What is Wobenzym medicine for?
The drug is often prescribed for complex treatment of various diseases. It is accepted in almost all medical fields.
In gynecology:
- inability to bear a child (especially in the 2nd and 3rd trimester);
- endometritis;
- mastopathy;
- chlamydia.
In dermatology:
- skin rash;
- itchy dermatosis.
In neurology:
- angina pectoris;
- myocardial infarction.
In ophthalmology:
- glaucoma;
- uveitis;
- hemophthalmos.
In oncology:
- chemotherapy and radiation therapy (to increase tolerance);
- reducing the likelihood of re-infection.
In pulmonology:
- pneumonia;
- tuberculosis;
- bronchitis.
In urology:
- genital infections;
- cystitis;
- prostatitis.
The medicine is also actively used in pediatrics, surgery, and endocrinology.
Other indications include:
- acclimatization;
- problems with microcirculation;
- negative manifestations after hormonal treatment;
- viral infections and resulting complications.
Contraindications
Before taking Wobenzym, you should familiarize yourself with the contraindications for its use, for which below are the conditions in which treatment with Wobenzym is absolutely prohibited:
- any pathologies that occur with an increased risk of bleeding ;
- age up to 5 years;
- personal hypersensitivity to active and/or additional components of drugs;
- carrying out hemodialysis .
How to take Wobenzym
The tablets are intended for oral administration. You should take it 25-30 minutes before meals with a glass of water.
The dose and duration of therapy is determined by the doctor, taking into account the problem and condition of the patient. An adult, depending on his condition, can be prescribed from 3 to 9 tablets. A prerequisite is three times a day. Most often, in the first 3 days of treatment, take 3 tablets 3 times a day. Afterwards, the number of tablets at one time can increase or decrease, but the multiplicity in any case remains the same.
For chronic diseases, treatment may take up to half a year.
For radiation and chemotherapy, it is recommended to use 5 tablets 3 times a day during the entire treatment period. This will have a positive effect on the patient’s condition and prevent possible infectious complications.
In order to prevent various diseases, it is prescribed to take 2 tablets 3 times a day for a month and a half. This course can be repeated no more than 3 times a year.
Compound
1 tablet of the drug contains the following active ingredients: 50 mg rutoside , 100 mg pancreatin , 45 mg bromelain , 18 mg papain , 12 mg trypsin , 10 mg amylase , 10 mg lipase , 0.75 mg chymotrypsin .
Additional ingredients: stearic acid, lactose, talc, corn starch, purified water, magnesium stearate, colloidal silicon dioxide.
Shell composition: povidone, shellac, sucrose, methyl methacrylate-methacrylic acid copolymer, vanillin, talc, white clay, titanium dioxide, macrogol 6000, carnauba wax, triethyl citrate, bleached wax, dyes (crimson 4R and yellow-orange S).
Side effects and overdose
Treatment with the drug usually does not lead to adverse reactions. To date, there is no data regarding the occurrence of negative manifestations after taking the medicine. There is also no addiction or withdrawal syndrome, even if the treatment was long-term and large doses were used.
In quite rare cases, urticaria may appear, as well as minor changes in the smell of stool and its consistency.
If, after taking it, the patient discovers undesirable effects, then you need to stop treatment and consult a doctor.
To date, no cases of overdose have been identified.
Side effects
Wobenzym therapy in most cases is tolerated without negative effects during treatment and without negative consequences after its completion. Also, so far there has been no evidence of side effects of the drug, addiction to it or the formation of a withdrawal syndrome , even in the case of long-term therapy using high dosages.
urticaria was noted , as well as minor deviations in the smell and consistency of stool, which were leveled out by reducing the dose of the drug or disappear after discontinuation of treatment.
Before prescribing Wobenzym, the patient must be warned that if he experiences any adverse reactions associated with taking the drug, his responsibility is to immediately stop therapy and further consult a doctor.
Is it possible to take Wobenzym with alcohol?
It is worth saying that with any disease and even in a healthy state, drinking alcohol, especially in large quantities, has a negative effect on the human body. When wondering about the possibility of combining the drug with alcohol, you need to keep in mind that it is prescribed not so often and mainly as part of a complex treatment, as a result of which various reactions may appear in the body. If the drug is taken in parallel with antibiotics or antiviral drugs, then drinking alcohol is strictly prohibited.
Wobenzym, 200 pcs., enteric-coated tablets
WOBENZYME is a combination of highly active proteolytic enzymes (proteases) of plant and animal origin, exhibiting stable pharmacological activity. When combined, enzymes have a pleiotropic (multiple) effect, having diverse effects on different target organs and biochemical processes. The drug's proteases realize their systemic effects through immunomodulatory, antiplatelet, fibrinolytic, decongestant, thrombolytic and secondary analgesic effects.
An important ability of the drug enzymes immobilized by endogenous antiproteases is the ability to move in the vascular bed and be present in various organs and tissues, which has important therapeutic significance in systemic inflammatory processes and lesions. The preparation realizes the ability of enzymes of plant and animal origin to cooperate and synergize, due to which their action is enhanced and complementary.
Entering the body, tablets of the drug, coated with a protective enteric coating, pass transiently through the upper gastrointestinal tract without injuring the stomach and without participating in digestion. The protective coating of the tablets dissolves in the small intestine, and the enzymes of the drug migrate through the intestinal wall (endocytosis, pinocytosis).
Some of the proteolytic enzymes of the drug are absorbed by resorption of intact molecules and form complexes with transport proteins in the blood - antiproteases (α-2-macroglobulin and α-1-antitrypsin). When combined with antiproteases, the proteolytic enzymes of the drug change the conformational structure of the transport macromolecules of antiproteases, as a result of which the antiproteases pass into an active form capable of regulating the level of cytokines, growth factors and hormones in the vascular bed.
The formation of a protease-antiprotease complex makes it possible to slow down the removal of exogenous proteolytic enzymes of the drug from the body and increase their circulation time in the bloodstream. In the complex, there is no irreversible inactivation of exogenous enzymes; they retain their activity and reactivity towards specific substrates with affinity for proteases.
Antiprotease (α-2-macroglobulin) masks the antigenic determinants of drug protease macromolecules, which ensures the movement of enzymes through the vascular bed without causing an allergic reaction of the immune system and their delivery to remote areas to the site of inflammation, regardless of the localization of the pathological process in the body.
Under the influence of the enzymes of the drug, the activated form of α-2-macroglobulin acquires the ability to regulate the level of pro-inflammatory cytokines and growth factors, carrying out their sorption, transportation and clearance. Thus, the enzymes of the drug indirectly, through the activation of endogenous antiproteases, can regulate the transition of a pro-inflammatory immune response to an anti-inflammatory one. Proteolytic enzymes interrupt the pathological cascade of inflammation, optimize the course of inflammation and prevent the transition of the inflammatory process to the chronic stage.
Activated antiproteases regulate the level of transforming growth factor β (TGF-β) in the circulation due to its sorption and elimination. TGF-β has an autocrine nature of regulation, which makes its control difficult, and is responsible for replacing damaged areas of organs with connective tissue. The enzymes of the drug indirectly through antiproteases reduce the level of TGF-β, i.e. regulating reparative processes, physiological growth of connective tissue and scar formation, while preventing the formation of a keloid scar and the development of adhesive disease.
Part of the proteolytic enzymes of the drug remaining in the intestine enters into digestive reactions, improves the breakdown of proteins, fats, carbohydrates and other substrates, and also helps restore the intestinal ecology and microbial balance between autochthonous (related) and opportunistic microflora.
The drug's enzymes have a positive effect on the course of the inflammatory process, limit the pathological manifestations of autoimmune and immune complex processes, restoring the body's immunological reactivity. The drug's proteases accelerate the breakdown of inflammatory mediators, normalize the activity of the complement system, stimulate and regulate the level of functional activity of monocytes-macrophages, natural killer cells and activate antitumor immunity. The drug reduces the level of pro-inflammatory cytokines (IL-1β, IL-6, IL-8, TNF-α, INF-γ) and increases the production of anti-inflammatory cytokines (IL-4, IL-10), regulates the level of Ig and antibodies, i.e. O. providing a multifaceted immunomodulatory effect, increasing the activity of phagocytes and stimulating interferonogenesis.
Under the influence of drug proteases, there is a decrease in the number of circulating immune complexes (antigen-antibody) and membrane deposits of immune complexes with acceleration of their elimination (removal) from tissues due to shedding (cleavage) of immune complexes and a decrease in the density of adhesive molecules.
The drug reduces the infiltration of the interstitium with plasma proteins, increases the elimination of protein detritus (cellular fragments) and fibrin deposits in the area of inflammation, accelerates the lysis of toxic products and necrotic tissues, i.e. improving tissue trophism, helping to reduce swelling and improve the penetration of drugs into the site of inflammation.
The enzymes of the drug optimize the physiological course of reparative processes, accelerate the resorption of hematomas and edema, normalize the permeability of vascular walls, improve microcirculation and trophic processes in the damaged area, reduce oncotic pressure in tissues, i.e. accelerating healing and recovery.
The drug reduces the concentration of thromboxane and platelet aggregation (sticking together), reduces the expression of adhesive molecules and the adhesion of blood cells on the endothelium, increases the ability of red blood cells to change their shape (deformability), improving their plasticity for passing vascular bifurcations, which promotes the effective delivery of oxygen to tissues.
The drug activates the blood anticoagulant system, helps restore the number of discocytes, reduces the number of activated forms of platelets, reduces the total number of platelet microaggregates, normalizes blood viscosity, i.e. improving the rheological properties of blood and microcirculation in tissues. The proteolytic enzymes of the drug increase the fibrinolytic activity of blood plasma, activate endothelial function, improve lymph flow, oxygen supply to tissues and improve metabolism in the body.
The drug reduces the risk of developing undesirable effects associated with taking hormonal drugs (hypercoagulation, platelet activation, thrombus formation, blood thickening).
The drug has a pronounced antioxidant effect, reduces lipid peroxidation, and normalizes lipid metabolism. The proteolytic enzymes of the drug reduce the level of endogenous cholesterol, increase the content of HDL, and reduce the level of LDL, i.e. exhibiting antiatherogenic effect. The drug improves the metabolism of polyunsaturated fatty acids, increases the antioxidant activity of plasma, reduces oxidative stress and helps prevent the development of systemic inflammation.
The proteolytic enzymes of the drug interrupt communications and intercellular interaction between bacteria, impede the formation of membranes and the matrix of biofilms, disrupt the growth of microbial colonies in biofilms (in vitro)
. Thus, the enzymes of the drug create favorable conditions for the penetration of antibiotics into microbial communities (biofilms), increasing the effectiveness of antibiotic therapy. The drug's proteases interrupt the frequency of transmission of antibiotic resistance factors (plasmid genes) between bacteria in microbial colonies, while reducing the risk of developing resistance to antibiotics. Violation by enzymes of cooperation and communication between bacteria to form a protective mechanism - biofilm, makes bacteria more vulnerable to antibiotics. The drug creates conditions for increasing the concentration of antibiotics at the site of infection, which increases the effectiveness of antibacterial therapy.
The drug's enzymes reduce the undesirable side effects of antibiotic therapy (dysbiosis, irritable bowel syndrome) by improving food digestion, breaking down substrates, normalizing microflora and restoring intestinal endoecology.
Proteases of the drug activate natural mechanisms of non-specific defense, increase the production of interferons, IgA and lysozyme, i.e. realizing antiviral and antimicrobial actions.
Reviews of Wobenzyme
Reviews about Wobenzyme on forums, as well as reviews from doctors about Wobenzyme, are quite contradictory and often lead to serious disputes among specialists and patients about the effectiveness, usefulness and safety of using this drug. The opinions of many doctors and people who have ever taken this drug differ radically on this matter, and when some claim that for them complex treatment with the inclusion of Wobenzym was much more effective and safer than without it, others immediately find many arguments against and declare the complete uselessness of this drug.
For example, some nutritionists advise taking Wobenzym for weight loss in combination with diet and exercise and explain this by the drug’s ability to normalize the function of the gastrointestinal tract and their microflora. Some patients who have undergone this course of diet therapy remain satisfied with its results and leave positive reviews about Wobenzym. The other part, which does not notice any special changes in body weight, naturally attributes the negative result to Wobenzym.
Reviews of the drug in gynecology when planning pregnancy, for mastopathy , endometritis , vulvovaginitis , gestosis , cervicitis , diseases of sexual etiology ( chlamydia , mycoplasmosis , ureaplasmosis ), as well as reviews of Wobenzyme during pregnancy are mostly positive, but there are also those who He sees this only as a coincidence and the effect of other medications taken at the same time.
In the current situation, it is not possible to draw any definite conclusions and therefore we can only advise you to rely on the opinion of your attending physician, especially if you trust him not only as a good specialist, but also as simply a decent person.
Wobenzyma price, where to buy
In Russia, the average price of a package is 40 pcs. – about 700 rubles, packs of 200 pcs. – about 2800 rubles.
In Ukraine, the average price of a package is 40 pcs. – about 200 hryvnia, packing 200 pcs. – about 900 hryvnia, packing 800 pcs. – about 3000 hryvnia.
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
PaniPharmacy
- Wobenzym tablets Wobenzym coated tablets No. 40 Germany, Mucos Emulsionsgesellschaft
216 UAH.order - Wobenzym tablets Wobenzym coated tablets No. 800 Germany, Mucos Emulsionsgesellschaft
3029 UAH. order
- Wobenzym tablets Wobenzym coated tablets No. 200 Germany, Mucos Emulsionsgesellschaft
903 UAH order
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Wobenzym during pregnancy and lactation
The list of contraindications for the use of Wobenzym does not include either pregnancy or breastfeeding . Moreover, during pregnancy, women are even recommended to take it to prevent miscarriage, starting from the second trimester, where the effect of the drug receives positive reviews. During pregnancy, the calculation of the dosage and duration of taking the tablets is determined individually, taking into account the general condition of the expectant mother, fetal health indicators and the course of the pregnancy itself.
