Pharmacodynamics and pharmacokinetics
Pharmacodynamics
A multivitamin preparation with various additives, the properties of which are determined by the complex of active substances included in the preparation. It has a diverse biological effect on the organs and systems of the body.
Vitamin A activates wound healing and restoration of the skin epithelium.
Vitamin E has an antioxidant effect and is necessary for the development of the muscular, reproductive and nervous systems.
Vitamin C increases the overall resistance of the body.
B vitamins influence metabolism, regulate the function of the cardiovascular and nervous systems, the digestive tract, and participate in the formation of red blood cells.
Vitamin PP is involved in oxidative processes, the synthesis of NAD and NADP.
Folic acid affects the biosynthesis of nucleic acids, proliferation of bone marrow cells, and cell division processes.
Rutin activates tissue respiration and participates in the process of collagen .
Pharmacokinetics
Fat-soluble vitamins (A, E) can accumulate in tissues and are excreted from the body after catabolism. Water-soluble vitamins (groups B, C and PP) combine with the apoenzyme, turn into coenzymes and are part of complex enzymes, and are excreted from the body in the form of various metabolites.
Decamevit tablets p/o No. 10x2
Name
Decamevit tablet p/o in blister. in pack No. 10x2
Basic physical and chemical properties
round tablets with a biconvex surface, yellow film-coated. They have a characteristic smell.
Compound
active ingredients: 1 tablet contains vitamin A 6,600 IU, vitamin E (?-tocopherol acetate) or dry vitamin E 50% 10 mg, vitamin B1 (thiamine hydrochloride) 20 mg, vitamin B2 (riboflavin) 10 mg, vitamin B6 (pyridoxine hydrochloride) 20 mg, vitamin C (ascorbic acid) 200 mg, folic acid (vitamin Bc) 2 mg, nicotinamide (vitamin PP) 50 mg, rutin (vitamin P) 20 mg, methionine 200 mg, vitamin B12 (cyanocobalamin) 0, 1 mg; excipients: croscarmellose sodium, mannitol (E 421), magnesium stearate; shell: mixture for film coating Opadry AMB II White: partially hydrolyzed polyvinyl alcohol, talc, titanium dioxide (E 171), glycerol monocaprylocaprate. sodium lauryl sulfate; film coating mixture Opadry II Yellow (polydextrose, talc, quinoline yellow aluminum varnish (E 104), hypromellose, maltodextrin, medium chain triglycerides, titanium dioxide (E 171)).
Pharmacotherapeutic group
Multivitamins in combination with other medications.
Pharmacological properties
Pharmacodynamics. A multivitamin medicine, the properties of which are determined by the vitamins included in its composition and which take an active part in almost all biochemical reactions of the body. A rationally selected composition contributes to the manifestation of a more pronounced and versatile biological effect of the drug. Vitamin A (retinol acetate) is necessary for the development of epithelial cells and the synthesis of visual pigment. Vitamin E (?-tocopherol acetate) is a fat-soluble vitamin that has a pronounced antioxidant and radioprotective effect, takes part in the biosynthesis of heme and proteins, cell proliferation and other most important processes of cellular metabolism, improves oxygen consumption by tissues, and also has an angioprotective effect, affecting vascular tone and permeability, stimulating the formation of new capillaries. Vitamin B1 (thiamine hydrochloride) normalizes the functional activity of the nervous, cardiovascular and digestive systems. Vitamin B2 (riboflavin) plays an important role in protein, fat and carbohydrate metabolism, takes part in maintaining normal visual acuity, and normalizes skin functions. Vitamin B6 (pyridoxine hydrochloride) is necessary for the regeneration of the skin and liver cells, restoration of the functioning of the nervous system, and improves fat metabolism in atherosclerosis. Vitamin C (ascorbic acid) plays an important role in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, normal capillary permeability, the formation of steroid hormones and connective tissue components, and helps increase the body's resistance to infectious diseases. Vitamin Bc (folic acid), in addition to its antianemic effect during pregnancy, protects the fetus from the influence of teratogenic factors and takes part in the metabolism and synthesis of amino and nucleic acids. Vitamin PP (nicotinamide) is a specific anti-pellagric agent that improves carbohydrate metabolism. Vitamin P (rutin) is a P-vitamin-like water-soluble substance, a flavonoid. Rutin interacts with ascorbic acid, takes part in the regulation of collagen formation in connective tissue, prevents the depolymerization of hyaluronic acid by hyaluronidase, and activates tissue respiration. The essential amino acid methionine plays a role in the synthesis of a number of biologically important compounds, activates the effects of hormones, vitamins and enzymes, and neutralizes toxic products. Vitamin B12 (cyanocobalamin) affects the processes of normal maturation of all cells of the body, especially blood and liver cells, and has a positive effect on the functioning of the nervous system and liver. Pharmacokinetics. Fat-soluble vitamins included in the drug (vitamin A, vitamin E) can be deposited in tissues. Water-soluble vitamins (vitamins B1, B2, B6, B12, C, PP) are converted into coenzymes and, combining with the apoenzyme, are part of complex enzymes. Since the lifespan of enzymes is limited, coenzymes break down and are excreted from the body in the form of various metabolites. Fat-soluble vitamins are also catabolic and excreted from the body, although more slowly than water-soluble vitamins.
Indications
As a therapeutic agent for hypovitaminosis and vitamin deficiency of vitamins A, E, C, B1, B2, B3, B6, B9, B12, occurring, for example, in the following conditions:
- inadequate and/or unbalanced nutrition (diet, malabsorption of various origins, chronic alcoholism);
- recovery period after long-term, severe illnesses;
- exhausting physical and mental stress;
- long-term antibiotic therapy.
Contraindications
Hypersensitivity to any of the components of the drug, severe renal dysfunction, gout, hyperuricemia, erythremia, erythrocytosis, thromboembolism, fructose intolerance, hypervitaminosis A and E, thyrotoxicosis, chronic glomerulonephritis, chronic heart failure, history of sarcoidosis, active peptic ulcer and duodenum, impaired iron or copper metabolism, thrombosis, tendency to thrombosis, thrombophlebitis, urolithiasis, incurable cobalamin deficiency, children under 18 years of age, pregnancy and lactation.
Drug interactions
The drug is not recommended to be prescribed together with other multivitamins, since an overdose of the latter in the body is possible. High doses of the drug reduce the effectiveness of tricyclic antidepressants, neuroleptics - phenothiazine derivatives, tubular reabsorption of amphetamine, and interfere with the excretion of mexiletine by the kidneys. Due to the possibility of developing hypervitaminosis A, concomitant use of the drug with other drugs containing vitamin A or with oral retinoids is not recommended. Retinol reduces the anti-inflammatory effect of glucocorticoids. It should not be used simultaneously with nitrites and cholestyramine, because they interfere with the absorption of retinol. Medicines containing iron inhibit the effect of vitamin E. Vitamin E should not be used together with medicines containing iron, silver, or drugs that have an alkaline environment (such as sodium bicarbonate, trisamine). indirect anticoagulants (such as dicoumarin, neodicoumarin). Alpha-tocopherol acetate enhances the effect of steroidal and non-steroidal anti-inflammatory drugs (such as diclofenac sodium, ibuprofen, prednisolone). Thiamine hydrochloride, influencing polarization processes in the area of neuromuscular synapses, can weaken the curare-like effect of muscle relaxants. Pyridoxine hydrochloride weakens the effect of levodopa, prevents the occurrence or reduces the toxic effects of isoniazid and other anti-tuberculosis drugs. When using short-acting sulfonamides with ascorbic acid, the risk of crystalluria increases. With simultaneous use, it enhances the effect of penicillin, increases the absorption of iron, reduces the effectiveness of heparin and indirect anticoagulants, enhances the absorption of aluminum (take into account during simultaneous treatment with antacids containing aluminum). Absorption of ascorbic acid is reduced when used simultaneously with oral contraceptives, consumption of fruit or vegetable juices, and alkaline drinking. Ascorbic acid can be used only 2 hours after the injection of deferoxamine. Long-term use of large doses of ascorbic acid reduces the effectiveness of treatment with disulfiram. Ascorbic acid increases the overall clearance of ethyl alcohol. Quinolone drugs, calcium chloride, salicylates, tetracyclines, and corticosteroids with long-term use reduce ascorbic acid reserves in the body. Ascorbic acid increases the excretion of oxalates in the urine and increases the risk of crystalluria during treatment with salicylates. Riboflavin is incompatible with streptomycin and antibacterial drugs (oxytetracycline, doxycycline, erythromycin, tetracycline and lincomycin). Tricyclic antidepressants, imipramine and amitriptyline inhibit riboflavin metabolism, especially in the heart. Folic acid reduces plasma concentrations of phenytoin with antiepileptic drugs, in particular phenobarbital, which causes a decrease in clinical effectiveness. Ethanol, cycloserine, glutethimide, and methotrexate may affect folate metabolism. The absorption of folic acid decreases when used simultaneously with analgesics, anticonvulsants, antacids, sulfonamides, antibiotics, and cytostatics. Cases of decreased or altered absorption may occur with concomitant use of cholestyramine and folic acid. Therefore, the drug should be taken 1 hour before or 4-6 hours after taking cholestyramine. It cannot be used together with mineral acids or reducing agents, since folic acid is inactivated. If you are taking any other medications, consult your doctor regarding the use of the drug.
Features of application
Before starting treatment, consult your doctor. The medicine is not intended for prophylactic use. Taking vitamins does not replace a balanced diet. Women who have used large doses of retinol (over 10,000 IU) can plan pregnancy no earlier than 6-12 months later. This is due to the fact that during this time there is a risk of improper development of the fetus under the influence of a high content of vitamin A in the body. It is possible that urine may turn yellow, which is completely harmless and is explained by the presence of riboflavin in the drug. Use with caution in patients with kidney disease, severe liver damage, a history of peptic ulcer of the stomach and duodenum, acute nephritis, cardiac decompensation, cholelithiasis, chronic pancreatitis, coronary heart disease, diabetes mellitus. The drug should be prescribed with caution to patients with neoplasms (except for cases accompanied by megaloblastic anemia). The drug is prescribed with caution to patients with anemia of unknown etiology, since folic acid may interfere with the diagnosis of pernicious anemia by improving the hematological manifestations of the disease, while allowing the progression of neurological complications. When using high doses or long-term use of the drug, it is necessary to monitor blood pressure levels. Simultaneous use of the drug with an alkaline drink reduces the absorption of ascorbic acid, so you should not drink it with alkaline mineral water. Also, the absorption of ascorbic acid may be impaired by intestinal dyskinesia, enteritis and achylia. Use with caution to treat patients with glucose-6-phosphate dehydrogenase deficiency. Ascorbic acid may interfere with laboratory results. For example, when determining the content of glucose, bilirubin, transaminase activity, lactate dehydrogenase in the blood. Large doses of the drug should not be prescribed to patients with increased blood clotting. Because ascorbic acid increases iron absorption, high doses may be harmful to patients with hemochromatosis, thalassemia, polycythemia, leukemia, and sideroblastic anemia. Patients with high iron content in the body should use the drug in minimal doses. Since ascorbic acid has a slight stimulating effect, it is not recommended to use the drug at the end of the day.
Use during pregnancy or breastfeeding
The use of the drug Decamevit during pregnancy and breastfeeding is not recommended due to the danger of an overdose of vitamin A for the fetus. The dose of vitamin A should not exceed 5,000 IU for pregnant women and women planning to become pregnant. During pregnancy or breastfeeding, use the drug only on the recommendation of a doctor. It is better to take vitamins during pregnancy that are specifically designed for pregnant women.
The ability to influence the reaction rate when driving vehicles or other mechanisms
Drivers and operators of complex machinery should consider the possibility of side effects such as dizziness and drowsiness.
Children
Due to the lack of data regarding safety and effectiveness, the drug should not be used in children. Method of administration and dosage: The drug should be prescribed for therapeutic purposes orally, after meals. adults: 1 tablet 1-2 times a day. The course of treatment is usually 20 days. Depending on the indications, repeated courses are possible with breaks between them of 2-3 months.
Overdose
Symptoms. In case of an overdose of the drug, dyspeptic symptoms may be observed (nausea, vomiting, diarrhea, epigastric pain, allergic reactions (itching, skin rash), changes in the skin and hair, headache, drowsiness, lethargy, facial flushing, irritability, increased excitability of the central nervous system , which can cause convulsions. Treatment. Discontinuation of the drug. Therapy is symptomatic. With long-term use in large doses, the function of the insular apparatus of the pancreas may be suppressed, requiring monitoring of the state of the latter. Overdose can lead to changes in the renal excretion of ascorbic and lactic acids during acetylation urine with risk of sedimentation
Side effects
The drug is generally well tolerated, but sometimes adverse reactions may occur, mainly when used in large doses. From the immune system: in persons with hypersensitivity, allergic reactions are possible, including anaphylactic shock, angioedema, hyperthermia; rarely - bronchospasm in persons with hypersensitivity to vitamins A, C, group B. From the endocrine system: damage to the insular apparatus of the pancreas (hyperglycemia, glycosuria) and impaired glycogen synthesis before the onset of diabetes mellitus. From the skin and subcutaneous tissue: rash, urticaria, itching, redness of the skin, eczema. From the cardiovascular system: arterial hypertension/hypotension. myocardial dystrophy. From the nervous system: headache, dizziness, increased excitability, fatigue, sleep disturbance, drowsiness, feeling of heat. From the gastrointestinal tract: dyspeptic disorders, heartburn, feeling of bitterness in the mouth, nausea, vomiting, diarrhea, anorexia; rarely - increased secretion of gastric juice is possible. From the kidneys and urinary system: damage to the glomerular apparatus of the kidneys, crystalluria, formation of urate, cystine and/or oxalate stones in the kidneys and urinary tract, renal failure. Metabolic disorders: metabolic disorders of zinc and copper. From the blood and lymphatic system: thrombocytosis, hyperprothrombinemia, thrombus formation, erythrocytopenia, neutrophilic leukocytosis; in patients with deficiency of glucose-6-phosphate dehydrogenase in blood cells, it can cause hemolysis of red blood cells, hemolytic anemia. Others: urine may turn yellow, sweating, blurred vision. With long-term use of the drug in large doses, the following are possible: irritation of the mucous membrane of the gastrointestinal tract, paresthesia, hyperuricemia, transient increase in the activity of AST, lactate dehydrogenase, alkaline phosphatase, decreased glucose tolerance, hyperglycemia, impaired renal function, dryness and cracks on the palms and soles , hair loss, seborrheic rashes, tachycardia, arrhythmia.
Best before date
2 years. The drug should not be used after the expiration date indicated on the package.
Storage conditions
Store in original packaging at a temperature not exceeding 25 °C. Keep out of the reach of children.
Storage conditions
Store in original packaging at a temperature not exceeding 25 °C. Keep out of the reach of children.
Vacation conditions
Over the counter.
Package
10 tablets in a blister; 2 blisters per pack.
Contraindications
Hypersensitivity to any of the components of Decamevit, chronic glomerulonephritis , thyrotoxicosis , gout , erythremia , thromboembolism , erythrocytosis , hyperuricemia , fructose intolerance, hypervitaminosis A and E , chronic heart failure , history of sarcoidosis , gastric ulcer , childhood, pregnancy .
Side effects
Decamevit is well tolerated, but in rare cases, due to exceeding recommended doses, adverse reactions may occur: hyperthermia, angioedema, allergic reactions, anaphylactic shock, and less commonly, bronchospasm (with hypersensitivity to vitamins B, A and C.
dyspeptic disorders , diarrhea may occur . On the skin - redness, itching, hives , rashes. Sometimes there are complaints of dizziness, drowsiness, headache, increased excitability, yellow urine, blurred vision, and sweating.
special instructions
Women who have used high doses of retinol (over 10,000 IU) can plan pregnancy no earlier than 6–12 months later. This is due to the fact that during this time there is a risk of improper development of the fetus under the influence of high levels of vitamin A in the body.
Urine may turn yellow, which is completely harmless and is explained by the presence of riboflavin in the drug.
Use with caution in patients with kidney disease, severe liver damage, a history of peptic ulcer of the stomach and duodenum, acute nephritis, cardiac decompensation, cholelithiasis, chronic pancreatitis, ischemic heart disease, diabetes mellitus.
The drug should be prescribed with caution to patients with neoplasms (except for cases accompanied by megaloblastic anemia).
The drug is prescribed with caution to patients with anemia of unknown etiology, since folic acid may interfere with the diagnosis of pernicious anemia by reducing the severity of hematological manifestations of the disease, while allowing neurological complications to progress.
When used in high doses or long-term use of the drug, it is necessary to monitor blood pressure levels. Simultaneous use of the drug with an alkaline drink reduces the absorption of ascorbic acid, so you should not drink it with alkaline mineral water. Also, the absorption of ascorbic acid may be impaired by intestinal dyskinesia, enteritis and achylia. Use with caution to treat patients with glucose-6-phosphate dehydrogenase deficiency. Ascorbic acid may interfere with laboratory results. For example, when determining blood glucose, bilirubin, transaminase activity, LDH.
High doses of the drug should not be prescribed to patients with increased blood clotting.
Because ascorbic acid increases iron absorption, high doses may be harmful to patients with hemochromatosis, thalassemia, polycythemia, leukemia, and sideroblastic anemia. Patients with high iron content in the body should use the drug in minimal doses.
Since ascorbic acid has a slight stimulating effect, it is not recommended to use the drug at the end of the day.
Use during pregnancy and lactation. During pregnancy and breastfeeding, the drug is taken only on the recommendation of a doctor. The dose of vitamin A should not exceed 5000 IU in pregnant women and those planning pregnancy.
You should not take retinol in high doses (over 10,000 IU) during breastfeeding due to the risk of developing hypervitaminosis A in infants.
Children. Due to the lack of data on safety and effectiveness, the drug is not used in children.
The ability to influence reaction speed when driving vehicles or working with other mechanisms. Drivers and operators of complex machinery should consider the possibility of side effects such as dizziness and drowsiness.
Interaction
It is not recommended to take Decamevit vitamins simultaneously with other medications containing vitamins, as well as cholestyramine and nitrites , since these drugs impede the absorption of retinol .
retinoids should not be prescribed simultaneously - this combination is toxic.
Vitamins A and E are synergists (strengthen their mutual effect). Retinol reduces the effectiveness of glucocorticoids . Vitamin C enhances the effect of penicillin and sulfonamides , increases the absorption of iron , and reduces the effectiveness of heparin . When vitamin C is prescribed simultaneously with oral contraceptives, its absorption is reduced.
Iron preparations reduce the effectiveness of vitamin E, so it cannot be prescribed together with silver, iron preparations and alkaline agents ( Trisamine , sodium bicarbonate), indirect anticoagulants.
Thiamine may weaken the curare-like effect. Riboflavin should not be prescribed with Streptomycin . In addition, Riboflavin reduces the effect of antibacterial drugs ( Erythromycin , Oxytetracycline
,
Tetracycline and Doxycycline ).
Overdose
Symptoms. an overdose of the drug may cause dyspeptic symptoms (nausea, vomiting, diarrhea, epigastric pain), allergic reactions (itching, skin rash), changes in the skin and hair, liver dysfunction, headache, drowsiness, lethargy, facial flushing, irritability, increased excitability of the central nervous system, which can cause convulsions.
Treatment. Stop using the drug. Therapy is symptomatic.
With long-term use in high doses, inhibition of the function of the insular apparatus of the pancreas is possible; monitoring of the state of the latter is required. Overdose may lead to changes in the renal excretion of ascorbic and uric acids during urine acetylation with the risk of precipitation of oxalate stones.
Analogs
Level 4 ATC code matches:
Makrovit
Tetravit
Aerovit
Gendevit
Sana-Sol
Hexavit
Revit
Vitasharm
Pikovit Forte
Pikovit
Vetoron for children
Vetoron E
Vetoron
Angiovitis
Undevit
Vitrum Performance
Pentovit
Biovital , Velwomen , Vitrum , Gerimax , Gerovital other Taiss , Kvadevit , Multimax , Undevit , Neurobeks , Unicap V , Pharmaton and others.
Decamevit price, where to buy
The price of Decamevit for package No. 20 in pharmacies in Moscow and other cities of Russia varies from 198 to 234 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
LuxPharma* special offer
- Decamevit tab.
p/o 20pcs 1600 rub. order
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Pharmacy24
- Decamevit N20 tablets PAT "Kiev Vitamin Plant", Kiev, Ukraine
53 UAH. order
Note!
Description of the drug Decamevit table. p/o No. 20 on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
