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Neomycin

Stylab / Catalog / Antibacterial drugs / Neomycin

STYLAB offers test systems for the determination of neomycin in milk and milk powder, honey, meat and other animal tissues, serum and blood plasma, as well as in urine by ELISA.

Enzyme-linked immunosorbent assay (ELISA), strip plate	5111NEO Neomycin ELISA
Antibacterial standards	Pure substances and aminoglycoside standards for analysis in accordance with GOST 32798-2014

Neomycin is a broad-spectrum antibiotic from the aminoglycoside group, which also includes gentamicin . It is a mixture of three substances. Even though this antibiotic was discovered in 1949, it is still used today because bacteria slowly develop resistance to it.

Neomycin is poorly absorbed when taken orally, so it is used to treat diseases of the gastrointestinal tract, such as enteritis and dysentery, and in preparation for operations on the gastrointestinal tract. However, more often it is used externally to treat wound infections, furunculosis, eczema and conjunctivitis. When applied to a large surface or damaged skin, neomycin is absorbed into the blood.

Neomycin is able to cross the placental barrier, and during pregnancy this antibiotic is used only for health reasons. Neomycin is ototoxic (causes hearing loss), neurotoxic and nephrotoxic. Other side effects include blood disorders, allergic reactions, nausea and vomiting. In addition, neomycin inhibits intestinal microflora.

In the Russian Federation and the countries of the Customs Union, the maximum permissible levels of neomycin in food products are specified in the “Unified Sanitary-Epidemiological and Hygienic Requirements for Goods Subject to Sanitary and Hygienic Supervision (Control).” According to them, the neomycin content in meat should not exceed 0.5 mg/kg, in milk – 1.5 mg/kg. Current standards can be found using the compact24.com

To analyze neomycin in food products, it is convenient to use ELISA test systems. They allow you to get results within 1 hour, do not require expensive equipment and are easy to use.

Literature

Neomycin: instructions, use and formula. Radar website.
NEOMYCIN (addendum). WHO FOOD ADDITIVES SERIES: 51.
Carman RJ, Simon MA, Petzold HE 3rd, Wimmer RF, Batra MR, Fernández AH, Miller MA, Bartholomew M. Antibiotics in the human food chain: establishing no effect levels of tetracycline, neomycin, and erythromycin using a chemostat model of the human colonic microflora. Regul Toxicol Pharmacol. 2005 Nov;43(2):168-80. Epub 2005 Aug 29.

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Neomycin 1.172% 16g aerosol for external use

pharmachologic effect

Aminoglycoside antibiotic.
It disrupts protein synthesis by suppressing the formation of the transport and messenger RNA complex. In low concentrations it has a bacteriostatic effect (due to disruption of protein synthesis in microbial cells), in high concentrations it has a bactericidal effect (damages the cytoplasmic membranes of microbial cells). Penetrates the microbial cell and binds to specific receptor proteins on the 30S ribosomal subunit. It disrupts the formation of the transport and messenger RNA complex (30S ribosomal subunit) and stops protein synthesis. Active against a number of gram-positive and gram-negative aerobic microorganisms: Staphylococcus spp., Streptococcus spp.; moderately active against aerobic bacteria - Corynebacterium diphtheriae, Listeria monocytogenes; enterobacteria - Escherichia coli, Salmonella spp., Shigella spp., Proteus spp., Enterobacter aerogenes, Klebsiella pneumonia, Vibrio cholerae; Mycobacterium tuberculosis, Haemophilus influenzae.

Does not affect Pseudomonas aeruginosa, anaerobic bacteria.

Resistance of microorganisms to neomycin develops slowly and to a small extent.

The drug Neomycin, an aerosol for external use, suppresses the development of bacterial flora in areas of skin inflammation. It also has a drying and cooling effect.

Composition and release form Neomycin 1.172% 16g aerosol for external use

Aerosol – 1 g:

Active substance: neomycin (in the form of sulfate) 11.72 mg.
Excipients: sorbitan trioleate - 10.3 mg, lecithin - 0.2 mg, isopropyl myristate - 134 mg, propellant (propane/butane/isobutane) - 843.8 mg.

16 g - aerosol cans (1) with a valve and a spray device - cardboard packs.

Description of the dosage form

Aerosol for external use in the form of a homogeneous suspension of white or almost white color with a characteristic odor.

Directions for use and doses

Externally. Before each use, shake the can vigorously several times. The affected areas are irrigated with an aerosol for 3 seconds, holding the bottle in a vertical position at a distance of about 15-20 cm from the surface of the skin.

The procedure is carried out 1-3 times a day at regular intervals. Usually the drug is used for 7-10 days.

Pharmacokinetics

Neomycin, applied to the intact surface of the skin, acts locally and is practically not absorbed into the blood. When applied to damaged skin, neomycin can be absorbed into the blood and cause systemic effects.

Indications for use Neomycin 1.172% 16g aerosol for external use

Infectious and inflammatory skin diseases caused by neomycin-sensitive microorganisms (including furunculosis, contagious impetigo);
infected burns and frostbite of the 1st and 2nd degrees.

Contraindications

Hypersensitivity to neomycin or other components included in the drug;
violation of skin integrity, extensive affected area, weeping at the site of application, trophic ulcers;
simultaneous use with other oto- and nephrotoxic drugs;
childhood.

Application of Neomycin 1.172% 16g aerosol for external use during pregnancy and breastfeeding

During pregnancy, the drug can be prescribed only in cases where the potential benefit to the mother outweighs the possible risk to the fetus.

If it is necessary to use the drug during lactation, breastfeeding should be stopped.

Use in children

Contraindicated for children

special instructions

It is necessary to avoid contact of the drug with mucous membranes and protect the eyes from the action of the aerosol. If the drug gets into your eyes or mucous membranes, rinse them thoroughly with cool water.

Do not inhale the sprayed product.

It is not recommended to apply the drug to a large surface of the skin, especially damaged skin, or under an occlusive dressing due to the possibility of absorption of the drug into the blood and the appearance of undesirable reactions characteristic of the systemic action of neomycin (ototoxicity, nephrotoxicity). If the above adverse events occur, the drug must be discontinued immediately.

In case of skin irritation at the application site, it is necessary to stop using the drug.

Long-term use of the drug can lead to the growth of resistant strains of bacteria and fungi.

The contents of the cylinder are under pressure. The cylinder must not be hit, heated or opened. The empty container must be thrown away. The drug is highly flammable. Do not spray near open flames. Keep away from open flames and active heating devices.

Impact on the ability to drive vehicles and operate machinery

The drug does not affect the ability to drive vehicles or engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Overdose

Symptoms: itching, rash, hyperemia, edema, nephrotoxicity, ototoxicity. Treatment: discontinuation of the drug, rapid elimination of the drug from the body, symptomatic therapy.

Side effects Neomycin 1.172% 16g aerosol for external use

Allergic reactions: itching, rash, hyperemia, swelling. Long-term use of neomycin can lead to contact allergies.

If the above side effects worsen or other side effects not listed in the instructions occur, you should consult a doctor.

Drug interactions

To avoid possible drug interactions with neomycin, it is recommended to use other drugs only after consultation with your doctor.

Long-term use of the drug simultaneously with oto- and nephrotoxic drugs (including gentamicin, ethacrynic acid, colistin) may increase the toxicity of neomycin.

Neomycin sulfate

Indications for use

Treatment and prevention of gastrointestinal diseases of young farm animals, incl. birds, colibacillosis, salmonellosis, gastroenterocolitis of bacterial etiology.

Composition and release form

NEOMYCIN SULFATE is a drug in powder form for the treatment of bacterial infections of the gastrointestinal tract of young farm animals, including birds, with an activity of at least 680 mcg/mg (calculated on dry matter). NEOMYCIN SULFATE is a yellowish-white to light brown powder, easily soluble in water, packaged in 50; 100; 200; 330; 500; 1000; 5000 and 10000 g in double polyethylene bags, polyethylene coated paper bags, plastic cans or plastic buckets.

Pharmacological properties

NEOMYCIN SULPHATE is a broad-spectrum antibiotic from the aminoglycoside group, effective against many gram-positive and gram-negative microorganisms, including Escherichia coli, Salmonella spp., Proteus spp., Staphylococcus spp., Corinebacterium spp., Listeria spp. and Bacillus anthracis. Protozoa, fungi and most strains of Pseudomonas aeruginosa are resistant to NEOMYCIN SULPHATE. The antibiotic has a bactericidal effect by disrupting protein synthesis on the ribosomes of the microbial cell.

When administered orally, NEOMYCIN SULFATE is practically not absorbed and has an antibacterial effect mainly in the gastrointestinal tract. It is excreted from the body mainly with feces and partly with urine. NEOMYCIN SULPHATE, in terms of the degree of impact on the body in accordance with GOST 12.1.007-76, belongs to hazard class 3 (moderately hazardous substances).

Dosage regimen

NEOMYCIN SULFATE is administered orally in a mixture with food or water (milk) 2-3 times a day at a daily dose of 10-20 mg per 1 kg of animal weight for 3-7 days.

Contraindications

The use of NEOMYCIN SULFATE is prohibited in case of severe damage to the liver and kidneys, as well as in case of individual hypersensitivity of animals to aminoglycosides.

The use of NEOMYCIN SULFATE simultaneously with other aminoglycoside antibiotics (streptomycin, kanamycin, gentamicin, apramycin) is not allowed due to a possible increase in toxic effect.

special instructions

The slaughter of animals, including birds, for meat is permitted no earlier than 7 days after the end of use of the drug. The meat of animals forcedly killed before the established deadline can be used as feed for fur-bearing animals.

Storage conditions and periods

Store in a dry place, protected from direct sunlight, at a temperature from 0 ° C to 25 ° C. Shelf life, subject to storage conditions, is 3 years from the date of manufacture.

Barcode

Can 330 g - 4606306000520 /4810956000094

Bucket 5 kg - 4606306002425 / 4810956001916