TOP 13 analogues of the drug Motilium: list of cheap substitutes for adults and children

Prohibited during breastfeeding

Has restrictions for children

Has restrictions for older people

Has limitations for liver problems

Has limitations for kidney problems

Motilium is an antiemetic, a central blocker of dopamine receptors. Release form: tablets and suspension. Active pharmaceutical substance: domperidone. The antiemetic effect is achieved by activating gastrointestinal motility.

Indications for the use of this drug are as follows:

• vomit;
• convulsive, jerky contractions of the diaphragm;
• nausea;
• intestinal atony;
• inflammation of the gallbladder;
• reflux esophagitis;
• local damage to the inner lining of the stomach;
• necessary acceleration of peristalsis before contrast radiography of the gastrointestinal tract;
• JVP;
• angiocholitis;
• excessive accumulation of gases in the intestines, etc.

Action of Motilium

Motilium has a relatively small list of contraindications, which can be found in the instructions. The presence of contraindications or the high price of it may cause the need to replace the medicine with an analogue. This article will discuss in detail the most common analogues of Motilium.

Dosage forms and composition

Motilium contains the active dose of the substance domperidone. It is a strong dopamine receptor blocker. Several types of the drug are available for oral administration:

1. Regular film-coated tablets: white, convex, engraved “10M”. Each contains 10 mg of domperidone, lactose, MCC, hydrogenated vegetable fat, starch, polyvidone and other auxiliary components. The package contains 1–3 blisters.
2. Lingual lozenges with a similar dosage, slightly minty taste. The active substance in them is supplemented with gelatin, menthol, aspartame and mannitol. Packed in 10–30 pieces.
3. Suspension for children. White, syrupy, sweetish liquid containing 1 mg of domperidone per 100 ml. Packaged in dark glass bottles with a screw cap. The drug also contains sodium saccharinate, water, sorbitol, polysorbate and stabilizers. Each package of the product has a special syringe for precise dosing.

Prices for the drug and its main analogues, average in Russia

One of the reasons for replacing the drug is its high price.
Information on prices for Motilium and its analogues is given in Table 1. Table 1 - Average prices for Motilium and its analogues

As can be seen from the table, Motilium is the most expensive drug compared to its analogues. There are cheaper antiemetics. Some of them contain the same active ingredient – ​​domperidone. There are also drugs that contain other active ingredients (prinfia bromide, bromopride), but their effect is similar to that of Motilium.

There are also analogues that are not sold in the Russian Federation (Domrid, Nausilium, Bromoprid, Brulium lingvatabs and others). If necessary, such a drug can be ordered online or purchased in another country.

Therapeutic effect

Motilium has the ability to eliminate nausea, stop vomiting, and gently activate intestinal motility. The active component of the drug, domperidone, exhibits some properties of an antipsychotic, suppressing sensitivity to dopamine. Unlike other inhibitors, it is more neutral: it does not cause dystonia, tremor, or nervous tics.

The drug increases the tone of muscle fibers and enhances contractions of the esophageal sphincter in its lower part. Thanks to this, the evacuation function of the stomach is normalized, signs of dyspepsia, indigestion, and other motility disorders and diseases of the gastrointestinal tract are eliminated.

The drug is absorbed by the mucous membranes within a few minutes and actively binds to blood proteins. Transformed by liver cells. It is excreted from the body by the kidneys and with intestinal contents within 0.5–1 days after administration.

Domperidone stimulates the release of prolactin. The secretion of gastric juice and its acidity are not affected. When consumed during or immediately after a meal, the effect of Motilium may slow down somewhat.

pharmachologic effect

Manufacturer: Catalent/Janssen-Cilag, UK or Italy
Release form: tablets, dispersible tablets, suspension

Active ingredient: domperidone

Synonyms: Motilak, Motonium, Passazhiks, Motizhekt, Motinorm, Motogastrik, etc.

The drug is a dopamine antagonist with antiemetic properties. Contains domperidone, which accelerates intestinal motility, improves the movement of food and prevents stagnation in the stomach.

At the same time, Motilium does not change gastric secretion and does not affect the production of hydrochloric acid, like proton pump inhibitors (Omez, Nolpaza, etc.).

Indications and doses

Treatment with Motilium includes a wide range of gastrointestinal pathologies:

• peptic ulcer - as part of complex therapy;
• intestinal atony;
• symptoms of delayed gastric emptying: heaviness, feeling of fullness, nausea;
• flatulence, intestinal cramps;
• hypokinetic cholecystitis;
• epigastric pain, heartburn, vomiting, belching and other symptoms of esophagitis;
• attacks of vomiting caused by intoxication, functional disorders, drug or radiotherapy.

Motilium is prescribed for quick cleansing of the stomach cavity and intestinal lumen in preparation for ultrasound and radiographic examinations, and other medical procedures.

For children, the drug is indicated for profuse vomiting, pathological regurgitation, signs of esophageal reflux, flatulence, and bloating.

It is recommended to use the product on an empty stomach, 30–40 minutes before. before meals. In some cases - before bed.

1. Children under 5 years of age are given a suspension at the rate of 2.5 ml for every 10 kg of body weight. Infants are administered Motilium from a special syringe or pipette 3-4 times a day. The bottle is shaken several times before using the mixture. The special syringe dispenser is washed with water after each set of medication.
2. Children over 1 year of age are allowed to double the dosage.
3. At the age of 5–12 years, 10–20 ml of suspension per dose or 1–2 tablets of the drug up to 4 times a day are allowed.

Adults can take the medicine 1-2 tablets as many times a day as necessary. The maximum recommended dose is 80 mg. With reduced liver function, the dosage should be reduced by 1.5–2 times. The drug does not harm those suffering from renal failure and is approved for use, since metabolites are excreted in the urine in an insignificant amount. No dose adjustment is required in such cases.

Indications for use of Motilium

The medicine is used to eliminate nausea and vomiting caused by organ pathologies, diseases, dietary errors, and the use of medications.

Since Motilium eliminates food stagnation in the stomach and enhances intestinal motility, it can be used to eliminate:

• heartburn;
• belching;
• nausea;
• vomiting;
• feeling bloated and full after meals;
• flatulence;
• epigastric pain.

Tablets are used in children weighing more than 35 kg and adults, suspension - in small children.

Side effects and interactions

When treating with Motilium, caution should be exercised when using antacids and agents that reduce secretory activity. It is recommended to separate them by time.

The simultaneous use of antifungal drugs, some drugs against HIV infection and macrolides contributes to the prolonged presence of Motilium in the blood. This is important to consider for people with impaired liver and endocrine system functions.

Most patients tolerate therapy well. In rare cases, the drug may cause menstrual irregularities or gynemastia due to changes in prolactin levels in women.

In case of an overdose, spasms in the intestinal area, loss of appetite, drowsiness, and an unpleasant taste in the mouth are likely to occur.

Analogues of Motilium

The medicine is used to eliminate many dyspeptic symptoms. The cost of 30 tablets is quite high. For an adult they last up to 10 days. Motilium substitutes differ in active substances, pharmacological group, and indications. Depending on the symptoms and cause, the following groups may be prescribed:

• enzyme preparations;
• synonyms – analogues according to INN;
• antidiarrheals;
• antacids;
• antispasmodics;
• sorbents;
• agents that regulate intestinal motility.

The choice of a cheap Motilium substitute should be entrusted to a gastroenterologist to determine the cause of dyspepsia and comprehensive treatment.

Motilium and structural analogues can be used on their own for up to 28 days without a doctor’s prescription, provided there are no side effects or worsening of the condition.

List of analogues on the Russian market with approximate prices

Synonyms

Motilium is presented in syrup for young patients and tablets for older children and adults. A synonym or analogue for the active substance in the form of a suspension based on domperidone is the Indian drug Motinorm. It is rarely found in pharmacies, it has been allowed since the year.

The drugs differ in technology and manufacturer, frequency of side effects and price. The high cost of Motilium is explained by the high costs of development and clinical research.

How to replace Motilium if treatment with the drug is not affordable:

• Passengers;
• Domperidone;
• Motonium;
• Motilak.

The difference between Passazhix and other synonyms is the convenient and fast-acting form of chewable tablets.

Enzyme preparations

If dyspeptic symptoms are associated with insufficient secretion of enzymes, Motilium can be replaced with a drug from this group.

Representatives:

• Pancreatin;
• Creon;
• Mezim;
• Enzistal;
• Festal;
• Hermital;
• Panzinorm et al.

Medicines compensate for the lack of enzymes necessary for the digestion and absorption of food and eliminate dyspeptic symptoms. Disadvantage: with constant use and abuse, the synthesis of enzymes in the body is disrupted.

Antacids

Drugs in this group are used for heartburn and stomach pain. They envelop the gastric mucosa, protecting against the negative effects of hydrochloric acid and other irritants.

Representatives:

• Maalox;
• Rennie;
• Phosphalugel;
• Gaviscon;
• Gastal et al.

Some medications can cause constipation.

Motilium analogues from the antacid group are used for symptomatic relief of heartburn, they do not treat it.

Duspatalin

Manufacturer: Mylan or Veropharm, Russia or Korea
Release form: tablets, capsules

Active ingredient: mebeverine

Synonyms: Niaspam, Sparex, Mebeverine

The medicine in tablets and capsules Duspatalin is used for pain and cramps in the intestines. The main component of the analogue is mebeverine. The product normalizes peristalsis and treats irritable bowel syndrome. This is a condition characterized by pain, stool disturbance, changes in its frequency, and flatulence. Not used in pediatrics.

The drug No-spasm has a similar effect to Duspatalin.

Smecta

Manufacturer: Bofur Ipsen Industry, France
Release form: powder or suspension

Active ingredient: dioctahedral smectite

Synonyms: Diosmectite, Neosmectin, Endosorb

Smecta is an analogue of Motilium in suspension or powder for its preparation, suitable for adults and children. Belongs to the group of antidiarrheal drugs. Acts in the lumen of the small intestine. This analogue of Motilium for children in suspension adsorbs bacteria, viruses, toxins, and allergens that cause diarrhea on the surface.

The advantage of Smecta is its low price, the disadvantage is its unpleasant taste.

Espumisan

Manufacturer: Berlin-Chemie, Germany
Release form: capsules, solution in drops

Active ingredient: simethicone

Synonyms: Bobotik, Sub Simlex, Simethicone with fennel, Espumisan extra

An analogue of Motilium syrup and tablets is the drug Espumisan, which is classified as a carminative. When it enters the gastrointestinal tract, it collapses gas bubbles and is excreted unchanged.

The imported analogue is used to eliminate bloating, flatulence, and colic in newborns. It is actively prescribed before examining the abdominal organs for accurate x-ray diagnostics.

The advantage of Espumisan is safety, possibility of use from the first days of life, small capsule size. The latter form can be swallowed without drinking water.

Enterofuril

Manufacturer: Bosnalek, Bosnia and Herzegovina
Release form: capsules, syrup

Active ingredient: nifuroxazide

Synonyms: Nifuroxazide, Elufor, Mirofuril, Ecofuril, Contrdiar, Nifural, Adisorb, Stopdiar

The drug Enterofuril is used to treat bacterial diarrhea. Belongs to the group of nitrofurans, antimicrobial agents. It can be used in the form of syrup from a month onwards and has a pleasant banana taste. The effect of the medicine occurs on the first day after use.

Other antidiarrheal drugs:

• Imodium (Russian analogue – Loperamide);
• Enterosgel;
• Polysorb;
• Furazolidone and others.

Motilium or Cerucal

Manufacturer: Merkle or Pliva, Germany or Croatia
Release form: tablets, injection solution

Active ingredient: metoclopramide

Medicines Cerucal and Motilium are antiemetics.

Cerucal is a prescription drug in tablets and ampoules, used for nausea and vomiting as prescribed by a doctor. Has many side effects. The cost of this analogue of Motilium is low - 100 tablets 120–160 rubles.

Motilium is prescribed not only for nausea and vomiting, but also for the treatment and relief of dyspeptic disorders. Available in suspension and regular and dispersible tablets.

Analogs have antiemetic properties and differ in composition and scope of application. In emergency cases, with nausea and vomiting, Cerucal is better for children and adults; for bloating, heaviness and heartburn, Motilium is more effective. Both analogues are imported.

Motilium or Domperidone – which is better?

Manufacturer: Alsi Pharma, Ozon, Russia
Release form: tablets

Active ingredient: domperidone

Domperidone and Motilium - drugs with the same composition, are synonymous. They have the same indications, contraindications, and side effects.

A significant disadvantage of the domestic analogue of Domperidone is the low quality of raw materials (from India or China) and the frequent occurrence of side effects. The cost of the substitute is several times lower.

Another difference between Domperidone and Motilium is the release form. Pharmacies stock only regular tablets; the imported analogue is presented in display cases as dispersible tablets and syrup for children.

Motilium or Motilak – which is better?

Manufacturer: Veropharm, Russia
Release form: tablets

Active ingredient: domperidone

Both drugs are used to restore gastrointestinal contractility. Eliminate abdominal pain, heartburn, bloating, heaviness in the abdomen and nausea. There is only one active ingredient – ​​domperidone.

The difference between drugs is in the form of release, manufacturer and pricing policy. Motilium is a regular and orally soluble tablet and suspension. Motilak is available in film-coated tablets. The cost of the second one is lower.

Motilium and Motilak are synonyms. However, for the quality, variety of release forms and the ability to use the express formula in early childhood, many patients and doctors prefer Motilium. The quality and effectiveness have been confirmed by clinical studies, on the basis of which the instructions have been compiled.

Motilium in syrup is better for a child. If the weight is more than 35 kg, you can replace it with an analogue - Motilak.

Motilium or Trimedat

Manufacturer: Valenta Pharm, Russia
Release form: tablets

Active ingredient: trimebutine

Synonyms: Neobutin, Neobutin retard, Trimedat forte

For GERD, Motilium or Trimedat may be prescribed. The first medicine has an antiemetic effect and regulates gastrointestinal motility. The second drug can replace Motilium for adults. Refers to antispasmodics that normalize intestinal motility.

The analogue of Motilium Trimedat is cheaper and is prescribed for children from 3 years of age. Indications: reflux disease, dyspeptic disorders, impaired intestinal motility (increased or decreased).

The drugs have similar actions, but different composition and mechanism. In each individual case, the choice is made based on the characteristics of the disease.

Motilium analogues are drugs from different pharmacological groups: antispasmodics, gastrointestinal motility regulators, antidiarrheals, sorbents, antacids, enzyme preparations. To make the right choice, consult your doctor for a diagnosis and determine the cause of the condition.

Motilium or Ganaton - which is better?

Manufacturer: Mylan, Japan
Release form: tablets

Active ingredient: itopride

Synonyms: Itomed, Retch, Itopra

An analogue of Motilium tablets is the Japanese drug Ganaton, often prescribed for GERD, and has positive reviews from doctors and patients. The medicine belongs to the group of stimulants of gastrointestinal motility and stimulators of acetylcholine release. Age limit – up to 16 years. Prescribed for dyspeptic symptoms and gastrointestinal motility disorders (reflux).

Motilium is available in additional forms - soluble tablets and syrup, and is used in pediatrics. It also affects intestinal motility and eliminates dyspeptic disorders.

The choice of medication and form is discussed with the doctor based on the diagnosis, symptoms, concomitant diseases, and restrictions.