Release form, packaging and composition of the drug Clinical-pharmacological group Pharmaco-therapeutic group Pharmacological action Indications for use Method of administration and doses Side effects Contraindications for use Use in children Special instructions Drug interactions
Registration Certificate Holder:
BALKANPHARMA-TROYAN, AD (Bulgaria)
ATX Code:
A06AD11
Active substance:
lactulose
Dosage form:
Good luck
| The drug is approved for use as an over-the-counter product | Good luck | Syrup reg. No.: LSR-003485/10 from 04/27/10 - Indefinitely |
Release form, packaging and composition of the drug Goodluck
Syrup
transparent, viscous, from light yellow to brownish-yellow in color, with the smell of caramel.
| 1 ml | |
| lactulose (as liquid lactulose) | 667 mg |
Excipients
: potassium sorbate (E202) - 0.7 mg, caramel flavor 12788 - 2 mg, purified water - up to 1 ml.
15 ml - multilayer foil bags (10) - cardboard packs. 200 ml - dark glass bottles (1) complete with a measuring cup - cardboard packs.
pharmachologic effect
Laxative drug. It has a hyperosmotic, laxative effect, stimulates intestinal motility, improves the absorption of phosphates and calcium salts, and promotes the excretion of ammonium ions.
Under the influence of the drug, Lactobacillus acidophilus, Lactobacillus bifidus multiply in the intestines, under the influence of which lactulose is broken down to form lactic acid (mainly) and partially formic and acetic acids. At the same time, the osmotic pressure increases and the pH in the lumen of the large intestine decreases, which leads to the migration of ammonia from the blood into the intestine, its ionization and retention, as well as an increase in the volume of feces and increased intestinal motility. The removal of bound ammonium ions occurs with the development of a laxative effect.
Inhibits the formation and absorption of nitrogen-containing toxins in the proximal colon.
Reduces the proliferation of salmonella.
The effect occurs 24-48 hours after administration, which is due to the duration of passage of the drug through the gastrointestinal tract.
Description of the drug
Goodluck is a laxative that stimulates intestinal motility. This effect is achieved due to the fact that this drug contains lactulose, a disaccharide.
Once in the intestines, lactulose is broken down by enzymes of the intestinal microflora to form organic acids such as lactic, acetic acid, etc.
As a result of this breakdown, processes begin in the body that lead to the movement of ammonia from the blood into the intestines. All these actions lead to an increase in the volume of feces, as well as to increased peristalsis in the intestines. Thus, the laxative effect of the drug is manifested.
In addition to lactulose, Goodluck contains the following excipients:
- purified water;
- potassium sorbate;
- caramel flavoring.
The drug is available in the form of a syrup with a yellowish color and a caramel smell in 200 ml bottles.
Mode of application
Goodluck is used to relieve constipation starting in childhood. The drug is used as a daily dose in the morning, once and with meals. If desired, you can wash it down.
The effect of the drug may not occur immediately, but within two days. If the drug does not have a laxative effect, then you can slightly increase the dose.
To achieve a therapeutic effect, Goodluck should be taken after eliminating constipation as a maintenance effect.
Recommended dose Goodluck
| Age | Initial dose for the first 3 days (ml) | Maintenance dose (ml) |
| Newborns and children up to one year old | 5 | 5 |
| Children from 1 year to 6 years | from 5 to 10 | from 5 to 10 |
| Children from 7 to 14 years old | 15 | from 10 to 15 |
| Children over 14 years old and adults | from 10 to 45 | from 10 to 25 |
Indications for use There are no data on an overdose of the drug Goodluck, but if pain or diarrhea occurs, it is better to stop using the drug.
Goodluck is used not only as a laxative. There are the following indications for its use:
- Constipation, chronic constipation, difficulty in defecation due to hemorrhoids;
- Recovery after surgery on the colon, anal area;
- Preparation for surgery;
- Improved bowel movements after hemorrhoidal surgery;
- Hepatic precoma, encephalopathy, coma.
Contraindications
Goodluck should be used only after consultation with a specialist or if you are sure you have no contraindications to its use.
Contraindications to treatment with Goodluck:
Rectal bleeding;- Signs of appendicitis;
- Presence of colostomy, ileostomy;
- Galactosemia;
- Individual lactose intolerance or deficiency;
- Intestinal obstruction;
- Excessive sensitivity to lactulose or other components of the drug.
Directions for use and doses
The daily dose is taken once in the morning with meals.
Daily doses are determined according to individual need and response. Due to the specific mechanism of action of the drug, the clinical effect occurs within 1-2 days.
If there is no effect after the first two days of taking the drug, the dose can be increased.
Constipation and the clinical need for relief of defecation
| Age | Initial daily dose (first 3 days) | Maintenance daily dose |
| Adults | 10-45 ml | 10-25 ml |
| Children 7-14 years old | 15 ml | 10-15 ml |
| Children 1-6 years old | 5-10 ml | 5-10 ml |
| Children < 1 year | 5 ml | 5 ml |
Hepatic precoma, coma and encephalopathy
The initial daily dose is 3 times 30-50 ml. The daily dose can be 90-190 ml. The maintenance daily dose is selected individually so that there are “soft stools” 2-3 times a day, with the calculation that the stool pH is in the range of 5.0-5.5.
Conditions and periods of storage of the product
The drug is stored at a temperature that does not exceed 25 0C, but it cannot be frozen. The shelf life of the drug is 2 years from the date of manufacture, which is usually indicated on the packaging.
After opening the drug, the shelf life is reduced to 28 days.
The drug should be stored in places that are difficult for children to reach to avoid undesirable consequences.
Side effect
From the digestive system:
in the first days of taking it, flatulence may appear (usually it gradually decreases and goes away); when taken in doses higher than recommended, abdominal pain and diarrhea are possible, which requires dose adjustment. Rarely - nausea.
When using the drug in high doses for a long time
for the prevention and treatment of hepatic precoma and coma, diarrhea and impaired water-electrolyte metabolism are possible.
From the nervous system:
rarely - convulsions, headache, dizziness.
Other:
possible allergic reactions; rarely - arrhythmias, myalgia, increased fatigue, weakness.
Good luck
Goodluck is a hyperosmotic laxative whose pharmacologically active component is lactulose. This substance does not undergo metabolic changes and is not absorbed in the small intestine, but enters the large intestine intact. Here, lactulose decomposes to form an acidic “cocktail” in the form of butyric, acetic, propionic and lactic acids, which can either be absorbed or remain in the intestines, increasing the acidity of the stool. These organic acids have pronounced osmotic (hyperosmotic) properties: this means that they cause water retention in the large intestine. Due to an increase in intraintestinal pressure and an increase in intestinal contents, peristalsis and motor activity of the intestine are activated, which leads to the acceleration of the movement of a bolus of food through it, which smoothly transforms into feces. The second mechanism by which goodluck stimulates intestinal peristalsis is an increase in the volume of intestinal contents due to the intensive growth and reproduction of bifidobacteria and lactobacilli caused by the products of enzymatic hydrolysis of lactulose. This circumstance makes itself felt much later than the main effects, but definitely contributes to the formation of a general laxative effect. Enzymatic breakdown processes lead to increased gas formation, which in some cases can cause bloating. In fact, flatulence is the only significant side effect of Goodluck (the incidence of other negative phenomena indicated in the instructions is unlikely to go beyond the statistical error).
Flatulence, as a rule, occurs 3-4 days after starting to take Goodluck and goes away on its own. Sometimes, to get rid of this phenomenon, a reduction in the dose of the drug is required. Flatulence can be prevented by implementing the principle of gradualism: start taking it with minimal doses, gradually increasing them to the limit established by the instructions. We should not forget that going beyond the “red flags” of the agreed therapeutic maximum is fraught with the development of persistent diarrhea. Another negative point: the intestinal microflora gradually gets used to daily coexistence with the drug, which over time can reduce the effectiveness of its work.
Goodluck has no age-related contraindications and is allowed for use in children of the first year of life. At the same time, if they experience functional constipation, it is recommended first of all to correct the diet, namely: the introduction of foods with a high content of dietary fiber (this applies to breast-fed children). If adjusting the baby’s diet does not bring the expected results, then goodluck or another lactulose-based drug is added.
Drugs that reduce acidity and some antibiotics reduce the effect of goodluck. If combined pharmacotherapy is used, then goodlac should be taken no earlier than 2 hours after taking other drugs. It should be borne in mind that taking goodluck leads to an increase in intestinal acidity, which affects the pH-dependent release of drugs in the enteric coating.
special instructions
If there is no clinical effect within several days or if constipation returns after stopping treatment, you should consult your doctor. The recommended daily doses for treating constipation and facilitating bowel movements can also be prescribed to patients with diabetes mellitus. Higher doses used for the treatment of hepatic precoma and coma should be prescribed with increased caution in the presence of diabetes mellitus. The drug contains galactose, and therefore its use is not recommended for patients with lactose intolerance, lactase deficiency, glucose-galactose malabsorption. With long-term use (more than 6 months) monitoring of potassium, chlorine and carbon dioxide ions in the plasma is necessary. For gastrocardial syndrome, doses should be gradually increased to avoid flatulence (which disappears on its own on the 2-3rd day of treatment). In elderly patients and weakened patients taking lactulose for more than 6 months, it is recommended to periodically monitor the concentration of electrolytes in the blood serum. If diarrhea occurs, treatment is canceled. Impact on the ability to drive vehicles and operate machinery
Goodluck does not affect the ability to drive vehicles or operate machinery.
Drug interactions
When Goodluck is used in combination with certain drugs/substances, the following effects may develop:
- antacids, drugs with antibacterial action (neomycin): decreased Goodluck effect;
- medications whose absorption/excretion from the body depends on the pH value in the intestine: the combination is not recommended.
Taking Goodluck leads to a decrease in the pH value of the intestinal environment, which may lead to a change in the pH-dependent release of enteric drugs.
It is not recommended to take lactulose within 2 hours after taking other medications.
