One of the causes of relapse of chronic dermatitis is a bacterial infection. Therefore, during treatment, it is important to influence not only the source of inflammation, but also the microorganisms that provoke it. External preparations must have bactericidal properties. And Akriderm GENTA ointment is just such a remedy. Its use makes it possible to successfully treat chronic dermatoses, especially secondarily infected ones. It has a versatile effect, aimed not only at reducing the severity of symptoms, but also at the cause of the disease. Let's take a closer look at what Akriderm GENTA (ointment) is used for and how to use it to achieve a long-lasting therapeutic effect.
Pharmacodynamics and pharmacokinetics
This combination drug combines the properties of a glucocorticosteroid and an aminoglycoside antibiotic.
of leukocytes is inhibited , the rapid release of lysosomal enzymes , as well as anti-inflammatory mediators in the area of inflammation. In this case, there is inhibition of phagocytosis , a decrease in vascular-tissue permeability and the formation of inflammatory swelling.
As for gentamicin, it is a broad-spectrum antibiotic belonging to the group of aminoglycosides. It is characterized by a bactericidal effect aimed at pathogens of both primary and secondary bacterial skin infections. Its activity is especially evident against various gram-negative and a number of gram-positive bacteria. Anaerobes, fungi and are not sensitive to this substance .
Composition of the drug
The uniqueness of this ointment lies in the combination of two active substances - betamethasone dipropionate and gentamicin sulfate. The first component is a synthetic glucocorticosteroid (GCS) with versatile effects. Being a diester, it is highly hydrophobic, quickly penetrates into the inflammatory focus and provides a long-lasting therapeutic effect. 100 g of ointment, calculated as 100%, contains 0.064 g of betamethasone. Gentamicin is a broad-spectrum antibiotic from the aminoglycoside group. Its task is to locally treat primary and secondary bacterial skin infections. The product contains 0.1 g of this ingredient.
Thanks to the combination of these active substances, Akriderm GENTA ointment combines the properties of a topical glucocorticosteroid and an antibiotic. The combination of betamethasone and gentamicin helps to correct the skin microbiome, which has a beneficial effect on the number of relapses in chronic dermatitis.
Auxiliary ingredients are also important, as they affect the level of comfort when using the drug. Akriderm GENTA also includes:
- propyl parahydroxybenzoate;
- liquid paraffin;
- isopropyl palmitate;
- petrolatum.
It is thanks to the additional components that the product can have a softening and occlusive effect on the pathological focus.
Indications for use
Akriderm Genta cream and ointment are prescribed for the treatment of:
- dermatitis;
- eczema;
- simple chronic lichen;
- diaper rash;
- psoriasis;
- itching.
Contraindications
The use of this product is not recommended for:
- hypersensitivity to it;
- skin tuberculosis;
- manifestation of syphilis on the skin;
- chicken pox;
- herpes simplex;
- skin post-vaccination reactions;
- open wounds;
- lactation;
- children under one year of age.
Side effects
Treatment with Akriderm Genta may be accompanied by: burning, irritation, dry skin, folliculitis, hypertrichosis , acne-like rashes, hypopigmentation , perioral dermatitis , allergic contact dermatitis. With prolonged application, especially under occlusive dressings, the development of skin maceration, secondary infection, skin atrophy, miliaria and purpura is possible.
The use of the drug for the treatment of children can cause systemic side effects such as: hyperglycemia, glucosuria, Cushing's syndrome, reversible inhibition of the adrenal cortex, and so on.
pharmachologic effect
Akriderm GENTA has 4 effects at once:
- anti-inflammatory;
- antibacterial;
- anti-fungal;
- antiallergic.
This effect was achieved thanks to betamethasone, which also has a vasoconstrictor effect. Local application of this glucocorticosteroid helps reduce itching, redness, reduces the release of inflammatory mediators, inhibits the activity of hyaluronidase and reduces the permeability of the vascular wall.
Gentamicin is bactericidal. This component is active against many gram-negative and gram-positive bacteria, including those resistant to other antibiotics.
Instructions for use Akriderm Genta (Method and dosage)
The instructions for the ointment state that it is used externally by applying a thin layer to damaged areas, 2 times daily. In special cases, the treatment regimen is established by the doctor, taking into account the severity of the disease. Mild forms of the disease allow the use of Akriderm Genta cream once every day.
The duration of therapy depends on tolerability and effectiveness, amounting to 2-4 weeks.
If there is no improvement for a long time, clarification of the diagnosis is required.
Directions for use and dosage
Depending on the patient’s age, there are two approaches to using the drug “Akriderm GENTA”. Adults are recommended to apply the product at least 2 times a day - morning and evening. It must be carefully and lightly rubbed into the affected area of the skin in a circular motion. If the inflammation is localized in an area with thicker skin or is located in places from which the product is easily washed off (for example, palms or feet), then it should be applied more often. The duration of treatment ranges from 2 to 4 weeks and is adjusted depending on the effectiveness and tolerability of therapy.
The drug can be prescribed to children over 2 years of age, but treatment is carried out under strict control and supervision. The period of use of Akriderm GENTA should be short, and the doses should be minimal. This is due to the area of the skin, which in children is larger in relation to body weight. In addition, the epidermis in childhood is still poorly developed, so there is a risk of developing systemic side effects.
special instructions
If signs of hypersensitivity, skin irritation and other undesirable symptoms caused by the use of the drug appear, you should abandon this treatment and choose a more suitable one.
Long-term therapy, application of the product to large surface areas of the skin, use of occlusive dressings and treatment of children can lead to systemic absorption of GCS.
The drug for the treatment of small children over one year of age can be used only as prescribed and under the supervision of a doctor to avoid the development of systemic side effects. If Akriderm Genta cream is used for a long time over large areas, this can lead to inhibition of the functions of the hypothalamic-pituitary-adrenal system, the development of hypercortisolism, decreased excretion of hormone and a significant increase in intracranial pressure.
Also, prolonged application to the face can cause atrophic changes to appear more quickly than in other areas. Therefore, it is necessary to adhere to the average therapeutic course of 5 days.
The use of any form of the drug in ophthalmology is not allowed. Avoid contact of the product with the eyes and mucous membranes.
Akriderm Genta
Akriderm Genta is a combination drug for local use containing the glucocorticosteroid betamethasone and the aminoglycoside antibiotic gentamicin. It is used in dermatological practice for the treatment of simple and allergic dermatitis, eczematous skin lesions of various etiologies, itchy lichenoid dermatitis, photodermatitis, Ritter's exfoliative dermatitis, psoriasis. Betamethasone prevents the development of inflammation and acute allergic response, exhibits antipruritic and antiexudative (eliminates increased vascular permeability and prevents the release of exudate into tissues) effect. Inhibits the accumulation of white blood cells, the release of tissue proteases, acid ribonuclease, phospholipase and other lysosomal enzymes and inflammatory mediators, suppresses the activity of phagocytes. Gentamicin has a wide therapeutic range. It has a bactericidal (causes the death of microorganisms) effect against pseudomonads, aerobacter, E. coli, Proteus klebsiella, streptococci, staphylococci. Does not affect anaerobic bacteria, fungi and viruses. Akriderm Genta is not used in persons with individual intolerance to betamethasone, gentamicin and/or auxiliary components of the drug, dermatoses caused by tuberculous mycobacteria, dermatological manifestations of syphilis, chickenpox, open wounds, as well as in those infected with the herpes simplex virus and women during breastfeeding.
In pediatric practice, Akriderm Genta is used starting from 1 year. Pregnancy is not a contraindication to taking the drug; however, during this period Akriderm Genta should be used in small doses and for a short time. The frequency of use of the drug according to general recommendations is twice a day. Depending on the clinical situation, the doctor may determine a different frequency of use of the drug. Doing this yourself is prohibited. For mild dermatoses, the drug can be used once a day. The duration of the drug course is determined by the severity of the therapeutic response and the patient’s tolerability of the drug and is usually about 2-4 weeks. If there is no improvement, you should consult a doctor to clarify the diagnosis. If patients have signs of hypersensitivity to the components of the drug, treatment should be interrupted and the issue of adequate replacement of the drug should be considered. With long-term drug courses, use of the drug over large areas or under an airtight bandage, systemic absorption of betamethasone is possible. In pediatric practice, the drug is used under strict medical supervision. When using Akriderm Genta on the skin of the face for a long time, the risk of atrophic changes increases. To avoid this, it is not recommended to use the drug on the skin of the face for more than five days.
Analogs
Level 4 ATX code matches:
Rederm
Losterine
Akriderm SK
Akriderm
Akriderm GK
Elokom S
Diprosalik
Belosalik
Triderm
Kanizon Plus
Betasalik
Triacutan
Momat-S
Main analogues: Triderm and Kanizon plus.
Reviews of Akriderm Ghent
In most cases, reviews of Akriderm Genta ointment are positive and confirm its effectiveness. This drug is usually prescribed to treat various skin diseases. However, many users report that improvement occurs within just a few days.
In addition, you can find reviews about Akriderm Genta cream, when after stopping its use the symptoms of the skin disease return. As one patient reported, this situation can arise when treating seborrheic dermatitis on the face. This drug was prescribed by a doctor and helped quickly eliminate the symptoms of the disease. However, after completing the 5-day course, spots and peeling appeared on the skin of the face again.
Unfortunately, such messages are not uncommon.
Moreover, some patients say that the treatment, on the contrary, contributed to the deterioration of the skin condition, so they replaced it with another drug.
When starting to use this remedy, you need to know that Akriderm Genta is a symptomatic drug with high activity. Such treatment is unlikely to help eliminate the cause of the disease, only suppressing its manifestations. An ointment or cream quickly alleviates the patient's condition, but to treat the disease, basic treatment is necessary.
Therefore, it is not recommended to take this drug without a doctor’s prescription, especially for treating children. It is also important that combination therapy is carried out with precise dosages and a competent regimen.
Advantages of Akriderm GENTA ointment
- Availability. The drug "Akriderm GENTA" has over-the-counter status and can be freely purchased in many pharmacies. The price will also please buyers. A 30 g package is much more economical compared to a 15 g package of another external product.
- A versatile solution to skin problems. For an affordable price, you will receive a product that has 4 effects at once - anti-inflammatory, antiallergic, antipruritic, antibacterial.
- Quick effect. Many patients noted the disappearance of itching and burning sensation and other improvements after just a single application.
- Complex treatment. Akriderm GENTA affects not only the symptoms, but also the cause of the disease.
Akriderm Genta price, where to buy
The price of Akriderm Ghent varies between 130-400 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Akriderm Genta ointment 0.05%+0.1% 30g JSC Akrikhin
383 rub. order - Akriderm Genta ointment 0.05%+0.1% 15gAO Akrikhin
RUB 253 order
- Akriderm Genta cream 15gAO Akrikhin
RUB 251 order
- Akriderm Genta cream 30gAO Akrikhin
RUR 379 order
Pharmacy Dialogue
- Akriderm GENTA cream (tube 15g) Akrikhin OJSC
RUB 261 order
- Akriderm GENTA ointment (tube 30g) Akrikhin OJSC
RUB 369 order
- Akriderm GENTA ointment (tube 15g) Akrikhin OJSC
RUB 241 order
- Akriderm GENTA ointment (tube 15g) Akrikhin JSC
RUB 253 order
- Akriderm GENTA cream (tube 30g) Akrikhin OJSC
RUB 371 order
show more
