PIPOLPHEN, PIPOLPHEN - instructions for use of the medicine, reviews, description, price

Pipolphen®

With long-term use of the drug, it is necessary to systematically monitor the peripheral blood count and liver function.

With extreme caution, especially in high doses, Pipolfen should be prescribed to elderly patients, because This category of patients has an increased risk of developing side effects.

When used simultaneously with Pipolfen, analgesics and hypnotics should be prescribed in smaller doses.

Pipolfen® should be used under strict medical supervision simultaneously with opioid analgesics, sedatives and hypnotics, anesthetics, tricyclic antidepressants and tranquilizers.

Pipolfen® may mask the ototoxic effect (tinnitus and dizziness) of co-administered medications.

Pipolfen® reduces the seizure threshold. This should be taken into account when prescribing the drug to patients prone to developing seizures, or simultaneously with other drugs with similar effects.

As an antiemetic drug, Pipolfen® should be used only for prolonged vomiting of known etiology.

With long-term use, the risk of developing dental diseases (caries, periodontitis, candidiasis) increases due to a decrease in salivation.

During the treatment period, alcohol consumption is prohibited.

While taking Pipolfen, a diagnostic pregnancy test may give a false positive result.

A possible increase in blood glucose levels in patients taking Pipolfen® should be taken into account when performing a glucose tolerance test.

To prevent distortion of the results of skin prick tests for allergens, the drug must be discontinued 72 hours before allergy tests.

Each tablet contains 95 mg of lactose, which should be taken into account if you are lactose intolerant.

Use in pediatrics

Pipolfen® should be prescribed to children with caution, since this makes it difficult to diagnose the underlying disease. Symptoms of undiagnosed encephalopathy and Reye's syndrome may be mistaken for side effects of Pipolphen.

Impact on the ability to drive vehicles and operate machinery

During the initial period of using Pipolfen, it is necessary to refrain from driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions. In the future, the degree of restrictions is determined depending on the patient’s individual tolerance.

Pipolfen solution d/iv and intramuscular injection 50mg/2ml 2ml No. 10

Compound

1 ampoule with a capacity of 2 ml contains:
Active substance: promethazine hydrochloride 50 mg.

Excipients: hydroquinone 0.4 mg, potassium disulfite 1.5 mg, sodium sulfite anhydrous 2 mg, sodium chloride 14 mg, water for injection up to 2 ml.

Pharmacokinetics

Absorption After oral administration, it is quickly and well absorbed from the gastrointestinal tract.

Distribution The binding of promethazine to plasma proteins is about 90%. Penetrates the BBB and placental barrier.

Metabolism: Intensively metabolized in the liver during the “first pass”, mainly through S-oxidation. Promethazine sulfoxides and N-demethyl-promethazine are the main metabolites that are detected in urine.

Elimination T1/2 of promethazine is 7-15 hours. It is excreted mainly by the kidneys; to a lesser extent - through the intestines.

Indications for use

Allergic diseases (including urticaria, serum sickness, hay fever, allergic rhinitis, allergic conjunctivitis, angioedema, itching);
auxiliary therapy of anaphylactic reactions (after relief of acute manifestations by other means, for example, epinephrine / adrenaline /);
as a sedative in the pre- and postoperative period;
to prevent or relieve nausea and vomiting associated with anesthesia and/or appearing in the postoperative period;
postoperative pain (in combination with analgesics);
kinetosis (to prevent and eliminate dizziness and nausea while traveling by transport);
as a component of lytic mixtures used to potentiate anesthesia in surgical practice (for parenteral use).

Contraindications

Comatose states or other types of deep depression of the central nervous system;
simultaneous use of MAO inhibitors and a period of 14 days after completion of their use;
angle-closure glaucoma;
alcohol intoxication, acute intoxication with hypnotics, opioid analgesics;
sleep apnea syndrome;
occasional vomiting in children of unspecified origin;
pregnancy;
lactation period;
children up to 2 months of age (for parenteral administration);
hypersensitivity to promethazine, other phenothiazine derivatives and any other component of the drug.

The drug should be prescribed with caution for acute and chronic respiratory diseases (due to suppression of the cough reflex), open-angle glaucoma, suppression of bone marrow function, diseases of the cardiovascular system, impaired liver and kidney function, peptic ulcer with pyloroduodenal obstruction, stenosis of the bladder neck and/or prostatic hypertrophy, predisposition to urinary retention, epilepsy, Reye's syndrome, as well as in elderly patients.

Directions for use and doses

Prescribed intramuscularly and intravenously.

The maximum daily dose for adults is 150 mg.

The drug is prescribed intramuscularly for adults 25 mg 1 time/day, if necessary 12.5-25 mg every 4-6 hours.

For the prevention and treatment of nausea and vomiting, the drug is prescribed orally or intramuscularly at a dose of 25 mg once. If necessary, 25 mg can be prescribed every 4-6 hours.

As a sedative in surgery on the eve of surgery, it is prescribed intramuscularly at a dose of 25-50 mg once at night. For preoperative preparation, 50 mg of Pipolfen is administered intramuscularly 2.5 hours before surgery as part of lytic mixtures; if necessary, the administration can be repeated after 1 hour.

For induction of anesthesia and analgesia during certain diagnostic and surgical procedures, such as repeated bronchoscopy, ophthalmological operations, Pipolfen® can be administered intravenously in doses of 0.15-0.3 mg/kg body weight.

For children over 2 months of age, the drug can be administered intramuscularly 3-5 times a day at a dose of 0.5-1 mg/kg body weight. In severe cases, a single dose for intramuscular administration can be increased to 1-2 mg/kg body weight.

Storage conditions

In a place protected from light at a temperature not exceeding 25 C. Keep out of the reach of children.

Best before date

5 years. Do not use the drug after the expiration date indicated on the package.

special instructions