ACRIDERM® PREPARATIONS FOR THE TREATMENT OF VARIOUS TYPES OF DERMATOSES

Akriderm GK is a combination product used in the treatment of dermatological diseases. The effectiveness of the medicine is ensured by its multicomponent composition and its effect on one of the causes of skin problems - bacteria or fungi.

The use has contraindications and limitations, so it is important to study the instructions before starting use.

Composition and release form

Akriderm®

in tubes of 15 or 30 g; in a cardboard pack 1 tube.

Akriderm® GENTA

in tubes of 15 or 30 g; in a cardboard pack 1 tube.

Akriderm® GK

in tubes of 15 or 30 g; in a cardboard pack 1 tube.

Akriderm® SK

in tubes of 15 g or 30 g; in a cardboard pack 1 tube.

Composition of the drug

Akriderm cream (30 g) is a product for external use that is white or almost white in color. The active substance of the drug is betamethasone dipropionate. Its amount, calculated as 100% of the substance, is 0.064 g, which is equivalent to 0.05 g of betamethasone per 100 g. This ratio classifies Akriderm as a potent drug.

Betamethasone has a variety of effects:

• anti-inflammatory;
• antiallergic;
• antipruritic;
• antiexudative.

Akriderm cream also contains excipients, including purified water, solid and liquid paraffin, petroleum jelly, emulsion wax, sodium sulfite, disodium edetate, propylene glycol and methyl parahydroxybenzoate. These components promote good absorption and penetration into the site of inflammation.

Characteristic

Akriderm®

Glucocorticosteroid for local use.

Akriderm® GENTA

Combined drug for external use (glucocorticosteroid + antibiotic-aminoglycoside).

Akriderm® GK

Combined preparation for external use (glucocorticosteroid + antibiotic-aminoglycoside + antifungal agent).

Akriderm® SK

Combined preparation for external use (glucocorticosteroid + keratolytic agent).

Pharmacodynamics

The corticosteroid betamethasone dipropionate inhibits the accumulation of leukocytes, the release of lysosomal enzymes and pro-inflammatory mediators at the site of inflammation, inhibits phagocytosis, reduces vascular tissue permeability, and prevents the formation of inflammatory edema.

Gentamicin is a broad-spectrum antibiotic from the aminoglycoside group. Has a bactericidal effect against pathogens of primary and secondary bacterial skin infections. Active against gram-negative bacteria: Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae; gram-positive bacteria: Streptococcus spp. (susceptible strains of group A beta- and alpha-hemolytic streptococcus), Staphytococcus spp. (coagulase-positive, coagulase-negative and some penicillinase-producing strains). Inactive against anaerobes, fungi and viruses.

Clotrimazole has an antifungal effect by disrupting the synthesis of ergosterol, which is an integral part of the cell membrane of fungi. Active against: Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis, Candida albicans, Malassezia furtur (Pityrosporum orbiculare).

Salicylic acid provides a keratolytic, antimicrobial effect, eliminates horny layers and promotes deeper penetration of GCS.

Indications of the drug Akriderm® SK

Akriderm®

Allergic skin diseases (including acute, subacute and chronic contact dermatitis, occupational dermatitis, seborrheic dermatitis, atopic dermatitis, solar dermatitis, neurodermatitis, pruritus, dyshidrotic dermatitis, eczema); acute and chronic forms of non-allergic dermatitis; psoriasis.

Akriderm® GENTA

Dermatitis (simple and allergic), especially secondarily infected, eczema (atopic, childhood, coin-shaped), atopic dermatitis (diffuse neurodermatitis), simple chronic lichen (limited neurodermatitis), solar dermatitis, exfoliative dermatitis, radiation dermatitis, diaper rash, psoriasis, itching.

Akriderm® GK

Treatment of dermatoses complicated by primary and/or secondary infection, pityriasis versicolor, limited and diffuse neurodermatitis, dermatomycosis (including inguinal, foot) caused by pathogens sensitive to the drug.

Akriderm® SK

Local treatment of dermatoses accompanied by hyperkeratosis: psoriasis, limited and diffuse neurodermatitis, lichen planus, eczema, dyshidrotic dermatitis, ichthyosis and ichthyosiform changes.

Indications for use

The use of Akriderm cream is advisable for acute and subacute conditions, since the product has average penetrating ability. Also suitable for wet and thin skin areas. Not recommended for long-term external use on the face.

The main indications for the use of the drug are skin pathologies that respond well to treatment with glucocorticosteroids. These include:

• atopic dermatitis;
• allergic contact dermatitis;
• various forms of eczema;
• contact dermatitis (including professional);
• other non-allergic dermatitis (including solar and radiation);
• allergic skin reactions to insect bites;
• psoriasis;
• bullous dermatoses;
• discoid lupus erythematosus;
• lichen planus;
• exudative multimorphic erythema;
• skin itching of various etiologies.

You can find out more detailed information about what Akriderm is used for from a specialist.

Contraindications

Hypersensitivity to any of the components of the drug, skin tuberculosis, skin manifestations of syphilis, chicken pox, herpes simplex, skin post-vaccination reactions, open wounds, lactation and children under 1 year of age; additionally for the drug Akriderm®: trophic ulcers of the leg, rosacea, acne vulgaris; additionally for the drug Akriderm® GK: in the treatment of external otitis - perforation of the tympanic membrane; additionally for the drug Akriderm® SK: perioral dermatitis.

Use during pregnancy and breastfeeding

The safety of topical use of GCS in pregnant women has not been established; the prescription of drugs in this group during pregnancy is justified only if the potential benefit outweighs the possible risk. During pregnancy, drugs in this group should not be used in high doses or for a long time.

It has not been established whether local use of GCS can cause them to appear in mother's milk, so the issue of stopping breastfeeding should be addressed.

Side effects

When GCS is applied topically, the following may be observed: burning, irritation, dry skin, folliculitis, hypertrichosis, acne-like rashes, hypopigmentation, perioral dermatitis, allergic contact dermatitis. With long-term use, as well as the use of occlusive dressings, skin maceration, secondary infection, skin atrophy, prickly heat, purpura.

Akriderm®

When applied to large surfaces of the body, mainly in children, systemic side effects of GCS may occur (hyperglycemia, glucosuria, reversible inhibition of adrenal function, manifestation of Cushing's syndrome).

Akriderm® GENTA

Akriderm® GK

When applied to large surfaces of the body, mainly in children, systemic side effects of GCS (hyperglycemia, glucosuria, reversible inhibition of adrenal cortex function, manifestation of Cushing's syndrome) and gentamicin (nephrotoxic and ototoxic effects) may occur.

Akriderm® SK

When applied to large surfaces of the body, mainly in children, systemic side effects of GCS and salicylates may occur.

If adverse reactions occur that are not described in the instructions, you should consult a doctor.

Akriderm ointment for external use 0.05% 15g

Compound

Active substance: betamethasone - 50 mg. Excipients: propyl parahydroxybenzoate - 0.05 g, liquid paraffin (vaseline oil) - 4 g, isopropyl myristate - 1 g, petroleum jelly - up to 100 g.

Pharmacokinetics

When the drug is applied cutaneously in therapeutic doses, transdermal absorption of the active substance into the blood is very insignificant. The use of occlusive dressings, inflammation and skin diseases increase the transdermal absorption of betamethasone, which may lead to an increased risk of systemic side effects.

Indications for use

Skin diseases amenable to glucocorticosteroid therapy:

• atopic dermatitis;
• allergic contact dermatitis;
• eczema (various forms);
• contact dermatitis (including occupational) and other non-allergic dermatitis (including solar and radiation dermatitis);
• reactions to insect bites;
• psoriasis;
• bullous dermatoses;
• discoid lupus erythematosus;
• lichen planus;
• exudative multimorphic erythema;
• skin itching of various etiologies.

Contraindications

• hypersensitivity to betamethasone or other components of the drug;
• lupus;
• skin manifestations of syphilis;
• bacterial, fungal, viral (chickenpox, herpes simplex) skin diseases;
• skin post-vaccination reactions;
• open wounds;
• trophic ulcers of the leg;
• rosacea, acne vulgaris;
• skin cancer, nevus, atheroma, melanoma, hemangioma, xanthoma, sarcoma;
• lactation period;
• children's age up to 1 year.

Directions for use and doses

Externally. Akriderm® ointment is applied in a thin layer to the affected area of ​​the skin 2 times a day - morning and evening, lightly rubbing. On areas with thicker skin (for example, elbows, palms and feet), as well as places from which the drug is easily washed off, Akriderm® ointment can be applied more often.

The duration of treatment depends on the effectiveness and tolerability of therapy and is usually no more than 4 weeks. Therapy may be repeated several times throughout the year.

If clinical improvement does not occur, it is necessary to clarify the diagnosis.

In children and patients with facial skin lesions, the course of treatment should not exceed 5 days.

Storage conditions

The drug should be stored out of the reach of children at a temperature of 15 to 25°C.

Best before date

4 years. Do not use after the expiration date.

special instructions

If there is no effect of treatment within two weeks, it is recommended to consult your doctor for a possible clarification of the diagnosis. If irritation or hypersensitivity reaction is observed when using the drug, treatment should be stopped and consult your doctor. For secondary fungal or bacterial infections, appropriate medications must be used. If there is no immediate positive effect, the use of Akriderm should be discontinued until all signs of infection are eliminated.

Long-term use of the drug on the skin of the face is not recommended. Akriderm should not be used in the eye area, because... in this case, the development of cataracts, glaucoma, fungal infection and exacerbation of herpetic infection is possible.

Use in pediatrics

Children may be more susceptible to the use of topical corticosteroids that cause hypothalamic-pituitary-adrenal (HPA) axis suppression than older patients due to increased drug absorption associated with their larger surface area to body weight ratio. The following side effects were observed in children taking local corticosteroids: suppression of the HPA system function, Cushing's syndrome, linear growth retardation, delayed weight gain, increased intracranial pressure. Symptoms of adrenal suppression in children include decreased plasma cortisol levels and lack of response to ACTH stimulation. Increased intracranial pressure is manifested by bulging of the fontanel, headache, and bilateral papilledema.

Description

Glucocorticosteroid for local use.

Dosage form

Ointment for external use 0.05% white to white with a yellowish tint, translucent.

Pharmacodynamics

Akriderm® is a glucocorticosteroid for external use. It has anti-inflammatory, antiallergic, antiexudative, vasoconstrictive, antipruritic and antiproliferative effects. Inhibits the accumulation of leukocytes, the release of lysosomal enzymes and pro-inflammatory mediators at the site of inflammation, inhibits phagocytosis, reduces vascular tissue permeability, and prevents the formation of inflammatory edema

When applied to the surface of the skin, the drug has a quick and strong effect at the site of inflammation, reducing the severity of objective symptoms (erythema, swelling, lichenification) and subjective sensations (itching, irritation, pain).

Side effects

.As a rule, it is mild in nature.
With external use of glucocorticosteroids, the following may be observed: skin itching, burning, irritation, dry skin, folliculitis, hypertrichosis, stretch marks, acne-like rashes (“steroid” acne), hypopigmentation, perioral dermatitis, allergic contact dermatitis.

With long-term use, as well as the use of occlusive dressings, skin maceration, secondary infection, skin atrophy, local hirsutism, telangiectasia, prickly heat, purpura.

When applied to large surfaces of the body, mainly in children, systemic side effects of glucocorticosteroids may occur (hyperglycemia, glucosuria, reversible inhibition of adrenal function, manifestation of Itsenko-Cushing syndrome).

If adverse reactions occur that are not described in the instructions, you should consult a doctor.

Use during pregnancy and breastfeeding

Due to the fact that the safety of the use of local corticosteroids in pregnant women has not been established, the use of drugs of this class during pregnancy is justified only if the benefit to the mother clearly outweighs the possible harm to the fetus. Drugs in this group should not be used by pregnant women in large doses for a long time.

Since it has not yet been established whether glucocorticosteroids, when applied topically and systemically absorbed, can pass into breast milk, a decision should be made to stop breastfeeding or discontinue the drug, taking into account how necessary its use is for the mother.

Interaction

No interaction of the drug with other drugs has been identified.

Overdose

Symptoms: excessive or prolonged use of local corticosteroids can cause inhibition of the function of the pituitary-adrenal system, which can cause the development of secondary adrenal insufficiency and the appearance of symptoms of hypercortisolism, including Cushing's syndrome.

Treatment: Appropriate symptomatic treatment is indicated. Acute symptoms of hypercortisolism are usually reversible. If necessary, correction of electrolyte imbalance is indicated. In case of chronic toxic effects, gradual withdrawal of GCS is recommended.

Impact on the ability to drive vehicles and operate machinery

Does not affect.

Directions for use and doses

Akriderm®

Akriderm® GENTA

Akriderm® GK

Externally. Apply a thin layer to the affected area of ​​the skin 2 times a day - morning and evening. Another frequency of use can be determined by the doctor, based on the severity of the disease. In mild cases, it is enough to apply the cream, as a rule, once a day; For more severe lesions, more frequent use may be necessary.

The duration of treatment depends on the effectiveness and tolerability of therapy and is 2–4 weeks.

If clinical improvement does not occur, it is necessary to clarify the diagnosis.

Akriderm® SK

Externally. Apply a thin layer to the affected area of ​​the skin 2 times a day - morning and evening. Another frequency of use can be determined by the doctor, based on the severity of the disease. In mild cases, it is enough to apply the ointment, as a rule, once a day; For more severe lesions, more frequent use may be necessary.

How to use Akriderm GK

The Akriderm GK instructions only provide for external use of ointment or cream.

The medicine is used twice a day, gently rubbed into affected areas of the skin. As prescribed by the doctor and depending on the severity of the pathology, an increase or decrease in the number of applications is allowed.

The course of treatment can reach 2-4 weeks, but positive changes are observed already in the first days of application.

It is not recommended to use the product with sealed bandages without a doctor’s recommendation in order to avoid accelerated absorption of the antibiotic and glucocorticosteroid, which increases the likelihood of side effects.

If no improvement is observed with regular use, it is necessary to clarify the diagnosis and reconsider the treatment regimen.

special instructions

If signs of hypersensitivity or skin irritation associated with the use of drugs are observed, treatment should be discontinued and adequate therapy should be selected for the patient.

With prolonged treatment, when applying drugs to large surfaces of the skin, when using occlusive dressings, and also in children, systemic absorption of GCS is possible.

For children over 1 year of age, medications are prescribed only according to strict indications and under medical supervision, because Systemic side effects associated with betamethasone may develop. When using the drug on large surfaces and/or under an occlusive dressing, suppression of the function of the hypothalamic-pituitary-adrenal system and the development of symptoms of hypercortisolism may occur; a decrease in the excretion of growth hormone and an increase in intracranial pressure may be observed.

On the skin of the face more often than on other surfaces of the body, after long-term treatment with topical corticosteroids, atrophic changes may appear; the course of treatment in this case should not exceed 5 days.

The cream and ointment are not intended for use in ophthalmology. Avoid getting the drug into your eyes.

With long-term use of the drug, its withdrawal should be carried out gradually.

Is Akriderm GK suitable for pregnant women and children?

No studies have been conducted to prove the absolute safety of the drug for pregnant and lactating women. Use ointment or cream with caution; apply only to small areas of the skin for a short period of time. Use is not recommended in the first trimester. If there is an urgent need to use ointment or cream during lactation, breastfeeding should be stopped for the period of treatment.

For children under two years of age, the drug in the form of an ointment is contraindicated according to the instructions. With long-term treatment, use on large skin surfaces and application of dressings, the glucocorticosteroid can penetrate into the systemic circulation.

In children from two to eighteen years of age, use with caution.

On the recommendation of a pediatrician or dermatologist, the cream can be used in the treatment of skin diseases in children over 1 year of age. But only for a short course and on small areas of the skin, since the epidermis in babies is not sufficiently developed and the risk of side effects increases.