Oreshko L.S., Tskhovrebova Z.M., Ledentsova S.S. Metabiotics of the latest generation in the treatment of indigestion syndrome in patients with celiac disease // Farmateka. – 2021. – No. 2 (335). pp. 50-55.


Compound

In 1 dropper tube 2 ml, mg: water, sodium acetate – 232.0;
lactic acid – 49.4; succinic acid – 32.4; formic acid – 21.0; acidity regulator (sodium hydroxide) – 18.2; L-lysine hydrochloride – 16.7; L-glutamic acid – 13.4; L-valine – 13.4; L-methionine – 6.8; L-alanine – 4.1; L-leucine – 3.0; glycine – 2.4; L-aspartic acid – 1.8. 2 dropper tubes contain at least 56 mg of succinic acid, which corresponds to 28% of the recommended daily intake according to the requirements of TR CU 022/2011.

pharmachologic effect

A new generation metabiotic, which is a complex of amino acids and organic acids - analogues of metabolites of probiotic bacteria. The synergistic effect of the components included in the complex increases physiological activity and stimulates the growth of a person’s own beneficial microflora, increasing its antagonistic activity against pathogenic microorganisms.

The human intestinal microflora performs many functions, the most important of which is metabolic. Bacteria produce metabolites that act as signaling molecules, having a direct effect on metabolism, intestinal, liver, brain functions, as well as processes in fat and muscle tissue.

Is low blood pressure dangerous?

Many people - most often thin women - live with hypotension for years and feel great. Doctors believe that these people are lucky: they are less likely to suffer from cardiovascular diseases.

However, if your blood pressure suddenly drops below normal levels, unpleasant symptoms may appear:

  • blurred vision;
  • dizziness;
  • fainting;
  • nausea or vomiting;
  • drowsiness;
  • feeling of weakness.

As a rule, at a young age, the health risk is associated not with low blood pressure itself, but with the reasons due to which it falls. The exception is fainting. “This is the most alarming symptom, since it often leads to injuries and accidents,” says Oksana Dikur, general practitioner, cardiologist at the Rassvet clinic. “If hypotension is accompanied by loss of consciousness, you should definitely consult a doctor.”

But for older people, low blood pressure can be really dangerous. Moreover, a drop in diastolic pressure is more dangerous than a decrease in systolic pressure.

“This can lead to deterioration of blood supply to the kidneys and brain, increasing the risk of stroke and kidney failure,” explains Oksana Dikur.

Indications for use

ACTOFLOOR-S is recommended as a metabiotic for restoring intestinal microflora and normalizing its metabolic activity, as well as as an additional source of amino acids, including essential ones, and organic acids with a proven regulatory effect. A complex of bacterial metabolites and amino acids restores the balance of intestinal microflora, which can be disturbed as a result of diseases of the gastrointestinal tract, stress, poor environmental conditions, unbalanced nutrition and other reasons, helps eliminate symptoms of intestinal disorders (diarrhea, constipation, bloating, pain), prevents the side effects of taking antibiotics, improves metabolism, and also has a positive effect on the immune system, increasing the body's overall resistance to infections and stress.

Actoflor-S

Actoflor-s 2ml n30 tube/droppers instructions for use Composition in 1 tube-dropper 2 ml, mg: water, sodium acetate - 232.0, lactic acid - 49.4, succinic acid - 32.4, formic acid - 21, 0, acidity regulator (sodium hydroxide) - 18.2, L-lysine hydrochloride - 16.7, L-glutamic acid - 13.4, L-valine - 13.4, L-methionine - 6.8, L-alanine - 4.1, L-leucine - 3.0, glycine - 2.4, L-aspartic acid - 1.8. ACTOFLOR®-S does not contain gluten, lactose and casein. Description Actoflor-S 2 ml - metabiotic (unidose) - a clear, colorless solution with a characteristic odor. The daily dose (2 dropper tubes) contains: at least 56 mg of succinic acid, which corresponds to 28% of the recommended level of daily intake according to the requirements of TR CU 022/ 2011. ACTOFLOR®-S is a new generation metabiotic, which is a complex of amino acids and organic acids - analogues of metabolites of probiotic bacteria. The synergistic effect of the components included in the complex increases physiological activity and stimulates the growth of a person’s own beneficial microflora, increasing its antagonistic activity against pathogenic microorganisms. The human intestinal microflora performs many functions, the most important of which is metabolic. Bacteria produce metabolites that act as signaling molecules, having a direct effect on metabolism, intestinal, liver, brain functions, as well as processes in fat and muscle tissue. ACTOFLOOR®-S is recommended as a metabiotic for restoring intestinal microflora and normalizing its metabolic activity, as well as as an additional source of amino acids, including essential ones, and organic acids with a proven regulatory effect. A complex of bacterial metabolites and amino acids restores the balance of intestinal microflora, which can be disturbed as a result of diseases of the gastrointestinal tract, stress, poor environmental conditions, unbalanced nutrition and other reasons, helps eliminate symptoms of intestinal disorders (diarrhea, constipation, bloating, pain), prevents the side effects of taking antibiotics, improves metabolism, and also has a positive effect on the immune system, increasing the body's overall resistance to infections and stress. Succinic acid, L-glutamic acid and the essential amino acids L-lysine and L-methionine are the most active growth stimulators of the probiotic strain E. coli M-17, recommended by the Ministry of Health of the Russian Federation for use in immunobiological preparations - coli-containing probiotics. L-methionine, according to modern data, is the most effective natural antioxidant. The components of ACTOFLOR®-S, especially succinic acid, have a positive effect on the proliferative activity of immune tissue cells, stimulating human immunity. Sodium acetate is a growth stimulator of bifidobacteria and other representatives of normal microflora, together with lactic and formic acids it increases the antagonistic activity of intestinal microflora, prevents the overgrowth of opportunistic bacteria and inhibits the growth of pathogenic strains of E. coli, as well as Salmonella enterica, which causes salmonellosis. In intestinal epithelial cells, adipocytes, immune and other cells, acetate interacts with its specific protein receptors (GPR40, GPR41, GPR43), which is accompanied by the induction of the expression of genes responsible for the production of a number of hormones responsible for the synthesis of energy sources, regulation of appetite and satiety, and motility. intestines and other functions. Sodium acetate increases blood circulation in the intestinal mucosa and is an energy substrate for muscle tissue, heart tissue, kidneys, and brain. Sodium acetate and lactic acid regulate the pH level, motor and secretory activity of the intestine, and have an antimicrobial effect. Along with formic and succinic acid, acetate is the main intermediate of microbial metabolism, participating in the synthesis of other metabolites important for the human body - butyric and propionic acids. L-glutamic acid is involved in protein and carbohydrate metabolism, prevents a decrease in redox potential, increases the body's resistance to hypoxia, normalizes metabolism, changing the functional state of the nervous and endocrine systems, and is a powerful neurotransmitter. As a result of its decarboxylation by intestinal bacteria, gamma-aminobutyric acid (GABA) is formed - another important mediator of the central nervous system, under the influence of which energy processes in the brain are activated, its blood supply is improved, the respiratory activity of tissues is increased, and glucose utilization is improved. The combined action of eight amino acids (L-alanine, L-aspartic acid, glycine, L-glutamic acid, L-valine, L-leucine, L-lysine and L-methionine), four of which are essential amino acids, significantly increases activity and effectiveness regulatory metabolites of ACTOFLOR®-S. All components of ACTOFLOR®-S have a pronounced synergistic effect and the absence of at least one of them significantly reduces the effectiveness of its action. ACTOFLOR®-S is hypoallergenic, does not have immunotoxic properties, does not cause side effects with long-term use, is compatible with any type of treatment and can be taken both during and after antibiotic therapy. Advantages of ACTOFLORA®-S: •Restores intestinal microflora •Prevents side effects of taking antibiotics •Helps improve metabolism •Increases the body's overall resistance to infections and stress Sales features Without a license Special conditions Dietary supplement (BAA) to food Not a medicine. It is recommended to consult a doctor before use. Indications: As a dietary supplement to food - a source of succinic acid. Contraindications Individual intolerance to product components

Source: https://apteka.ru/catalog/aktoflor-s-2ml-n30-tyubik-kapeln_5721ff730f288/ © Apteka.RU

Actoflor-s 2ml tube/droppers instructions for use

,

Composition in 1 dropper tube 2 ml, mg: water, sodium acetate - 232.0, lactic acid - 49.4, succinic acid - 32.4, formic acid - 21.0, acidity regulator (sodium hydroxide) - 18, 2, L-lysine hydrochloride - 16.7, L-glutamic acid - 13.4, L-valine - 13.4, L-methionine - 6.8, L-alanine - 4.1, L-leucine - 3, 0, glycine - 2.4, L-aspartic acid - 1.8.

,

ACTOFLOR®-S does not contain gluten, lactose and casein.

,

Description Actoflor-S 2 ml - metabiotic (unidose) - a clear, colorless solution with a characteristic odor. The daily dose (2 dropper tubes) contains: at least 56 mg of succinic acid, which corresponds to 28% of the recommended level of daily intake according to the requirements of TR CU 022/ 2011. ACTOFLOR®-S is a new generation metabiotic, which is a complex of amino acids and organic acids - analogues of metabolites of probiotic bacteria. The synergistic effect of the components included in the complex increases physiological activity and stimulates the growth of a person’s own beneficial microflora, increasing its antagonistic activity against pathogenic microorganisms. The human intestinal microflora performs many functions, the most important of which is metabolic. Bacteria produce metabolites that act as signaling molecules, having a direct effect on metabolism, intestinal, liver, brain functions, as well as processes in fat and muscle tissue. ACTOFLOOR®-S is recommended as a metabiotic for restoring intestinal microflora and normalizing its metabolic activity, as well as as an additional source of amino acids, including essential ones, and organic acids with a proven regulatory effect. A complex of bacterial metabolites and amino acids restores the balance of intestinal microflora, which can be disturbed as a result of diseases of the gastrointestinal tract, stress, poor environmental conditions, unbalanced nutrition and other reasons, helps eliminate symptoms of intestinal disorders (diarrhea, constipation, bloating, pain), prevents the side effects of taking antibiotics, improves metabolism, and also has a positive effect on the immune system, increasing the body's overall resistance to infections and stress. Succinic acid, L-glutamic acid and the essential amino acids L-lysine and L-methionine are the most active growth stimulators of the probiotic strain E. coli M-17, recommended by the Ministry of Health of the Russian Federation for use in immunobiological preparations - coli-containing probiotics. L-methionine, according to modern data, is the most effective natural antioxidant. The components of ACTOFLOR®-S, especially succinic acid, have a positive effect on the proliferative activity of immune tissue cells, stimulating human immunity. Sodium acetate is a growth stimulator of bifidobacteria and other representatives of normal microflora, together with lactic and formic acids it increases the antagonistic activity of intestinal microflora, prevents the overgrowth of opportunistic bacteria and inhibits the growth of pathogenic strains of E. coli, as well as Salmonella enterica, which causes salmonellosis. In intestinal epithelial cells, adipocytes, immune and other cells, acetate interacts with its specific protein receptors (GPR40, GPR41, GPR43), which is accompanied by the induction of the expression of genes responsible for the production of a number of hormones responsible for the synthesis of energy sources, regulation of appetite and satiety, and motility. intestines and other functions. Sodium acetate increases blood circulation in the intestinal mucosa and is an energy substrate for muscle tissue, heart tissue, kidneys, and brain. Sodium acetate and lactic acid regulate the pH level, motor and secretory activity of the intestine, and have an antimicrobial effect. Along with formic and succinic acid, acetate is the main intermediate of microbial metabolism, participating in the synthesis of other metabolites important for the human body - butyric and propionic acids. L-glutamic acid is involved in protein and carbohydrate metabolism, prevents a decrease in redox potential, increases the body's resistance to hypoxia, normalizes metabolism, changing the functional state of the nervous and endocrine systems, and is a powerful neurotransmitter. As a result of its decarboxylation by intestinal bacteria, gamma-aminobutyric acid (GABA) is formed - another important mediator of the central nervous system, under the influence of which energy processes in the brain are activated, its blood supply is improved, the respiratory activity of tissues is increased, and glucose utilization is improved. The combined action of eight amino acids (L-alanine, L-aspartic acid, glycine, L-glutamic acid, L-valine, L-leucine, L-lysine and L-methionine), four of which are essential amino acids, significantly increases activity and effectiveness regulatory metabolites of ACTOFLOR®-S. All components of ACTOFLOR®-S have a pronounced synergistic effect and the absence of at least one of them significantly reduces the effectiveness of its action. ACTOFLOR®-S is hypoallergenic, does not have immunotoxic properties, does not cause side effects with long-term use, is compatible with any type of treatment and can be taken both during and after antibiotic therapy.

,

Advantages of ACTOFLORA®-S: •Restores intestinal microflora •Prevents side effects of taking antibiotics •Helps improve metabolism •Increases the body’s overall resistance to infections and stress

,

Features of sale Without a license

Special conditions Biologically active food supplement (BAA) is not a medicine. It is recommended to consult a doctor before use.

Indications: As a dietary supplement to food - a source of succinic acid.

Contraindications Individual intolerance to product components

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