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Buy Adrenaline hydrochloride injection solution 0.1% 1ml No. 5 in pharmacies

Buy Adrenaline hydrochloride in pharmacies Adrenaline hydrochloride in the drug directory DOSAGE FORMS solution 0.1%

MANUFACTURERS Moscow endocrine plant (Russia) Ferein (Russia)

GROUP Drugs that stimulate alpha and beta adrenergic receptors

COMPOSITION Active substance: Epinephrine.

INTERNATIONAL NON-PROPENTED NAME Epinephrine

SYNONYMS Adrenaline, Synthetic adrenaline, Adrenaline hydrochloride-Vial

PHARMACOLOGICAL EFFECT Cardiostimulating, vasoconstrictor, hyperglycemic, hypertensive. Stimulates alpha and beta adrenergic receptors. When administered parenterally, it is very quickly destroyed by monoamine oxidase and catechol-O-methyltransferase in liver cells, kidneys, intestinal mucosa, and axons. The half-life is 1-2 minutes. Excretion of metabolites is carried out by the kidneys. It has a pronounced effect on the smooth muscles of internal organs, the cardiovascular and respiratory systems, and activates fat and carbohydrate metabolism. The first phase of action is primarily due to stimulation of beta-adrenergic receptors of various organs and is manifested by tachycardia, increased cardiac output, increased excitability and conductivity of the myocardium, arteriolo- and bronchodilation, as well as decreased uterine tone, inhibition of allergic reactions and mobilization of glycogen from the liver and fatty acids from fatty acids. depot Then alpha-adrenergic receptors are excited and the vessels of the abdominal organs, skin, mucous membranes, and, to a lesser extent, skeletal muscles narrow, blood pressure (mainly systolic), and general peripheral vascular resistance increase; the pressor effect can cause a short-term reflex slowing of the heart rate.

INDICATIONS FOR USE Anaphylactic shock, bronchospastic syndrome, hypoglycemia due to insulin overdose, open-angle glaucoma.

CONTRAINDICATIONS Arterial hypertension, widespread atherosclerosis, thyrotoxicosis, diabetes mellitus, angle-closure glaucoma, pregnancy. Adrenaline should not be used during anesthesia with fluorotane or cyclopropane (due to the development of arrhythmias).

SIDE EFFECTS Increased blood pressure, cardiac arrhythmias, ventricular fibrillation, anxiety, tremor of skeletal muscles, angina pectoris, tachycardia, headache, nausea.

INTERACTION Enhances the effect of aminophylline and drugs that increase thyroid function.

METHOD OF APPLICATION AND DOSAGE Therapeutic doses of adrenaline hydrochloride for parenteral administration are usually 0.3-0.5-0.75 ml of a 0.1% solution for adults. Depending on age, children are administered 0.1-0.5 ml of solution. Higher single doses: 0.1% solution of adrenaline hydrochloride and 0.18% solution of adrenaline hydrotartrate for adults under the skin: single 1 ml, daily 5 ml.

OVERDOSE No information available.

SPECIAL INSTRUCTIONS For the prevention of arrhythmias against the background of epinephrine, beta-blockers are indicated

STORAGE CONDITIONS List B. Store in a cool, dry place.

Indications for use

Adrenaline is used in many areas of medicine:

Allergology - during the occurrence of acute allergic reactions during anaphylactic shock caused by the body's reaction to allergens, and anaphylactoid situations that can occur suddenly, due to the body's reaction to factors that did not previously cause sensitization;

Ophthalmology - for the treatment of open-angle glaucoma;

Cardiology - in the treatment of cardiogenic shock;

ENT and dentistry - decongestants of the mucous membrane. Used after bleeding procedures - removal of teeth, tonsils;

Anesthesiology - because in combination with local anesthetics it prolongs the analgesic effect.

Drugs containing (Epinephrine analogues)

Level 4 ATC code matches:
Norepinephrine

Mezaton

Dobutamine

Dopamine

Adrenalin

Analogs of Epinephrine: Adrenaline, Epinephrine hydrotartrate, Adrenaline hydrotartrate solution 0.18% for injection, Adrenaline-Hydrochloride-Vial, Adrenaline tartrate .

Articaine and Epinephrine are included in the following drugs: Alfacaine SP, Articaine INIBSA, Artifrin, Primacaine with adrenaline, Ubistezin, Ultracaine D-S, Brilocaine-adrenaline, Cytokartin, Articaine DF, Articaine Perrel with adrenaline, Septanest with adrenaline .

special instructions

The substance is not recommended for use after myocardial infarction , as it can provoke ischemia .

During infusion, a measuring device must be used to regulate the rate of administration of the substance. It is best if the infusion is carried out into a large vein, preferably a central one.

Intracardiac administration of the drug is recommended only in emergency cases, if other methods of administration are not available, as the risk of pneumothorax and cardiac tamponade .

During treatment with the drug, it is recommended to periodically determine the concentration of potassium in the blood serum, measure blood pressure , diuresis , perform an ECG , and monitor central venous pressure .

When endotracheally , absorption and achievement of maximum plasma concentrations of the substance may be unpredictable.

Administration of the drug in a state of shock does not replace the lost volume of circulating blood; it is still necessary to perform a blood or plasma transfusion, to administer blood replacement fluids or saline solutions to the patient.

Long-term therapy with Epinephrine is highly discouraged, as this can lead to the development of gangrene or necrosis.

Also, the medicine cannot be used to correct blood pressure during childbirth; uterine atony and bleeding may develop, and the second stage of labor may be delayed.

With long-term use, it is necessary to reduce the dose gradually; sudden discontinuation of the drug can cause a decrease in blood pressure.

The solution is easily destroyed with an alkali or an oxidizing agent .

If the solution turns brown or turns pink, or a sediment has formed at the bottom of the ampoule, it must be discarded.

Panic attacks and willpower

There are a number of common points in the treatment of panic attacks and neuroses - their therapy involves searching for the internal cause of the attacks. Usually these reasons are psychological trauma and severe stress. However, if a person with a strong will was able to suppress them and displace the strongest experiences into the subconscious, then deeply hidden emotions will make themselves felt. Since a person has not allowed himself to fully experience a strong emotion - joy, grief, excitement, etc., this feeling will find a way out for the realization of nervous excitement. As a result, a panic attack may develop. But having found out the true cause of the disease, the psychotherapist can, using the patient’s volitional qualities, eliminate the source of the panic state. Therefore, treating panic attacks through psychotherapy is quite successful and effective, as it combats the underlying cause of the disease.

Contraindications

Epinephrine should not be used:

if you have hypersensitivity to this substance;
patients with high blood pressure ;
for ischemic heart disease and tachyarrhythmia ;
persons with ventricular fibrillation ;
pregnant women;
with pheochromocytoma ;
during lactation;
with hypertrophic cardiomyopathy .

During treatment, special care should be taken:

patients with metabolic acidosis ;
with hypercapnia ;
after cold injury;
for atrial fibrillation, ventricular arrhythmia and hypoxia ;
patients with pulmonary hypertension ;
after myocardial infarction ;
with hemorrhagic, cardiogenic, traumatic or any other shock not caused by allergies;
patients with thyrotoxicosis ;
for occlusive vascular diseases;
patients with atherosclerosis or Buerger's disease ;
for diabetic endarteritis ;
patients with Raynaud's disease ;
for cerebral atherosclerosis ;
patients with diabetes mellitus or closed-angle glaucoma ;
patients with Parkinson's disease ;
with increased convulsive activity;
if inhalation agents for general anesthesia ( cyclopropane, Ftorotan, chloroform ) are used at the same time;
with prostatic hypertrophy ;
elderly patients;
children.

Adrenaline is a neurotransmitter

Neurotransmitters are substances with a diverse chemical structure that meet certain criteria:

produced in the bodies of nerve cells and their endings and stored in synaptic vesicles;
respond to electrical stimuli through which they are released and then connect to specific receptors, after which they induce a response in postsynaptic neurons;
when introduced into the body from the outside, they act by analogy with substances naturally produced by the body;
After performing their function in the body, they are removed from the site of action by a certain mechanism.

Adrenaline meets all of the above criteria, being a neurotransmitter characterized by synaptic and extrasynaptic release. It is also a peripheral pain mediator that temporarily increases the body's tolerance to pain.

Side effects

After administration of the drug, the following may develop:

angina pectoris, tachycardia , palpitations, bradycardia , increased or decreased blood pressure ;
ventricular arrhythmia , chest pain, cardiac arrhythmia (high dosages of the drug);
anxiety, tremor , headaches, dizziness;
less often than usual - feeling tired, feeling hot or cold, nervousness ;
insomnia , spontaneous muscle contractions, nervous system excitement, memory loss, disorientation , panic and aggression, paranoia , disorders similar to schizophrenia (rare);
vomiting, problems with urination, pain during urination, nausea;
allergic skin rashes, bronchospasm , angioedema , erythema multiforme ;
sweating, hypokalemia – rare;
cramps , persistent and strong erection , muscle tightening.

During intramuscular injection, pain and burning may occur at the injection site.