Korilip, 10 pcs., 25 mg+2 mg+12 mg, rectal suppositories

Composition and release form

in a blister pack made of PVC film 5 pcs.; in a cardboard pack 2 packs.

What is "Korilip"? This is an innovative development of the Scientific Center for Children of the Russian Academy of Medical Sciences, a universal drug for the whole family, which helps the body of both adults and children to always remain strong, reliably resist bacteria and viruses and not get sick.

Experts came up with the name “Korilip” for a reason. It contains all three of the most important and effective components that make up the innovative drug, and is composed of the first letters of their names. What are these components?

• Cocarboxylase hydrochloride – activates tissue metabolism, participates in the synthesis of vital amino acids, regulates carbohydrate metabolism and the synthesis of nucleic acids;
• Riboflavin (vitamin B2) - plays an important role in the synthesis of hemoglobin and the regulation of redox reactions in the cells of our body;
• Lipoic (thiocotic) acid plays an important role in the process of energy formation in the body, has a hepatoprotective effect, improves the detoxification function of the liver, and protects against the effects of exo- and endotoxins.

It is the complex effect of the three key components that make up the drug “Corilip” that allows you to achieve effective results in the treatment of various pathological conditions in both adults and children. Regular saturation of the body with these important vitamins and acids is the key to the excellent functioning of all its organs and systems and strong immunity. "Korilip" allows you to mobilize the body's own forces in the fight against various viruses and infections that can enter the body from the outside.

Who and when will the innovative drug “Korilip” be especially needed? Of course, adults who are daily exposed to serious physical and emotional stress that causes serious damage to their health. Children during a period of active growth and development. For kids who are preparing for vaccinations, entering kindergarten or school. For women planning pregnancy and pregnant women who want to go through the long journey of nine months without unnecessary worries, worries and complications and prepare for an easy birth. And, of course, for newborns and infants, whose immunity needs additional care and protection.

Taking care of the smallest children and babies born prematurely, specialists from the Scientific Center for Children of the Russian Academy of Medical Sciences created a special drug “Korilip-NEO” - an absolutely safe and effective remedy that is used to prevent various pathologies and complications, helps to quickly strengthen and fully mature all organs and systems of the body.

It is very easy to use the drug "Corilip". Finally, both adults and children will be able to forget about numerous pills, painful injections and complex medication regimens. It is enough to complete a 10-day course of treatment with suppositories and repeat it several times with an interval of 20 days. After the first dose of the drug, you will be able to appreciate all its advantages, and the full course of treatment will fill your body with strength, energy and give you excellent health.

The drug is prescribed by a doctor and sold in pharmacies with a prescription.

Pharmacodynamics

A combined drug, the effect of which is determined by the effects of its constituent vitamins and coenzymes, as well as their synergistic effect.

Cocarboxylase (coenzyme) catalyzes the carboxylation and decarboxylation of α-keto acids and participates in the processes of carbohydrate metabolism.

Through participation in the pentose cycle, it indirectly promotes the synthesis of nucleic acids, proteins, and lipids. Helps correct metabolic acidosis and cellular hypoxia, as well as other metabolic disorders (failure of liver, kidney, cardiovascular system, chronic intoxication).

Riboflavin (vitamin B2) as a coenzyme of flavin proteins is involved in the regulation of redox reactions (processes of carbohydrate, protein and fat metabolism). Plays an important role in the synthesis of hemoglobin, maintaining normal visual function of the eye and the condition of the mucous membranes and skin.

Thioctic acid is involved in the oxidative decarboxylation of pyruvic acid and α-keto acids, in the regulation of lipid and carbohydrate metabolism, and plays an important role in the process of energy formation in the body. Thioctic acid has a hepatoprotective effect, improves the detoxification function of the liver, and protects against the effects of exo- and endotoxins.

Korilip-Neo improves tissue metabolism in various physiological and pathological conditions that require correction with cofactors and substrates.

Korilip, 10 pcs., 25 mg+2 mg+12 mg, rectal suppositories

Pharmaceutical action.

A combined drug, the effect of which is determined by the effects of its constituent vitamins and coenzymes. Cocarboxylase hydrochloride has a metabolic effect and activates tissue metabolism. In the body, it catalyzes the carboxylation and decarboxylation of alpha-keto acids, participates in the processes of carbohydrate metabolism, and through participation in the pentose cycle indirectly promotes the synthesis of nucleic acids, proteins, and lipids. The drug is used to correct metabolic acidosis, cellular hypoxia and other metabolic disorders, chronic intoxications, and helps normalize the function of the liver, kidneys, and cardiovascular system. Riboflavin (vitamin B2), as a coenzyme of flavin proteins, is involved in the regulation of redox processes, as well as carbohydrate, protein and fat metabolism, plays an important role in the synthesis of hemoglobin and in maintaining normal visual function of the eye, the condition of the mucous membranes and skin. Lipoic acid is involved in the oxidative decarboxylation of pyruvic acid and alpha-keto acids, in the regulation of lipid and carbohydrate metabolism, and plays an important role in the process of energy formation in the body. Lipoic acid has a hepatoprotective effect, improves the detoxification function of the liver, and protects against the effects of exo- and endotoxins. Korilip improves tissue metabolism in various physiological and pathological conditions that require correction with cofactors and substrates.

Indications.

Chronic tissue hypoxia, decreased immunity (bacterial and viral infections), chronic somatic diseases, chronic intoxication, condition after severe illness, malnutrition (hypotrophy). Periods of intensive growth and development of new functions in a child, intense physical and mental stress, stress. Period of epidemic of infectious diseases (prevention).

Contraindications.

Hypersensitivity, proctitis, anorectal bleeding.

Dosage regimen.
Rectally,
after preliminary bowel movement. Children from 1 to 6 years old - 1 supp. per day, from 6 to 14 years - 1-2 supp. per day. The duration of treatment is 10 days. A total of 3-4 courses at intervals of 20 days (3-4 months).

Side effects.

Rarely - allergic reactions: urticaria, itching, bronchospasm; dyspepsia.

Interaction.

No negative interactions were noted. The drug can be used in complex therapy.

Special instructions.

The criteria that determine the duration of therapy, along with the clinical condition, are cytochemical indicators of the activity of peripheral blood leukocyte enzymes (succinate dehydrogenase and glycerophosphate dehydrogenase).

Composition, physical and chemical properties, price

The drug is available in the form of torpedo-shaped rectal suppositories, odorless, yellow in color. Possible inclusions of orange-yellow color.

1 suppository contains (Korilip/Korilip-Neo):

Active ingredients:

• 25/12.5 mg cocarboxylase hydrochloride;
• 2/1 mg riboflavin;
• 12/6 mg thioctic (α-lipoic) acid.

Auxiliary components: solid fat or cocoa butter (~ 930.5 mg).

Suppositories are placed in contour cell packaging made of polyvinyl chloride film, 5 pieces each, in cardboard packs, 2 packages each.

Price: No. 10: 210-270 rub.

Advantages and disadvantages of candles

Rectal suppositories are intended for insertion into the rectum. They contain an active substance and various auxiliary components. The candles soften and melt at the temperature of the human body, ensuring the supply of the active substance, and at room temperature they retain their shape.

Maintaining candles does not require outside help or special medical education, is a non-invasive treatment method, does not cause nausea and vomiting, and in most cases does not cause discomfort. Thanks to these advantages, rectal suppositories have gained popularity and are considered an effective remedy for hemorrhoids.

Like any other dosage form, suppositories also have disadvantages. Firstly, they require storage at low temperatures, often in a refrigerator. Secondly, using candles is not always convenient. Thirdly, some components of suppositories cannot be stored for a long time, so it is not recommended to buy suppositories for hemorrhoids for future use. Remember, candles cannot be used if they are cracked or damaged, or if their color or smell has changed.

Features of application

When using suppositories, it is necessary to take into account their features and follow some rules:

• Carefully study the instructions for use and pay attention to storage conditions.
• Do not hold the candle in your hands for a long time, as it may begin to melt.
• If suppositories are used once a day, it is best to use them at night. If twice, then in the morning and in the evening.
• It is necessary to insert the suppository with clean hands while lying on your side, after bowel movements and performing hygiene procedures.

You can find out which suppositories for hemorrhoids are best for the patient, as well as how to take them correctly and for how long, after consultation with a specialist.

A comprehensive plan is drawn up individually for each patient, taking into account his age, gender, presence and absence of concomitant pathology and individual characteristics of the body.

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Indications for use

The drug is prescribed as primary or auxiliary therapy for certain pathological conditions in children (more often) and adults, as well as for their prevention.

Indications:

• tissue hypoxia of a chronic nature;
• viral and bacterial infections, including intestinal;
• somatic diseases in chronic form;
• chronic intoxication;
• decreased immunity;
• malnutrition;
• recovery period after serious illness;
• intense physical and mental stress;
• stressful situations;
• periods of intensive growth and development of new skills in children.

In pediatrics and adult practice, it is prescribed as a general restorative prophylactic during epidemics of infections.

Korilip-Neo suppositories are often used in complex therapy for premature babies and babies born on time, but with a complicated adaptation period.

Contraindications

• Rectal bleeding;
• Proctitis;
• Hypersensitivity to the components of the drug (active or auxiliary).

As for the use of the drug during pregnancy, it is not recommended to prescribe suppositories, since no studies have been conducted. Meanwhile, there is evidence of the drug being prescribed during pregnancy to relieve severe toxicosis in order to relieve attacks of nausea and improve the general condition of the expectant mother, which has a beneficial effect on the course of pregnancy.

Dosage

Suppositories are used rectally: freed from packaging and carefully inserted into the anus after defecation.

Korilip:

• Newborns and children up to 12 months: 1/2 suppository per day.
• Children 1-6 years old: 1 sup. per day.
• Children 6-14 years old: 1-2 supp. per day.
• Adults: 1 sup. 2 times a day.

Korilip-Neo:

• Children under 12 months: 1 sup. per day.

The duration of the course is 10 days, the total duration of therapy: 3-4 courses with an interval of 20 days.

Effects of rectal suppositories

Anesthesia

Reduce pain due to analgesic components (novocaine, lidocaine, etc.). Anesthetic suppositories for hemorrhoids are prescribed for acute pain.

Reduce blood clot formation

Achieved through anticoagulants, which block blood clotting mechanisms. After taking such suppositories, blood stops clotting normally, so patients with a tendency to bleed are advised to first consult a doctor.

Anti-inflammatory effect

You can relieve inflammation with the help of non-steroidal anti-inflammatory drugs (aspirin, diclofenac), as well as hormonal drugs (drugs containing glucocorticosteroids). Natural substances (sea buckthorn oil, propolis) are also widely used.

Stop bleeding

In this case, drugs that are opposite in action to anticoagulants are used. That is, they activate the blood clotting process, stop bleeding, but can lead to the formation of blood clots if used uncontrolled.

Strengthening veins

Achieved by increasing their tone, strengthening the wall, and increasing elasticity.
In order to increase the effectiveness of suppositories for hemorrhoids and ensure ease of use, they sometimes include several active ingredients. For example, suppositories with analgesic, anti-inflammatory and hemostatic effects are popular.