down carbohydrates, and proteases work on protein foods.

The auxiliary components of the drugs are also not harmful to humans and, in addition, pancreatin is not absorbed into the bloodstream, but is excreted from the body with feces.

Considering all of the above, gynecologists and therapists often recommend Mezim to eliminate digestive problems in pregnant women. In each case of prescribing a drug during pregnancy, the doctor bears full responsibility for his decision.

Therefore, you should only take the medicine if you completely trust your doctor.

It is recommended that pregnant women take the tablets while sitting or standing, because in the lying position the tablet moves more slowly through the digestive canal and may begin to dissolve before reaching the stomach.

Use of Mezim during breastfeeding

Use during breastfeeding is possible according to doctor's orders, which are made taking into account the ratio of the expected therapeutic effect for the mother's body and the potential risks for the infant.

Reviews of Mezim Forte

Reviews about Mezim Forte are either good or very good. The product is an excellent remedy for heartburn , bloating , early satiety, belching , nausea , and flatulence .

Most people believe that the drug is indispensable for those who like to eat delicious food, confirming this with the words: “... If your stomach hurts after overeating, take Mezim, and the feeling of heaviness goes away.”

The appearance of lightness in the stomach after taking the pill most likely served as a prerequisite for the emergence of the opinion that the drug could be used for weight loss. However, this is nothing more than a myth - Mezim is not intended to treat obesity and eliminate excess weight problems, it only helps to normalize digestion and facilitate the work of the life-sustaining system.

How much does Mezim Forte cost?

In Russia, Mezim forte No. 20 tablets cost about 70 rubles. You can buy Mezim 20000 No. 20 tablets for about 250 rubles.

The price of Mezim forte 10000 No. 20 in Ukraine is about 100 hryvnia, Mezim 20000 No. 20 tablets are about 170 hryvnia.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Mezim forte tablets p.p.o.
  80 pcs. Berlin - Chemie AG / ZAO Berlin Pharma RUB 291 order
• Mezim 20000 tablets p.p.o. enteric solution 20 pcs. Berlin-Chemie AG DE

  RUB 259 order

• Mezim forte tab. p.o. 20 pcs. Berlin - Chemie AG / JSC Berlin Pharma

  82 RUR order

• Mezim pro tablets p.p.o 20 pcs. Catalent Germany Eberbach GmbH/ZAO Berlin-Pharma

  180 rub. order

• Mezim neo 10000 caps. ksh/sol. 10000 units 20 pcs. Adair Pharmaceuticals S.r.l./Berlin-Chemie AG

  RUB 242 order

Pharmacy Dialogue

• Mezim neo 10000 (caps. intestinal plant. 10000 units No. 20)Adair Pharmaceuticals

  240 rub. order

• Mezim Forte (table p/o No. 80)Berlin-Chemie AG/Berlin-Pharma ZAO

  RUB 309 order

• Mezim Forte (tablet No. 20)Berlin-Chemie AG/Menarini

  70 rub. order

• Mezim Pro (tab.kish.sol.p.v. No. 20) Berlin-Pharma ZAO

  166 RUR order

• Mezim neo 10000 (caps. intestinal plant. 10000 units No. 50)Adair Pharmaceuticals

  485 rub. order

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Pharmacy24

• Mezim forte 10000 No. 20 tablets Menarini Von Heyden GmbH/ Berlin Chemi AG (Menarini Group), Nimechchina/Nimechchina
  101 UAH.order
• Mezim forte 10000 No. 10 tablets Menarini von Heyden GmbH/ Berlin Chemi AG (Menarini Group), Nimecchina/Nimecchina

  51 UAH order

• Mezim forte 20000 No. 20 tablets Berlin Chemi AG (Menarine Group), Nimechchina

  169 UAH order

PaniPharmacy

• Mezim forte 10000 tablets Mezim forte 10000 tablets. p/o No. 10 Germany, Berlin-Chemie

  53 UAH order

• Mezim forte 10000 tablets Mezim forte 10000 tablets. p/o No. 20 Germany, Berlin-Chemie

  105 UAH order

• Mezim forte 20000 tablets Mezim forte 20000 tablets. p/o No. 20 Germany, Berlin-Chemie

  185 UAH order

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