In many people's medicine cabinets you can find Validol. This cheap but effective drug has a quick effect, helps relieve nervous tension, rapid heartbeat, and normalize blood pressure. Indications for the use of Validol are quite wide; it is used as a vasodilator, sedative, and analgesic. A wide spectrum of action and rapid onset of therapeutic effect make Validol in demand and popular for many years.
Compound
According to Wikipedia, the INN (international nonproprietary name) of Validol is levomenthol solution in menthylisovalerate , chemical formula is C15H28O2.
Composition of Validol tablets: 60 mg of levomenthol solution in menthylisovalerate - the active ingredient. Additional components: calcium stearate, sucrose.
Composition of Validol in capsules: 50 mg or 100 mg of levomenthol solution in menthylisovalerate - the active ingredient. Additional ingredients: pharmaceutical gelatin, methyl parahydroxybenzoate, glycerol , propyl parahydroxybenzoate, purified water.
Pharmacodynamics and pharmacokinetics
Validol is a complex substance obtained during the process of dissolving menthol (levomenthol) in menthylisovalerate (menthyl ester of isovaleric acid). In the case of sublingual use of validol , for which tablets or capsules of the drug should be placed under the tongue, its pharmacological effect is manifested due to the influence of its two active ingredients - menthol and menthylisovalerate .
The action of menthol in the oral cavity is aimed at irritating the nerve endings located on the mucous membrane. It has been proven that such irritation leads to a reflex dilation of blood vessels (including coronary vessels).
The effect of menthylisovalerate is manifested due to its ability to stimulate in the central nervous system the production and further release of peptides ( dynorphin , endorphin , kinin , enkephalin ) and the mediator histamine , which are regulators of pain and vascular permeability . In this case, the combined effect of these substances acts as an analgesic and sedative compound.
As a result of the general effect of the active ingredients of validol, the observed pain sensations , peripheral blood circulation , and a calming (sedative) effect is manifested, from which validol helps with various painful conditions associated with the cardiovascular system.
Absorption of the active ingredients of the drug in the oral cavity occurs very quickly and within a few minutes their maximum concentrations circulate in the systemic bloodstream. The effect of validol , in the case of its sublingual use, is felt within 3-5 minutes.
Partial transformation of validol occurs in the liver with the formation of products ( glucuronides ) excreted in bile and urine, as well as in the air exhaled by a person.
Indications for use of Validol
Indications for use of Validol are:
- states of hysteria ;
- functional cardialgia ;
- various neuroses ;
- sensations of headaches ,
- arising during nitrate ;
- motion sickness syndrome (including symptoms of nausea / vomiting due to air and/or seasickness ).
When is it appointed?
Due to its sedative and hypotensive properties, the drug has a wide range of indications. It is prescribed for:
- Mental overload, stress, neuroses.
- Hysteria.
- Pain in the area of the heart, sternum. But only in case of pain, pressing discomfort, it is better to exclude Nitroglycerin.
- Hypertension.
- Seasickness.
- Cardiopalmus.
- Convulsions are provoked by cervical and thoracic osteochondrosis.
It does not accumulate in the body and has virtually no side effects.
Contraindications
Before taking Validol tablets or capsules, you must familiarize yourself with the contraindications to their use, which include personal hypersensitivity to the ingredients of the dosage form of the drug and the pathology of sugar intolerance (if they are present in the dosage form).
sucrose as an additional component , which is why Validol tablets should be taken with caution by people suffering from diabetes .
Description
The tablets are white or with a yellowish tint. Sometimes they are produced with grayish inclusions. The shape is flat-cylindrical, the medicine has a noticeable menthol smell.
Capsules with a gel-like shell, soft to the touch. Inside there is a clear oily liquid with a menthol smell.
The solution is produced in ampoules of 5 ml, has a thick oily consistency, and a strong menthol odor.
Important! Some believe that Validol contains peppermint and valerian. This is wrong. Some manufacturers do indeed include impurities in the drug, but there are very few of them.
Side effects
allergic manifestations may occur , including itching / rash on the skin, Quincke's edema and urticaria .
The use of validol in large dosages and over a long period of time can lead to lacrimation , dizziness and nausea . These manifestations usually disappear when dosages are reduced or therapy is temporarily discontinued.
Lowers or increases blood pressure
Blood pressure refers to a physical measurement that controls the force that the liquid component of blood presses against the walls of blood vessels from the inside.
When answering the question whether Validol lowers or increases blood pressure, it should be noted that it dilates blood vessels and, in complex therapy, slightly reduces blood pressure for a while and protects the vascular bed.
But this drug should not be used as the main treatment for hypertension, it can only be a last resort in emergency cases, after which you need to consult a doctor.
Moreover, the drug could not help in a severe crisis.
Instructions for use of Validol
Before starting therapy with Validol, it is advised to establish the body’s personal sensitivity to its ingredients and, depending on their tolerance, determine how many tablets or capsules can be taken in 24 hours and whether taking large dosages is harmful in this particular case.
Capsules and tablets Validol, instructions for use
Instructions for use of Validol in capsules and tablets recommend their sublingual (under the tongue) use. Any form of the drug should be placed in the oral cavity under the tongue and kept there until it is completely absorbed. A single dose is considered to be one tablet (60 mg) or one capsule (50 mg or 100 mg). The average number of daily doses is 2-4 times, the maximum allowable dosage in 24 hours is 600 mg (10 tablets; 12 capsules of 50 mg or 6 capsules of 100 mg). It is better to limit the duration of alternating courses of therapy to 7 days. If the drug has zero or insufficient effectiveness 5-10 minutes after its complete absorption, the possibility of using other drugs should be considered.
Instructions for using Validol with glucose are identical to the above description.
Drug substitutes
The Radar Directory includes the following Validol Analogs:
- Cormenthol - has a similar effect, is available in the form of capsules, which are intended for use under the tongue. Indications for use: neuroses, high blood pressure, hysteria, antiemetic for sea and air sickness;
- Corvalol is a combined antispasmodic, sedative medicine used for various cardiovascular pathologies. The drug is available in capsules and drop form. Contains alpha-bromoisovaleric acid ethyl ester, sodium phenobarbital, peppermint oil and other components;
- Riboxin is a drug with a metabolic effect, one of the precursors of ATP. Riboxin is prescribed for diseases of the heart and blood vessels, for the treatment of coronary artery disease, myocarditis, heart defects and other conditions. The product is produced in the form of tablets, capsules, solution for injection;
- Corvalment – has the international name Corvalmentum. The therapeutic effect of this drug is due to the menthol included in its composition. The drug is used for the symptomatic treatment of angina pectoris, neuroses, hysteria and other conditions. Corvalment has a sedative, vasodilator, and mild hypnotic effect.
Only a few analogues of Validol are described above. The list of drugs that have a similar effect is very extensive. To prescribe one or another remedy, you should consult a doctor.
Overdose
Taking large doses of the drug leads to Validol lowering blood pressure or increasing the risk of side effects and their severity.
Overdose, that is, the use of an excessive number of tablets or capsules at a time, enhances both the positive and negative effects of the drug and can lead to a sharp decrease cardiac function , , the formation of severe headaches and severe nausea leading to vomiting , overexcitation and even depression functionality of the central nervous system.
In this case, depending on the observed manifestations and their intensity, symptomatic treatment .
special instructions
Shelf life – 24-36 months (depending on the manufacturer). It should be stored in a dark place at a temperature of 9-16 degrees.
It is not recommended to take the drug in parallel with alcoholic beverages, since alcohol can have a suppressive effect on the central nervous system, which can lead to more severe adverse reactions.
If you use Validol together with psychotropic drugs, the effectiveness of the latter will increase.
After taking it, you should stop driving for a while.
Interaction
Parallel use with opioid analgesics , psychotropic drugs , ethanol-containing drugs and anesthesia drugs increases their effects.
Combined use with nitrates reduces the feeling of headache that occurs during their use.
Combined use with antihypertensive drugs may potentiate their effectiveness.
Analogs
Level 4 ATC code matches:
Eltacin
Tonginal
Tricardin
Instenon
Pumpan
Barboval
Corvalment
If for some reason the use of Validol is impossible, doctors can recommend the following analogues:
- Advocard;
- Gulidol;
- Cardiolin;
- Dystonin;
- Cardiofit;
- Cormenthol;
- Kratal;
- Pumpan;
- Barboval;
- Tonginal;
- Instenon;
- Rhythmocore;
- Tricardin , etc.
Validol during pregnancy and lactation
The question of whether pregnant or breastfeeding women can take sedatives should be considered on a case-by-case basis, with the understanding that even when a single dose of a minimal dose of a sedative is completely normal, continued use may cause harm to the fetus, mother or breastfeeding child. to kid. In this regard, deciding whether Validol can be taken during pregnancy and breastfeeding should be left to the consideration of the attending physician.
Comparison with other drugs
Patients are often interested in which is better – Validol or Corvalol. Some people are interested in the question, which product should be preferred, Nitroglycerin or Validol? Doctors unanimously say that choosing medications on your own is not recommended. Each product has a specific effect and must be used strictly as prescribed by a specialist. Each of these drugs has a similar effect. This is what gives rise to so many questions. Be that as it may, it is impossible to accurately answer which of the remedies is better. The doctor selects the drug individually for the patient, based on his condition and diagnosis.
Reviews about Validol
The vast majority of people leave purely positive reviews about Validol, especially when this drug is used occasionally to relieve various anxiety , stress or other similar conditions. Also, this medicine copes well with headaches nitrate therapy , and is a weak hypnotic and hypotonic .
Effect on pressure
Taking Validol in combination with other substances during a hypertensive crisis relieves pain and spasms. When a patient suffers from osteochondrosis, the drug reduces discomfort in the neck and sternum.
The drug is also indispensable for heart diseases, when the slightest stress or physical activity overwhelms the patient, increases the pulse rate, increases blood pressure and causes pain in the sternum.
One tablet can normalize the condition until the ambulance arrives.
A person's blood pressure can be either low with hypotension or high with hypertension.
With a sharp increase in pressure, Validol relieves spasms and dilates blood vessels, which, in combination with other medications, reduces pain and normalizes blood flow. As a result, the pressure drops, but in case of a severe attack, such treatment will not save the patient.
The drug is often used for atherosclerosis, as it eliminates the narrowing of blood vessels, which prevents blood from entering the brain. But this does not affect the reason itself in the form of strong pressure in the Validol stream.
Validol price, where to buy
The price of Validol, depending on the manufacturer and the number of tablets or capsules in secondary packaging, varies slightly, but still remains affordable for any consumer, since you can buy 10 tablets or capsules of the drug for 30-40 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Validol caps.
roach 0.1g 20pcs JSC Marbiopharm 46 RUR order - Validol tablets 60 mg 16 pcs. AO Update PFK
87 RUR order
- Validol tab. 60 mg n10 JSC Pharmstandard (ICN) Leksredstva Kursk
46 RUR order
- Validol with glucose tablets 60 mg 10 pcs. JSC Pharmstandard (ICN) Leksredstva Kursk
40 rub. order
- Validol sublingual tablets 60 mg 10 pcs. JSC Tatkhimfarmpreparaty
36 RUR order
Pharmacy Dialogue
- Validol (caps. 0.05g 20 pcs. pack. cell. contact. (2), packs of cards) Lumi LLC
65 rub. order
- Validol (tab. 60 mg No. 16)Update of PFC CJSC
95 rub. order
- Validol (tablet. 60 mg No. 10) Usolye-Sibirsky CFC
43 RUR order
- Validol with glucose (60 mg tablet No. 20)Update of PFC JSC
94 RUR order
- Validol (caps. 100 mg No. 20) Marbiopharm OJSC
47 RUR order
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Pharmacy24
- Validol 0.06 g N10 tablets PAT "Lubnipharm", Ukraine
3 UAH. order - Validol Darnitsa No. 10 tablets PrAT” Pharmaceutical company “Darnitsa”, Ukraine
4 UAH order
- Validol 0.06 g No. 10 tablets PAT "Farmak", Ukraine
4 UAH order
- Validol Darnitsa No. 6 tablets PrAT” Pharmaceutical company “Darnitsa”, Ukraine
3 UAH order
PaniPharmacy
- Validol tablets Validol tablets. 0.06g No. 10 Ukraine, Darnitsa ChAO
5 UAH order
- Validol tablets 0.06g No. 10 Ukraine, Farmak
4 UAH order
- Validol tablets Validol tablets. 6mg No. 10 Ukraine, Lubnyfarm PJSC
4 UAH order
- Validol tablets Validol tablets. 0.06g No. 6 Ukraine, Darnitsa ChAO
3 UAH order
- Validol tablets Validol tablets. 0.06g No. 6 Ukraine, Lubnyfarm PJSC
2 UAH order
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