Lisinopril Stada tablets 5 mg 30 pcs ➤ instructions for use

Compatibility of Lisinopril and alcohol

? Lisinopril represents a clinical and pharmacological group of drugs for lowering blood pressure. It is also characterized by cardioprotective, vasodilating, natriuretic effects.

The drug increases the production of special prostaglandins responsible for normalizing blood pressure. The result of its intake is the dilation of blood vessels.

All alcoholic drinks have the same effect on the human body. When they are combined, the pressure drops to levels dangerous to health.

Brief characteristics of the drug

Renin is a component of the renin-angiotensin system that normalizes blood pressure. It is its production that increases in the body after taking the medicine. The lumen of veins, arteries, capillaries increases, blood circulation and the supply of organs with oxygen and nutrients improves.

Cardiologists prescribe an antihypertensive drug to patients with the following diseases:

• arterial hypertension;
• kidney damage due to metabolic disorders due to diabetes mellitus;
• acute myocardial infarction;
• chronic heart failure.

The medicine increases the immunity of the myocardium to the effects of negative external and internal factors. It is often included in therapeutic regimens after strokes, myocardial infarctions, and angina pectoris.

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How does Lisinopril work?

The drug acts on the renin-angiotensin system of the heart, interfering with dilatation of the left ventricle. At the same time, there is a decrease in the load on the myocardium. The substance reduces pressure in the capillaries of the lungs, as well as in peripheral vessels. When treated with Lisinopril, the tolerance of the cardiac myocardium to increased stress increases. In addition, the activity of renil in plasma increases.

After taking a single dose, the first positive effect occurs after 50-60 minutes. The manifestation of the therapeutic effect intensifies within 7 hours and persists throughout the day. Therapy lasting for several weeks achieves the maximum possible hypotensive effect.

Eating does not interfere with the absorption of the active substance, but at the same time does not contribute to it. Therefore, taking the medicine does not depend on the time of eating. Absorption of Lisinopril reaches 25%. The drug molecules bind weakly to blood proteins. Half-life occurs after 12 hours. Substances are excreted unchanged by the kidneys. Lisinopril does not form metabolites.

Use of the drug for alcoholism

It is actively used in the complex therapy of chronic alcoholism. At the stage of withdrawal syndrome, the patient suffers from surges in blood pressure. His body “learns” to function without ethanol built into its metabolism.

What happens when you suddenly quit drinking alcohol:

1. Pain occurs in the cardiac region.
2. Blood circulation in the brain and lower extremities is impaired.
3. Auditory and visual disorders develop.

This medicine helps improve the functioning of the cardiovascular system. If a person with alcohol addiction does not seek medical help, then taking the drug is possible. But only if you completely abstain from alcohol-containing drinks.

After all, it was their consumption that led to irreversible damage to the myocardium and blood vessels.

The heart has difficulty pumping blood through them, which causes a sharp rise in pressure, tachycardia. The drug will help reduce the load on the myocardium and stop the death of its tissue.

Using the drug for a hangover

The consequences of drinking alcohol in large quantities are severe hangover symptoms. A person suffers from dry mouth, headaches, stomach and muscle pain, digestive disorders, and peristalsis.

Complications from the cardiovascular system also arise:

• chest pain;
• decreased heart rate;
• slowing heartbeat.

These signs of a hangover are contraindications for using the medicine. Taking it will cause a rapid deterioration in your health.

The drug is used to treat high blood pressure due to alcohol poisoning. But only when its toxic metabolite acetaldehyde was excreted from the body in urine. Taking an antihypertensive drug to prevent a hangover is not advisable.

Contraindications to the use of Lisinopril

Contraindications to the use of Lisinopril are pregnancy and breastfeeding. If the expectant mother suffers from hypertension, her condition is monitored in a hospital setting. High blood pressure in such cases is corrected with safe doses of diuretics.

If replacing the drug during breastfeeding is not possible, you should definitely transfer the child to artificial feeding or feeding with donor milk.

Other contraindications are:

• excess potassium in the blood;
• renal dysfunction;
• gout;
• renal artery stenosis;
• elderly age;
• cerebrovascular insufficiency;
• hypotension;
• childhood;
• tissue obstruction that interferes with normal outflow;
• availability of a donor kidney.

Consequences of drinking alcohol

The combination will not reduce blood pressure due to ethanol destroying the active ingredient of the drug. In clinical practice, there have been cases of its sharp decline due to excessive expansion of blood vessels. There is a high probability of developing negative reactions from almost all vital systems.

They are manifested by the following side symptoms:

• chest pain, bradycardia, tachycardia, myocardial infarction;
• drowsiness, confusion;
• bronchospasms, shortness of breath;
• changes in taste sensations, dry mouth;
• pain in the liver, attacks of nausea, vomiting, heartburn;
• hypersensitivity to sunlight;
• increased sweating;
• rare urination;
• neuropsychic weakness.

The consequence of an undesirable combination is joint pain. Muscle spasms and tremors, turning into convulsions, are possible. Local side effects are less common - rash, itching, redness of the skin.

Organs affected by the toxin

The combined use of pharmacological agents and alcohol has a toxic effect on the internal organs and environments of the body. Alcohol, entering into a chemical reaction with a medicine, leads to poisoning, disrupts physiological processes, enhances or weakens the healing properties of drugs.

The liver suffers more than other organs. She gets hit twice. Many medications have a side effect - hepatotoxicity, destroy cells, and disrupt the physiology of the organ. In the liver, alcohol breaks down to ethanal, a substance 20-30 times more toxic than ethanol, which causes the death of hepatocytes.

Dangerous groups of drugs for the organ in combination with alcohol:

• anti-inflammatory;
• hormonal;
• antibacterial;
• antifungal;
• glucose control agents for diabetes mellitus;
• anti-tuberculosis;
• cytostatics (chemotherapy drugs);
• tranquilizers (anti-epileptic, psychotropic).

In second place among the internal organs exposed to the harmful effects of alcohol together with medications are the heart and vascular system. Strong drinks during drug therapy constrict blood vessels and increase blood pressure. The simultaneous intake of alcohol and chemical substances leads to failure of the myocardium and increases the risk of developing an attack of angina pectoris and a heart attack.

A mixture of ethanol and pharmaceuticals disrupts the quality of the blood and reduces clotting. This is dangerous due to internal bleeding and strokes.

Lisinopril: active ingredients

The name of the drug is identical to its active substance - lisinopril dihydrate. Separately, you can find the drug under other trade names. As a rule, its cost under other names is significantly higher.

The following can be used as auxiliary components by various manufacturers:

• corn starch or pregelatinized;
• calcium hydrogen phosphate;
• mannitol;
• magnesium stearate;
• colloidal silicon dioxide;
• microcrystalline cellulose;
• talc.

The drug is produced in the form of oblong white tablets. Its edges are rounded and there is a risk in the center. Each tablet contains 5 mg, 10 mg or 20 mg of active ingredient. The medicine is packaged in 10 tablets in a blister. The package contains 30 doses (3 blisters).

Rules for taking medications and alcohol

Drinking alcohol during treatment minimizes the clinical effect of therapy and creates a risk of developing complications of the disease.

If this cannot be avoided, follow the rules of behavior that will reduce the occurrence of negative consequences:

1. Do not drink strong drinks (vodka, cognac, whiskey), choose dry wine (100-150 ml), beer (no more than 300 ml). Don't drink alcohol on an empty stomach.
2. The interval between taking the medicine and alcohol should be at least 2 hours.
3. To reduce the toxic effect, take medications that protect the liver (hepatoprotectors), pancreas (pancreatin), and stomach (antacids ─ Rennie, Almagel).

If a person takes antiviral medications for colds, anti-inflammatory drugs, alcohol in moderation does not pose a threat to the body.

Alcoholic drinks during treatment are strictly contraindicated in cases of liver cirrhosis, severe infectious diseases, and during a course of chemotherapy.

Lisinopril: instructions for use

The drug is taken once a day. It is important to observe the time interval between medication doses. Superimposing the effect of one dose on another threatens severe hypotension, up to loss of consciousness.

If the first tablet was taken at lunch, then the second tablet should not be taken in the morning hours of the next day. It is important to keep taking your medication at lunchtime.

A single dose is prescribed by the attending physician based on the following studies:

• blood pressure conditions;
• heart function;
• vascular health;
• risk factors.

If an increase in the single dose is not required, as a rule, a single dose of 2.5 mg of Lisinopril is sufficient to normalize the patient's condition. Dose adjustments can be made no earlier than after 4 weeks of continuous use of the drug, since it is after this time that the maximum possible therapeutic effect is achieved.

If increasing the dose does not give the required result, a similar drug from a different pharmacological group is prescribed, the action of which in a different way will help normalize blood pressure.

If treatment of an insulin-dependent patient is required, Lisinopril is taken under the strict supervision of a specialist in a hospital setting.

Medicines, alcohol and chronic diseases

If a person has chronic diseases, simultaneous use of alcohol and medications is potentially dangerous for the functioning of vital organs. Since patients systematically take prescribed medications, the influence of alcohol can lead to negative consequences.

People with chronic heart disease (angina pectoris, heart defects) develop arrhythmias of varying severity. Heart attacks with severe pain syndrome develop, which is not relieved by Nitroglycerin, and the risk of developing myocardial infarction increases significantly.

In case of chronic liver diseases (viral hepatitis, hepatosis), alcohol during treatment can become a trigger in the development of cirrhosis and hepatocellular carcinoma (cancer).

Drinking alcohol during cirrhosis leads to the following consequences:

• bleeding into the abdominal cavity;
• liver decomposition, infection, peritonitis;
• hepatic coma;
• death.

If a person is on long-term treatment with sedatives, psychotropic drugs, tranquilizers, he is contraindicated in drinking alcohol. This leads to severe depression and the appearance of obsessive states (hallucinations, phobias). Suicidal feelings develop. Such a patient needs constant monitoring and assistance from a psychiatrist.

The most dangerous combinations and consequences

The combination of alcohol and chemical-based drugs can lead to serious disorders in the body, and in some cases to fatal consequences.

List of medications and their side effects in combination with alcohol:

Features of Lisinopril

Lisinopril is a medicine used to treat hypertension. The drug is also prescribed in the presence of the following pathologies:

• chronic form of heart failure;
• acute form of myocardial infarction;
• nephropathy formed against the background of type 1 or 2 diabetes mellitus;

The effect of the drug is to slow down the production of a hormone such as angiotensin, which provokes an increase in blood pressure. In addition, the presented remedy provokes an improvement in the production of prostaglandins. The drug reduces blood vessel resistance and preload. Under its influence, blood pressure is normalized, and minute blood volume and cardiac output are increased.

But despite this positive effect of the drug, there are several contraindications to its use:

• the presence of an allergic reaction to the active substance of the drug;
• congenital pathology in the form of lactase enzyme deficiency;
• the presence of hypersensitivity to other drugs included in the group of ACE inhibitors;
• presence of angioedema;

The medicine is available in tablet form. You need to take 1 tablet per day, the maximum permissible daily dose of the drug is 40 milligrams. According to numerous reviews from doctors, the effect of Lisinopril begins within an hour after administration, and the maximum concentration of the drug in the blood is achieved after 6-7 hours. If the drug is used in a course, the first positive effects from its effects appear within a few days. A lasting effect of the drug is formed after 1-2 months of regular use of Lisinopril.

The drug is removed from the body, on average, after 12 hours.