Buy Analgin injection solution 50% 2ml No. 10 in pharmacies

Composition of the substance

The medicine is a strictly cylindrical tablet, designed with a chamfer and a score for convenient division into equal parts. Analgin tablets are usually dense white, sometimes with yellow splashes and a uniform yellowish tint.

The main active ingredient of the drug is metamizole sodium monohydrate. One tablet contains 500 mg. There are also tablets with a reduced dose of the active substance, equal to 250 mg.

In addition, the medicine contains a number of excipients, for example, potato starch, talc, calcium stearate and sodium lauryl sulfate.

The active components of the drug provide the drug with a pronounced analgesic, antipyretic and anti-inflammatory effect. Absorption of the components occurs in a short time through the gastrointestinal tract. After a certain period of time, it is excreted from the body by the kidneys without causing harm.

Chemical properties

Metamizole Sodium is a drug, antipyretic , analgesic , belongs to the group of pyrazolones . The substance was synthesized back in 1920. Since the 70s, due to the risk of developing agranulocytosis, the medicine began to be excluded from sale in some European countries, Sweden, Australia, and Japan. At the moment, the product is sold strictly according to prescription. In the Russian Federation in 2009 it was removed from the list of vital and essential drugs. Metamizole sodium is commercially available. The substance was assigned OKPD code 24.42.13.673.

According to its physical properties, the medicine is a white or white-yellow crystalline powder that quickly decomposes at high humidity. The product is highly soluble in water, the pH of the finished solution is from 6 to 7.5. Poorly soluble in alcohol, practically insoluble in acetone , ether and chloroform . Molecular weight of Metamizole = 311.4 grams per mole; Metamizole sodium – 333.3 grams per mole. The chemical compound is given in the form of tablets, suppositories, drops and injection solution.

Indications and contraindications

The scope of application of Analgin, instructions for which are included in the pack, is very diverse. It is used for pain of various origins, including those associated with injuries and surgical interventions, as well as those caused by tumor processes.

The instructions for use of the drug say that Analgin reduces pain in chronic pain of various origins. It facilitates the course of the disease in cases where it is not yet possible to carry out other correct treatment.

The pronounced antipyretic function allows the drug to be used at high temperatures during infectious diseases. It is used when other antipyretic drugs have failed to cope with elevated temperatures.

Most often, Analgin is used for headaches or toothaches, but its use is much wider than indicated in the instructions for the drug. In combination with antispasmodics, Analgin has shown high effectiveness in the fight against renal or biliary colic.

Analgin is strictly contraindicated for children.

There are not as many prohibitions on the use of the drug as there are for other similar drugs. However, you should be careful and not take the drug uncontrollably. It is important to take into account the patient’s condition and consult with a doctor to choose the right treatment regimen.

Analgin

Analgin

Registration number: LS – 002585

Trade name of the drug: Analgin

International nonproprietary name: Metamizole sodium

Chemical rational name:

Sodium 1-Phenyl-2,3-dimethyl-4-methylaminopyrazolone-5-N-methanesulfonate

Dosage form: tablets

Compound

active substance: metamizole sodium - 500 mg

excipients: refined sugar (sucrose), potato starch, calcium stearate 1-water, talc.

Description

Tablets are white or white with a slightly yellowish tint, flat-cylindrical in shape, scored and chamfered.

Pharmacotherapeutic group

Analgesic non-narcotic drug.

ATX code: [ N 02 BB 02 ]

Pharmacological properties

It has analgesic, antipyretic and weak anti-inflammatory effects, and is a derivative of pyrazolone.

Pharmacodynamics

Analgin non-selectively blocks cyclooxygenase and reduces the formation of prostaglandins from arachidonic acid, and prevents the conduction of painful extra- and proprioceptive impulses. Analgin has a weak anti-inflammatory effect, which causes little effect on water-salt metabolism (sodium and water retention) and the gastrointestinal mucosa. It has an antispasmodic effect on the smooth muscles of the urinary and biliary tract. The action develops 20-40 minutes after ingestion.

Pharmacokinetics

It is well and quickly absorbed from the gastrointestinal tract, which ensures rapid development of the clinical effect. When taken in therapeutic doses, it penetrates into mother's milk.

Maximum plasma concentration is achieved 1-1.5 hours after oral administration. In the intestinal wall it is hydrolyzed to form the active metabolite, 4-methyl-amino-antipyrine, which in turn is metabolized to 4-formyl-amino-antipyrine and other metabolites. The level of binding of the active metabolite to proteins is 50-60%. Excretion of metabolites occurs through the kidneys. In addition, metabolites are excreted in breast milk.

Indications for use

Feverish syndrome against the background of infectious and inflammatory diseases, headaches of various origins, pain syndrome of mild and moderate severity: neuralgia, myalgia, arthralgia, biliary colic, intestinal colic, renal colic, trauma, radiculitis, myositis, postoperative pain syndrome, algodismenorrhea.

Contraindications

Hypersensitivity, inhibition of hematopoiesis (agranulocytosis, neutropenia), liver and/or renal failure, hereditary hemolytic anemia associated with deficiency of glucose-6-phosphate dehydrogenase and other types of anemia, “aspirin” asthma, leukopenia, pregnancy (especially in the first trimester and in the last 6 weeks), lactation period, children up to 8 years of age.

Carefully

The drug should be taken with caution in case of kidney diseases (pyelonephritis, glomerulonephritis - including a history), with moderately severe liver and kidney disorders, bronchial asthma, a predisposition to the development of arterial hypotension, and long-term alcohol abuse.

Directions for use and doses

Orally, after meals, adults are prescribed 250-500 mg 2-3 times a day, the maximum single dose is 1000 mg, the daily dose is 3000 mg. Single doses for children 8-14 years old - 250-300 mg, frequency of administration 2-3 times a day. The duration of use without consulting a doctor is no more than 5 days.

Side effect

From the urinary system: impaired renal function, oliguria, anuria, proteinuria, interstitial nephritis, red staining of urine.

Allergic reactions: urticaria (including on the conjunctiva and mucous membranes of the nasopharynx), angioedema, in rare cases - malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), bronchospastic syndrome, anaphylactic shock.

From the hematopoietic organs: agranulocytosis, leukopenia, thrombocytopenia.

Other: lowering blood pressure.

Overdose

Symptoms: nausea, vomiting, gastralgia, oliguria, hypothermia, decreased blood pressure, tachycardia, shortness of breath, tinnitus, drowsiness, delirium, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, acute renal and/or liver failure, convulsions, respiratory muscle paralysis .

Treatment: gastric lavage, saline laxatives, activated charcoal, forced diuresis, hemodialysis, with the development of convulsive syndrome - intravenous administration of diazepam and fast-acting barbiturates.

Interaction with other drugs: Concomitant administration with other non-narcotic analgesics, tricyclic antidepressants, contraceptive hormonal drugs and allopurinol may lead to increased toxicity; sedative and anxiolytic drugs enhance the analgesic effect of metamizole sodium. Metamizole sodium enhances the effects of alcohol; simultaneous use with chlorpromazine or phenothiazine can lead to the development of severe hyperthermia. Radiocontrast drugs, colloidal blood substitutes and penicillin should not be used during treatment with metamizole sodium.

With simultaneous administration of cyclosporine, the concentration of the latter in the blood decreases. Metamizole sodium, displacing oral hypoglycemic drugs, indirect anticoagulants, corticosteroids and indomethacin from protein binding, increases their activity. Phenylbutazone, barbiturates and other inducers of microsomal liver oxidation, when administered simultaneously, reduce the effectiveness of metamizole sodium.

special instructions

When treating children under 8 years of age and patients receiving cytotoxic drugs, Analgin should only be taken under medical supervision.

Patients with atopic bronchial asthma and hay fever have an increased risk of developing allergic reactions. While taking Analgin, agranulocytosis may develop, and therefore, if an unmotivated rise in temperature, chills, sore throat, difficulty swallowing, stomatitis is detected, as well as with the development of vaginitis or proctitis, immediate discontinuation of the drug is necessary. With long-term use, it is necessary to monitor the peripheral blood picture.

It is not permissible to use it to relieve acute abdominal pain (until the cause is determined).

Release form

Tablets 500 mg. 10 tablets in blister or cell-free packaging. 2 or 3 blister packs along with instructions for use are placed in a cardboard pack. It is allowed to place contour cell or cell-free packages with an equal number of instructions for use in a box made of cardboard.

Conditions for dispensing from pharmacies

Without a doctor's prescription.

Storage conditions:

List B. In a dry place, protected from light, at a temperature not exceeding 25 ° C.

Best before date:

5 years. Do not use after the date indicated on the package.

Units:

pack

Instructions for use

Independent and uncontrolled treatment with the drug is not allowed. Consultation with a doctor before using the tablets is required. This can be done at the MedArt clinic by making an appointment at a convenient time.

It is recommended to swallow each tablet whole without chewing it first. Be sure to drink plenty of water.

For acute pain, it is recommended to take a tablet with a dosage of 500 mg. If the intensity is pronounced, you can take two tablets at once, but keep in mind that no more than 3-4 tablets can be used per day. In this case, the course should not exceed five days from the start of treatment.

Analgin, the use of which is caused by spasms or fever, requires determining the exact dosage. As an antipyretic, tablets are taken in the smallest amount that is safe for the body, and also gives a reaction to high temperature. The course of treatment is no more than three days.

For children over 8 years old to 14 years old and weighing from 32 to 53 kg, a single dosage of the substance is 500 mg of the active component of the drug, that is, take one Analgin tablet. You can take up to four tablets per day, which is a multiple of 2000 mg of the substance.

Adult patients and adolescents over 15 years of age and weighing more than 53 kg can take 1-2 tablets at a time, which is a multiple of 1000 mg of the active ingredient. You are allowed to take no more than eight tablets per day, which is equal to 4000 mg of the active ingredient.

There are special conditions for elderly patients, as well as people suffering from kidney or liver failure. In this case, the minimum effective dosage of the drug is taken. High doses should be avoided, or the course of taking the drug should be significantly shortened.

Analgin, the dosage of which is determined by the nature of the disease, is effective and is often present in the medicine cabinet.

This is due to the difficulties of removing the breakdown products of the substance from the body. Since they are excreted by the kidneys, in such cases excretion will be slow or difficult, so the dosage is reduced to the minimum effective. During a long course of treatment, the doctor prescribes constant monitoring of the patient’s condition with regular leukocyte counts and blood monitoring.

Indications for use

The medicine is used:

• for arthralgia , chorea , rheumatism , various types of pain;
• for relief of dental, headache, menstrual pain;
• for neuralgia , myalgia , sciatica ;
• in patients with renal, hepatic and intestinal colic;
• for myocardial infarction , pulmonary infarction, thrombosis of the great vessels;
• for the treatment of pleurisy , lumbago , pneumonia , myocarditis ;
• to relieve pain from burns, various injuries, decompression sickness, tumors;
• for orchitis , herpes zoster , peritonitis , pancreatitis ;
• in patients with pneumothorax and esophageal perforation;
• with priapism , post-transfusion complications;
• as part of complex treatment of acute infections, urological and purulent diseases;
• for bites from bees, mosquitoes, and gadflies.

Side effects

It is forbidden to use the drug for severe pain in the stomach, the origin of which has not been identified. Until a proper diagnosis is made, Analgin is not used in therapy. If the dosage and duration of the course of taking the tablets are not observed by the doctor, as well as when taking the drug under existing contraindications, allergic reactions may occur.

Most often, side effects are manifested by a skin rash, quite intense, as well as Quincke's edema. Less commonly observed are Lyell's and Stevens-Johnson syndromes, as well as anaphylactic shock. With long-term use of the drug as an anesthetic, changes occur in the blood formula.

Instructions for use of analgin highlight several side effects:

• risk of developing thrombocytopenia or leukopenia;
• bronchospasm attack;
• a strong decrease in blood pressure;
• malfunctions of the renal system.

When the first signs of deterioration in the patient’s condition appear, it is important to immediately stop taking the drug and report the incident to the treating doctor. To change painkillers, you need to visit a doctor to clarify the need to change the medication.

An overdose of a substance occurs in case of prolonged use of the drug, more than a week in a course in increased dosages, as a pain reliever. This may be manifested by nausea and vomiting, delirium, impaired consciousness, shortness of breath, and a sharp decrease in blood pressure.

If dangerous conditions of the body are determined, you should immediately consult a doctor and stop taking the drug. It is important to perform gastric lavage and also start using saline laxatives. They also increase their drinking regime and follow a diet. In particularly difficult cases, you will have to go to the hospital and undergo a hemodialysis procedure.

Pregnancy and lactation

Research on the effects on the body of pregnant women taking Analgin has not been carried out to a sufficient extent. As a result of animal studies, no serious disturbances in the functioning of the body were identified.

And yet, the drug can provoke serious perinatal problems, so taking the drug in the first and third trimester is strictly prohibited. The use of a substance in the second trimester occurs with extreme caution, under the supervision of a doctor, and only when the potential benefit to the mother is higher than the well-being of the fetus.

The drug is also not used during breastfeeding, as it easily passes into breast milk and can harm the baby. Feeding is allowed only 48 hours after completion of the drug.

The dosage of analgin for children is also prescribed by the doctor. Self-medication is not allowed in case of pathologies or fever in a child. Even half of a pill taken can have a detrimental effect on the body, so you should first undergo tests and get detailed advice from a qualified doctor. Only a doctor can prescribe medication in accordance with the nature of the disease.

Pharmacodynamics and pharmacokinetics

According to the mechanism of action, Metamizole Sodium is similar to other NSAIDs. The drug does not selectively inhibit the enzyme cyclooxygenase and inhibits the formation of inflammatory mediators prostaglandins from arachidonic acid . The substance makes it difficult to carry out proprio- and extrareceptive impulses along the Burdach and Gaulle , increases the threshold of excitability of the pain sensitivity center in the thalamus, and increases the degree of heat transfer.

The anti-inflammatory effect of taking the drug is slightly expressed, the substance has practically no effect on water-salt metabolism, does not retain water and sodium ions, and does not irritate the mucous membrane of the digestive tract. Metamizole Sodium has some antispasmodic effect on the biliary and urinary tract.

After oral administration of the medicine, the effect of it develops within 20-30 minutes, reaching its maximum after 4 hours. Metamizole lowers the temperature much faster than paracetamol and ibuprofen , the drug has the most pronounced analgesic effect. In the gastrointestinal tract, the substance is absorbed quickly and almost completely. In the intestines (on the walls), the drug undergoes hydrolysis , where its active metabolite is formed. Pure Metamizole is absent in blood plasma after oral administration.

After intravenous administration, a small concentration of the unchanged compound is detected in the blood plasma. The degree of binding to plasma proteins ranges from 50 to 60%. The substance is also metabolized in the liver. Excreted via the kidneys.

Interaction with other drugs

In the case of simultaneous use of Analgin with cyclosporine, the level of the latter in the blood can be significantly reduced. It is important to inform your doctor about this; you may need to increase the dosage of the drug if you need to take a painkiller.

Severe hyporemia can occur when the substance is combined with chlorpromazine. Elderly patients are at high risk of developing hematological toxicity when used concomitantly with methotrexate.

Analgin should be used with acetylsalicylic acid and bupropion with great caution. The drug interacts and reduces the effectiveness of antihypertensive substances.

Interaction

Combination use of the drug with analgesics, antipyretics and non-steroidal anti-inflammatory drugs can lead to increased toxicity of the drugs.

When taken simultaneously with inducers of microsomal liver enzymes, the effectiveness of Metamizole may decrease.

Combined use with indirect anticoagulants, oral hypoglycemic agents, glucocorticosteroids, and indomethacin enhances the effectiveness of the latter.

Phenothiazine can provoke the development of severe hyperthermia .

When combining the drug with anxiolytics and sedatives, its analgesic effect is enhanced.

The simultaneous use of Metamizole Sodium and tricyclic antidepressants, allopurinol , oral contraceptives disrupts the processes of normal drug metabolism and increases the toxicity of Metamizole.

Caffeine enhances the effect of the drug.

Cyclosporine reduces the plasma concentration of the drug.

The substance can be combined with pitofenone hydrochloride and fenpiverinium bromide . Farming is being strengthened. the effects of all drugs, relaxation of smooth muscles, normalization of body temperature, reduction in the severity of pain.

Precautionary measures

Particular care should be taken when treating patients who receive cytostatic drugs, as well as people with atopic bronchial asthma and hay fever.

If symptoms of sore throat, stomatitis, chills, difficulty swallowing or fever are detected, you must immediately stop taking the drug and consult a specialist.

For acute abdominal pain, Analgin should not be used until the exact diagnosis is determined. Also, with long-term use of the drug, it is necessary to monitor and check the flow of peripheral blood by counting leukocytes.

Contraindications

The product is not recommended for use:

• if you are allergic to the active ingredient;
• patients with granulocytosis , neutropenia ;
• during lactation;
• for liver and kidney diseases;
• patients with hereditary hemolytic anemia associated with a deficiency of the enzyme glucose-6-phosphate dehydrogenase ;
• for anemia , leukopenia , aspirin-induced asthma ;
• pregnant women in the first trimester and in the last.

Caution is recommended:

• in newborns under 3 months of age;
• for pyelonephritis , glomerulonephritis and other kidney diseases;
• patients who abuse alcohol;
• when administered intravenously to patients with low blood pressure;
• with unstable blood circulation ( shock , myocardial infarction , multiple injuries).

Where to buy, how much it costs

You can buy the drug at almost any pharmacy; it is available without a prescription. At the same time, the price of analgin is affordable for every patient. The cost of a pack of blisters containing 20 tablets of the substance is about 1 ruble.

Analgin is a medicine that was actively used by our grandmothers during the USSR period, when a variety of drugs similar to today’s was not available on the pharmaceutical market. Traditionally, today it is one of the most accessible and inexpensive medicines with a wide range of applications in various pathologies. It is prescribed to adults and children when severe spasms occur. Or taken urgently in case of increased body temperature.

Preparations containing (Metamizole Sodium analogues)

Level 4 ATC code matches:
Analdim

Reopirin

Tempalgin

Spazgan

Benalgin

Pentalgin ICN

Pentalgin N

Pentalgin

Analgin

Renalgan

Tetralgin

Spasmalin

Maxigan

Sedal-M

Piralgin

Baralgin M

Sedalgin Plus

Baralgetas

Revalgin

Andipal

Analogues (trade names) of medicines: Analgin , Optalgin , Analgin solution in ampoules , Analgin-Ultra , Spazdolzin for children , Baralgin M , Analgin Avexima and so on.

The combination of Metamizole Sodium + fenpiverinium bromide + pitofenone . Drugs of this kind are considered more effective. Trade names Metamizole Sodium, pitofenone , fenpiverinium bromide : Spazmalgon , Spazmalin , Revalgin , Baralgetas , Trinalgin , Plenalgin , Renalgan , Spazmofarm , Spazgan , Bral , Maksigan , Bralangin , Spasmaton and so on.

Reviews

You can find a huge number of positive reviews online, as this is a time-tested medicine. The use of analgin is due to the low price of packaging the substance, as well as the popularity of the drug, because our mothers and fathers used it when such a variety of drugs was not on the market.

An excellent product, inexpensive and effective. I only get relief from headaches with Analgin. I always have it in my first aid kit and recommend it to my family. It’s very nice that regardless of price increases, a box of tablets can be purchased for just a ruble.

Anna, 45 years old

In a big city, headaches and muscle pain are constant companions. I always save myself with Analgin when I can’t stand the spasms. I carry it with me and always have a supply in the car. The low price of the drug is considered a huge advantage.

Sergey, 32 years old

I have been using Analgin for many years and don’t even look towards newfangled expensive products. He saves 100%. An excellent product that the whole family uses.

Valeria, 62 years old

There are practically no negative reviews of Analgin. Users consider the only disadvantage to be inconvenience in swallowing and poor dissolution of the tablets. In this case, it is recommended to simply drink it with plenty of liquid so that it gets into the gastrointestinal tract more quickly.