pharmachologic effect
A combined drug, the effect of which is determined by the effects of its constituent components.
- Paracetamol has a pronounced analgesic and antipyretic effect due to the inhibition of COX in the central nervous system and its effect on the center of pain and thermoregulation.
- Ascorbic acid (vitamin C) is involved in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, synthesis of steroid hormones, reduces vascular permeability and increases the body's resistance to various adverse environmental factors.
- Pheniramine maleate is a histamine H1 receptor blocker, has an antiallergic effect, reduces nasal discharge, nasal congestion, lacrimation and eliminates sneezing.
Directions for use and doses
The drug is taken orally. The contents of the sachet should be poured into a mug, filled with warm water, and stirred until dissolved. The prepared solution must be consumed warm.
Adults and adolescents over 18 years of age are prescribed 1 sachet 2-3 times a day. The interval between doses of the drug should be at least 4 hours.
In case of severe renal failure (creatinine clearance <10 ml/min), the interval between the first and second dose should be at least 8 hours.
The drug should not be taken for more than 3 days as an antipyretic and for more than 5 days as an analgesic.
Buy Antigrippin powder Chamomile No. 10 in pharmacies
AntiGrippin Buy AntiGrippin in pharmacies DOSAGE FORMS powder for the preparation of a solution for oral administration, chamomile
MANUFACTURERS Natur Product Pharma Sp.Zo.o (Netherlands)
GROUP Analgesics-antipyretics - para-aminophenol derivatives
INTERNATIONAL NON-PROPENTED NAME Paracetamol + Chlorphenamine + Ascorbic acid
SYNONYMS Antiflu Kids
Description of AntiGrippin
Compound
Paracetamol - 500 mg, Ascorbic acid - 200 mg, Chlorphenamine maleate - 10 mg
Package
10 sachets.
pharmachologic effect
Antigrippin is a combination drug to eliminate the symptoms of acute respiratory infections and colds. Paracetamol has an analgesic and antipyretic effect; eliminates headaches and other types of pain, reduces fever. Ascorbic acid (vitamin C) is involved in the regulation of redox processes, carbohydrate metabolism, and increases the body's resistance. Chlorphenamine is a blocker of H1-histamine receptors, has an antiallergic effect, facilitates breathing through the nose, reduces nasal congestion, sneezing, lacrimation, itching and redness of the eyes.
Indications
Infectious and inflammatory diseases (ARVI, influenza), accompanied by fever, chills, headache, joint and muscle pain, nasal congestion and pain in the throat and sinuses.
Contraindications
Hypersensitivity to the components of the drug. Erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase). Severe renal and/or liver failure. Alcoholism. Angle-closure glaucoma. Prostatic hyperplasia. Children's age (up to 15 years). Pregnancy (I and III trimester) and lactation period.
With caution - renal and/or liver failure, glucose-6-phosphate dehydrogenase deficiency, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), viral hepatitis, alcoholic hepatitis, old age.
Directions for use and doses
Inside. Adults and children over 15 years old: 1 sachet 2-3 times a day. The contents of the sachet should be completely dissolved in a glass (200 ml) of warm water (50-60 °C) and the resulting solution should be drunk immediately. It is better to take the drug between meals. The interval between doses of the drug should be at least 4 hours.
The duration of use without consulting a doctor is no more than 5 days when prescribed as an analgesic and 3 days as an antipyretic.
Side effects
When using the drug Antigrippin, patients experienced the development of the following side effects: From the central nervous system: dizziness, headache, increased fatigue, disturbance of sleep and wakefulness. From the cardiovascular system and hematopoietic organs: anemia, including hemolytic anemia, thrombocytopenia, hyperemia of the face and upper body. From the gastrointestinal tract: nausea, vomiting, dry mouth, pain in the epigastric region. Allergic reactions: skin rash, itching, urticaria, exudative eczema multiforme, toxic epidermal necrolysis. In isolated cases, the development of anaphylactoid reactions, including Quincke's edema and anaphylactic shock, is possible. From the urinary system: interstitial nephritis, papillary necrosis, urinary retention. Others: hypervitaminosis, decreased blood glucose levels up to hypoglycemic coma, metabolic disorders.
Drug interactions
With simultaneous use, the drug reduces the therapeutic effect of phenothiazide derivatives, and also reduces the tubular reabsorption of tricyclic antidepressants and amphetamine. When using the drug simultaneously with antidepressants, antiparkinsonian drugs, glucocorticosteroids, phenothiazide derivatives, the risk of developing side effects characteristic of chlorpheniramine maleate (dry mouth, urinary retention, glaucoma) increases. When the drug is used simultaneously with inducers of microsomal oxidation, the risk of developing intoxications increases due to an increase in the amount of hydroxylated metabolites of paracetamol. Simultaneous use of the drug with microsomal oxidation inhibitors leads to a decrease in the amount of hydroxylated metabolites of paracetamol, reducing the risk of intoxication. With simultaneous use of the drug with diflunisal, an increase in plasma concentrations of paracetamol is observed. Barbiturates reduce the therapeutic effect of paracetamol when used simultaneously and increase the excretion of ascorbic acid.
The drug reduces the therapeutic effect of uricosuric drugs. When using the drug simultaneously with ethyl alcohol, there is a risk of developing pancreatitis and an increase in the effect of chlorpheniramine maleate is noted. The drug helps to increase plasma concentrations of benzylpenicillin and tetracyclines. Ascorbic acid, which is part of the drug Antigrippin, increases the absorption of iron in the gastrointestinal tract. When using the drug to treat patients taking short-acting salicylates and sulfonamides, the risk of developing crystalluria increases. The drug reduces plasma concentrations of oral contraceptives when used simultaneously. The drug Antigrippin, when used simultaneously, reduces the chronotropic effect of isoprenaline. With simultaneous use of the drug with anticoagulants, it is possible to either reduce or increase the effectiveness of the latter.
Overdose
When using excessive doses of the drug, patients experience the development of nausea, vomiting, headache, stool disorders, decreased appetite, pain in the epigastric region and increased sweating, which are symptoms of acute paracetamol poisoning. In addition, the development of fainting, increased excitability, disturbances in sleep and wakefulness, depression and seizures caused by an overdose of chlorpheniramine maleate is possible. Symptoms of a drug overdose may develop within a few hours after using excessive doses of the drug (acute overdose) or several days after increasing the dose of the drug (chronic overdose). In case of overdose of the drug, gastric lavage, intake of enterosorbents and symptomatic treatment are indicated. In acute paracetamol poisoning, intravenous acetylcysteine or oral methionine is indicated. Treatment of acute overdose of paracetamol should be carried out in a hospital setting.
Storage conditions
Store in a dry place, protected from light at a temperature of 10-30°C.
Best before date
3 years.
Contraindications
- erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;
- liver failure;
- angle-closure glaucoma;
- urinary retention associated with prostatic hyperplasia;
- blood diseases (including sideroblastic anemia, thalassemia, leukopenia, thrombocytopenia);
- portal hypertension;
- diabetes;
- deficiency of glucose-6-phosphate dehydrogenase;
- hyperoxaluria;
- nephrourolithiasis;
- sucrase/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption (due to the presence of sucrose);
- pregnancy;
- breastfeeding period;
- children and adolescents up to 18 years of age, because the content of ascorbic acid in the daily dose of the drug (400 and 600 mg) exceeds the maximum daily dose for children (300 mg);
- hypersensitivity to one or more components included in the drug.
special instructions
Patients should be warned that if fever persists for more than 3 days and pain persists for more than 5 days while using the drug, they should consult a doctor.
When using the drug, it is possible to distort the results of some laboratory tests (quantitative determination of glucose in blood and urine, bilirubin, uric acid in blood plasma, activity of liver transaminases and LDH).
During treatment, it is necessary to monitor the peripheral blood picture, blood pressure, laboratory indicators of the functional state of the liver, the insular apparatus of the pancreas, and the adrenal glands.
It is necessary to inform patients that the recommended dosage of the drug should not be exceeded.
Patients with impaired renal function should consult a doctor before using the drug.
Patients with diabetes mellitus or patients on a low-sugar diet should take into account that each sachet of the drug contains 11.555 g of sucrose, which corresponds to 1.16 XE (powder for oral solution /lemon/) or 11.835 g of sucrose, which corresponds to 1.18 XE (powder for oral solution /raspberry/) or 11.837 g of sucrose, which corresponds to 1.18 XE (powder for oral solution /blackcurrant/).
During the treatment period, it is necessary to refrain from drinking alcoholic beverages, because development of hepatotoxicity is possible.
The use of the drug may provoke the development of drowsiness, so you should refrain from driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Antigrippin powder d/d/internal pack No. 10 chamomile
Compound
Active ingredients:
- paracetamol - 500 mg;
- chlorphenamine maleate - 10 mg;
- ascorbic acid - 200 mg.
Excipients: sodium bicarbonate - 644 mg, citric acid - 1328 mg; sorbitol - 317 mg; povidone - 16 mg; sucrose - 1793 mg; sodium cyclamate - 42 mg; aspartame - 20 mg; acesulfame potassium - 15 mg; lemon flavoring - 55 mg, caramel coloring - 15 mg, honey flavoring - 45 mg.
Indications for use
Infectious and inflammatory diseases (ARVI, influenza), accompanied by fever, chills, headache, joint and muscle pain, nasal congestion and pain in the throat and sinuses.
Contraindications
- erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase);
- severe renal and/or liver failure;
- alcoholism;
- angle-closure glaucoma;
- phenylketonuria;
- prostatic hyperplasia;
- children under 15 years of age;
- pregnancy;
- lactation period;
- hypersensitivity to paracetamol, ascorbic acid, chlorphenamine or any other component of the drug.
With caution: renal and/or liver failure, glucose-6-phosphate dehydrogenase deficiency, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), viral hepatitis, alcoholic hepatitis, old age.
Directions for use and doses
The drug is taken orally. The contents of the sachet should be completely dissolved in a glass (200 ml) of warm water (50-60°C) and the resulting solution should be drunk immediately. It is better to take the drug between meals.
Adults and children over 15 years old - 1 sachet 2-3 times a day. The interval between doses of the drug should be at least 4 hours. The maximum daily dose is 3 sachets.
In patients with impaired liver or kidney function and elderly patients, the interval between doses of the drug should be at least 8 hours.
The duration of use of the drug without consulting a doctor is no more than 5 days when prescribed as an analgesic and 3 days as an antipyretic.
Storage conditions
The drug should be stored out of the reach of children at a temperature of 10-30°C.
Best before date
3 years. Do not use after the expiration date.
special instructions
If you are taking metoclopramide, domperidone or cholestyramine, you should also consult your doctor.
With long-term use in doses significantly higher than recommended, the likelihood of impaired liver and kidney function increases; monitoring of the peripheral blood picture is necessary.
Paracetamol and ascorbic acid can distort laboratory tests (quantitative determination of glucose and uric acid in blood plasma, bilirubin, liver transaminase activity, LDH).
To avoid toxic liver damage, paracetamol should not be combined with alcoholic beverages, or taken by persons prone to chronic alcohol consumption. The risk of developing liver damage increases in patients with alcoholic hepatosis.
Prescribing ascorbic acid to patients with rapidly proliferating and intensively metastasizing tumors can aggravate the process.
In patients with high iron levels in the body, ascorbic acid should be used in minimal doses.
1 sachet of chamomile powder contains 2.058 g of sugar, which corresponds to 0.17 XE.
Description
A drug for the symptomatic treatment of acute respiratory diseases.
Dosage form
Chamomile powder for the preparation of a solution for oral administration of varying degrees of granulation, consisting of particles from white to beige and light brown in color, with a specific odor; inclusions of brown color are allowed.
Use in children
The use of the drug is contraindicated under the age of 15 years.
Action
Combined drug.
Paracetamol
has analgesic and antipyretic effects; eliminates headaches and other types of pain, reduces fever.
Chlorphenamine
- a blocker of histamine H1 receptors, has an antiallergic effect, facilitates breathing through the nose, reduces the feeling of nasal congestion, sneezing, lacrimation, itching and redness of the eyes.
Ascorbic acid (vitamin C)
participates in the regulation of redox processes, carbohydrate metabolism, increases the body's resistance.
Side effects
The drug is well tolerated in recommended doses.
From the nervous system: in isolated cases - headache, feeling of fatigue.
From the digestive system: in isolated cases - nausea, pain in the epigastric region.
From the endocrine system: in isolated cases - hypoglycemia (up to the development of coma).
From the hematopoietic system: in isolated cases - anemia, hemolytic anemia (especially for patients with glucose-6-phosphate dehydrogenase deficiency); extremely rarely - thrombocytopenia.
Allergic reactions: in isolated cases - skin rash, itching, urticaria, Quincke's edema, anaphylactoid reactions (including anaphylactic shock), exudative erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome ).
Other: in isolated cases - hypervitaminosis C, metabolic disorders, feeling of heat, dry mouth, accommodation paresis, urinary retention, drowsiness.
The patient should report all side effects of the drug to the doctor.
Use during pregnancy and breastfeeding
The use of the drug during pregnancy and lactation is contraindicated.
Interaction
- Ascorbic acid
Increases the concentration of benzylpenicillin and tetracyclines in the blood.
Improves the absorption of iron preparations in the intestines (converts ferric iron to divalent iron); may increase iron excretion when used concomitantly with deferoxamine.
Increases the risk of developing crystalluria during treatment with salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), and reduces the concentration of oral contraceptives in the blood.
Increases overall ethanol clearance.
When used simultaneously, it reduces the chronotropic effect of isoprenaline.
It can either increase or decrease the effect of anticoagulant drugs.
Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.
Concomitant use of barbiturates increases the excretion of ascorbic acid in the urine.
- Chlorphenamine maleate
Chlorphenamine maleate enhances the effect of hypnotics.
Antidepressants, antiparkinsonian drugs, antipsychotic drugs (phenothiazine derivatives) increase the risk of side effects (urinary retention, dry mouth, constipation).
Glucocorticoids increase the risk of developing glaucoma.
Ethanol enhances the sedative effect of chlorphenamine maleate.
- Paracetamol
When paracetamol interacts with inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), the production of hydroxylated active metabolites increases, which makes it possible to develop severe intoxications with small overdoses.
While taking paracetamol, ethanol contributes to the development of acute pancreatitis.
Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxicity.
The simultaneous use of diflunisal and paracetamol increases the plasma concentration of the latter by 50%, increasing hepatotoxicity.
Concomitant use of barbiturates reduces the effectiveness of paracetamol.
Paracetamol reduces the effectiveness of uricosuric drugs.
Overdose
Symptoms of a drug overdose are caused by the substances included in its composition. The clinical picture of acute intoxication with paracetamol develops within 6-14 hours after taking it. Symptoms of chronic intoxication appear 2-4 days after an overdose.
Symptoms of acute paracetamol intoxication: diarrhea, loss of appetite, nausea and vomiting, abdominal discomfort and/or abdominal pain, increased sweating.
Symptoms of chlorphenamine intoxication: dizziness, agitation, sleep disturbances, depression, convulsions.
Treatment: symptomatic.
Impact on the ability to drive vehicles and operate machinery
The use of this medicine may cause drowsiness, especially at the beginning of treatment. This effect is enhanced by the consumption of alcoholic beverages or alcohol-containing medications. During the treatment period, you should not drive vehicles, work with potentially dangerous mechanisms and engage in other activities associated with increased concentration.
