Comparing Akriderm and Akriderm GK | Determining the best

Updated: 04/23/2021 15:11:06

Expert: Abramova Tsilya

Akriderm is an ointment for topical use based on betamethasone. Akriderm GK is a drug with an additional composition and a wider range of applications. We analyzed both ointments to understand in which cases it is better to give preference to one or the other.

Description of Akriderm and Akriderm GK

Akriderm hormonal ointment is based on betamethasone. This is a potent remedy that must be used according to indications. It is usually prescribed when non-hormonal ointments do not provide the desired result. Manufacturer: Akrikhin, Russian Federation.

Betamethasone is a glucocorticosteroid substance that can inhibit the release of inflammatory mediators. The pronounced effect of the drug allows it to be used to quickly eliminate dermatological manifestations such as swelling, itching, redness in severe diseases.

Akriderm GK contains not only betamethasone, but the following substances:

1. gentamicin – antibacterial agent;
2. Clotrimazole is an antifungal agent.

pharmachologic effect

"Akriderm" is a glucocorticosteroid for external use. In addition to the above-mentioned actions of betamethasone dipropionate, the drug has a vasoconstrictor and antiproliferative effect. The use of this drug prevents the accumulation of leukocytes, and also inhibits the release of lysosomal enzymes and pro-inflammatory mediators at the site of inflammation. In addition, the drug:

• inhibits phagocytosis;
• reduces vascular tissue permeability;
• prevents the formation of inflammatory edema.

Thus, when using Akriderm, the severity of various manifestations of skin diseases, including swelling, erythema, pain, irritation and itching, decreases.

Research and effectiveness

Before determining the causative agent of the disease, combination drugs with a wide spectrum of antibacterial action are prescribed. These include Akriderm GK. It may be the drug of choice, as it is active against common bacterial and fungal pathogens.

Research results show a good therapeutic effect of the ointment in the treatment of dermatoses, chronic inflammatory diseases, and fungal-bacterial infections. Using the product gives a quick anti-inflammatory effect. Due to its effectiveness and relative safety, it is recommended for dermatoses of various origins. The use of the drug provides a high level of bacterial cure.

Source

to: Kasikhina E.I., Glazko I.I. “Problems of mixed infection: solutions and features of pathogenesis,” 2014.

Contraindications

Each glucocorticosteroid drug has strict restrictions on its use. Akriderm is not prescribed until one year of age or during pregnancy. When it is necessary to treat a child, the ointment can only be used under the supervision of a doctor.

Betamethasone can disrupt hormonal levels, so the ointment is used with caution in childhood and during lactation.

Other contraindications for use:

1. viral skin diseases;
2. benign and malignant neoplasms;
3. open wounds;
4. perioral dermatitis;
5. lupus;
6. post-vaccination reactions;
7. intolerance to components and allergies to them.

Side effects

Corticosteroid ointment can provoke systemic reactions, since when applied topically, a certain amount enters the bloodstream. If any unpleasant symptoms appear, you should immediately visit a doctor for symptomatic treatment and choose another medicine.

Possible side effects from using the ointment:

1. allergies – itching, dry skin, irritation;
2. rash, urticaria;
3. prickly heat;
4. folliculitis;
5. atrophic processes of the skin;
6. maceration;
7. hyperglycemia;
8. hypertrichosis;
9. swelling;
10. osteoporosis;
11. increased blood pressure.

Dosage

The ointment is applied to the skin in a thin layer 2 times a day. The frequency of use may be changed by the doctor depending on the course of the disease. Do not allow the product to come into contact with the eyes. The course of treatment usually lasts up to 4 weeks. Treatment for more than a month may lead to an overdose. If there is no effect of use, you should consult a dermatologist.

For acne

For acne, HA may be prescribed. Its use allows you to quickly get rid of skin problems. For dry skin types, ointment is used, for oily skin types, cream is used. The drug is effective for purulent rashes. It can be used for the face for no longer than 5 days, for the body - up to 2 weeks. The ointment is applied pointwise to the rash with a sterile cotton swab.

From deprivation

GK ointment can be used for lichen. It is effective because it copes well with itching, inflammation and swelling of the skin. It also fights fungus and bacteria. In this case, regular Akriderm ointment will help prevent skin thickening. The course of use of the product is about 2 weeks, after which you need to undergo a re-examination by a doctor.

For allergies

For allergic diseases, corticosteroid ointment may be prescribed when other local remedies are ineffective. If allergies are complicated by bacterial skin lesions, Akriderm GK or SK should be used.

Akriderm medications themselves can also cause allergies. Treatment is permissible only as prescribed by a doctor. If after the first application, the symptoms intensify, you need to abandon this medicine and choose an analogue together with your doctor.

From fungus

Due to the content of the antifungal agent clotrimazole, Akriderm GK can be used for fungal skin infections. It is used for 14-30 days, 2 times a day.

For eczema

For eczema, all types of ointments can be used. The most effective treatment option is medicated bandages. The drug is applied 2 times for 40-50 minutes. The course is standard – up to 3 weeks.

Treatment can lead to dry skin, so it is recommended to use a natural moisturizing cream in parallel.

Results and discussion

As a result of an open observational study, data were obtained on the high effectiveness of Akriderm GK

(betamethasone + gentamicin + clotrimazole) in the treatment of steroid-sensitive dermatoses complicated by bacterial and/or fungal infection.
The use of the drug Akriderm GK
(betamethasone + gentamicin + clotrimazole) was assessed at the end of the observation.
An excellent assessment of the effectiveness of the drug was established in 70 (97.2%) patients, good in 2 (2.8%), satisfactory and unsatisfactory were not recorded in any case. Clinical cure was established in 97.2% of patients, significant improvement in 2.8%. Not a single patient remained without effect from the therapy. Excellent tolerability of the drug was noted in 98.6% of patients, good - in 1.4% (mild itching was noted, which went away on its own after 3 days). There were no significant side effects requiring discontinuation of the drug in our study. When using Akriderm GK
(beta-methasone + gentamicin + clotrimazole), the DIQL of patients statistically significantly improved.

We present clinical cases.

The patient is 13 years old, diagnosed with atopic dermatitis, complicated by bacterial and fungal infection (Fig. 1, a). When contacted, the patient complained of weeping in the axillary folds and itchy skin. Local status: against the background of brightly colored inflammatory erythema, yellow crusts, infiltration, and weeping are visible. Budding (yeast) cells were found in the scraping. Based on the clinical picture (layering of yellow crusts), we can talk about the addition of a bacterial (streptococcal) infection. The patient received the following treatment: fucorcin 1-2 times a day for 5-7 days, 10-15 minutes after drying, apply Akriderm GK

2 times a day for 7 days. During treatment, a decrease in the brightness of manifestations and inflammatory phenomena was noted. After treatment, the pathological process was completely resolved (fucorcin residues are visible) (see Fig. 1, b). Since the patient is a teenager, bristly hair growth is visible in the axillary areas. After 14 days and 1 month from the start of treatment, the patient was examined. The pathological process was in remission.

Rice.
1. Atopic dermatitis, complicated by bacterial and fungal infection, in a 13-year-old patient. a - before treatment; b - after treatment. The patient is 23 years old, diagnosed with microbial (coin-shaped) eczema: abortive form (eczematid) (Fig. 2, a). Differential diagnosis was made with mycosis of smooth skin. The pathological foci were erythematous-squamous, large in size, round, with clear boundaries, in the center there were areas of resolution with peeling. No threads of septate mycelium were found in the scraping. The following treatment was prescribed: Akriderm GK

2 times a day for 14 days. During treatment, the pathological lesions resolved completely (see Fig. 2, b), only light temporary pigmentation remained visible. The patient did not show up for further examination.

Rice.
2. Foci of numular eczema. a - before treatment, b - their regression after 14 days of therapy. The patient is 63 years old, diagnosed with atopic dermatitis, complicated by a fungal infection (Fig. 3, a, 4, a). The patient suffered from atopic dermatitis as a child. I did not notice any exacerbations with age. Complained of dry skin. On examination, dry skin and pronounced skin patterns in the elbow and popliteal folds were noted. When contacted, he complained of dry skin in the area of ​​the palms, rashes in the area of ​​the inguinal folds, accompanied by itching. In the area of ​​the palms, powdery small folds and cracks were revealed; in the area of ​​the inguinal folds there is a spot of hyperemia with clear sharp boundaries in the form of a roller consisting of crusts, scales, and erosions. Threads of septate mycelium were found in scrapings from the palms and inguinal folds. The following treatment was prescribed: Akriderm GK

2 times a day for 14 days on the groin area,
Akriderm GK
2 times a day for 14 days on the palms. After 14 days, the pathological process in the area of ​​the palms and inguinal folds was completely resolved (see Fig. 3, b, 4, b). No threads of septate mycelium were found in scrapings from the palms and inguinal folds. The patient was examined 1 month after the start of therapy. The pathological process was in remission.

Rice. 3. Rashes due to atopic dermatitis on the hands of a 63-year-old patient. Fungal contamination has been proven. a — before treatment, b — after treatment.

Rice.
Fig. 4. Erythematous-squamous lesions in the area of ​​the inguinal-femoral fold (a) and their regression in the same patient after therapy (b). The patient is 25 years old, diagnosed with allergic contact dermatitis, complicated by a bacterial infection (Fig. 5, a). On the skin around the mouth, against the background of bright hyperemia, yellow crusts and weeping are visible. The patient was prescribed the following treatment: sodium thiosulfate 30%, 10 ml intravenously for 10 days; Levocyterizine 10 mg orally 1 time per day (10 days); topical cream Akriderm GK

2 times a day (7 days). After 7 days, the pathological process was completely resolved: the rash around the mouth disappeared (see Fig. 5, b). The prescription of combination drugs containing topical corticosteroids and antibiotics for bacterial infections quite often provokes the growth of saprophytic candidiasis microflora, which worsens the course of the underlying disease. Therefore, the most effective combination therapy is drugs that contain corticosteroids, antibacterial and antimycotic agents, which makes it possible to simultaneously influence all parts of the pathological process [13].

Rice.
5. Manifestations of allergic contact dermatitis with impetiginization in a 25-year-old patient. a - before treatment; b - after treatment. Patient, 46 years old, diagnosed with chronic eczema of the hands, complicated by a secondary infection (fungal). The patient has been suffering from chronic eczema of the hands since the age of 20. It is also known from the medical history that the patient works as a driver. Hands often come into contact with lubricants. Periodically over the course of 26 years, exacerbations occur, which are replaced by remissions. The latest exacerbation is associated with nervous shock. At the time of treatment, the pathological process is represented by foci of mild hyperemia, there are yellow crusts, scales, scratches, small pink papular elements, cracks (Fig. 6, a, b). Noteworthy is the absence of supracungual skin (a sign of a candidiasis infection). Yeast-like cells were found in scrapings from the periungual ridges. The following treatment was prescribed: Akriderm GK

2 times a day for 14 days.
When examined after 14 days, the pathological process resolved: hyperemia disappeared, dry skin, peeling, and isolated crusts remained. Akriderm
ointment was prescribed 2 times a day (10 days). When examined after 10 days, the pathological process resolved completely (see Fig. 6, c, d). After 1 month from the start of therapy, the patient was examined. The pathological process was in remission.

Rice.
6. Chronic eczema of the hands, complicated by mycotic infection in a 46-year-old patient. a, b — skin status before treatment; c — after two weeks of external treatment with a three-component drug; d - after additional use of phonophoresis with the ointment used. The average for the group at the time of the first visit was 14 points (8; 18); 14 days after the start of therapy - 1 point (1; 5) ( p

<0.05);
1 month after the start of therapy - 1 point (1; 3) ( p
<0.05). At the time of the first visit, the high DIQL is explained by the fact that any manifestations of dermatoses lead to psycho-emotional problems in the patient. Moreover, even minor rashes are accompanied by high DIQL values, since they are located on an open area of ​​the skin and are visible to others.

Who is it suitable for?

Akriderm has anti-inflammatory, decongestant, antiexudative, antihistamine effects. This allows it to be used for various skin lesions when more gentle drugs do not have an effect.

Main indications for the use of different types of ointment:

Akriderm GK is a combined local remedy containing an antibiotic and an antifungal agent. This leads to wider application.

Reviews from doctors

Petr Petrovich, 49 years old, dermatologist, Moscow

Akriderm GK cream is an inexpensive analogue of Triderm. The medication can be used to treat insect bites, dermatoses, and fungal diseases. The product helps eliminate itching, burning, swelling and hyperemia of the skin.

Victor Vitalievich, 55 years old, dermatologist, Murmansk

The drug Akriderm is an effective remedy for the treatment of eczema, psoriasis, and neurodermatitis. The drug contains a synthetic hormone, so it is recommended to use the ointment during the acute phase of inflammation for 3 weeks. With the correct treatment regimen, the medication does not have a negative effect on the body.

Cost and analogues

The following products are analogues of Akriderm:

1. Beloderm is a local remedy based on betamethasone, acts strongly and quickly directly at the site of the inflammatory process, reduces external manifestations and subjective sensations such as pain, irritation, itching, and constant discomfort;
2. Diprospan is a drug in a solution based on betamethasone, which is prescribed in severe cases to relieve symptoms during the acute period of the disease;
3. Celestoderm-B is a betamethasone-based cream used for skin diseases with a secondary infection.

As an alternative to these drugs, the doctor may prescribe analogues of action, but with other active ingredients. Popular products include Triderm, Betaderm, Celeston, Diprosalik, Candid-B, Kanzinon.

Which drug is better

Classic ointment is considered safer

and is prescribed for many chronic skin diseases. It is well suited for allergic dermatitis and urticaria. This drug is less likely to cause adverse reactions. However, it is not always effective. When there is a bacterial or fungal complication, the combined ointment Akriderm GK is used.

It is recommended to use the HA product

for acute symptoms of a dermatological disease with a short course. When the classic ointment turns out to be ineffective, its supplemented version is also shown. For bacterial and fungal infections - only Akriderm GK, since the classic remedy is useless in these cases.

You should not give preference to Akriderm GC just because it is “stronger”. Firstly, this does not make sense when the indications allow the use of ordinary ointment. Secondly, the cost of the HA product is almost 4 times higher.

Both medications can be purchased without a prescription, but self-medication is highly discouraged. Hormonal ointments have many side effects and contraindications. Before use, be sure to consult a doctor.

Characteristics of Akriderm

Release form of the drug: cream and ointment. The composition of 1 g of the drug includes betamethasone dipropionate (active ingredient), in the amount of 0.64 mg.

The drug has anti-inflammatory, anti-allergic, anti-exudative, anti-edematous and antipruritic effects.

Akriderm is prescribed for eczema.

The active component of the drug, being a corticosteroid, helps to inhibit the increase in the number of leukocytes, the release of lysosome enzymes and inflammatory mediators in the inflamed area. In addition, the drug suppresses phagocytosis, reduces the permeability of blood vessels and tissues, and prevents the appearance of swelling in areas of the body with inflammation.

The medicine is intended for the treatment of dermatological diseases such as:

• dermatitis (contact, seborrheic, dyshidrotic);
• neurodermatitis;
• photodermatosis;
• eczema;
• psoriasis.

The drug can only be used externally. It is necessary to distribute the product in an even layer over the damaged areas of the skin. It is advisable to perform the procedure in the morning and evening. Therapy with this drug lasts from 14 to 28 days.

While using the medicine, the following side effects may occur:

• itching;
• rash;
• redness;
• irritation;
• dryness;
• increased body hair growth;
• purulent inflammation of the hair follicle.

If side symptoms occur, you must stop using the external remedy.

It is prohibited to use the medication if you have:

• hypersensitivity to drug substances;
• tuberculosis skin disease;
• skin manifestations of syphilis;
• chicken pox;
• herpetic rashes;
• allergic reaction to the vaccine;
• open skin lesions (wounds);
• trophic ulcerative lesions of the leg;
• rosacea;
• acne.

The drug is also contraindicated for use during the lactation period and for children under 12 months.