Atropine sulfate tablets 0.0005 g

Pharmacodynamics and pharmacokinetics

The main pharmacological property of atropine is that it is able to fully block M-cholinergic receptors. The substance can also have a somewhat weaker effect on H-cholinergic receptors. Therefore, it is considered a non-selective M-cholinergic receptor blocker.

After the introduction of atropine into the body, there is a decrease in the secretion of salivary, bronchial, gastric, sweat and pancreas, heart contractions become more frequent, and the tone of smooth muscle organs decreases. The effect of atropine is strongest when the tone of the vagus nerve is high, but in any case its mechanism of action is quite complex.

The use of atropine leads to a strong dilation of the pupils, depending on the degree of relaxation of the fibers of the orbicularis muscle in the area of ​​the iris, innervated by parasympathetic fibers. Along with the dilation of the pupil, intraocular pressure may increase due to impaired outflow of fluid from the chamber. In this case, relaxation of the ciliary muscles of the ciliary body of the eye leads to paralysis of accommodation, which is a violation of visual perception.

Eye diseases for which Atropine is prescribed

Eye drops and solution for injection "Atropine" are used to treat the following ophthalmological pathologies:

1. Iritis. Infectious inflammation of the iris. It manifests itself as lacrimation, decreased vision, redness of the eyeball, photophobia, eye pain and headache. They are characterized by a change in the color of the iris, its swelling, and constriction of the pupil.
2. Choroiditis. Inflammation of the choroid of the eye. Caused by various infections (staphylococcus, streptococcus, brucellosis, toxoplasmosis, etc.). It is characterized by the formation of an inflammatory infiltrate and the formation of scar tissue. Not accompanied by visual disturbances or eye pain. There is hemorrhage in the choroid and vitreous body. When the peripheral parts are affected, it causes a decrease in twilight vision, and spots appear before the eyes. Pathology is diagnosed using ophthalmoscopy.
3. Myopia, or nearsightedness. Characterized by visual impairment, when distant objects are poorly distinguished, but at the same time the person sees well near. Myopia is accompanied by visual fatigue, progressive deterioration of visual acuity, and headache.
4. Keratitis is inflammation of the cornea of ​​the eye. It manifests itself as redness and pain in the eyes, clouding of the cornea, and decreased vision. Frequent symptoms: lacrimation, cutting pain in the eyes, sensation of a foreign body in the eye, photophobia. The nature of occurrence is infectious.
5. Iridocyclitis, or uveitis, is an inflammation of the iris and ciliary body. Characteristic manifestations: blurred vision, redness, constriction of the pupil, photophobia, blurred vision. It develops as a result of the penetration of viruses and infections, and can also be a complication of common diseases.
6. Embolism of the central retinal artery. It occurs in older people and is characterized by a sharp and sudden loss of vision in one eye. The disease is based on acute blockade of the central ophthalmic artery and subsequent retinal ischemia.

Indications for use

The main indications for the use of Atropine sulfate are:

• peptic ulcer of the stomach and duodenum;
• pyloric spasms;
• cholelithiasis;
• bronchial asthma;
• the need to reduce the secretion of the salivary, gastric and bronchial glands;
• bradycardia;
• spasms of the intestines and urinary tract;
• pain caused by spasms of smooth muscles, as part of complex therapy.

Atropine can also be used in anesthesiological practice before anesthesia and surgery, which helps prevent the development of broncho- and laryngospasms , limit the secretion of the salivary and bronchial glands, reduce other reflex reactions and undesirable phenomena caused by excitation of the vagus nerve, and so on.

In ophthalmology, atropine is used when it is necessary to dilate the pupil to conduct a diagnostic examination of the eye, determine true refraction, and so on. In addition, the drug is used to treat:

• iritis – inflammation of the iris;
• iridocyclitis – simultaneous inflammation of the iris and cornea of ​​the eyes;
• keratitis - inflammation of the cornea and some eye injuries.

Thanks to the relaxation of the eye muscles, functional rest is ensured and the elimination of a number of pathologies is accelerated.

Atropine sulfate tablets 0.0005 g

Release form: tablets (blister packs) 0.5 mg

Pharmacological group - m-anticholinergic

pharmachologic effect

• bronchodilator
• antiarrhythmic
• m-anticholinergic
• antiulcer
• antispasmodic

Ingredients - atropine 0.5 mg

Indications

• Gastrojejunal ulcer
• Pain in the abdomen and pelvis
• Pain localized in the upper abdomen
• Pain associated with urination
• Diseases of the eye and its adnexa
• Diseases of the vocal folds and larynx, not elsewhere classified
• Diseases of the gallbladder, biliary tract and pancreas
• Salivary gland disease
• Painful urination, unspecified
• Anomalies of pupillary function
• Asthma
• Asthma, unspecified
• Asthma with a predominance of an allergic component
• Secondary parkinsonism
• Bile duct stones without cholangitis or cholecystitis
• Bile duct stones with cholangitis
• Bile duct stones with cholecystitis
• Iridocyclitis
• Cholinesterase inhibitors
• Keratitis
• Keratoconjunctivitis
• Accommodation disorders
• Refractive and accommodation disorders
• Disorders of the secretion of the salivary glands
• Second degree atrioventricular block
• Complete atrioventricular block
• First degree atrioventricular block
• Atrioventricular (atrioventricular) block and left bundle branch block (His)
• Retinal vascular occlusions
• Pylorospasm, not elsewhere classified
• Renal colic, unspecified
• Acute bronchiolitis
• Acute pancreatitis
• Acute cholecystitis
• Poisoning by drugs, medications and biological substances
• Poisoning with drugs acting primarily on the autonomic nervous system
• Non-allergic asthma
• Peptic ulcer of unspecified localization
• Symptoms and signs related to the urinary system
• Symptoms and signs related to the digestive system and abdominal cavity
• Spasm of the larynx
• Mixed asthma
• Trauma to the eye and orbit
• Injuries, poisoning and some other consequences of external causes
• Chronic pancreatitis of alcoholic etiology
• Chronic cholecystitis
• Chorioretinal inflammation
• Chorioretinal inflammation, unspecified
• Cholecystitis
• Cholecystitis, unspecified
• Other and unspecified atrioventricular block
• Other parasympathomimetic (cholinergic) drugs
• Other diseases of the eye and its adnexa
• Other diseases of the pancreas
• Other diseases of the stomach and duodenum
• Other retinal arterial occlusions
• Other and unspecified abdominal pain
• Other superficial keratitis without conjunctivitis
• Other chronic pancreatitis
• Other forms of cholelithiasis
• Other forms of cholecystitis
• Cholelithiasis
• Corneal ulcer
• Duodenal ulcer
• Stomach ulcer

Composition by components

• atropine

Description

White crystalline or granular powder, soluble in water and alcohol.

Pharmacodynamics

An alkaloid contained in plants of the nightshade family, a blocker of m-cholinergic receptors. Prevents the stimulating effect of acetylcholine, reduces the secretion of the salivary, gastric, bronchial, lacrimal, sweat glands, and pancreas. Reduces the tone of the muscles of the gastrointestinal tract, bile ducts and gallbladder; causes tachycardia, improves AV conduction. After intravenous administration, the maximum effect appears after 2-4 minutes, after oral administration (in the form of drops) after 30 minutes. Stimulates the cerebral cortex (in high doses). Dilates the pupils, impedes the outflow of intraocular fluid, increases intraocular pressure, and causes paralysis of accommodation. The pupil dilated with atropine does not constrict when instilled with cholinomimetic drugs. Maximum pupil dilation occurs after 30-40 minutes and disappears after 7-10 days.

Pharmacokinetics

Communication with plasma proteins - 18%. Passes through the BBB. Excreted by the kidneys (50% unchanged).

Application

Peptic ulcer of the stomach and duodenum, pylorospasm, cholelithiasis, cholecystitis, acute pancreatitis, hypersalivation (parkinsonism, poisoning with heavy metal salts), spasms of the intestines and urinary tract, hepatic and renal colic, bronchial asthma, to prevent broncho- and laryngospasm, AV blockade , poisoning with m-cholinomimetics (fly agaric), anticholinesterase drugs, premedication before surgery. Locally (in ophthalmology): to examine the fundus of the eye, to dilate the pupil and achieve accommodation paralysis in order to determine the true refraction of the eye; for the treatment of iritis, iridocyclitis, choroiditis, keratitis, embolism and spasms of the central retinal artery and some eye injuries.

Dosage regimen

SC, IM or IV 0.25-1 mg 1-2 times a day. In ophthalmology: instill 1-2 drops of a 1% solution (in children a solution of a lower concentration is used) into the affected eye, frequency of application - up to 3 times with an interval of 5-6 hours. In some cases, a 0.1% solution is administered subconjunctivally 0.2-0.5 ml or parabulbar - 0.3-0.5 ml. Using electrophoresis, a 0.5% solution is administered through the eyelids or an eye bath.

Side effects

Dry mouth, mydriasis, intestinal atony, dizziness, tachycardia, difficulty urinating, hyperemia of the skin of the eyelids, photophobia, swelling of the conjunctiva of the eyelids and eyeball. Xerostomia, mydriasis, paralysis of accommodation, tachycardia, intestinal atony, bladder atony, headache, dizziness, loss of touch.

Contraindications

Hypersensitivity, angle-closure glaucoma, urinary disorders in prostate adenoma.

special instructions

When instilling the solution into the eye, it is necessary to press the lower lacrimal punctum to avoid the solution entering the nasopharynx. With subconjunctival or parabulbar administration, it is advisable to prescribe validol to reduce tachycardia.

Instructions for Atropine sulfate (Method and dosage)

According to the instructions for use of Atropine sulfate, the drug can be used in different ways: taken orally, parenterally and locally. Quite often it is administered by injection: by injection into a vein, muscle or under the skin. In this case, the dosage of the drug is established by the attending physician, taking into account the type, complexity of the disease and the characteristics of the patient’s body.

In ophthalmic practice, eye drops with a concentration of 0.5-0.1% of the active substance are used. The therapeutic dosage is 1-2 drops instilled 2-6 times a day. Particularly severe cases are supplemented by applying 1% atropine ointment to the eyelids in the evenings.

Note!

The description of the drug Atropine on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.

Overdose

In case of an overdose, severe dryness in the mouth, burning sensation, difficulty swallowing, severe photophobia, redness and peeling of the skin, fever, rash, nausea, vomiting, tachycardia and arterial hypertension may occur.

The drug may have effects on the nervous system, often causing anxiety, tremors , confusion, agitation, hallucinations and delirium, as well as excessive drowsiness and stupor. Such conditions often result in death, which can lead to cardiovascular or respiratory failure.

In particularly severe cases, the administration of Physostigmine , and Diazepam . All this time it is necessary to constantly monitor the airway. Inhalation with oxygen or carbon dioxide will help prevent the development of respiratory failure.

of fever appear , it is better to use cold compresses or wiping with water, and organize adequate fluid intake. If necessary, urethral catheterization is performed.

Features of use during pregnancy and lactation

It is known that the active substance of the drug can cross the placental barrier. The components of the drug are also found in breast milk in small concentrations. The effect of the drug on pregnancy has not been studied, so its use during this period is allowed only if the expected benefit to the mother significantly outweighs the potential risk to the child.

It is not prescribed to women whose pregnancy is complicated by gestosis, since in this case the risk of arterial hypertension increases. During lactation, if treatment is necessary, breastfeeding should be stopped.

Interaction

The use of this drug helps to weaken the effect of m-cholinomimetics and anticholinesterase drugs. Significantly enhance the effectiveness of Atropine sulfate by drugs with anticholinergic activity, Diphenhydramine and Promethazine.

Simultaneous use with antacids that contain Al3+ or Ca2+ leads to a decrease in the absorption of the active component from the gastrointestinal tract. Combination with tricyclic antidepressants, Amantadine, Phenothiazine, Quinidine , antihistamines and other drugs with m-anticholinergic properties often enhances the manifestation of systemic undesirable effects. Some nitrates cause an increase in intraocular pressure, while atropine sometimes alters the absorption of Levodopa and Mexiletine.

Side effects

When using Atropine eye drops, the following side effects may develop:

• redness and swelling of the conjunctiva;
• tachycardia;
• irritation of the mucous membrane of the eye;
• redness of the skin of the eyelids;
• conjunctivitis;
• impaired salivation and dry mouth;
• tingling sensation;
• increased intraocular pressure;
• mydriasis (pathological dilation of the pupil);
• paralysis of accommodation.

All negative phenomena are transient, and vision functions are restored within 2–7 days. It should be borne in mind that “Atropine sulfate” cannot be used in conjunction with monoamine oxidase inhibitors. This combination can cause heart rhythm disturbances. Patients must be warned that after instilling Atropine solution into the eyes, they should not drive a vehicle for at least two hours.

special instructions

When using Atropine sulfate, you must strictly monitor the presence of conditions in which the drug is prescribed with extreme caution, for example, disorders of the cardiovascular system:

• tachycardia;
• atrial fibrillation;
• coronary heart disease;
• chronic heart failure;
• arterial hypertension;
• mitral stenosis and other diseases.

It is necessary to maintain an interval of at least an hour between the use of Atropine and antacid drugs. To reduce tachycardia, the patient should be given a Validol . During treatment, it is also necessary to exercise caution when engaging in hazardous activities and driving a car.

Analogues of Atropine sulfate

Level 4 ATC code matches:
Belladonna extract

Becarbon

As the Pharmacopoeia indicates, analogues of this drug are: Appamide Plus, Bellacechol, Cyclomed, Hyoscyamine, Midriacil, Midrimax, Bekarbon and Cycloptic.

Reviews of Atropine sulfate

As you know, this drug is one of the most popular, which is why reviews of Atropine sulfate are found on the Internet quite often. Although discussions of its effectiveness rarely involve those who have ever been prescribed it.

Usually, opinions about it are left by relatives of patients who have ever taken this drug or people who have just been prescribed Atropine sulfate for use.

Quite often, users note how important it is to follow the dosage of this drug. The fact is that an overdose can lead to severe poisoning, the symptoms of which can manifest themselves in all their diversity. There are also a number of recommendations when this drug should be used with extreme caution - this also needs to be remembered.

According to medical experts, Atropine sulfate is a specific and potent drug. To buy it at a pharmacy, a prescription is written in Latin. It can only be taken strictly as prescribed by a doctor, strictly observing the dosage and established therapeutic regimen.

Atropine sulfate price, where to buy

You can buy Atropine sulfate in the form of a solution for a price starting from 8 rubles.

The cost of eye drops is from 40 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Atropine sulfate 0.1% solution amp.
  1ml No. 10 JSC Dalkhimfarm 54 rub. order

Pharmacy Dialogue

• Atropine sulfate (amp. 0.1% 1 ml No. 10) DHF JSC

  46 RUR order

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PaniPharmacy

• Atropine liquid Atropine sulfate h/c 1% 5ml Ukraine, OZ GNTsLS LLC
  39 UAH.order
• Atropine ampoule Atropine sulfate solution d/in. 0.1% amp. 1ml No. 10 Ukraine, Darnitsa ChAO

  31 UAH order

• Atropine ampoule Atropine sulfate solution d/in. 0.1% amp. 1ml No. 10 Ukraine, OZ GNTsLS LLC

  20 UAH order

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